Malignant otitis externa

H8_EXT_MALIGN

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H60.2 Hospital discharge: ICD-9 — 3801C Cause of death: ICD-10 — H60.2 Cause of death: ICD-9 — 3801C 2 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	64

Control definitions (FinnGen only)

Control exclude: H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H60
Name in latin: Otitis externa [maligna]

NAME	H8_EXT_MALIGN
CONTROL_EXCLUDE	H8_EXTERNAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H602
HD_ICD_9	3801C
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H602
COD_ICD_9	3801C
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Malignant otitis externa based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	540	251	283
Only index persons	480	228	252
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.45	50.70	57.43
Only index persons	53.03	48.66	56.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	64	28	36
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	57.63	47.51	65.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
68: Matched controls
680

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H60.2

ICD-10 Finland

Malignant otitis externa

+∞

94.8

H60.9

ICD-10 Finland

Otitis externa, unspecified

22.3

20.0

H60.8

ICD-10 Finland

Other otitis externa

92.5

18.9

H60.3

ICD-10 Finland

Other infective otitis externa

39.9

14.8

DC1AD

NOMESCO Finland

Temporalbone CT

129.1

10.7

H66.9

ICD-10 Finland

Otitis media, unspecified

12.4

10.0

H60

ICD-10 Finland

Otitis externa

12.7

9.1

Z01.1

ICD-10 Finland

Examination of ears and hearing

5.6

8.6

UDC00

NOMESCO Finland

Ear microscopy

9.1

8.1

H66.0

ICD-10 Finland

Acute suppurative otitis media

8.3

7.7

H60.0

ICD-10 Finland

Abscess of external ear

+∞

7.4

J01MA02

ATC

ciprofloxacin; systemic

3.8

7.0

169

H70.1

ICD-10 Finland

Chronic mastoiditis

76.8

6.5

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

29.7

6.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

9.90

19.76

3.9

1.9

—

(3000494) Fungus identified in Specimen by Culture

5.90

10.54

3.8

1.5

—

(3042936) Bacteria identified in Isolate by Culture

3.94

6.14

5.1

2.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

187

3.15

5.13

4.9

3.5

18.22

4.17

mg/mmol

1.03

119

(3006315) Basophils [#/volume] in Blood

274

3.32

5.07

10.6

6.6

0.05

0.04

e9/l

0.94

242

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.67

4.92

4.8

1.5

—

(3012516) Albumin [Mass/volume] in Urine

186

2.99

4.70

4.2

3.1

94.69

32.30

mg/l

0.68

121

(3019198) Lymphocytes [#/volume] in Blood

282

3.16

4.67

10.8

6.6

1.88

1.83

e9/l

0.15

256

(3001604) Monocytes [#/volume] in Blood

273

3.12

4.66

10.8

6.6

0.60

0.59

e9/l

0.15

240

(3013115) Eosinophils [#/volume] in Blood

283

3.14

4.62

11.1

6.9

0.17

0.19

e9/l

0.56

254

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.46

4.36

4.9

1.7

—

(42870588) Differential panel, method unspecified - Blood

163

2.82

4.18

10.8

5.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.10

4.18

4.7

1.9

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

7.22

4.13

3.2

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

198

2.74

4.02

4.2

2.9

7.25

8.24

mmol/l

0.54

171

(3012544) pH of Venous blood

3.57

3.98

5.1

2.4

7.35

7.39

—

(3023368) Bacteria identified in Blood by Culture

146

2.72

3.81

10.4

4.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

4.84

3.70

4.8

2.8

24.21

25.16

mmol/l

0.27

(3021447) Carbon dioxide [Partial pressure] in Venous blood

3.35

3.63

5.2

2.5

5.79

5.68

kpa

0.19

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.84

3.62

10.6

3.1

400.43

169.85

ng/l

0.29

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

508

4.26

3.33

9.7

5.8

44.11

39.70

mmol/mol

1.78

479

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

6.94

3.27

1.9

1.8

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

4.17

3.26

4.4

2.6

118.55

135.17

g/l

1.40

(3019060) Gas panel - Arterial blood

4.32

3.13

10.2

4.2

—

(3007566) Smooth muscle Ab [Titer] in Serum

7.18

2.93

1.2

1.3

—

(3000991) Gas panel - Venous blood

3.11

2.91

18.2

5.9

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.44

2.80

1.7

1.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.63

2.78

6.4

1.9

11.29

15.65

umol/l

1.78

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.35

2.64

2.6

1.8

—

(3019977) pH of Arterial blood

2.72

2.61

19.7

6.0

7.41

7.43

—

(3020891) Body temperature

3.83

2.59

8.2

3.1

36.99

36.94

°c

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.83

2.59

21.7

7.8

24.34

24.02

mmol/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.60

2.51

17.9

3.4

1.15

1.02

mmol/l

0.51

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

4.46

2.43

1.0

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

6.63

2.41

1.2

1.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

3.00

2.34

5.9

2.5

4.32

4.46

kpa

0.07

(3032080) INR in Blood by Coagulation assay

269

2.05

2.18

24.3

10.3

1.27

1.16

inr

0.60

231

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.48

2.17

5.3

2.2

0.75

0.62

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.48

2.17

5.4

2.3

1.19

1.21

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

502

2.66

2.11

6.7

5.3

1.90

1.94

mu/l

0.12

462

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

4.28

2.09

1.3

1.2

—

(3018418) pH of Serum or Plasma

157

2.06

14.8

4.0

7.41

7.40

0.36

114

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.72

2.05

20.2

6.1

1.21

1.30

mmol/l

0.23

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.37

1.92

2.4

1.7

—

(3021589) Normoblasts [#/volume] in Blood

233

1.92

1.84

25.9

11.9

0.00

e9/l

0.26

193

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.21

1.83

19.0

6.2

103.44

103.89

mmol/l

0.15

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.13

1.77

4.9

2.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.13

1.76

2.3

1.7

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

3.76

1.64

1.2

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

120

1.94

1.57

3.1

2.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

225

1.80

1.53

5.1

3.9

53.40

24.89

ng/l

0.71

157

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.67

1.49

2.9

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

547

2.51

1.49

7.3

5.6

2.47

2.70

mmol/l

1.06

512

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.13

1.45

7.5

1.9

20.59

26.52

1.10

(40761511) CBC panel - Blood by Automated count

565

2.56

1.42

33.7

13.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.97

1.40

6.4

2.8

1.62

1.28

e6/l

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.09

1.38

1.8

1.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.03

1.38

8.1

1.8

2.22

2.39

g/l

0.56

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

525

2.21

1.36

6.0

4.8

6.32

5.93

mmol/l

1.39

488

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

339

1.73

1.32

5.3

3.2

—

(40768804) Tissue Pathology biopsy report

234

1.69

1.29

2.4

2.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

361

1.73

1.28

8.4

4.3

—

27.00

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

103

1.87

1.28

8.3

3.7

0.78

0.80

mmol/l

0.33

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.53

1.27

4.3

2.0

24.27

24.30

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

145

1.76

1.27

5.6

3.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

112

1.83

1.25

2.1

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.94

1.24

6.4

3.0

1.14

3.04

e6/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

104

1.85

1.24

1.4

1.3

12.04

14.35

iu/ml

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.25

1.23

26.4

7.3

93.04

94.72

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.25

1.23

26.3

7.2

0.64

0.68

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

228

1.66

1.20

2.8

2.0

85.59

91.38

pmol/l

0.36

122

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.19

1.20

26.3

7.1

1.74

1.52

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.61

1.17

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.61

1.17

1.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

239

1.64

1.16

11.1

4.3

33.97

36.05

g/l

1.75

232

(3007164) IgA [Mass/volume] in Serum or Plasma

123

1.76

1.16

1.5

1.4

2.47

2.20

g/l

0.29

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

258

1.64

1.16

5.1

2.5

—

estimate

—

(3021960) Folate [Moles/volume] in Serum or Plasma

149

1.70

1.15

1.9

1.7

15.93

20.86

nmol/l

0.93

127

(3030467) Casts [#/volume] in Urine by Automated count

158

1.69

1.14

7.1

2.9

0.15

0.33

e6/l

0.65

116

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

539

1.96

1.09

6.3

4.8

4.44

4.60

mmol/l

0.52

507

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.25

1.09

1.6

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

169

1.65

1.08

3.5

2.4

—

(3000492) Spirometry study

1.92

1.01

1.1

1.6

—

(3019150) Specific gravity of Urine by Refractometry

137

1.65

0.99

7.2

4.0

1.02

kg/l

0.02

(36660697) Celiac disease serology panel - Serum

1.96

0.98

1.1

1.2

—

(3023520) Reticulocytes [#/volume] in Blood

1.97

0.91

1.8

1.6

67.20

73.20

e9/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.88

0.88

11.9

3.4

—

(3015736) pH of Urine

233

1.51

0.87

6.6

3.2

6.21

6.16

0.10

144

(40761535) Cells panel - Urine sediment

1.84

0.86

5.0

3.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

196

1.53

0.86

5.2

3.3

37.46

28.99

u/l

0.56

186

(40758558) Short blood count panel - Blood

178

1.54

0.85

8.2

6.6

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.96

0.84

30.2

7.2

23.67

23.74

mmol/l

—

(3033658) Prothrombin time (PT) actual/Normal

134

1.58

0.83

9.4

3.8

94.26

91.78

0.20

134

(3002582) Erythrocytes [#/volume] in Urine

179

1.53

0.83

7.0

3.2

15.44

21.66

e6/l

0.29

139

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

538

1.73

0.81

6.1

4.7

1.32

1.45

mmol/l

1.38

504

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.79

0.0

1.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

513

1.69

0.79

5.0

4.0

1.64

1.27

mmol/l

2.18

479

(40760892) CBC W Ordered Manual Differential panel - Blood

128

1.55

0.76

8.6

6.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.08

0.74

4.6

2.2

—

(1761868) Lipid panel - Serum or Plasma

229

0.66

0.73

3.6

3.1

—

(4024509) Urine culture

1.85

0.67

1.8

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.66

0.67

1.4

1.7

—

(4035726) Immunohistochemistry procedure

1.68

0.64

1.1

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

117

1.48

0.59

2.1

1.6

0.37

1.20

mg/l

2.77

107

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.52

0.56

2.0

1.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.49

0.55

8.9

8.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

107

0.61

0.54

1.6

1.4

—

(3002256) Pathology report gross observation

1.58

0.53

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

303

1.32

0.47

6.9

3.7

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

304

1.31

0.46

6.9

3.6

0.00

estimate

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.55

0.42

1.2

2.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.42

0.0

1.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.42

0.0

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.39

0.0

1.4

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.39

0.0

1.5

—

293.48

—

(3021601) Nitrite [Presence] in Urine by Test strip

299

1.27

0.39

6.9

3.5

0.00

estimate

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.40

0.39

1.4

1.3

0.98

10.73

u/ml

—

(40761536) Microorganisms panel - Urine sediment

1.36

0.35

5.3

2.8

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

455

1.28

0.33

52.0

20.3

332.69

332.63

g/l

0.02

455

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

225

1.25

0.33

2.8

2.0

1.71

1.32

mmol/l

0.79

191

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.36

0.32

1.7

1.5

—

(40768797) Stomach Pathology biopsy report

1.33

0.26

2.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

17.09

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

2.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

50.82

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3022145) Colonoscopy Study observation

0.71

0.18

1.4

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

237

1.16

0.17

6.6

3.5

0.00

estimate

—

(3003694) ABO and Rh group [Type] in Blood

170

1.16

0.16

1.4

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

176

0.88

0.11

4.4

2.8

0.00

estimate

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.81

0.08

1.8

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.13

0.06

1.5

1.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

171

0.99

0.00

5.5

4.9

18.82

21.35

—

(3013512) EKG study

178

1.02

0.00

5.1

3.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.9

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.2

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

9.3

—

182.62

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

2.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.4

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.5

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

13.69

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.3

—

6.72

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.98

-0.00

2.3

2.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

2.8

—

6.28

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

12.0

—

0.61

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

9.30

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_EXT_MALIGN and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
H8_EXT_MALIGN	1.384 [0.95, 2.01]	0.086
Birth year	0.989 [0.98, 1.0]	0.022

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 238 males with H8_EXT_MALIGN died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXT_MALIGN.

N-year risk	Females	Males
1	No data	0.279%
5	No data	1.591%
10	No data	4.158%
15	No data	8.048%
20	No data	13.472%

Relationships between endpoints

↥

Index endpoint: H8_EXT_MALIGN – Malignant otitis externa

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Malignant otitis externa

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints