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Physiological and behavioural disorders associated with sexual development and orientation

DOID Endpoint Browser PheWeb

F5_SEXUAL

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F66
  • Hospital discharge: ICD-9 — 3020
  • Cause of death: ICD-10 — F66
  • Cause of death: ICD-9 — 3020

2 out of 7 registries used, show all original rules.

70

4. Check minimum number of events

None

70

5. Include endpoints

None

70

6. Filter based on genotype QC (FinnGen only)

61

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F63-F69
Name in latin
Perturbationes psychologicae et modi se gerendi ad formationem et orientationem sexualem adjunctae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 587 240 347
Only index persons 527 218 309
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population - 35.04 23.08
Only index persons 26.20 32.73 21.59

-FinnGen-

Key figures

All Female Male
Number of individuals 61 38 23
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 33.84 35.76 30.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
64
Matched controls
640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
18.5
32.5
42
60
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
34.1
24.2
32
18
E66.01
ICD-10 Finland
Obesity due to excess calories
12.4
22.0
29
40
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
23.8
19.2
28
20
F32.9
ICD-10 Finland
Depressive episode, unspecified
10.5
18.9
28
44
N05AX12
ATC
aripiprazole; systemic
29.0
17.1
23
12
N06AB04
ATC
citalopram; systemic
8.7
17.0
33
70
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
21.9
16.9
25
18
F66.9
ICD-10 Finland
Psychosexual development disorder, unspecified
+∞
16.3
15
*
E66.9
ICD-10 Finland
Obesity, unspecified
35.4
15.9
20
8
N06AX16
ATC
venlafaxine; oral
8.4
15.3
27
51
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.7
15.0
25
44
ZY010
NOMESCO Finland
Hospital outpatient
20.2
14.6
22
16
E66.8
ICD-10 Finland
Other obesity
17.2
14.3
23
20
N06AB03
ATC
fluoxetine; oral
14.9
13.4
23
23
N05AF03
ATC
chlorprothixene; systemic
87.9
13.2
14
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
12.9
12
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
12.9
12
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
48.0
12.9
15
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
8.0
12.4
21
37
N05AA02
ATC
levomepromazine; systemic
29.8
12.3
16
7
N05AX08
ATC
risperidone; systemic
14.3
12.2
21
21
N05AH03
ATC
olanzapine; systemic
13.0
11.7
21
23
Z2446
NOMESCO Finland
Social worker
15.3
11.5
19
17
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
14.5
11.2
19
18
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
12.7
11.1
20
22
A10BA02
ATC
metformin; oral
5.9
10.9
28
74
F66.01
ICD-10 Finland
Disorder in sexual maturity homosexual
+∞
10.7
10
*
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
10.7
10
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
18.9
10.7
16
11
E66.00
ICD-10 Finland
Metabolic syndrome
21.2
10.5
15
9
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
17.3
10.4
16
12
N05BA04
ATC
oxazepam; oral
5.2
9.8
32
103
N06AB06
ATC
sertraline; oral
5.9
9.6
22
52
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
19.4
9.6
14
9
Z2445
NOMESCO Finland
Psychologist
15.9
9.5
15
12
T36
ICD-10 Finland
Poisoning by systemic antibiotics
22.8
9.4
13
7
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
6.2
9.4
20
44
F31.8
ICD-10 Finland
Other bipolar affective disorders
28.9
9.3
12
5
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
14.6
9.1
15
13
N03AX09
ATC
lamotrigine; oral
13.6
8.9
15
14
N05AH02
ATC
clozapine; systemic
24.1
8.9
12
6
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
32.6
8.8
11
*
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
17.7
8.6
13
9
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
103.1
8.6
9
*
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
14.5
8.6
14
12
N06AX12
ATC
bupropion; oral
9.2
8.5
18
26
F66.00
ICD-10 Finland
Disorder in sexual maturity heterosexual
+∞
8.5
8
*
3020A
ICD-9 Finland
Sexual deviations and disorders, Ego-dystonic homosexuality
+∞
8.5
8
*
Z3226
NOMESCO Finland
Physiotherapist
5.1
8.4
23
63
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
26.0
8.3
11
5
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
26.0
8.3
11
5
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
15.9
8.3
13
10
Z3231
NOMESCO Finland
Registered nurse
4.6
8.1
29
98
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
11.1
8.1
15
17
N05BA06
ATC
lorazepam; systemic, sublingual
18.1
8.1
12
8
IGY99
NOMESCO Finland
Other psychiatric treatment contact
18.1
8.1
12
8
F34.1
ICD-10 Finland
Dysthymia
12.4
8.0
14
14
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
14.4
8.0
13
11
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
51.5
7.9
9
*
N06AX03
ATC
mianserin; oral
21.7
7.9
11
6
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
10.5
7.9
15
18
P29
ICPC
Psychological sympt/compl other
5.4
7.6
18
43
ZY000
NOMESCO Finland
Hospital inpatient
90.1
7.6
8
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
18.6
7.5
11
7
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
10.8
7.5
14
16
A10BJ06
ATC
semaglutide; parenteral
12.2
7.4
13
13
F60.9
ICD-10 Finland
Personality disorder, unspecified
+∞
7.4
7
*
F66.80
ICD-10 Finland
Other specified disorder of psychosexual development heterosexual
+∞
7.4
7
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
34.3
7.4
9
*
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
34.3
7.4
9
*
N05AB03
ATC
perphenazine; systemic, rectal
16.2
7.2
11
8
N05BE01
ATC
buspirone; oral
16.2
7.2
11
8
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
13.1
7.1
12
11
N06AB10
ATC
escitalopram; oral
4.1
6.9
28
102
F29
ICD-10 Finland
Unspecified nonorganic psychosis
12.0
6.9
12
12
T90
ICPC
Diabetes non-insulin dependent
4.6
6.9
21
62
N03AG01
ATC
valproic acid; systemic, rectal
9.9
6.7
13
16
F20.9
ICD-10 Finland
Schizophrenia, unspecified
13.0
6.6
11
10
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
77.2
6.6
7
*
E11
ICD-10 Finland
Type 2 diabetes mellitus
5.1
6.5
16
39
N05CD07
ATC
temazepam; oral
9.3
6.5
13
17
N06AX11
ATC
mirtazapine; oral
3.8
6.4
33
141
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
30.0
6.4
8
*
103
Kela drug reimbursment
Diabetes, insulin-treated
4.2
6.4
22
71
F66.09
ICD-10 Finland
Disorder of sexual maturity other or indefinite
+∞
6.3
6
*
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
9.6
6.2
12
15
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
9.6
6.2
12
15
IGY02
NOMESCO Finland
Psychiatric monitoring contact
10.8
6.1
11
12
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.1
6.0
21
68

