No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
170 |
4. Check minimum number of eventsNone |
170 |
5. Include endpointsNone |
170 |
6. Filter based on genotype QC (FinnGen only) |
149 |
Control definitions (FinnGen only)
- Control exclude
- F5_PERSOBEH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F60-F62
- Name in latin
- Commutationes personalitatis persistentes non laesioni neque morbo cerebri ascribendae
Similar endpoints
↥List of similar endpoints to
Enduring personality changes
based on the number of shared cases.
Similar with more cases:
- Disorders of adult personality and behaviour
- Any mental disorder
- Psychiatric diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1229 | 593 | 625 |
| Only index persons | 1114 | 557 | 557 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 43.28 | 42.70 | 43.81 |
| Only index persons | 42.94 | 42.65 | 43.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 149 | 82 | 67 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 45.58 | 42.87 | 48.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 157
- Matched controls
- 1570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F62.9
ICD-10 Finland
Enduring personality change, unspecified
+∞
60.4
54
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
18.7
59.6
55
44
N05AH04
ATC
quetiapine; oral
11.5
54.9
93
176
N05AX08
ATC
risperidone; systemic
15.9
54.8
56
53
N05AX12
ATC
aripiprazole; systemic
22.6
52.4
42
25
F62.0
ICD-10 Finland
Enduring personality change after catastrophic experience
+∞
50.8
46
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
14.7
50.8
54
54
F32.9
ICD-10 Finland
Depressive episode, unspecified
11.4
50.4
72
109
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
16.6
46.5
44
36
N05AH03
ATC
olanzapine; systemic
14.6
46.1
48
46
F62.8
ICD-10 Finland
Other enduring personality changes
+∞
45.0
41
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
20.2
42.2
35
22
N06AB04
ATC
citalopram; systemic
8.6
40.9
78
161
N06AX16
ATC
venlafaxine; oral
8.3
38.0
71
142
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
8.8
35.9
58
98
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
15.2
34.4
33
27
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
13.0
32.8
35
34
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
9.2
32.7
48
72
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.3
32.7
54
93
N03AX09
ATC
lamotrigine; oral
11.6
28.1
32
34
P29
ICPC
Psychological sympt/compl other
7.9
26.8
44
74
N06AX11
ATC
mirtazapine; oral
5.8
26.7
101
370
N05CD07
ATC
temazepam; oral
7.8
26.3
43
72
N06AB06
ATC
sertraline; oral
7.0
26.1
49
95
N05BA01
ATC
diazepam; systemic, rectal
6.9
26.1
50
99
N03AG01
ATC
valproic acid; systemic, rectal
10.3
25.8
32
38
N06AB03
ATC
fluoxetine; oral
6.8
25.8
51
104
F60.9
ICD-10 Finland
Personality disorder, unspecified
295.0
25.5
25
*
N05AA02
ATC
levomepromazine; systemic
26.1
25.3
35
17
ZY010
NOMESCO Finland
Hospital outpatient
9.9
24.4
31
38
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
147.5
24.4
25
*
N03AE01
ATC
clonazepam; systemic
10.6
24.1
29
33
P76
ICPC
Depressive disorder
7.7
23.8
39
65
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
27.2
22.8
31
14
N05AB03
ATC
perphenazine; systemic, rectal
27.0
21.3
29
13
N06AA09
ATC
amitriptyline; systemic
7.3
21.0
35
59
F62.1
ICD-10 Finland
Enduring personality change after psychiatric illness
+∞
20.2
19
*
N05BA04
ATC
oxazepam; oral
4.7
20.2
74
252
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
8.0
19.4
29
43
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
19.1
18
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
8.2
18.0
26
37
N05BA12
ATC
alprazolam; oral
6.0
17.1
35
72
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
5.2
17.0
43
107
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
189.3
16.8
17
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
189.3
16.8
17
*
N06AX21
ATC
duloxetine; oral
4.9
16.5
45
119
SPAT1240
SPAT
Therapeutic discussion
5.2
16.5
40
96
N05CF01
ATC
zopiclone; oral
4.0
16.4
77
305
F29
ICD-10 Finland
Unspecified nonorganic psychosis
13.4
16.1
28
25
N03AX16
ATC
[U] pregabalin
4.2
16.0
59
197
N05AF03
ATC
chlorprothixene; systemic
20.5
15.7
23
13
F43.1
ICD-10 Finland
Post-traumatic stress disorder
12.8
15.2
27
25
Z2446
NOMESCO Finland
Social worker
6.6
15.2
27
48
N06AX03
ATC
mianserin; oral
12.7
14.7
26
24
P74
ICPC
Anxiety disorder/anxiety state
6.6
14.2
25
44
F34.1
ICD-10 Finland
Dysthymia
11.7
14.1
26
26
N03AX12
ATC
[U] gabapentin; oral
4.1
13.7
47
147
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
14.8
13.4
22
17
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
6.4
13.3
24
43
N06AB05
ATC
paroxetine; oral
6.6
13.2
23
40
L28
ICPC
Limited function/disability (L)
4.2
13.0
42
125
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
12.9
56
205
N05BA06
ATC
lorazepam; systemic, sublingual
11.5
12.5
23
23
F32.1
ICD-10 Finland
Moderate depressive episode
5.1
12.3
29
67
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.8
12.1
31
77
N06AX12
ATC
bupropion; oral
5.2
12.0
27
60
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
32.9
11.9
15
5
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.6
11.8
24
29
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
129.1
11.6
12
*
F60.5
ICD-10 Finland
Anankastic personality disorder
46.9
11.1
13
*
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
9.1
11.1
23
29
F32.8
ICD-10 Finland
Other depressive episodes
23.5
10.9
15
7
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
9.0
10.5
22
28
N05AD01
ATC
haloperidol; systemic
14.5
10.4
17
13
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.1
10.4
24
54
N05AN01
ATC
lithium; oral
11.2
10.3
19
19
IGY02
NOMESCO Finland
Psychiatric monitoring contact
9.1
10.2
21
26
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
13.4
10.1
17
14
IGY99
NOMESCO Finland
Other psychiatric treatment contact
10.6
10.1
19
20
F41.1
ICD-10 Finland
Generalized anxiety disorder
4.9
10.0
24
56
A01
ICPC
Pain general/multiple sites
4.0
10.0
32
94
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
14.7
9.9
16
12
P01
ICPC
Feeling anxious/nervous/tense
3.4
9.9
43
155
SPAT1260
SPAT
Consultation of another employee
3.5
9.7
41
145
N06CA01
ATC
amitriptyline and psycholeptics; systemic
4.4
9.7
27
71
WZC00, ,
SPAT
3.7
9.6
36
118
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
10.5
9.6
18
19
N04AA02
ATC
biperiden; systemic
23.4
9.5
13
6
F61
ICD-10 Finland
Mixed and other personality disorders
+∞
9.5
9
*
F40.1
ICD-10 Finland
Social phobias
12.6
9.3
16
14
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
8.5
9.0
19
25
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
8.9
31
96
N06AA12
ATC
doxepin; systemic
7.2
8.8
21
33
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
9.9
8.8
17
19
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.6
8.8
15
13
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.5
8.7
20
30
L03
ICPC
Low back symptom/complaint
2.8
8.6
64
311
SPAT1307
SPAT
Psychosocial counselling and guidance
5.1
8.6
19
41
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
29.3
8.6
11
*
A06AD11
ATC
lactulose; oral
3.8
8.6
30
93
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
13.8
8.6
14
11
N06AB10
ATC
escitalopram; oral
2.9
8.5
53
234
C03CA01
ATC
furosemide; systemic
3.0
8.5
46
188
N06AX26
ATC
vortioxetine; oral
4.2
8.4
24
64
N06AG02
ATC
moclobemide; oral
7.6
8.4
19
28
F99
ICD-10 Finland
Mental disorder, not otherwise specified
12.7
8.3
14
12
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.1
8.2
25
70
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
18.4
8.2
12
7
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
8.1
26
76
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
6.6
8.0
20
34
R02
ICPC
Shortness of breath/dyspnoea
3.5
7.9
30
98
R53
ICD-10 Finland
Malaise and fatigue
2.7
7.8
55
258
N05AB01
ATC
dixyrazine; systemic
47.4
7.8
9
*
J01FF01
ATC
clindamycin; systemic
2.7
7.7
57
274
N07BB01
ATC
disulfiram; oral
7.1
7.7
18
28
P03
ICPC
Feeling depressed
3.4
7.6
31
106
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
9.1
7.5
15
18
N03AF01
ATC
carbamazepine; oral, rectal
6.9
7.5
18
29
F60.8
ICD-10 Finland
Other specific personality disorders
83.9
7.5
8
*
ZYC01
NOMESCO Finland
Remote contact by phone
4.3
7.2
20
52
N06AA04
ATC
clomipramine; systemic
21.2
7.2
10
5
N05AL01
ATC
sulpiride; systemic
21.2
7.2
10
5
SPAT1263
SPAT
Sampling
2.5
7.2
74
415
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.4
7.1
19
48
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
7.1
32
117
N02BF02
ATC
pregabalin; oral
4.2
7.1
20
53
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.9
7.0
41
173
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
6.2
7.0
18
32
R11
ICD-10 Finland
Nausea and vomiting
3.8
7.0
23
68
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
7.0
40
167
R52.2
ICD-10 Finland
Other chronic pain
6.4
6.8
17
29
ICB01, ,
SPAT
41.9
6.8
8
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.6
6.7
24
75
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.4
6.7
26
86
Z2445
NOMESCO Finland
Psychologist
5.8
6.7
18
34
P99
ICPC
Psychological disorders other
7.4
6.7
15
22
M54.4
ICD-10 Finland
Lumbago with sciatica
2.7
6.7
43
191
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
10.7
6.7
12
12
Z3231
NOMESCO Finland
Registered nurse
2.5
6.7
54
269
M54.5
ICD-10 Finland
Low back pain
2.4
6.6
74
426
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
6.6
51
248
F41.8
ICD-10 Finland
Other specified anxiety disorders
6.5
6.5
16
27
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
6.5
73
421
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
15.1
6.5
10
7
F21
ICD-10 Finland
Schizotypal disorder
72.7
6.5
7
*
ICB03, ,
SPAT
72.7
6.5
7
*
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
11.7
6.4
11
10
N05BE01
ATC
buspirone; oral
6.8
6.3
15
24
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
6.3
6
*
SPAT1219
SPAT
Assessment of need for vocational rehabilitation
+∞
6.3
6
*
N05CF02
ATC
zolpidem; oral
2.7
6.3
39
170
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
9.2
6.2
12
14
F43.9
ICD-10 Finland
Reaction to severe stress, unspecified
6.5
6.2
15
25
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.7
6.1
20
59
S06.0
ICD-10 Finland
Concussion
3.3
6.1
25
86
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.3
6.1
25
86
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
97
577
2.78
8.82
9.9
7.9
1.21
1.21
mmol/l
0.04
89
507
49
205
3.02
8.72
2.2
1.7
395.40
65363569.80
pmol/l
0.50
43
179
90
522
2.70
8.51
10.0
7.3
1.20
1.21
mmol/l
0.50
85
501
86
505
2.55
7.68
2.2
2.0
97.93
96.70
pmol/l
0.08
54
272
33
121
3.19
7.26
16.7
11.7
10.61
13.09
kpa
2.19
33
116
33
121
3.19
7.26
16.8
11.7
5.45
5.17
kpa
1.16
33
115
21
57
4.10
7.19
3.3
2.8
1.73
1.20
mmol/l
—
10
46
22
63
3.90
7.01
1.5
1.3
—
—
—
0
0
26
85
3.47
6.84
2.7
1.4
0.39
0.31
mg/l
0.32
13
35
59
316
2.39
6.14
4.6
3.6
1.02
1.02
kg/l
1.45
39
203
11
12
9.75
5.89
15.3
12.1
0.75
0.63
mmol/l
0.56
11
12
33
141
2.70
5.46
2.4
1.6
—
—
—
0
0
41
196
2.48
5.40
2.5
1.8
—
—
—
0
0
70
425
2.17
5.24
2.3
3.3
2.35
2.36
mmol/l
0.66
65
396
54
298
2.24
5.10
2.5
2.1
2.87
2.62
mg/l
0.32
46
260
127
995
2.45
4.76
8.7
8.4
81.52
76.59
u/l
0.59
122
952
33
152
2.48
4.66
2.4
1.6
—
—
—
0
0
14
33
4.55
4.45
3.8
2.8
23.47
24.70
mmol/l
0.56
14
33
60
363
2.06
4.38
3.5
2.9
0.43
0.29
e6/l
0.31
41
261
34
164
2.37
4.33
17.0
7.0
104.85
104.24
mmol/l
0.50
34
164
129
1040
2.35
4.16
6.6
4.2
14.43
14.51
pmol/l
0.12
121
981
38
207
2.10
3.59
2.5
2.7
3.98
2.11
e6/l
0.60
14
101
8
14
5.96
3.38
2.6
1.1
—
—
—
0
0
59
383
1.87
3.35
4.0
4.0
2.27
8.84
mg/mmol
2.89
36
239
11
29
4.00
3.25
3.7
2.8
8.65
8.52
kpa
0.10
11
29
37
210
2.00
3.11
2.8
2.0
—
—
—
0
0
95
732
1.75
2.92
4.9
3.5
0.00
0.00
estimate
-0.00
25
143
96
743
1.75
2.89
4.9
3.5
0.04
0.00
estimate
0.49
25
143
38
225
1.91
2.81
2.6
2.6
0.74
0.98
e6/l
0.25
16
119
67
472
1.73
2.80
5.3
3.4
23.73
51.44
ng/l
1.10
47
286
16
67
2.55
2.73
2.5
4.0
24.38
24.09
mmol/l
0.22
16
67
46
293
1.81
2.70
2.0
1.9
0.81
1.07
mg/l
0.44
35
225
17
74
2.45
2.69
3.2
2.8
0.75
0.65
%
0.60
17
74
17
75
2.42
2.62
3.2
2.9
1.85
1.09
%
0.92
17
75
95
748
1.68
2.56
4.9
3.6
0.00
0.00
estimate
-0.00
23
137
38
232
1.84
2.55
3.1
2.1
—
—
—
0
0
24
127
2.05
2.42
2.6
2.0
—
—
—
0
0
90
705
1.65
2.42
6.9
7.0
8.98
11.29
umol/l
3.11
82
682
7
17
4.26
2.39
6.0
3.6
17.77
15.84
%
—
7
17
97
783
1.62
2.24
9.9
10.5
4.40
3.90
e9/l
0.98
85
685
48
328
1.67
2.16
3.6
3.1
661.43
904.43
ng/l
0.62
41
273
20
106
2.02
2.02
2.5
1.9
—
—
—
0
0
5
11
4.65
1.95
32.0
20.5
691.20
858.64
nmol/l
—
5
11
53
383
1.58
1.88
5.1
3.7
0.00
0.00
estimate
-0.00
24
135
18
95
2.01
1.84
4.3
2.4
89.50
73.83
ml/min/173m2
—
6
36
138
1247
1.88
1.83
7.8
5.0
1.80
1.86
mu/l
0.26
130
1174
22
126
1.87
1.79
2.5
2.8
46.53
29.27
u/l
0.30
15
103
118
1025
1.61
1.79
5.1
4.1
11.38
9.19
mm/h
1.03
113
972
8
30
2.75
1.75
1.0
1.4
—
—
—
0
0
8
30
2.75
1.75
2.3
1.5
—
—
—
0
0
15
77
2.05
1.65
21.3
7.9
25.67
24.87
mmol/l
0.60
15
77
5
14
3.65
1.63
1.0
1.3
—
—
—
0
0
43
306
1.56
1.61
2.2
2.3
—
—
—
0
0
82
671
1.46
1.56
4.0
3.0
88.50
96.21
ug/l
0.16
75
643
6
22
2.79
1.45
2.3
1.5
—
—
—
0
0
13
67
2.03
1.43
1.5
1.6
—
—
—
0
0
13
69
1.96
1.33
1.8
1.7
—
2904.95
u/l
—
0
22
5
20
2.55
1.16
5.2
2.1
3.36
2.27
u/ml
—
5
20
5
20
2.55
1.16
1.0
1.1
—
—
—
0
0
14
83
1.75
1.05
1.0
1.7
—
—
—
0
0
45
352
1.39
1.03
1.4
1.4
0.79
1.64
u/ml
—
10
103
9
48
1.93
1.02
2.1
1.2
—
—
—
0
0
137
1286
1.51
0.93
20.4
12.7
91.22
87.99
ml/min/173m2
1.04
123
1187
8
42
1.95
0.90
1.1
1.9
—
—
—
0
0
23
163
1.48
0.88
2.3
3.1
3.39
6.58
umol/l
2.25
18
150
6
31
1.97
0.85
1.3
1.4
—
180.93
—
0
9
12
75
1.65
0.77
1.6
1.4
—
—
—
0
0
6
34
1.79
0.77
4.0
1.6
—
—
—
0
0
30
231
1.37
0.75
3.6
3.3
38.57
336.23
ng/l
1.20
21
155
5
25
2.03
0.73
1.0
1.1
—
—
—
0
0
7
40
1.78
0.72
1.3
1.8
—
—
—
0
0
16
110
1.51
0.71
1.8
1.2
69.63
160.38
u/ml
2.29
16
102
7
43
1.66
0.67
1.6
2.2
—
—
—
0
0
92
1004
0.80
0.67
3.3
3.5
—
—
—
0
0
65
568
1.25
0.64
5.6
3.4
0.00
0.01
estimate
0.50
19
128
5
29
1.75
0.64
1.8
1.5
—
—
—
0
0
10
63
1.63
0.63
1.1
1.4
—
—
—
0
0
10
65
1.58
0.57
2.9
1.9
39.00
37.15
nmol/l
—
10
65
6
39
1.56
0.53
1.5
3.1
191.67
173.41
%
—
6
39
15
109
1.42
0.53
1.6
1.4
—
—
—
0
0
14
101
1.42
0.51
2.1
1.7
20.79
24.89
iu/l
—
8
85
141
1360
1.36
0.50
21.8
13.4
24.28
22.23
mg/l
0.27
122
1074
5
31
1.63
0.43
1.0
1.2
—
—
—
0
0
5
31
1.63
0.43
1.0
1.2
—
—
—
0
0
5
31
1.63
0.43
1.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
4.8
—
83.91
—
0
15
16
124
1.32
0.40
13.2
7.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
13.58
—
0
18
0
19
0.00
0.39
0.0
1.1
—
20.15
—
0
8
15
116
1.32
0.38
6.7
2.9
—
—
—
0
0
68
624
1.16
0.36
2.5
2.7
—
—
estimate
—
0
0
6
45
1.35
0.34
1.3
2.9
94.50
97.78
%
—
6
45
118
1222
0.86
0.30
27.2
16.8
331.85
333.38
g/l
0.87
118
1215
125
1284
0.87
0.24
4.6
4.1
1.57
1.27
mmol/l
3.57
120
1203
32
286
1.15
0.24
1.4
1.3
91.70
28.86
iu/ml
—
10
87
5
37
1.36
0.24
1.0
1.1
—
14.96
—
0
7
5
39
1.29
0.23
1.2
1.4
—
—
—
0
0
5
40
1.26
0.22
4.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
5.1
—
716.54
—
0
13
46
429
1.10
0.18
4.9
3.0
0.00
0.01
estimate
0.50
17
121
36
338
1.08
0.12
1.4
1.6
—
—
—
0
0
133
1349
0.91
0.11
5.1
4.7
1.34
1.46
mmol/l
2.45
128
1274
61
586
1.07
0.11
2.0
1.9
1.75
1.41
mmol/l
1.18
49
512
25
267
0.92
0.09
2.8
2.6
0.43
0.71
ug/l
2.25
18
143
33
346
0.94
0.07
4.1
4.2
18.05
22.01
%
0.94
11
140
10
89
1.13
0.07
1.1
1.0
—
—
—
0
0
27
260
1.05
0.03
1.3
1.3
1.31
6.79
u/ml
1.55
11
103
26
263
0.99
0.00
1.6
1.5
—
—
—
0
0
137
1365
1.03
0.00
5.6
5.2
2.73
2.78
mmol/l
0.30
132
1291
5
59
0.84
-0.00
1.4
1.7
—
—
—
0
0
149
1487
1.04
-0.00
33.2
20.6
90.80
90.71
fl
0.08
149
1478
0
5
0.00
-0.00
0.0
2.6
—
44.44
—
0
5
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
149.33
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
149
1487
1.04
-0.00
35.7
21.0
41.23
41.14
%
0.10
149
1476
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
20.58
—
0
6
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
1.29
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
149
1488
1.03
-0.00
33.9
20.8
136.97
137.74
g/l
0.27
149
1480
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.87
-0.00
1.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_PERSOCHANGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSOCHANGE | 3.327 [2.45, 4.53] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 515 females with F5_PERSOCHANGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSOCHANGE | 2.806 [2.0, 3.94] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 545 males with F5_PERSOCHANGE died.
Mortality risk
Mortality risk for people of age
years, who have F5_PERSOCHANGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.583% |
| 5 | 1.694% | 3.167% |
| 10 | 4.18% | 7.849% |
| 15 | 7.833% | 15.454% |
| 20 | 14.019% | 26.046% |
Relationships between endpoints
↥Index endpoint: F5_PERSOCHANGE – Enduring personality changes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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