Other secondary gout

GOUT_SCND

gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M10.4
  • Cause of death: ICD-10 M10.4

2 out of 7 registries used, show all original rules.

133

4. Check minimum number of events

None

133

5. Include endpoints

None

133

6. Filter based on genotype QC (FinnGen only)

117

Control definitions (FinnGen only)

Control exclude
GOUT

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M10
Name in latin
Alia arthritis urica secundaria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 964 358 599
Only index persons 824 302 522
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 71.27 76.27 68.30
Only index persons 70.71 75.58 67.90

-FinnGen-

Key figures

All Female Male
Number of individuals 117 37 80
Unadjusted period prevalence (%) 0.03 0.01 0.04
Median age at first event (years) 67.88 68.14 67.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
119
Matched controls
1190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M10.4
ICD-10 Finland
Other secondary gout
+∞
171.8
119
*
M10.9
ICD-10 Finland
Gout, unspecified
47.2
85.3
56
22
M04AA01
ATC
allopurinol; systemic
24.9
73.2
83
101
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
12.8
33.1
38
42
M10.0
ICD-10 Finland
Idiopathic gout
58.7
32.2
37
9
C03CA01
ATC
furosemide; systemic
7.0
22.5
87
334
B01AA03
ATC
warfarin; systemic
5.6
19.5
60
184
A46
ICD-10 Finland
Erysipelas
5.9
18.3
44
108
212
Kela drug reimbursment
Gout
+∞
18.2
17
*
I50.9
ICD-10 Finland
Heart failure, unspecified
5.1
17.2
55
171
I50.0
ICD-10 Finland
Congestive heart failure
6.0
17.1
38
86
M10
ICD-10 Finland
Gout
17.1
17.0
27
20
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
31.5
16.2
21
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
37.2
15.3
19
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
14.1
60
227
C03DA01
ATC
spironolactone; oral
4.9
13.7
39
108
N18.8
ICD-10 Finland
Other chronic renal failure
19.7
13.5
20
12
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.2
13.5
59
226
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.5
13.4
31
72
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
13.1
49
167
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.3
12.6
44
142
M13.9
ICD-10 Finland
Arthritis, unspecified
6.7
12.5
22
39
K78
ICPC
Atrial fibrillation/flutter
5.6
12.4
27
59
H02AB06
ATC
prednisolone; systemic
4.3
12.3
85
439
A11CC03
ATC
alfacalcidol; systemic
19.0
12.1
18
11
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.8
12.1
25
52
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.5
11.9
37
109
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.8
11.9
32
84
I50.1
ICD-10 Finland
Left ventricular failure
6.1
11.8
23
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
11.6
87
469
205
Kela drug reimbursment
Chronic hypertension
3.7
11.5
60
254
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.2
11.3
27
64
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.2
11.2
38
119
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.1
10.9
39
127
B03XA02
ATC
darbepoetin alfa; parenteral
18.2
10.7
16
10
A10BH05
ATC
linagliptin; oral
5.5
10.2
22
47
WX002
NOMESCO Finland
Sedation and analgesia
3.8
10.1
41
145
D64.9
ICD-10 Finland
Anaemia, unspecified
4.2
10.0
32
95
ZXD05
NOMESCO Finland
Urgent procedure
3.4
9.9
55
238
C01DA14
ATC
isosorbide mononitrate; oral
3.7
9.9
42
153
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
9.7
34
108
L04AA06
ATC
mycophenolic acid; systemic
33.0
9.6
12
*
C07AB07
ATC
bisoprolol; oral
3.7
9.5
87
506
N19
ICD-10 Finland
Unspecified kidney failure
8.0
9.4
21
31
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.2
9.3
21
47
207
Kela drug reimbursment
Chronic arrhythmias
3.6
9.1
39
142
SPAT1229
SPAT
Assessment of need for aid
5.3
9.0
20
44
N02AA05
ATC
oxycodone; systemic
3.4
9.0
45
181
R50.9
ICD-10 Finland
Fever, unspecified
3.8
8.9
34
114
C09AA02
ATC
enalapril; systemic
3.4
8.9
44
175
Z49.1
ICD-10 Finland
Extracorporeal dialysis
30.0
8.6
11
*
A28
ICPC
Limited function/disability NOS
3.4
8.6
42
165
M01AB01
ATC
indometacin; systemic, rectal
4.6
8.6
23
59
R06.0
ICD-10 Finland
Dyspnoea
3.2
8.6
54
248
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
96.6
8.5
9
*
J01MA12
ATC
levofloxacin; systemic
3.4
8.5
40
154
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
8.5
29
90
Z94.0
ICD-10 Finland
Kidney transplant status
+∞
8.4
8
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.1
8.4
57
272
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.4
8.4
24
65
B01AF02
ATC
apixaban; oral
3.8
8.3
31
102
A12AA04
ATC
calcium carbonate; oral
24.0
8.2
11
5
L28
ICPC
Limited function/disability (L)
3.3
7.9
40
160
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
7.9
28
89
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
7.9
44
187
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
48.2
7.8
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
7.8
41
168
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.6
7.7
20
50
AA1AD
NOMESCO Finland
CT of head and brain
2.9
7.6
54
262
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.6
7.6
29
97
N02AX02
ATC
tramadol; systemic, rectal
2.9
7.5
69
383
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
3.0
7.5
48
219
J01FF01
ATC
clindamycin; systemic
3.0
7.5
46
205
137
Kela drug reimbursment
Uraemia requiring dialysis
85.2
7.5
8
*
B05DA
ATC
Isotonic solutions
85.2
7.5
8
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
7.5
28
92
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
17.1
7.4
11
7
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
4.4
7.3
20
52
V03AE01
ATC
polystyrene sulfonate; oral
21.6
7.3
10
5
A10AE04
ATC
insulin glargine; parenteral
3.8
7.2
25
78
A10AB05
ATC
insulin aspart; parenteral
4.2
7.1
21
58
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.9
7.0
48
226
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
6.9
56
288
127
Kela drug reimbursment
Transplant complication
42.5
6.8
8
*
AN1
HP
Coronary angiography
3.5
6.8
27
92
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
24.1
6.8
9
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
24.1
6.8
9
*
J01DB01
ATC
cefalexin; oral
4.6
6.8
107
786
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.2
6.7
33
129
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
6.6
26
88
A06AD11
ATC
lactulose; oral
3.2
6.5
31
118
R11
ICD-10 Finland
Nausea and vomiting
4.2
6.5
19
52
B05DB
ATC
Hypertonic solutions
73.6
6.5
7
*
AN2
HP
Balloon angioplasty, including several vessels
10.1
6.5
12
13
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.8
6.5
46
220
H02AB04
ATC
methylprednisolone; systemic
3.3
6.4
28
101
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
4.4
6.4
17
43
N03AX12
ATC
[U] gabapentin; oral
3.1
6.4
31
120
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
6.3
34
139
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.9
6.3
20
58
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.8
6.3
17
33
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
6.3
6
*
M10.3
ICD-10 Finland
Gout due to impairment of renal function
+∞
6.3
6
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
6.3
6
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.8
6.2
43
202
K90
ICPC
Stroke/cerebrovascular accident
8.8
6.0
12
15

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
83
254
8.50
29.40
6.4
3.2
442.72
356.34
umol/l
6.15
76
214
77
325
4.88
16.08
7.9
4.8
—
—
—
0
0
54
193
4.29
13.62
4.1
3.0
0.81
0.81
mmol/l
0.02
47
184
66
276
4.12
13.30
3.5
2.1
3.94
3.13
mg/l
0.53
61
232
41
121
4.64
13.28
8.2
4.2
7.36
7.39
ph
2.85
28
74
85
433
4.37
12.72
6.2
2.8
191.73
143.44
ug/l
0.94
80
394
30
71
5.31
12.61
9.0
4.5
24.68
24.37
mmol/l
0.13
30
71
74
350
3.95
12.16
10.2
5.7
—
—
—
0
0
39
120
4.35
11.83
8.0
4.3
2.32
1.73
mmol/l
0.27
34
101
34
98
4.46
11.18
18.6
10.8
—
—
—
0
0
92
523
4.35
11.15
20.3
7.3
1.20
1.21
mmol/l
0.36
85
445
73
360
3.66
10.89
6.4
3.5
116.02
245.81
e6/l
0.29
65
281
69
341
3.44
10.02
5.0
2.5
—
—
—
0
0
43
159
3.67
9.88
3.4
1.9
—
—
—
0
0
84
473
3.64
9.78
17.7
6.8
1.20
1.21
mmol/l
0.51
77
431
88
515
3.72
9.54
11.3
6.6
0.05
0.04
e9/l
1.11
74
434
35
115
3.89
9.52
2.5
1.8
—
—
—
0
0
89
528
3.72
9.36
43.6
13.9
1.57
1.28
inr
3.57
79
430
88
522
3.63
9.18
11.3
6.7
1.53
1.91
e9/l
2.46
76
454
87
514
3.58
9.10
11.4
6.6
0.70
0.63
e9/l
1.05
73
434
31
97
3.97
8.99
4.5
2.6
64.62
66.74
g/l
0.79
31
91
34
114
3.78
8.94
4.4
2.9
75.75
70.55
e9/l
0.47
19
83
74
400
3.25
8.93
8.3
4.1
71.36
124.99
e6/l
0.47
64
293
81
464
3.34
8.80
3.0
2.1
87.15
93.07
pmol/l
0.45
54
239
91
571
3.52
8.26
13.8
11.0
4.81
4.44
e9/l
0.71
81
495
63
321
3.05
8.25
10.7
4.7
7.40
7.40
ph
0.08
50
227
38
144
3.41
8.24
1.3
1.3
33.31
10.56
u/ml
—
10
57
87
532
3.36
8.23
12.1
6.7
0.23
0.19
e9/l
0.71
76
454
26
78
3.99
7.93
4.7
2.4
—
—
—
0
0
12
10
13.17
7.26
1.8
1.5
—
—
—
0
0
60
315
2.82
7.18
6.6
3.4
1.25
0.43
e6/l
0.57
52
239
35
139
3.15
6.91
14.5
7.7
7.40
7.41
ph
0.12
20
84
38
160
3.02
6.78
1.4
1.3
19.06
34.22
iu/ml
—
9
49
35
145
3.00
6.38
14.2
7.4
11.95
11.65
kpa
0.14
35
139
35
145
3.00
6.38
14.2
7.4
4.94
5.16
kpa
0.68
35
139
11
11
10.87
6.17
2.0
1.1
—
—
—
0
0
11
11
10.87
6.17
4.1
5.5
14.56
11.57
mg/l
0.65
11
11
17
35
5.49
6.03
5.5
3.5
2.30
1.86
index
—
10
21
57
316
2.54
5.83
3.9
3.1
—
—
—
0
0
61
350
2.52
5.78
7.8
4.0
21.97
11.39
mg/mmol
0.83
50
219
74
465
2.56
5.77
5.3
2.8
—
—
estimate
—
0
0
23
79
3.37
5.68
17.8
8.6
23.68
24.76
mmol/l
0.67
23
79
59
337
2.49
5.60
7.2
3.3
101.70
66.29
mg/l
0.48
51
220
32
136
2.85
5.51
1.3
1.3
—
—
—
0
0
27
105
3.03
5.44
16.1
9.0
1.48
1.29
mmol/l
0.54
27
105
26
101
3.01
5.24
2.4
1.5
—
—
—
0
0
12
19
6.89
5.23
1.6
1.2
—
—
—
0
0
37
175
2.62
5.16
3.7
1.9
31.38
29.31
s
0.73
37
169
37
177
2.58
5.03
6.4
3.3
0.80
1.53
e6/l
0.53
18
96
29
123
2.80
4.98
2.4
1.6
—
—
—
0
0
21
75
3.19
4.85
5.2
3.2
—
—
—
0
0
68
446
2.22
4.36
18.9
13.2
0.02
0.01
e9/l
0.48
50
361
14
42
3.64
4.19
6.9
3.3
36.84
33.96
mg/l
0.12
14
37
14
42
3.64
4.19
6.9
3.3
56.64
45.44
mg/l
0.40
14
37
31
148
2.48
4.16
2.3
1.8
—
—
—
0
0
49
287
2.20
4.11
12.1
7.4
—
—
—
0
0
14
37
4.15
4.05
6.3
3.1
3.60
1.30
ratio
—
8
18
42
239
2.17
3.73
2.4
1.7
1.48
1.70
mg/l
0.24
36
187
18
70
2.85
3.58
1.8
1.7
1.28
1.27
g/l
0.01
18
63
7
10
7.35
3.41
1.1
1.1
—
—
—
0
0
10
23
4.65
3.39
2.8
1.2
—
—
—
0
0
11
28
4.22
3.39
1.0
1.2
—
—
—
0
0
17
69
2.71
3.12
1.8
1.4
—
—
—
0
0
16
63
2.78
3.11
8.5
3.0
—
—
—
0
0
35
201
2.05
2.96
2.0
1.4
2.66
3.14
g/l
0.43
21
118
10
27
3.95
2.96
1.3
1.8
1.24
1.12
g/l
—
10
27
10
27
3.95
2.96
1.3
1.8
0.25
0.22
g/l
—
10
27
19
85
2.47
2.89
2.4
2.3
10.52
10.11
g/l
0.17
19
77
18
81
2.44
2.70
4.6
5.8
0.78
0.27
%
—
9
33
14
56
2.70
2.64
1.4
1.6
—
—
—
0
0
12
44
2.92
2.63
3.8
2.8
—
—
—
0
0
8
20
4.21
2.62
5.9
2.8
—
—
—
0
0
8
20
4.21
2.62
1.0
1.2
—
—
—
0
0
23
119
2.16
2.52
1.9
1.6
—
—
—
0
0
8
21
4.01
2.51
1.9
1.2
—
—
—
0
0
19
92
2.27
2.43
2.2
2.3
369.79
396.02
nmol/l
0.16
19
84
8
22
3.82
2.41
1.4
1.2
—
—
—
0
0
70
531
1.77
2.38
5.5
4.3
0.00
0.00
estimate
-0.00
13
123
6
13
4.80
2.30
1.0
1.2
99.33
105.69
pmol/l
—
6
13
18
88
2.23
2.25
6.6
5.6
0.95
1.03
%
—
10
40
5
9
5.74
2.23
1.2
1.2
—
—
—
0
0
8
24
3.50
2.22
1.1
3.0
—
—
—
0
0
10
36
2.94
2.20
1.7
1.5
0.10
0.30
mg/l
—
5
13
70
540
1.72
2.17
6.1
4.3
0.00
0.04
estimate
0.50
12
113
16
76
2.28
2.14
4.0
3.3
117.50
128.58
g/l
1.30
16
71
17
83
2.22
2.14
6.4
6.6
0.00
0.28
%
—
7
29
17
83
2.22
2.14
6.8
5.9
0.13
0.21
%
—
8
34
5
10
5.16
2.09
2.8
2.3
—
—
—
0
0
11
44
2.65
2.08
1.3
1.5
—
—
—
0
0
6
15
4.15
2.06
1.3
1.2
—
—
—
0
0
12
51
2.50
2.02
3.1
2.9
1.66
1.37
%
0.61
12
46
5
11
4.69
1.96
1.2
1.2
—
—
—
0
0
40
274
1.69
1.87
5.8
3.3
—
0.33
—
0
6
5
12
4.30
1.84
1.8
2.3
93.10
88.93
%
—
5
12
11
48
2.42
1.76
3.2
2.0
2.55
6.46
ug/l
0.28
11
41
5
13
3.96
1.73
2.6
1.7
12.84
10.77
%
—
5
13
67
533
1.59
1.68
6.1
4.3
0.00
0.00
estimate
-0.00
12
126
96
836
1.77
1.65
5.7
5.0
2.06
1.98
mu/l
0.26
90
738
56
429
1.58
1.64
4.6
3.8
5.79
6.23
ph
0.92
24
255
5
14
3.68
1.63
4.8
3.1
4.26
4.64
e9/l
—
5
14
6
21
2.95
1.52
4.5
3.2
59.50
60.64
%
—
6
21
24
355
0.59
1.46
2.3
3.5
—
—
—
0
0
5
16
3.21
1.45
10.2
3.1
—
—
—
0
0
57
451
1.51
1.38
9.2
4.6
42.52
43.87
ng/l
0.05
48
352
20
123
1.75
1.35
1.5
1.4
—
—
—
0
0
9
43
2.18
1.33
2.8
2.2
—
—
—
0
0
9
44
2.13
1.30
3.2
2.0
—
—
—
0
0
22
324
0.61
1.29
2.7
3.5
0.74
0.79
ug/l
0.12
17
220
6
25
2.47
1.26
1.0
1.2
—
—
—
0
0
12
65
1.94
1.18
1.8
1.9
—
—
—
0
0
5
20
2.56
1.16
2.8
2.7
4.98
4.70
kpa
—
5
20
5
20
2.56
1.16
2.8
2.7
10.64
8.48
kpa
—
5
20
7
31
2.33
1.12
2.7
2.5
7.39
7.41
ph
—
7
31
13
81
1.68
0.85
6.8
3.8
—
—
—
0
0
97
893
1.47
0.84
6.9
5.4
6.35
6.11
mmol/l
0.83
92
803
0
25
0.00
0.80
0.0
1.2
—
—
—
0
0
5
26
1.96
0.71
1.2
1.2
—
—
—
0
0
14
94
1.55
0.70
1.4
1.3
—
—
—
0
0
46
390
1.29
0.64
2.6
2.2
—
—
—
0
0
32
258
1.33
0.63
1.8
1.4
—
—
—
0
0
8
50
1.64
0.63
1.5
1.5
—
—
—
0
0
0
23
0.00
0.59
0.0
1.7
—
—
—
0
0
7
49
1.45
0.47
1.0
1.2
—
—
—
0
0
97
920
1.29
0.46
6.9
6.1
2.17
2.57
mmol/l
4.97
97
837
25
206
1.27
0.42
8.4
7.1
—
—
—
0
0
92
870
1.25
0.42
5.5
4.5
1.60
1.28
mmol/l
2.41
92
785
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
32
364
0.83
0.33
2.8
2.0
1.49
1.33
mmol/l
0.54
32
289
48
525
0.86
0.31
4.5
5.9
1.43
3.12
ug/l
1.36
42
464
10
75
1.36
0.31
1.3
1.2
—
—
—
0
0
13
105
1.27
0.26
1.8
1.6
—
—
—
0
0
11
88
1.28
0.23
6.1
4.2
—
—
—
0
0
98
950
1.18
0.23
42.0
15.7
—
—
—
0
0
16
135
1.21
0.23
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
175.83
—
0
13
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
38
407
0.90
0.16
6.4
4.4
0.00
0.00
estimate
—
10
106
33
314
1.07
0.08
5.1
4.4
0.00
0.00
estimate
—
10
113
9
87
1.04
0.07
2.1
1.5
—
—
—
0
0
29
299
0.96
0.03
6.2
3.9
0.00
0.00
estimate
—
9
98
0
6
0.00
0.00
0.0
2.3
—
9.90
—
0
6
6
63
0.95
0.00
3.7
4.1
36.72
36.96
°c
—
6
63
0
5
0.00
0.00
0.0
1.8
—
25.72
—
0
5
0
5
0.00
0.00
0.0
1.4
—
2280.00
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
1680.00
—
0
5
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
7.49
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
16.44
—
0
8
5
54
0.92
-0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
137.86
—
0
7

Mortality – FinRegistry

Association

Association between endpoint GOUT_SCND and mortality.

Females

Parameter HR [95% CI] p-value
GOUT_SCND 2.432 [1.7, 3.49] < 0.001
Birth year 0.994 [0.99, 1.0] 0.198

During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 306 females with GOUT_SCND died.

Males

Parameter HR [95% CI] p-value
GOUT_SCND 3.031 [2.18, 4.21] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 515 males with GOUT_SCND died.

Mortality risk

Mortality risk for people of age

years, who have GOUT_SCND.

N-year risk Females Males
1 0.272% 0.647%
5 1.404% 3.526%
10 3.392% 7.938%
15 6.578% 14.883%
20 11.242% 24.572%

Relationships between endpoints

Index endpoint: GOUT_SCND – Other secondary gout

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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