Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
80 |
4. Check minimum number of eventsNone |
80 |
5. Include endpointsNone |
80 |
6. Filter based on genotype QC (FinnGen only) |
68 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H74
- Name in latin
- Aliae abnormitates acquisitae ossiculorum auditoriorum
Similar endpoints
↥List of similar endpoints to
Abnormalities of ear ossicles
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 581 | 315 | 265 |
| Only index persons | 568 | 307 | 261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 47.99 | 48.47 | 47.44 |
| Only index persons | 47.28 | 47.17 | 47.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 68 | 44 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 51.04 | 49.46 | 53.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
102.0
71
*
UDC00
NOMESCO Finland
Ear microscopy
17.8
29.9
30
28
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
125.8
24.5
25
*
DFF00
NOMESCO Finland
Pure tone audiometry
12.6
23.1
29
37
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
22.0
20
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
9.7
19.1
30
50
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
54.5
17.4
20
5
H80.9
ICD-10 Finland
Otosclerosis, unspecified
109.7
16.4
17
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
73.1
15.6
17
*
DDA00
NOMESCO Finland
Stapedotomy
101.4
15.3
16
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
14.0
13
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
14.0
13
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
12.9
12
*
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
11.8
11
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
11.8
11
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
71.0
11.0
12
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
10.7
10
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
12.3
10.0
18
19
DFF15
NOMESCO Finland
Speech audiometry
15.5
10.0
16
13
DAX08
NOMESCO Finland
Fitting of hearing aid
11.1
9.5
18
21
ZXC10
NOMESCO Finland
Use of laser
17.3
8.6
13
9
DDW99
NOMESCO Finland
Other operation on ossicles of ear
+∞
8.5
8
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
8.5
8
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
25.6
8.3
11
5
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
7.4
7
*
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
+∞
7.4
7
*
YPA00
NOMESCO Finland
Excision of blood vessel for transplantation
+∞
7.4
7
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.5
6.9
21
61
Z97.4
ICD-10 Finland
Presence of external hearing-aid
10.0
6.4
12
14
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
6.3
6
*
DCA30
NOMESCO Finland
Exploration of middle ear
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
6
15
4.26
2.08
1.5
2.3
—
—
—
0
0
5
20
2.61
1.17
1.4
1.5
—
249.09
—
0
11
12
195
0.54
1.13
2.8
2.1
130.92
148.02
u/l
0.14
12
186
13
202
0.56
1.04
2.1
3.5
0.00
0.00
estimate
—
5
63
20
271
0.64
0.90
3.0
3.8
0.00
0.00
estimate
—
5
65
59
528
1.69
0.86
20.4
20.3
333.93
331.42
g/l
1.60
59
528
5
91
0.52
0.73
20.2
7.4
103.40
103.97
mmol/l
—
5
91
15
208
0.65
0.72
3.7
3.6
0.00
0.00
estimate
—
5
70
0
20
0.00
0.61
0.0
2.6
—
—
—
0
0
20
254
0.70
0.60
3.4
3.5
20.91
32.93
ng/l
0.49
11
177
30
356
0.73
0.60
3.1
3.9
0.00
0.00
estimate
—
5
77
6
35
1.78
0.59
3.0
2.2
176.00
297.72
ng/l
—
6
30
30
355
0.73
0.58
3.2
3.9
0.00
0.00
estimate
—
5
79
11
153
0.67
0.53
2.7
2.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
2.6
—
98.80
—
0
9
19
230
0.76
0.40
3.2
4.0
9.64
11.50
mg/mmol
0.10
13
146
33
290
1.26
0.37
2.6
3.0
—
—
estimate
—
0
0
11
83
1.38
0.34
2.9
6.7
1.21
1.04
mmol/l
0.83
11
77
14
112
1.31
0.31
1.1
1.5
—
—
—
0
0
33
365
0.82
0.30
3.2
3.9
0.00
0.00
estimate
—
5
77
34
371
0.84
0.25
6.1
4.9
6.70
6.66
mmol/l
0.03
29
343
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
3.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
5.3
—
62.13
—
0
13
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
8
69
1.18
0.17
6.9
7.0
—
—
—
0
0
6
77
0.76
0.16
1.2
1.6
—
—
—
0
0
32
298
1.13
0.15
2.7
3.2
106.67
114.96
ug/l
0.09
32
272
21
231
0.87
0.15
2.8
3.2
—
—
—
0
0
15
132
1.17
0.14
3.3
3.6
334.50
241.29
ng/l
—
10
96
15
169
0.86
0.14
1.7
2.1
1.94
2.98
mg/l
1.30
15
148
12
134
0.87
0.09
1.3
1.7
411.17
509.99
pmol/l
0.75
12
108
5
48
1.04
0.09
1.8
1.5
—
—
—
0
0
6
70
0.84
0.08
1.7
2.3
—
—
—
0
0
6
74
0.79
0.08
1.3
1.7
—
—
—
0
0
12
108
1.13
0.08
2.3
3.4
0.84
0.81
mmol/l
0.30
12
101
27
283
0.93
0.06
1.5
2.0
91.33
102.97
pmol/l
—
10
131
11
101
1.11
0.04
1.3
1.8
—
—
—
0
0
15
141
1.08
0.04
6.1
5.0
17.56
22.71
%
—
7
64
51
502
1.06
0.02
3.7
4.5
11.63
11.93
mm/h
0.04
46
460
11
104
1.07
0.01
2.6
3.3
0.77
0.84
e6/l
—
6
55
17
176
0.96
0.00
2.2
2.9
344.76
336.55
umol/l
0.13
17
149
23
233
0.98
0.00
9.5
3.7
28.91
32.08
u/l
0.39
23
217
13
126
1.04
0.00
2.1
1.8
—
—
—
0
0
18
181
0.99
0.00
2.6
3.1
1666.62
927.75
ng/l
0.41
13
150
13
129
1.01
0.00
1.2
1.4
1.26
12.23
u/ml
—
7
57
40
404
0.98
0.00
3.1
3.1
—
—
—
0
0
31
314
0.98
0.00
6.9
7.9
1.19
1.21
mmol/l
0.74
26
274
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
55.50
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
103.14
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
13.95
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
64
637
1.05
-0.00
14.8
15.6
27.33
21.93
mg/l
0.62
53
509
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
4.20
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
11.17
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
144.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
-0.00
2.3
1.7
1.48
1.31
%
—
9
73
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.7
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.31
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
1.0
—
119.40
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H8_OSSICABN and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_OSSICABN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_OSSICABN – Abnormalities of ear ossicles
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data