macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
204 |
4. Check minimum number of eventsNone |
204 |
5. Include endpointsNone |
204 |
6. Filter based on genotype QC (FinnGen only) |
180 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other proliferative retinopathy
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1077 | 486 | 586 |
| Only index persons | 954 | 436 | 518 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 57.82 | 60.71 | 55.52 |
| Only index persons | 57.13 | 59.71 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 180 | 81 | 99 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 54.46 | 51.52 | 56.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 184
- Matched controls
- 1840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
62.9
116.7
68
17
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
115.0
98
*
A10AB01
ATC
insulin (human); parenteral
79.3
114.3
63
12
A10AA02, ,
ATC
71.4
110.2
62
13
T89
ICPC
Diabetes insulin dependent
51.1
104.8
64
19
A10AC01
ATC
insulin (human); parenteral
26.5
103.5
86
59
A10AA01, ,
ATC
70.9
98.2
55
11
XCW99
NOMESCO Finland
Other investigative procedure of eye
22.1
89.6
80
62
XCK10
NOMESCO Finland
Photography of fundus of eye
20.3
87.0
82
70
A10AB05
ATC
insulin aspart; parenteral
20.9
86.2
79
64
CKC12
NOMESCO Finland
Photocoagulation of retina
605.0
79.3
73
*
H35.20
ICD-10 Finland
Proliferative vitreoretinopathy
+∞
79.0
70
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
306.4
77.9
74
*
A10AE04
ATC
insulin glargine; parenteral
15.9
76.3
85
94
A10AB04
ATC
insulin lispro; parenteral
40.6
72.3
46
15
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
16.6
66.3
66
60
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
65.6
59
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
138.7
62.7
64
7
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
226.1
62.3
61
*
A10AE05
ATC
insulin detemir; parenteral
21.8
61.3
50
31
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.4
60.3
51
34
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
97.8
56.3
60
9
H3603, E103,
ICD-10 Finland
+∞
55.0
50
*
XCH00
NOMESCO Finland
Eye pressure measurement
20.2
53.9
45
29
103
Kela drug reimbursment
Diabetes, insulin-treated
8.9
49.8
116
297
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
14.7
46.8
47
42
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
43.5
40
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
86.8
42.4
46
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.9
42.1
82
170
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.4
42.0
100
254
Z96.1
ICD-10 Finland
Presence of intraocular lens
8.4
37.2
60
100
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
34.5
32
*
H3603, E113,
ICD-10 Finland
+∞
31.1
29
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
45.8
30.7
37
10
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
178.0
29.6
30
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
178.0
29.6
30
*
S01ED51
ATC
timolol, combinations; ophthalmic
9.0
29.3
41
57
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
27.8
26
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
27.8
26
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
314.4
27.5
27
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
+∞
26.7
25
*
H04AA01
ATC
glucagon; nasal, parenteral
52.9
