Other specified/unspecified disorders of middle ear and mastoid

H8_MIDDMASTNAS

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H74.8, H74.9 Hospital discharge: ICD-9 — 385[8-9] Cause of death: ICD-10 — H74.8, H74.9 Cause of death: ICD-9 — 385[8-9] 2 out of 7 registries used, show all original rules.	104
4. Check minimum number of events None	104
5. Include endpoints None	104
6. Filter based on genotype QC (FinnGen only)	92

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	H8_MIDDMASTNAS
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H74[8-9]
HD_ICD_9	385[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H74[8-9]
COD_ICD_9	385[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other specified/unspecified disorders of middle ear and mastoid based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	788	397	384
Only index persons	681	343	338
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	49.36	49.06	49.54
Only index persons	49.00	48.89	49.11

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	92	57	35
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	54.06	51.18	58.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
94: Matched controls
939

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H74.9

ICD-10 Finland

Disorder of middle ear and mastoid, unspecified

663.4

42.7

H74.8

ICD-10 Finland

Other specified disorders of middle ear and mastoid

+∞

35.7

UDC00

NOMESCO Finland

Ear microscopy

10.8

23.1

Z01.1

ICD-10 Finland

Examination of ears and hearing

8.3

22.2

3858X

ICD-9 Finland

Other disorders of middle ear and mastoid

+∞

19.4

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

+∞

13.9

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

11.7

H65.2

ICD-10 Finland

Chronic serous otitis media

+∞

11.7

H65.3

ICD-10 Finland

Chronic mucoid otitis media

123.1

10.6

H66.0

ICD-10 Finland

Acute suppurative otitis media

12.1

10.0

DFF00

NOMESCO Finland

Pure tone audiometry

5.3

9.8

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

110.6

9.6

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

3.8

7.7

103

H92.0

ICD-10 Finland

Otalgia

9.7

7.7

H74.1

ICD-10 Finland

Adhesive middle ear disease

+∞

7.4

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

32.8

7.3

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

43.2

6.9

DC1AD

NOMESCO Finland

Temporalbone CT

74.6

6.5

38100

ICD-8 Finland

Otitis media without mention of mastoiditis, Acute

+∞

6.3

3859X

ICD-9 Finland

Other disorders of middle ear and mastoid, Unspecified disorder of middle ear and mastoid

+∞

6.3

H66.9

ICD-10 Finland

Otitis media, unspecified

8.2

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

2.81

3.91

3.9

1.6

—

(3000494) Fungus identified in Specimen by Culture

2.65

3.40

2.2

1.5

—

(3021440) Promyelocytes/Leukocytes in Blood

2.59

2.65

5.1

3.1

0.00

0.24

—

(3018010) Neutrophils/Leukocytes in Blood

398

1.92

2.42

7.7

5.9

53.16

57.59

1.42

382

(3002030) Lymphocytes/Leukocytes in Blood

401

1.89

2.34

8.5

6.0

30.61

27.57

0.79

381

(3019069) Monocytes/Leukocytes in Blood

394

1.87

2.26

8.5

5.9

8.78

8.55

0.22

370

(3035933) Granulocytes/Leukocytes in Blood

4.49

2.18

7.3

2.6

53.00

60.74

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

135

2.04

2.17

1.4

1.3

1.65

8.17

u/ml

—

(3017181) Myelocytes/Leukocytes in Blood

2.33

2.17

5.1

3.0

0.33

1.25

—

(3022096) Basophils/Leukocytes in Blood

389

1.83

2.14

8.9

5.8

0.59

0.63

0.20

362

(3035715) Granulocytes [#/volume] in Blood

5.20

2.09

5.8

3.0

6.51

5.32

e9/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.15

2.08

1.5

1.8

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.73

1.96

1.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

156

1.92

1.95

1.7

1.9

314286112.90

464.18

pmol/l

0.48

132

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

148

1.94

1.95

1.5

1.3

29.31

36.02

iu/ml

—

(40760892) CBC W Ordered Manual Differential panel - Blood

190

1.85

1.91

6.4

5.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

105

2.01

1.79

1.5

1.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.03

1.76

1.3

1.4

—

(3002179) Metamyelocytes/Leukocytes in Blood

2.17

1.69

5.7

2.9

0.17

0.61

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

276

1.70

1.68

2.5

49.21

69.52

u/l

0.72

262

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

208

1.73

1.61

1.5

1.7

1.82

1.43

mg/l

0.17

169

(3002256) Pathology report gross observation

102

1.94

1.58

1.3

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

106

1.86

1.41

4.9

6.1

1.06

1.07

mmol/l

0.11

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.26

1.38

2.0

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

328

1.57

1.31

2.1

2.0

1.49

1.33

mmol/l

0.55

276

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.87

1.30

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

1.73

1.28

1.7

1.9

—

(42870588) Differential panel, method unspecified - Blood

274

1.58

1.27

9.5

5.1

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

14.21

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.84

0.97

1.3

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.78

0.86

1.5

1.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

332

1.41

0.85

4.1

3.9

19.86

31.37

ng/l

0.70

231

(3015736) pH of Urine

361

1.41

0.85

5.6

4.0

6.14

6.33

0.65

215

(3022621) pH of Urine by Test strip

0.50

0.83

3.8

2.1

6.00

6.07

—

(40768804) Tissue Pathology biopsy report

344

1.40

0.81

2.5

2.2

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.80

0.0

2.0

—

124.06

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.80

0.0

1.8

—

(40768793) Breast Pathology biopsy report

0.00

0.79

0.0

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

627

1.45

0.79

5.1

4.5

14.64

15.09

pmol/l

0.69

573

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.23

0.77

1.2

—

(3042936) Bacteria identified in Isolate by Culture

118

1.54

0.75

3.4

2.1

—

(4035726) Immunohistochemistry procedure

1.70

0.75

1.0

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.05

0.74

1.2

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

740

1.54

0.72

6.3

5.5

1.98

1.91

mu/l

0.24

682

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.62

0.69

3.6

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.62

0.69

3.4

2.1

312.00

388.56

nmol/l

0.53

(40768797) Stomach Pathology biopsy report

112

1.51

0.69

1.1

1.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.65

0.68

5.7

2.0

9.58

10.20

g/l

0.27

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.68

0.68

1.2

1.3

—

(3020891) Body temperature

1.64

0.66

3.6

4.1

37.10

36.95

°c

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

122

1.48

0.65

1.4

1.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.76

0.64

1.2

1.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

123

1.46

0.63

3.9

6.6

103.76

104.22

mmol/l

0.11

123

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

768

1.52

0.62

6.6

5.1

5.87

5.92

mmol/l

0.18

710

(1002224) Polysomnography panel

1.70

0.62

1.0

1.1

—

(4034850) Laboratory test

0.00

0.61

0.0

8.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.52

0.59

2.3

1.3

1.16

1.15

g/l

—

(3009508) Creatinine [Moles/volume] in Urine

278

1.29

0.49

2.4

3.4

7.53

7.54

mmol/l

0.01

232

(40761536) Microorganisms panel - Urine sediment

1.52

0.49

4.6

3.9

—

(3018418) pH of Serum or Plasma

269

1.29

0.48

5.6

4.5

7.39

0.14

200

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

158

1.34

0.46

1.3

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

196

1.30

0.45

2.1

2.3

—

(3019060) Gas panel - Arterial blood

1.49

0.44

3.6

4.5

—

(3049717) Cytology report of Urine Cyto stain

1.64

0.43

1.0

2.5

—

(3019150) Specific gravity of Urine by Refractometry

207

1.28

0.42

8.1

4.6

1.02

kg/l

0.55

145

(3027945) Reticulocytes/Erythrocytes in Blood

106

1.38

0.42

3.5

3.2

1.62

1.77

0.21

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

3.2

—

1.18

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.41

0.0

1.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

3.2

—

106.07

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

3.2

—

3.97

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.5

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.41

0.0

2.9

—

16.22

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

421

1.23

0.40

7.3

1.20

1.21

mmol/l

0.57

363

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.39

0.0

1.3

—

31.63

—

(3012516) Albumin [Mass/volume] in Urine

266

1.24

0.39

2.5

3.3

49.53

66.99

mg/l

0.26

178

(46235355) HIV 1 and 2 tests - Meaningful Use set

153

1.30

0.39

1.6

1.7

—

(3018095) Leukocytes [#/volume] in Urine

334

1.23

0.39

3.6

3.9

59.13

75.42

e6/l

0.12

232

(3020630) Protein [Mass/volume] in Serum or Plasma

1.43

0.38

2.0

2.2

70.00

66.38

g/l

—

(3023368) Bacteria identified in Blood by Culture

229

1.25

0.37

5.5

4.2

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.61

0.37

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.61

0.37

1.4

1.3

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

669

1.25

0.35

30.8

21.7

331.28

g/l

0.00

669

(3002582) Erythrocytes [#/volume] in Urine

299

1.21

0.34

3.1

3.4

49.60

267.45

e6/l

0.48

222

(3030467) Casts [#/volume] in Urine by Automated count

251

1.22

0.34

2.9

3.2

0.12