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
54
4.58
6.47
1.4
1.2
—
—
—
0
0
8
9
9.95
4.42
2.0
1.6
—
—
—
0
0
7
6
12.87
4.38
1.4
2.0
9.23
8.28
kpa
—
7
6
9
15
6.78
3.97
2.3
1.5
—
—
—
0
0
25
126
2.61
3.24
11.2
3.1
7.40
7.39
ph
0.20
18
84
26
135
2.56
3.16
3.6
3.6
36.61
60.72
mg/l
0.36
16
93
41
264
2.54
3.14
8.4
6.4
0.58
0.55
e9/l
0.32
35
232
33
193
2.47
3.10
3.1
1.7
88.92
95.85
pmol/l
0.45
23
105
41
265
2.52
3.10
8.4
6.4
0.04
0.04
e9/l
0.21
35
232
15
60
2.96
2.96
3.3
2.6
8.60
5.10
umol/l
—
10
55
7
13
5.90
2.95
1.1
3.9
—
—
—
0
0
45
308
2.55
2.94
17.7
11.0
3.94
4.02
e9/l
0.09
40
267
41
271
2.43
2.87
9.5
6.4
1.98
1.83
e9/l
0.57
36
244
22
110
2.52
2.85
11.1
4.0
—
—
—
0
0
11
35
3.58
2.81
7.2
7.5
—
—
—
0
0
10
30
3.75
2.74
1.8
1.4
—
—
—
0
0
10
30
3.75
2.74
1.8
1.4
—
—
—
0
0
13
50
3.01
2.73
4.3
7.9
105.62
104.02
mmol/l
1.22
13
50
9
25
4.01
2.69
5.9
2.4
24.42
25.02
mmol/l
—
9
25
10
31
3.63
2.65
1.8
1.4
—
—
—
0
0
10
31
3.63
2.65
1.8
1.4
—
—
—
0
0
41
277
2.34
2.65
11.0
6.5
0.19
0.18
e9/l
0.11
36
247
25
137
2.35
2.63
4.0
4.2
8.64
10.16
mg/mmol
0.10
14
91
8
21
4.20
2.56
1.9
1.4
—
—
—
0
0
18
87
2.49
2.47
5.7
3.4
755.36
107.05
ng/l
0.39
11
57
7
17
4.48
2.43
6.1
10.5
24.96
25.28
mmol/l
—
7
17
9
29
3.44
2.33
1.9
1.4
—
—
—
0
0
27
162
2.15
2.23
9.3
5.8
—
—
—
0
0
25
146
2.17
2.21
5.1
2.7
70.61
18.12
e6/l
0.54
20
109
9
31
3.21
2.17
1.1
1.1
—
—
—
0
0
5
11
4.83
1.98
4.0
2.2
64.08
59.07
%
—
5
11
9
34
2.91
1.95
5.2
2.9
5.13
4.09
kpa
—
9
34
8
28
3.11
1.94
3.9
2.6
1.84
1.84
%
—
8
28
26
161
2.04
1.93
9.0
5.7
—
—
—
0
0
14
67
2.39
1.93
2.4
1.5
—
—
—
0
0
5
12
4.42
1.86
7.4
2.1
0.00
5.00
index
—
5
5
22
130
2.05
1.84
6.9
2.3
—
—
—
0
0
15
76
2.27
1.83
2.6
1.9
—
—
—
0
0
6
18
3.56
1.79
4.7
11.7
24.67
25.33
mmol/l
—
6
18
33
228
1.92
1.76
3.9
3.3
6.17
6.22
ph
0.09
18
139
7
25
3.01
1.70
1.9
2.8
0.54
0.72
%
—
7
25
27
178
1.89
1.63
6.1
3.1
43.39
103.58
e6/l
0.32
20
115
6
20
3.20
1.62
4.8
12.5
93.65
92.40
%
—
6
20
6
20
3.20
1.62
5.0
12.3
0.47
0.72
%
—
6
20
6
21
3.04
1.54
5.0
11.9
1.58
1.39
%
—
6
21
13
68
2.14
1.46
1.5
1.5
—
—
—
0
0
7
29
2.58
1.44
37.7
6.8
8.86
8.01
mmol/l
—
7
29
22
141
1.85
1.42
1.5
1.3
1.92
2.20
g/l
0.72
13
78
18
271
0.53
1.42
2.4
2.5
—
—
—
0
0
32
232
1.76
1.37
2.0
2.0
1.57
1.45
mmol/l
0.39
25
202
8
34
2.54
1.35
5.0
7.6
1.40
1.61
mmol/l
—
8
34
5
18
2.92
1.31
6.6
1.6
—
—
—
0
0
20
130
1.78
1.22
5.1
2.3
—
—
estimate
—
0
0
47
388
1.80
1.22
13.2
7.6
83.55
75.65
u/l
0.74
47
361
23
156
1.74
1.22
4.4
2.6
—
0.40
—
0
5
31
231
1.66
1.16
23.9
8.4
0.00
0.00
e9/l
-0.00
23
181
7
32
2.33
1.12
1.3
1.1
—
—
—
0
0
35
271
1.64
1.11
5.2
3.6
0.00
0.00
estimate
—
6
51
5
22
2.38
1.05
1.6
1.3
—
—
—
0
0
23
162
1.66
1.04
3.0
2.5
0.00
0.03
estimate
—
5
38
7
129
0.49
1.02
2.0
1.5
—
—
—
0
0
11
62
1.93
1.01
1.1
1.3
—
—
—
0
0
7
36
2.06
1.00
1.3
1.2
—
—
—
0
0
35
277
1.58
0.98
5.4
3.7
0.00
0.00
estimate
—
6
51
35
278
1.57
0.96
4.5
3.8
0.00
0.00
estimate
—
5
49
13
192
0.59
0.86
1.4
1.6
—
—
—
0
0
18
126
1.60
0.82
5.9
4.5
—
—
—
0
0
14
92
1.67
0.81
3.6
1.7
—
—
—
0
0
7
38
1.94
0.76
3.9
2.3
—
—
—
0
0
22
166
1.50
0.72
5.9
2.2
—
—
—
0
0
27
213
1.46
0.71
4.5
3.5
0.00
0.00
estimate
—
5
43
5
29
1.78
0.65
1.6
1.4
—
0.45
—
0
10
5
30
1.72
0.62
1.2
1.4
—
—
—
0
0
31
259
1.38
0.57
6.5
3.0
128.32
88.43
ug/l
0.32
31
253
31
262
1.36
0.52
3.4
2.6
—
—
estimate
—
0
0
23
186
1.37
0.50
3.0
1.9
—
—
—
0
0
59
557
1.76
0.49
33.6
12.0
26.09
21.13
mg/l
0.50
51
435
15
114
1.41
0.46
4.5
1.8
—
—
—
0
0
15
114
1.41
0.46
1.5
1.3
34.60
23.95
iu/ml
—
5
26
5
31
1.66
0.44
3.8
2.5
—
224.23
—
0
11
26
219
1.32
0.43
2.5
1.8
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
15
0.00
0.42
0.0
1.0
—
0.32
—
0
8
0
16
0.00
0.41
0.0
1.0
—
5.46
—
0
8
6
42
1.47
0.37
11.2
3.2
7.39
7.38
ph
—
6
31
20
166
1.30
0.36
1.7
1.3
0.57
1.77
u/ml
—
7
35
7
52
1.39
0.32
1.7
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
9.42
—
0
6
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
0.99
—
0
7
7
61
1.17
0.18
1.1
1.2
—
—
—
0
0
5
69
0.70
0.18
2.2
2.0
—
—
—
0
0
8
70
1.16
0.17
1.6
1.2
—
—
—
0
0
58
584
0.93
0.09
30.1
10.2
—
—
—
0
0
7
64
1.11
0.08
1.1
1.4
—
—
—
0
0
19
177
1.10
0.07
4.9
3.3
37.25
19.88
ng/l
0.38
12
96
13
139
0.92
0.04
2.8
1.7
—
—
—
0
0
16
153
1.06
0.01
3.5
4.0
0.00
0.02
estimate
—
6
45
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
1.30
—
0
6
0
7
0.00
-0.00
0.0
2.3
—
196.69
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
7.00
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
29.62
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.70
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.2
—
9.20
—
0
5
0
5
0.00
-0.00
0.0
2.6
—
32.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
137.32
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
117.60
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_SEXUAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_SEXUAL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: F5_SEXUAL – Physiological and behavioural disorders associated with sexual development and orientation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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