26.5
31
7
CKC10
NOMESCO Finland
Local photocoagulation of retina
300.8
26.4
26
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.9
25.8
95
328
XCD20
NOMESCO Finland
Photoangiography of eye
287.4
25.3
25
*
A10AD01
ATC
insulin (human); parenteral
44.4
24.8
30
8
C02AC05
ATC
moxonidine; oral
10.5
23.6
28
31
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
261.2
23.2
23
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.4
22.6
99
382
H3601, E103,
ICD-10 Finland
+∞
22.3
21
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
130.6
22.1
23
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
42.9
21.4
26
7
H3603, E106,
ICD-10 Finland
+∞
21.3
20
*
A10AE06
ATC
insulin degludec; parenteral
23.6
21.2
30
15
SPAT1262
SPAT
Handing over of treatment supplies
4.9
20.3
57
155
WX140
NOMESCO Finland
Parabulbar anesthesy
25.1
20.2
28
13
H26.4
ICD-10 Finland
After-cataract
6.7
19.8
35
62
XCK00
NOMESCO Finland
Perimetry
7.6
18.9
29
44
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
49.6
18.7
22
5
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
74.3
18.1
20
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
18.0
17
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
105.4
17.9
19
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
16.9
16
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
99.3
16.9
18
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
27.5
16.4
22
9
C10AX09
ATC
ezetimibe; oral
4.1
16.0
56
177
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
21.7
16.0
23
12
H3601, E113,
ICD-10 Finland
+∞
15.9
15
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
174.2
15.7
16
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
6.1
15.7
30
57
ZXA05
NOMESCO Finland
Left side
3.7
15.7
70
262
C03CA01
ATC
furosemide; systemic
3.5
15.5
83
349
A10AA03, ,
ATC
49.6
15.4
18
*
C09AA02
ATC
enalapril; systemic
3.9
15.0
58
196
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
87.2
14.8
16
*
H3600, E103,
ICD-10 Finland
+∞
14.8
14
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
14.8
14
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
14.8
14
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
162.4
14.7
15
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.5
14.4
70
275
T90
ICPC
Diabetes non-insulin dependent
3.6
14.3
66
250
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
22.2
14.1
20
10
C10AA01
ATC
simvastatin; oral
3.3
14.1
99
484
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
11.0
13.8
26
27
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.8
13.8
23
38
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
13.7
13
*
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
23.4
13.6
19
9
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
150.7
13.6
14
*
Z94.0
ICD-10 Finland
Kidney transplant status
43.6
13.4
16
*
A11CC03
ATC
alfacalcidol; systemic
21.0
13.2
19
10
127
Kela drug reimbursment
Transplant complication
31.0
13.2
17
6
E10
ICD-10 Finland
Type 1 diabetes mellitus
31.0
13.2
17
6
205
Kela drug reimbursment
Chronic hypertension
3.3
13.2
69
281
L04AD02
ATC
tacrolimus; systemic
75.2
12.8
14
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
12.6
12
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
12.6
12
*
H26.2
ICD-10 Finland
Complicated cataract
40.5
12.4
15
*
137
Kela drug reimbursment
Uraemia requiring dialysis