0.43

e6/l

1.97

177

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

765

1.30

0.33

21.0

16.0

80.20

80.31

ml/min/173m2

0.01

710

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.40

0.32

2.0

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

263

1.20

0.30

7.4

4.4

0.00

estimate

-0.00

(3014051) Protein [Presence] in Urine by Test strip

236

1.20

0.28

4.0

3.3

—

0.00

—

(3032080) INR in Blood by Coagulation assay

395

1.16

0.25

19.0

11.9

1.29

1.22

inr

0.30

326

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

356

1.16

0.24

2.5

2.1

79.07

96.91

pmol/l

2.23

172

(3044640) Blood type and Crossmatch panel - Blood

278

1.17

0.24

2.1

2.2

—

(3013512) EKG study

288

1.17

0.24

3.4

3.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

406

1.16

0.24

2.5

2.7

—

estimate

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.73

0.23

1.9

2.0

—

(3022145) Colonoscopy Study observation

100

0.78

0.22

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.6

—

91.32

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.7

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

350

1.14

0.20

7.4

4.4

0.00

0.01

estimate

0.49

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.20

0.0

2.2

—

2.98

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.20

0.0

1.5

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.20

0.0

2.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.21

0.20

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.71

0.17

2.4

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

788

1.19

0.17

23.8

16.5

19.66

23.79

mg/l

0.84

662

(3000492) Spirometry study

1.19

0.16

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

247

1.13

0.15

4.7

3.7

0.00

estimate

-0.00

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.79

0.15

1.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.21

0.15

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.79

0.14

5.4

5.0

32.13

33.48

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.79

0.14

7.4

3.6

260.50

257.83

u/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

127

0.85

0.13

1.6

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

450

1.09

0.11

6.9

4.3

0.00

estimate

-0.00

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.16

0.10

16.2

8.1

—

(3003694) ABO and Rh group [Type] in Blood

243

1.10

0.10

1.6

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.09

0.10

1.2

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

194

1.10

0.10

1.8

1.4

2.19

2.73

g/l

0.70

108

(3035350) Ketones [Presence] in Urine by Test strip

452

1.08

0.09

7.1

4.3

0.00

estimate

-0.00

(3011397) Hemoglobin [Presence] in Urine by Test strip

224

1.09

0.09

7.8

4.0

—

0.00

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

175

1.11

0.09

4.9

4.8

19.61

21.30

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.05

0.08

1.3

1.9

—

(40758558) Short blood count panel - Blood

264

1.08

0.08

8.4

6.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.04

0.08

2.5

9.4

92.20

93.68

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.80

0.08

1.8

1.6

—

(36660697) Celiac disease serology panel - Serum

1.09

0.08

1.1

1.2

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.86

0.07

2.9

38.86

30.29

u/l

—

(3000963) Hemoglobin [Mass/volume] in Blood

855

1.22

0.07

36.6

24.9

132.74

134.60

g/l

0.55

847

(3035941) MCH [Entitic mass]

855

1.22

0.07

36.3

24.6

30.04

30.24

0.53

848

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

855

1.22

0.07

36.4

25.1

39.99

40.07

0.06

847

(3024731) MCV [Entitic mean volume] in Red Blood Cells

855

1.22

0.07

36.4

24.6

90.28

90.99

0.84

848

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

217

1.08

0.06

1.4

1.3

0.68

0.96

u/ml

—

(1761868) Lipid panel - Serum or Plasma

302

0.94

0.05

3.8

3.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

278

1.06

0.05

3.0

3.9

10.12

11.06

mg/mmol

0.05

176

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

279

1.06

0.04

3.4

3.1

1242.43

1224.31

ng/l

0.02

232

(40761511) CBC panel - Blood by Automated count

818

0.92

0.04

24.0

13.7

—

(3026008) Bacteria identified in Urine by Culture

283

1.03

0.01

5.5

3.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

323

1.03

0.01

6.0

3.4

—

(3009261) Glucose [Presence] in Urine by Test strip

464

1.02

0.00

7.0

4.3

0.00

estimate

-0.00

(3020564) Creatinine [Moles/volume] in Serum or Plasma

835

1.05

0.00

29.8

21.2

78.18

76.85

umol/l

0.12

829

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

509

1.00

0.00

3.1

2.9

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

0.0

1.7

—

7.97

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.3

—

16.97

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

7.3

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.3

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.3

—

(40761535) Cells panel - Urine sediment

0.90

-0.00

13.3

3.7

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.0

—

115.40

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

1.31

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

9.20

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3000991) Gas panel - Venous blood

0.95

-0.00

2.3

8.5

—

(3025941) Bacteria identified in Stool by Culture

0.85

-0.00

1.4

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

74.71

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.93

-0.00

1.6

1.36

1.35

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.0

—

1.36

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.6

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

18.00

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.02

-0.00

2.2

2.6

1.76

1.01

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

50.40

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

8.18

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.00

-0.00

1.8

2.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

1.6

—

0.89

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.02

-0.00

2.2

2.6

0.62

0.63

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

2017.40

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_MIDDMASTNAS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
H8_MIDDMASTNAS	1.128 [0.74, 1.72]	0.576
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 259 males with H8_MIDDMASTNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_MIDDMASTNAS.

N-year risk	Females	Males
1	No data	0.187%
5	No data	1.065%
10	No data	2.818%
15	No data	5.374%
20	No data	9.128%

Relationships between endpoints

↥

Index endpoint: H8_MIDDMASTNAS – Other specified/unspecified disorders of middle ear and mastoid

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified/unspecified disorders of middle ear and mastoid

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints