tympanic membrane disease: A disease involving the tympanic membrane.
Other specified/unspecified disorders of tympanic membrane
H8_MYRINGNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
156 |
4. Check minimum number of eventsNone |
156 |
5. Include endpointsNone |
156 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified disorders of tympanic membrane
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1266 | 625 | 640 |
| Only index persons | 1097 | 546 | 551 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 23.61 | 27.60 | 19.73 |
| Only index persons | 30.17 | 35.67 | 24.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 73 | 65 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 59.57 | 55.58 | 64.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 145
- Matched controls
- 1450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
109.8
91
*
UDC00
NOMESCO Finland
Ear microscopy
19.7
66.8
64
56
H73.9
ICD-10 Finland
Disorder of tympanic membrane, unspecified
+∞
57.1
51
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
17.5
51.6
49
41
DFF00
NOMESCO Finland
Pure tone audiometry
10.9
39.9
54
75
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
37.1
34
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
9.0
35.5
58
100
H66.9
ICD-10 Finland
Otitis media, unspecified
14.6
34.9
35
31
H65.3
ICD-10 Finland
Chronic mucoid otitis media
344.1
28.8
28
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
172.0
27.7
28
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
23.6
22
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
23.6
22
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
7.9
20.6
32
50
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.5
14.5
45
132
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
47.8
14.5
17
*
DC1AD
NOMESCO Finland
Temporalbone CT
55.3
13.1
15
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
76.8
12.8
14
*
H73.0
ICD-10 Finland
Acute myringitis
76.8
12.8
14
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
12.7
12
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
12.7
12
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
41.4
12.5
15
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
11.6
11
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
11.6
11
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.8
10.7
21
41
H60.3
ICD-10 Finland
Other infective otitis externa
13.6
10.2
17
14
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
43.3
10.1
12
*
R01AD08
ATC
fluticasone; nasal
3.2
10.0
58
251
4122
FHL
Tympanostomy (tympanic tube)
+∞
9.5
9
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
9.5
9
*
DFF15
NOMESCO Finland
Speech audiometry
7.8
8.9
20
29
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
95.4
8.5
9
*
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
+∞
8.4
8
*
H65.0
ICD-10 Finland
Acute serous otitis media
35.5
8.2
10
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.8
8.0
95
586
H04
ICPC
Ear discharge
11.8
8.0
14
13
H01
ICPC
Ear pain/earache
3.6
7.9
30
99
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
47.6
7.8
9
*
WX720
NOMESCO Finland
Own respiration
7.2
7.7
18
28
H92.0
ICD-10 Finland
Otalgia
6.5
7.5
19
33
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
7.3
7
*
H61.2
ICD-10 Finland
Impacted cerumen
4.3
7.0
19
49
H60.8
ICD-10 Finland
Other otitis externa
7.8
6.9
15
21
DAX08
NOMESCO Finland
Fitting of hearing aid
4.4
6.9
18
45
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
23.8
6.8
9
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
10.8
6.7
12
12
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
8.0
6.6
14
19
TDA90
NOMESCO Finland
Removal wax from ear
15.2
6.5
10
7
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
72.9
6.5
7
*
3848X
ICD-9 Finland
Other disorders of tympanic membrane, Other specified disorders of tympanic membrane
+∞
6.3
6
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
6.3
6
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.5
6.2
52
263
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
238
2.22
4.34
5.5
4.1
509.26
354.78
ng/l
0.17
31
179
53
310
2.12
4.29
6.4
3.8
1.02
1.02
kg/l
0.34
41
200
85
630
1.84
3.20
3.6
3.0
112.26
104.52
ug/l
0.17
79
588
62
430
1.77
2.81
4.8
4.1
2.38
13.57
mg/mmol
3.78
43
265
28
150
2.07
2.76
7.6
8.2
1.32
0.98
mmol/l
0.34
21
128
5
8
6.42
2.39
2.0
2.0
13.46
13.50
%
—
5
8
26
151
1.88
2.04
9.3
8.1
5.10
5.08
kpa
0.08
26
146
70
543
1.56
1.86
5.5
3.7
0.00
0.01
estimate
—
10
136
58
434
1.56
1.80
6.3
3.3
2.34
2.36
mmol/l
1.14
53
389
112
974
1.66
1.77
6.6
4.4
14.48
14.73
pmol/l
0.57
103
887
6
18
3.43
1.76
5.8
2.2
14.00
10.06
mmol/l
—
6
18
69
541
1.53
1.71
2.7
1.9
1.29
1.29
mmol/l
0.01
63
452
129
1173
1.90
1.65
7.4
5.4
1.94
1.94
mu/l
0.01
122
1076
10
44
2.37
1.59
1.3
2.0
—
—
—
0
0
70
558
1.49
1.57
2.2
2.0
95.99
98.44
pmol/l
0.21
37
297
31
206
1.64
1.55
1.9
1.8
—
—
—
0
0
30
198
1.65
1.54
2.0
2.1
27.95
29.56
s
0.89
30
193
5
15
3.41
1.53
1.0
1.1
—
—
—
0
0
77
631
1.47
1.48
14.5
7.6
1.21
1.21
mmol/l
0.03
71
557
51
385
1.50
1.47
2.1
2.3
109.15
313.73
u/l
0.67
46
369
85
711
1.47
1.46
5.5
3.9
0.00
0.03
estimate
—
10
145
9
39
2.39
1.46
1.7
1.6
—
0.01
—
0
9
36
253
1.56
1.43
1.1
1.3
9.11
31.23
iu/ml
2.63
12
78
84
706
1.45
1.38
5.5
3.9
0.00
0.00
estimate
-0.00
11
156
118
1062
1.60
1.37
31.2
20.0
334.31
332.68
g/l
1.57
118
1057
9
43
2.16
1.33
1.2
1.7
—
—
—
0
0
45
338
1.48
1.32
2.5
2.3
2.36
2.80
mg/l
0.72
39
299
90
772
1.44
1.29
7.8
5.0
6.84
6.68
mmol/l
0.27
84
720
15
85
1.85
1.28
1.5
1.6
—
—
—
0
0
52
404
1.45
1.28
4.8
3.5
0.00
0.01
estimate
0.50
11
127
60
479
1.43
1.27
3.7
3.9
42.33
34.33
ng/l
0.20
38
341
82
697
1.41
1.20
5.5
3.8
0.00
0.00
estimate
-0.00
11
158
27
187
1.55
1.14
7.1
7.7
104.04
103.78
mmol/l
0.10
27
187
23
154
1.59
1.12
2.0
1.7
—
—
—
0
0
46
357
1.42
1.12
6.1
4.9
20.95
21.45
%
0.07
20
181
7
31
2.32
1.12
1.3
2.1
134.43
129.21
g/l
—
7
24
27
190
1.52
1.07
1.6
1.4
—
—
—
0
0
126
1172
1.57
1.03
7.7
6.3
39.38
39.13
mmol/mol
0.12
120
1106
13
78
1.73
0.95
6.0
3.6
4.50
4.59
pmol/l
0.10
13
69
138
1322
1.91
0.93
26.0
20.3
79.85
76.39
umol/l
0.34
138
1307
47
377
1.36
0.93
1.7
1.6
21.20
21.73
nmol/l
0.09
39
316
26
189
1.46
0.89
2.0
1.7
936.54
1166.37
nmol/l
0.81
21
149
127
1192
1.53
0.89
6.2
5.1
5.97
5.94
mmol/l
0.10
117
1106
36
280
1.38
0.86
1.4
1.6
—
—
—
0
0
6
33
1.85
0.80
1.3
1.2
—
—
—
0
0
8
132
0.58
0.78
2.5
2.9
20.00
30.79
u/l
—
8
112
137
1316
1.74
0.78
16.1
12.4
28.43
26.02
u/l
0.92
132
1287
5
24
2.12
0.75
1.2
1.2
—
—
—
0
0
7
38
1.88
0.75
1.1
1.4
—
—
—
0
0
33
261
1.34
0.71
1.8
1.7
267857575.79
476.49
pmol/l
0.49
28
219
35
281
1.32
0.68
1.9
1.7
0.75
1.44
mg/l
1.36
26
220
90
818
1.26
0.66
3.2
2.9
—
—
—
0
0
20
149
1.40
0.62
2.2
1.7
—
—
—
0
0
69
612
1.24
0.61
3.0
2.9
—
—
estimate
—
0
0
0
20
0.00
0.61
0.0
1.8
—
—
—
0
0
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
5
90
0.54
0.57
1.2
1.4
—
—
—
0
0
6
36
1.69
0.57
1.5
1.5
—
—
—
0
0
93
859
1.23
0.54
3.9
3.6
77.01
49.27
u/l
0.53
88
821
131
1261
1.40
0.52
20.0
15.3
20.26
23.09
mg/l
0.48
114
1028
6
40
1.52
0.52
1.2
1.9
24.33
24.78
mmol/l
—
6
40
6
40
1.52
0.52
1.2
1.5
—
—
—
0
0
12
86
1.43
0.46
1.7
1.2
105.27
391.71
u/ml
0.78
12
79
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
14
106
1.36
0.41
10.0
4.2
100.57
80.63
ng/l
0.19
14
96
26
216
1.25
0.40
2.8
3.0
2.82
2.37
e6/l
0.12
17
113
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
33
381
0.83
0.39
3.3
3.2
0.18
0.54
e6/l
1.00
27
281
39
341
1.20
0.38
1.3
1.3
0.75
1.82
u/ml
—
8
92
9
70
1.30
0.37
3.8
2.9
0.87
1.16
%
—
9
70
6
46
1.32
0.33
1.5
1.3
—
—
—
0
0
6
46
1.32
0.33
4.2
2.5
—
—
—
0
0
19
156
1.25
0.33
1.6
1.9
1.47
1.52
%
0.14
19
136
8
66
1.22
0.27
1.4
1.3
—
—
—
0
0
9
73
1.25
0.26
1.0
1.0
—
—
—
0
0
37
337
1.13
0.22
1.7
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
6
48
1.26
0.20
1.2
1.9
—
—
—
0
0
20
175
1.17
0.20
1.8
2.3
—
—
—
0
0
12
143
0.82
0.19
7.7
6.8
—
—
—
0
0
125
1224
1.15
0.19
6.3
5.0
1.41
1.48
mmol/l
1.24
120
1135
111
1080
1.12
0.18
27.3
19.3
13.48
13.53
%
0.19
111
1070
13
110
1.20
0.18
1.6
1.3
—
—
—
0
0
26
235
1.13
0.17
2.7
2.9
0.74
1.10
e6/l
0.82
17
131
122
1197
1.12
0.15
15.2
15.4
81.28
83.90
ml/min/173m2
0.64
113
1101
12
105
1.16
0.11
3.1
2.4
—
—
—
0
0
5
43
1.17
0.10
7.4
2.9
85.84
182.78
mg/l
—
5
37
5
43
1.17
0.10
7.4
2.9
43.12
29.96
mg/l
—
5
37
25
268
0.92
0.10
4.0
3.3
0.82
0.78
ug/l
0.14
18
173
5
46
1.09
0.09
2.8
1.4
28.40
22.91
iu/l
—
5
39
6
54
1.12
0.09
1.0
1.4
—
—
—
0
0
38
398
0.94
0.08
5.1
3.8
0.00
0.00
estimate
-0.00
11
143
13
117
1.12
0.08
2.2
2.5
0.49
0.14
e6/l
0.42
13
112
5
62
0.80
0.08
2.0
2.5
49.40
39.38
u/l
—
5
54
25
235
1.08
0.08
1.3
1.3
7.89
10.53
u/ml
—
10
91
20
187
1.08
0.07
1.9
2.5
—
—
—
0
0
11
121
0.90
0.06
3.5
3.3
4.24
4.35
kpa
0.07
11
115
125
1243
1.04
0.01
7.6
5.8
2.53
2.65
mmol/l
0.86
120
1161
48
478
1.01
0.00
3.3
3.2
—
—
—
0
0
13
135
0.96
0.00
2.5
3.1
—
—
—
0
0
14
135
1.04
0.00
2.4
2.7
0.17
0.22
g/l
1.82
14
129
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.2
1.4
—
13.61
—
0
8
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
6.7
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
0.67
—
0
6
8
80
1.00
0.00
4.1
4.6
25.04
24.06
mmol/l
—
8
80
0
6
0.00
0.00
0.0
3.0
—
215.67
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
92
0.98
-0.00
2.4
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
4.8
3.7
17.33
601.51
u/ml
—
6
55
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
1.13
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.01
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H8_MYRINGNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_MYRINGNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_MYRINGNAS – Other specified/unspecified disorders of tympanic membrane
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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