40.5
12.4
15
*
S97
ICPC
Chronic ulcer skin
5.5
12.1
25
51
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
50.2
12.1
14
*
C08CA01
ATC
amlodipine; oral
2.9
11.6
93
476
H3601, E106,
ICD-10 Finland
+∞
11.6
11
*
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
11.6
11
*
H3603, E107,
ICD-10 Finland
+∞
11.6
11
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
16.5
11.6
18
12
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
127.7
11.6
12
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
127.7
11.6
12
*
J01FF01
ATC
clindamycin; systemic
3.0
11.3
68
297
S01EA05
ATC
brimonidine; ophthalmic
13.1
11.1
19
16
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.4
11.1
23
47
ZXA10
NOMESCO Finland
Bilateral
3.3
10.9
51
192
S01EE01
ATC
latanoprost; ophthalmic
5.2
10.6
23
49
L04AA06
ATC
mycophenolic acid; systemic
17.4
10.6
16
10
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
10.5
10
*
H3600, E113,
ICD-10 Finland
+∞
10.5
10
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
20.2
10.4
15
8
C10AA05
ATC
atorvastatin; oral
2.7
10.2
94
509
B05DA
ATC
Isotonic solutions
42.6
10.1
12
*
C10AA07
ATC
rosuvastatin; oral
2.8
10.1
77
379
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.9
10.0
63
279
S01EC01
ATC
acetazolamide; systemic
10.5
10.0
19
20
Z49.1
ICD-10 Finland
Extracorporeal dialysis
21.5
10.0
14
7
XCW10
NOMESCO Finland
Assessment of vision
27.8
10.0
13
5
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
27.8
10.0
13
5
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
9.8
94
517
B05DB
ATC
Hypertonic solutions
58.1
9.8
11
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
58.1
9.8
11
*
A10AD05
ATC
insulin aspart; parenteral
16.2
9.7
15
10
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.9
9.6
59
257
A12AA04
ATC
calcium carbonate; oral
18.8
9.6
14
8
NHQ40
NOMESCO Finland
Amputation of toe
18.8
9.6
14
8
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
9.5
9
*
H3603, E108,
ICD-10 Finland
+∞
9.5
9
*
M65.3
ICD-10 Finland
Trigger finger
5.2
9.3
20
42
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
38.8
9.1
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
9.1
38
132
N18.8
ICD-10 Finland
Other chronic renal failure
13.5
9.0
15
12
TK800
NOMESCO Finland
Hemodialysis
11.6
9.0
16
15
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.8
8.9
30
90
I10
ICD-10 Finland
Essential (primary) hypertension
2.7
8.8
126
826
114
Kela drug reimbursment
Glaucoma
4.0
8.8
27
76
B01AC04
ATC
clopidogrel; oral
3.0
8.8
46
183
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
52.5
8.8
10
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
52.5
8.8
10
*
H40.0
ICD-10 Finland
Glaucoma suspect
4.4
8.6
23
58
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
21.3
8.6
12
6
N18.0
ICD-10 Finland
End-stage renal disease
29.1
8.6
11
*
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
29.1
8.6
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
8.4
80
430
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
8.4
8
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
+∞
8.4
8
*
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
+∞
8.4
8
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
8.4
8
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
8.4
8
*
H3601, E116,
ICD-10 Finland
+∞
8.4
8
*
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
15.4
8.3
13
9
C09AA05
ATC
ramipril; oral
2.7
8.2
59
277
C08CA02
ATC
felodipine; oral
3.8
7.9
26
77
Z3229
NOMESCO Finland
Other healthcare associate professional
3.9
7.9
25
72
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
47.0
7.8
9
*
Z49.2
ICD-10 Finland
Other dialysis
47.0
7.8
9
*
C08CA13
ATC
lercanidipine; oral
3.1
7.7
37
139
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
7.7
43
176
H26.02
ICD-10 Finland
Presenil cataract
9.5
7.7
15
17
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
7.7
7.7
17
24
S01ED01
ATC
timolol; ophthalmic
7.0
7.6
18
28
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
4.1
7.6
22
59
V03AE02
ATC
sevelamer; oral
83.3
7.5
8
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
83.3
7.5
8
*
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
11.6
7.4
13
12
RJ120, ,
NOMESCO Finland
+∞
7.3
7
*
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
7.3
7
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
7.3
7
*
H3603, H3520,
ICD-10 Finland
+∞
7.3
7
*
V03AE01
ATC
polystyrene sulfonate; oral
16.6
7.3
11
7
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.1
7.3
17
26
C07AB02
ATC
metoprolol; systemic
2.7
7.3
46
201
S01EA03
ATC
apraclonidine; ophthalmic
31.4
7.2
9
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
31.4
7.2
9
*
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
21.0
7.2
10
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
7.2
60
300
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
7.2
66
345
Z3231
NOMESCO Finland
Registered nurse
2.4
7.2
64
330
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.5
7.1
58
287
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.2
7.1
31
110
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
7.1
54
259
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.4
7.0
18
44
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
4.0
7.0
21
58
C07AB07
ATC
bisoprolol; oral
2.3
6.9
101
642
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
17.5
6.8
10
6
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
17.5
6.8
10
6
G63.2
ICD-10 Finland
Diabetic polyneuropathy
41.6
6.8
8
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
41.6
6.8
8
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
41.6
6.8
8
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
23.5
6.7
9
*
ZXA00
NOMESCO Finland
Right side
2.4
6.7
57
287
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.5
6.7
51
244
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
6.6
32
121
H53.1
ICD-10 Finland
Subjective visual disturbances
3.7
6.5
22
66
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.0
6.5
10
7
TK820
NOMESCO Finland
Peritoneal dialysis
72.3
6.5
7
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
72.3
6.5
7
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
8.6
6.4
13
16
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
18.8
6.3
9
5
A10BB01
ATC
glibenclamide; oral
6.2
6.3
16
28
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
6.3
6
*
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
+∞
6.3
6
*
H3601, H3520,
ICD-10 Finland
+∞
6.3
6
*
H3601, E118,
ICD-10 Finland
+∞
6.3
6
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
6.3
6
*
S01EX03, ,
ATC
10.5
6.1
11
11
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
6.1
71
406
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.8
6.0
33
133
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
465
3.84
18.27
9.2
4.0
35.67
10.08
mg/mmol
2.69
90
307
105
495
3.61
16.56
8.6
3.2
5.99
8.08
mmol/l
7.04
99
429
23
24
10.78
12.15
3.7
1.9
251.97
144.12
ug/min
0.24
17
11
51
186
3.41
11.48
23.5
6.6
1.19
1.03
mmol/l
2.22
51
171
116
728
2.61
8.92
22.4
7.1
1.21
1.21
mmol/l
0.23
109
639
45
180
2.99
8.48
8.4
8.1
0.65
0.98
mmol/l
0.22
35
144
45
184
2.91
8.13
3.4
5.0
229.71
233.24
u/l
0.14
45
175
29
91
3.60
8.07
3.3
3.2
1.66
1.76
mmol/l
0.05
19
62
20
52
4.19
7.19
1.4
1.2
—
—
—
0
0
128
894
2.42
7.05
12.6
5.0
8.91
6.57
mmol/l
10.65
123
837
88
525
2.30
7.05
7.2
3.3
—
—
—
0
0
28
94
3.33
7.01
7.7
7.6
23.44
24.64
mmol/l
1.06
28
94
76
432
2.29
6.77
3.4
3.4
2219.62
1344.83
ng/l
0.95
67
362
74
434
2.18
5.96
5.8
3.2
0.66
0.31
e6/l
0.80
51
311
50
249
2.38
5.94
4.8
2.8
1.55
1.37
e6/l
0.09
27
116
99
665
2.06
5.44
3.8
2.4
72.88
75.99
nmol/l
0.48
93
602
8
6
13.85
5.12
7.3
1.5
233.13
62.78
ng/l
—
8
6
61
354
2.08
4.89
1.7
1.3
3.08
2.35
u/ml
0.15
20
104
26
103
2.78
4.88
1.7
1.6
—
—
—
0
0
51
277
2.16
4.85
4.1
2.7
0.88
0.75
e6/l
0.14
29
143
79
507
1.98
4.77
4.8
3.2
2.32
2.35
mmol/l
1.49
79
462
49
269
2.12
4.50
2.4
1.9
—
—
—
0
0
14
34
4.37
4.31
1.5
1.3
—
—
—
0
0
51
289
2.06
4.29
5.9
3.4
429.54
316.49
ng/l
0.11
39
213
21
80
2.83
4.23
1.3
2.4
1.61
1.55
g/l
0.13
21
72
39
200
2.21
4.23
2.1
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
36
4.12
4.09
3.4
2.7
0.29
0.29
iu/ml
—
6
17
118
900
1.87
3.94
11.5
10.0
4.23
4.11
e9/l
0.24
104
803
37
191
2.17
3.94
2.2
1.7
—
—
—
0
0
21
84
2.69
3.87
1.4
1.5
—
—
—
0
0
13
34
4.03
3.78
2.4
1.3
—
—
—
0
0
30
146
2.26
3.67
3.6
3.1
—
—
—
0
0
55
339
1.89
3.58
1.6
1.8
1.09
1.21
mg/l
0.16
43
267
40
222
2.02
3.52
8.5
7.7
103.13
104.14
mmol/l
0.63
40
222
62
407
1.79
3.26
5.1
2.8
370.48
351.53
umol/l
0.83
56
359
9
20
4.67
3.15
10.4
3.4
17.94
10.82
pmol/l
—
9
20
8
16
5.17
3.08
3.5
4.2
1358.88
637.81
mg
—
8
16
12
36
3.49
3.08
1.1
1.9
—
—
—
0
0
18
76
2.52
3.00
10.0
8.9
15.94
15.86
%
0.05
18
71
83
612
1.65
2.78
4.7
4.0
829.21
46.16
ng/l
0.62
67
422
5
6
8.52
2.76
1.0
1.0
—
—
—
0
0
8
20
4.13
2.60
1.4
1.2
—
—
—
0
0
40
249
1.77
2.46
1.6
1.6
1333.67
1156.40
nmol/l
0.31
31
195
13
52
2.61
2.41
1.1
1.9
103.77
89.85
%
1.82
13
52
19
93
2.16
2.31
2.2
1.6
—
—
—
0
0
102
817
1.56
2.28
6.0
3.7
0.00
9.23
estimate
0.50
18
176
85
657
1.55
2.20
2.3
2.0
96.15
93.84
pmol/l
0.23
43
349
102
827
1.52
2.09
6.1
3.7
0.07
1.84
estimate
0.47
15
163
100
808
1.52
2.08
6.0
3.6
0.00
0.00
estimate
-0.00
18
174
10
38
2.72
2.04
2.7
1.4
—
—
—
0
0
5
11
4.64
1.95
1.0
1.0
—
—
—
0
0
9
34
2.73
1.89
2.8
2.2
113.44
125.91
g/l
—
9
23
12
53
2.35
1.85
2.5
1.9
—
—
—
0
0
5
12
4.25
1.83
1.8
1.3
—
—
—
0
0
8
29
2.84
1.81
3.0
1.7
—
—
—
0
0
13
61
2.22
1.76
3.8
2.3
—
—
—
0
0
0
47
0.00
1.73
0.0
1.7
—
53.84
—
0
37
42
293
1.56
1.67
2.1
1.7
437.83
425.75
pmol/l
0.14
35
257
140
1247
1.51
1.59
40.2
19.4
13.85
13.61
%
1.05
135
1238
21
124
1.78
1.55
5.0
2.4
62.83
64.05
ml/min/173m2
0.04
12
57
5
15
3.40
1.53
1.0
1.3
—
—
—
0
0
0
45
0.00
1.52
0.0
1.4
—
1.02
—
0
25
0
45
0.00
1.52
0.0
1.4
—
0.95
—
0
25
0
45
0.00
1.52
0.0
1.4
—
1.14
—
0
25
7
29
2.47
1.40
1.1
1.4
—
—
—
0
0
84
693
1.39
1.39
3.9
2.9
—
—
estimate
—
0
0
74
601
1.39
1.33
3.0
1.9
1.48
1.44
mmol/l
0.13
67
510
9
45
2.05
1.25
2.0
1.6
—
—
—
0
0
11
56
2.03
1.25
3.6
1.9
—
—
—
