No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
110 |
4. Check minimum number of eventsNone |
110 |
5. Include endpointsNone |
110 |
6. Filter based on genotype QC (FinnGen only) |
101 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H92
- Name in latin
- Otorrhoea
Similar endpoints
↥List of similar endpoints to
Otorrhoea
based on the number of shared cases.
Similar with more cases:
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1405 | 620 | 781 |
| Only index persons | 922 | 434 | 488 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 14.43 | 23.40 | 7.15 |
| Only index persons | 38.46 | 44.95 | 32.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 101 | 67 | 34 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 55.50 | 52.62 | 61.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 105
- Matched controls
- 1050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H92.1
ICD-10 Finland
Otorrhoea
+∞
151.4
105
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
11.4
31.9
43
60
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
13.4
26.9
29
29
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
119.5
26.1
27
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
51.1
23.1
27
7
UDC00
NOMESCO Finland
Ear microscopy
23.4
22.9
33
20
H66.0
ICD-10 Finland
Acute suppurative otitis media
7.1
21.5
46
104
H65.3
ICD-10 Finland
Chronic mucoid otitis media
22.8
20.7
30
18
H60.9
ICD-10 Finland
Otitis externa, unspecified
8.9
16.9
24
34
DFF00
NOMESCO Finland
Pure tone audiometry
13.2
13.6
24
23
H66.9
ICD-10 Finland
Otitis media, unspecified
5.5
13.2
32
78
H65.2
ICD-10 Finland
Chronic serous otitis media
28.6
12.9
17
7
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
24.6
11.0
15
7
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
+∞
10.6
10
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
29.3
10.1
13
5
H04
ICPC
Ear discharge
15.5
10.1
16
12
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
60.8
9.8
11
*
DC1AD
NOMESCO Finland
Temporalbone CT
109.5
9.6
10
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
109.5
9.6
10
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
109.5
9.6
10
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.6
9.0
19
40
H71
ICD-10 Finland
Cholesteatoma of middle ear
54.7
8.8
10
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
14.5
8.7
14
11
H65.0
ICD-10 Finland
Acute serous otitis media
12.3
8.6
15
14
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
8.4
8
*
H92.0
ICD-10 Finland
Otalgia
7.2
8.0
19
31
TDA90
NOMESCO Finland
Removal wax from ear
48.8
7.8
9
*
DCD00
NOMESCO Finland
Myringoplasty
85.9
7.5
8
*
DFF15
NOMESCO Finland
Speech audiometry
32.5
7.3
9
*
DAX08
NOMESCO Finland
Fitting of hearing aid
32.5
7.3
9
*
R02
ICPC
Shortness of breath/dyspnoea
3.8
6.5
23
73
H60.8
ICD-10 Finland
Other otitis externa
12.1
6.5
11
10
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
6.3
6
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
+∞
6.3
6
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
6.3
6
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.9
6.3
21
64
ZXA10
NOMESCO Finland
Bilateral
3.2
6.0
29
112
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
135
3.25
6.82
2.5
2.1
—
—
—
0
0
26
103
3.03
5.12
2.2
1.9
—
—
—
0
0
25
105
2.81
4.40
2.3
2.0
—
—
—
0
0
8
10
8.54
4.14
3.3
4.9
—
—
—
0
0
6
5
12.60
3.81
1.0
1.0
118.17
90.60
%
—
6
5
77
564
2.37
3.76
8.8
11.1
4.06
3.96
e9/l
0.17
66
479
7
9
8.23
3.61
3.3
5.3
9.71
6.44
%
—
7
9
6
6
10.50
3.54
1.2
1.0
—
—
—
0
0
6
6
10.50
3.54
1.2
1.0
—
—
—
0
0
6
6
10.50
3.54
1.2
1.0
—
—
—
0
0
6
6
10.50
3.54
1.2
1.0
—
—
—
0
0
30
153
2.35
3.51
5.0
3.4
529.59
385.05
ng/l
0.16
20
115
54
350
2.12
3.50
2.6
2.0
100.12
96.65
pmol/l
0.18
34
172
46
290
2.04
3.12
1.4
1.6
1.96
2.49
u/ml
—
9
59
10
27
3.98
2.97
1.9
2.2
—
—
—
0
0
7
13
5.68
2.92
1.3
1.4
—
—
—
0
0
7
13
5.68
2.92
1.3
1.4
—
—
—
0
0
7
13
5.68
2.92
1.3
1.4
—
—
—
0
0
14
55
2.78
2.74
1.6
1.7
—
—
—
0
0
8
19
4.47
2.74
1.4
1.5
—
—
—
0
0
9
25
3.84
2.64
1.4
2.6
—
—
—
0
0
84
680
2.18
2.62
5.8
4.3
13.38
11.71
mm/h
0.47
79
633
10
31
3.45
2.60
1.9
1.1
—
—
—
0
0
9
26
3.69
2.55
2.3
2.2
—
—
—
0
0
82
671
2.01
2.30
9.1
7.6
78.64
91.30
u/l
1.55
77
629
38
248
1.83
2.19
4.1
3.4
1056.71
1255.67
ng/l
0.17
33
208
61
478
1.66
1.74
15.7
8.2
1.23
1.22
mmol/l
0.78
55
421
5
13
3.98
1.73
2.4
1.2
—
—
—
0
0
10
40
2.65
1.72
2.1
1.5
0.25
0.24
g/l
—
10
40
10
41
2.59
1.70
2.1
1.5
1.33
1.22
g/l
—
10
41
8
32
2.62
1.63
2.9
1.9
—
—
—
0
0
5
14
3.69
1.63
2.4
1.7
—
—
—
0
0
97
889
2.19
1.52
26.4
15.4
17.20
24.51
mg/l
1.70
83
703
42
309
1.60
1.48
5.4
3.8
17.09
31.72
ng/l
1.21
23
215
99
919
2.35
1.40
29.4
18.8
74.60
70.15
umol/l
0.74
99
904
6
24
2.59
1.32
1.8
1.3
—
—
—
0
0
5
18
2.86
1.30
2.6
1.6
—
—
—
0
0
71
602
1.55
1.27
3.7
3.2
—
—
—
0
0
14
79
1.89
1.24
2.2
1.5
—
—
—
0
0
23
152
1.66
1.22
5.5
2.7
11.65
13.60
umol/l
0.91
23
142
19
119
1.73
1.22
1.5
1.7
856.14
1064.80
nmol/l
0.44
14
96
61
507
1.48
1.16
6.1
4.1
0.00
0.00
estimate
-0.00
11
107
37
278
1.51
1.15
5.0
3.9
28.30
13.16
mg/mmol
0.42
25
174
50
400
1.48
1.15
2.8
3.0
—
—
estimate
—
0
0
60
498
1.48
1.14
6.1
4.0
0.00
0.00
estimate
—
9
112
20
130
1.67
1.13
5.7
2.9
19.55
23.17
%
0.91
20
124
30
216
1.54
1.13
4.1
3.6
1.02
1.02
kg/l
0.94
19
154
12
67
1.89
1.10
2.1
1.4
—
—
—
0
0
60
501
1.46
1.09
6.1
4.1
0.00
0.00
estimate
—
10
110
28
201
1.54
1.06
3.4
2.5
1.53
1.72
mg/l
0.07
22
159
28
203
1.52
1.02
2.5
3.0
—
—
—
0
0
36
276
1.46
1.00
6.9
3.8
0.00
0.00
estimate
-0.00
11
103
45
367
1.40
0.88
6.3
3.8
0.00
0.00
estimate
—
8
92
15
98
1.62
0.84
11.2
5.9
-0.41
1.65
mmol/l
—
9
79
16
108
1.57
0.79
17.6
9.2
13.64
11.95
kpa
0.45
16
102
16
108
1.57
0.79
17.7
9.2
4.79
5.14
kpa
0.69
16
102
16
108
1.57
0.79
17.7
9.3
-1.30
0.91
mmol/l
0.82
16
88
20
143
1.49
0.77
6.1
2.8
2.28
2.37
g/l
0.40
20
132
5
23
2.23
0.77
2.6
1.5
—
—
—
0
0
5
23
2.23
0.77
2.2
1.2
—
—
—
0
0
16
109
1.55
0.76
2.5
2.4
—
—
—
0
0
5
24
2.14
0.75
2.2
1.6
48.20
37.88
nmol/l
—
5
24
5
25
2.05
0.73
2.0
1.1
—
—
—
0
0
5
25
2.05
0.73
7.2
2.6
128.20
135.63
g/l
—
5
19
81
742
1.40
0.70
23.6
15.1
78.26
82.13
ml/min/173m2
0.81
76
676
5
29
1.76
0.64
2.6
1.4
—
—
—
0
0
10
63
1.65
0.64
2.3
2.3
—
—
—
0
0
80
738
1.35
0.61
4.7
4.3
1.31
1.21
mmol/l
0.84
74
675
5
86
0.56
0.59
10.4
4.6
2.48
11.28
ug/l
—
5
73
75
807
0.75
0.59
29.9
19.5
13.77
13.52
%
1.21
75
801
14
99
1.48
0.57
2.4
2.4
—
—
—
0
0
30
245
1.31
0.55
2.4
1.8
—
—
—
0
0
9
64
1.44
0.53
2.9
2.5
8.64
10.44
nmol/l
—
9
54
84
787
1.34
0.52
25.6
20.4
332.88
332.14
g/l
0.29
84
787
20
155
1.36
0.52
1.1
1.2
1.28
8.67
u/ml
—
5
52
11
77
1.48
0.48
3.5
3.3
—
—
—
0
0
8
55
1.49
0.44
2.6
2.2
—
—
—
0
0
16
124
1.34
0.42
18.5
9.7
106.25
104.52
mmol/l
0.69
16
124
0
16
0.00
0.41
0.0
2.8
—
17.72
—
0
16
31
264
1.25
0.41
6.8
3.6
0.00
0.00
estimate
—
7
92
87
827
1.30
0.41
7.0
5.4
1.82
1.99
mu/l
0.87
82
767
0
17
0.00
0.41
0.0
5.3
—
5.92
—
0
17
5
34
1.49
0.41
4.2
2.0
—
—
—
0
0
83
786
1.27
0.39
5.6
5.0
1.48
1.51
mmol/l
0.22
78
722
83
787
1.26
0.38
5.8
5.1
4.62
4.61
mmol/l
0.02
78
729
6
88
0.66
0.34
1.2
2.9
26.83
30.73
u/l
—
6
73
19
157
1.26
0.32
4.6
4.7
26.33
22.20
%
—
7
82
7
52
1.37
0.32
7.1
5.1
43.00
43.99
%
—
7
52
7
53
1.34
0.31
3.6
3.7
4.37
4.91
pmol/l
—
7
48
16
193
0.80
0.30
3.9
3.8
1.42
0.82
e6/l
—
9
106
9
74
1.24
0.26
16.9
4.7
1.22
1.23
mmol/l
—
9
67
10
78
1.31
0.25
11.8
5.8
22.57
24.50
mmol/l
—
10
78
83
800
1.18
0.23
6.9
5.8
2.70
2.67
mmol/l
0.12
78
737
10
123
0.79
0.21
3.6
3.4
0.55
0.73
ug/l
—
10
83
0
11
0.00
0.21
0.0
4.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
62.37
—
0
5
0
10
0.00
0.21
0.0
3.9
—
0.50
—
0
10
6
47
1.29
0.21
1.2
1.3
—
—
—
0
0
6
49
1.24
0.20
2.7
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
4.9
—
95.55
—
0
14
6
52
1.16
0.19
3.3
5.0
1.35
1.26
%
—
6
52
6
52
1.16
0.19
2.3
2.3
17.55
19.01
iu/l
—
6
37
14
119
1.20
0.19
18.6
11.9
23.76
25.17
mmol/l
0.51
14
119
10
87
1.17
0.10
3.6
6.7
—
—
—
0
0
9
84
1.08
0.07
1.1
1.1
—
—
—
0
0
19
180
1.07
0.04
4.7
4.0
3.33
3.18
e6/l
0.03
12
95
30
304
0.98
0.00
8.4
4.1
0.63
0.35
e6/l
0.34
24
231
14
141
0.99
0.00
1.9
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
213.40
—
0
5
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
13.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
0.31
—
0
6
0
5
0.00
-0.00
0.0
2.4
—
4.44
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.31
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
10.66
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
10.53
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTORRHOEA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTORRHOEA | 1.491 [1.02, 2.18] | 0.04 |
| Birth year | 0.997 [0.99, 1.01] | 0.447 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 558 females with H8_OTORRHOEA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTORRHOEA | 1.271 [0.9, 1.79] | 0.173 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 707 males with H8_OTORRHOEA died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTORRHOEA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.25% |
| 5 | 1.008% | 1.486% |
| 10 | 2.378% | 3.85% |
| 15 | 4.442% | 7.101% |
| 20 | 8.02% | 11.758% |
Relationships between endpoints
↥Index endpoint: H8_OTORRHOEA – Otorrhoea
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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