0
0
5
20
2.54
1.16
1.6
1.4
—
—
—
0
0
48
371
1.40
1.14
3.9
2.4
—
—
—
0
0
10
51
2.02
1.13
1.3
2.2
255.60
184.16
%
—
10
51
7
32
2.23
1.09
1.3
1.3
—
—
—
0
0
7
32
2.23
1.09
1.3
1.3
—
—
—
0
0
14
82
1.77
1.08
2.0
3.5
4.01
4.55
pmol/l
1.36
14
69
35
262
1.41
0.99
1.1
1.3
1.24
9.70
u/ml
2.70
14
107
11
184
0.57
0.99
4.0
4.5
32.09
30.99
%
0.16
11
122
0
30
0.00
0.98
0.0
1.2
—
—
—
0
0
36
465
0.72
0.98
4.3
4.1
28.15
22.91
%
0.63
15
209
46
366
1.34
0.91
5.6
3.7
1.02
1.02
kg/l
0.30
39
235
8
43
1.90
0.88
1.9
1.6
—
—
—
0
0
8
44
1.85
0.87
2.5
2.7
—
—
—
0
0
8
45
1.81
0.85
1.8
1.7
—
—
—
0
0
15
97
1.59
0.84
3.1
2.3
456.33
235.89
ng/l
0.34
15
86
26
345
0.71
0.83
2.9
2.9
1.09
0.79
ug/l
0.72
16
206
22
300
0.70
0.82
1.5
1.7
—
—
—
0
0
55
457
1.29
0.80
6.0
3.7
0.00
0.00
estimate
-0.00
15
154
5
24
2.11
0.75
1.6
1.1
—
—
—
0
0
7
43
1.65
0.67
1.1
1.3
—
—
—
0
0
5
29
1.74
0.64
1.6
1.6
—
—
—
0
0
72
633
1.23
0.64
5.8
3.6
0.13
0.00
estimate
0.48
16
148
5
30
1.68
0.62
1.8
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
17
227
0.72
0.57
1.5
2.3
—
—
—
0
0
15
204
0.71
0.56
1.4
2.1
—
—
—
0
0
6
39
1.56
0.53
1.5
1.5
—
—
—
0
0
5
83
0.59
0.47
1.2
1.4
—
—
—
0
0
109
1018
1.17
0.46
3.3
3.3
—
—
—
0
0
5
31
1.63
0.43
2.8
1.5
6.20
5.46
u/ml
—
5
31
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
4.1
—
25.91
—
0
8
0
16
0.00
0.41
0.0
2.3
—
13.13
—
0
16
5
34
1.48
0.40
1.2
1.6
—
—
—
0
0
157
1520
1.22
0.39
39.6
15.5
21.24
23.54
mg/l
0.50
143
1241
6
42
1.44
0.36
1.2
1.1
—
17.06
—
0
5
6
43
1.41
0.35
1.0
1.5
—
11.56
—
0
9
51
463
1.14
0.30
5.7
3.2
0.00
0.18
estimate
0.50
16
139
9
75
1.21
0.25
1.0
1.0
—
—
—
0
0
5
38
1.32
0.23
1.6
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
3.8
—
205.15
—
0
13
31
280
1.13
0.20
1.3
1.3
11.99
30.37
iu/ml
—
7
91
19
165
1.17
0.20
7.5
7.8
—
—
—
0
0
7
63
1.12
0.17
1.1
1.2
0.87
0.92
g/l
—
7
63
11
92
1.21
0.16
1.0
2.6
—
—
—
0
0
10
83
1.22
0.16
1.0
2.5
—
—
—
0
0
162
1642
0.89
0.15
53.6
23.8
39.30
40.82
%
3.43
162
1627
21
189
1.13
0.14
1.4
1.5
—
—
—
0
0
162
1641
0.89
0.14
52.1
23.4
90.58
90.99
fl
0.59
162
1627
5
45
1.11
0.10
1.4
1.5
—
—
—
0
0
5
62
0.80
0.08
1.0
1.2
1.32
1.52
g/l
—
5
62
160
1591
1.04
0.03
46.2
19.6
107.72
79.13
umol/l
3.53
160
1567
13
131
0.99
0.00
1.7
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
1.49
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
9.41
—
0
7
0
9
0.00
-0.00
0.0
2.4
—
48.29
—
0
9
6
62
0.97
-0.00
2.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
11.67
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
31.94
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PROLIFRETINOPATHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.757 [1.36, 2.28] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.222 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 421 females with H7_PROLIFRETINOPATHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.773 [1.38, 2.27] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 508 males with H7_PROLIFRETINOPATHOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_PROLIFRETINOPATHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.26% |
| 5 | 0.924% | 1.798% |
| 10 | 2.162% | 4.647% |
| 15 | 4.478% | 9.113% |
| 20 | 8.041% | 15.572% |
Relationships between endpoints
↥Index endpoint: H7_PROLIFRETINOPATHOTH – Other proliferative retinopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data