mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
298 |
4. Check minimum number of eventsNone |
298 |
5. Include endpointsNone |
298 |
6. Filter based on genotype QC (FinnGen only) |
238 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F70-F79
- Name in latin
- Retardatio mentalis moderata
Similar endpoints
↥List of similar endpoints to
Moderate mental retardation
based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation, excluding more controls
- Mental retardation, wide definition
- Psychiatric diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8871 | 3898 | 4958 |
| Only index persons | 7776 | 3383 | 4393 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.11 | 0.14 |
| Only index persons | 0.15 | 0.12 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 20.27 | 22.12 | 18.75 |
| Only index persons | 19.66 | 21.47 | 18.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 238 | 114 | 124 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | 21.98 | 22.82 | 21.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 253
- Matched controls
- 2530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
134.8
117
*
N03AG01
ATC
valproic acid; systemic, rectal
20.2
112.4
103
83
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
19.9
99.0
88
66
N05AX08
ATC
risperidone; systemic
14.6
93.8
107
121
G40.9
ICD-10 Finland
Epilepsy, unspecified
27.0
88.4
65
32
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
+∞
87.7
79
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
87.7
79
*
N05BA09
ATC
clobazam; oral
43.0
69.9
43
12
P85
ICPC
Mental retardation
+∞
69.0
63
*
N05AA02
ATC
levomepromazine; systemic
19.9
65.2
54
34
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
63.2
58
*
N05BA01
ATC
diazepam; systemic, rectal
9.4
61.7
94
149
N03AF01
ATC
carbamazepine; oral, rectal
17.8
61.5
54
38
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
9.1
58.7
92
150
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
+∞
56.4
52
*
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
646.7
54.7
52
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
22.4
52.1
40
21
F71.9
ICD-10 Finland
Moderate mental retardation, without mention of impairment of behaviour
+∞
50.8
47
*
N03AX14
ATC
levetiracetam; systemic
17.2
47.9
42
29
N05CD08
ATC
midazolam; nasal, systemic
15.6
43.5
40
30
N03AX09
ATC
lamotrigine; oral
9.8
43.1
56
71
N03AX11
ATC
topiramate; oral
14.6
42.8
41
33
F83
ICD-10 Finland
Mixed specific developmental disorders
16.5
41.6
37
26
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
468.3
41.4
40
*
R62.0
ICD-10 Finland
Delayed milestone
15.0
35.5
33
25
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.5
35.4
58
96
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
+∞
34.1
32
*
183
Kela drug reimbursment
Lamotrigin and topiramate
33.6
30.9
40
14
R56.8
ICD-10 Finland
Other and unspecified convulsions
7.3
30.7
51
85
N05AH03
ATC
olanzapine; systemic
6.2
27.6
54
106
N05BA06
ATC
lorazepam; systemic, sublingual
9.8
26.9
33
38
N03AF02
ATC
oxcarbazepine; oral
8.9
23.5
31
39
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.8
23.3
62
159
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
26.0
23.3
32
14
EBA15
NOMESCO Finland
Extraction of multiple teeth
10.0
22.5
27
30
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.4
22.1
49
107
OAB43, ,
SPAT
0.1
21.6
7
661
A06AD11
ATC
lactulose; oral
4.8
21.5
57
145
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.6
21.2
37
64
F71
ICD-10 Finland
Moderate mental retardation
+∞
21.1
20
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
20.8
93
345
N05AC02
ATC
thioridazine; oral
26.0
20.5
28
12
A28
ICPC
Limited function/disability NOS
4.4
20.3
60
166
31299
ICD-8 Finland
Moderate mental retardation, Other and unspecified
+∞
20.1
19
*
N05AX12
ATC
aripiprazole; systemic
5.9
19.6
38
73
N03AE01
ATC
clonazepam; systemic
7.1
19.3
31
49
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
23.1
19.1
27
13
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
19.0
18
*
N05AH04
ATC
quetiapine; oral
3.6
18.7
83
304
N05AD01
ATC
haloperidol; systemic
16.0
18.6
30
21
G03DC03
ATC
lynestrenol; oral
18.0
17.0
26
16
N03AG04
ATC
vigabatrin; oral
96.6
16.8
18
*
L28
ICPC
Limited function/disability (L)
3.9
16.6
58
180
N04AA02
ATC
biperiden; systemic
17.2
16.1
25
16
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
90.8
15.8
17
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.1
15.6
50
145
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.1
15.5
48
136
3180A
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS,EI KÄYTÄYT.HÄIR]
+∞
14.7
14
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
21.6
14.0
20
10
181
Kela drug reimbursment
Retigabine and vigabatrin
79.6
13.7
15
*
G40.10
ICD-10 Finland
Simple partial seizures
36.3
13.7
17
5
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
13.7
13
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
147.6
13.6
14
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
22.7
13.5
19
9
K03.66
ICD-10 Finland
Tooth plaque
3.4
13.3
55
189
Z31.5
ICD-10 Finland
Genetic counselling
4.4
12.8
35
90
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
12.6
12
*
N05AF03
ATC
chlorprothixene; systemic
10.1
12.3
24
26
G40.89
ICD-10 Finland
Other epilepsy
22.6
12.2
17
8
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.3
12.1
34
89
N03AX23
ATC
brivaracetam; systemic
49.1
12.0
14
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.3
11.8
52
185
N03AX18
ATC
lacosamide; systemic
31.7
11.8
15
5
N88
ICPC
Epilepsy
24.3
11.7
16
7
WYA20
NOMESCO Finland
Home visit
14.6
11.7
19
14
R1260
NOMESCO Finland
Evaluation of communicative skills
14.6
11.7
19
14
N03AF03
ATC
rufinamide; oral
+∞
11.5
11
*
M01AH05
ATC
etoricoxib; oral
0.3
11.4
44
1008
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
11.3
59
232
H52.2
ICD-10 Finland
Astigmatism
5.6
11.3
22
42
G40.39
ICD-10 Finland
Other or unspecified generalized epileptic syndromes with atonic, clonic, myoclonic or tonic-clonic seizures
26.4
11.3
15
6
TLC00
NOMESCO Finland
Insertion of intrauterine device
4.9
11.2
26
58
OAA65, ,
SPAT
0.1
11.0
*
341
SDA02
NOMESCO Finland
Periodontal treatment, brief
2.4
11.0
125
723
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
29.5
10.8
14
5
SPAT1229
SPAT
Assessment of need for aid
5.6
10.8
21
40
Z2446
NOMESCO Finland
Social worker
3.4
10.5
42
140
3170A
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,EI KÄYTÄYTYM.HÄIRIÖTÄ]
+∞
10.5
10
*
G40.1
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
+∞
10.5
10
*
F79
ICD-10 Finland
Unspecified mental retardation
+∞
10.5
10
*
3199A
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS,EI KÄYTTÄYTYMIHÄIRI]
+∞
10.5
10
*
F72.1
ICD-10 Finland
Severe mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
10.5
10
*
N05AA01
ATC
chlorpromazine; systemic, rectal
19.8
10.4
15
8
N03AX22
ATC
perampanel; oral
24.6
10.4
14
6
K05.18
ICD-10 Finland
Chronic gingivitis
3.4
10.3
40
131
R5110, ,
SPAT
4.2
10.3
29
76
M03BX02
ATC
tizanidine; oral
0.3
9.9
45
973
OAA67, ,
SPAT
0.1
9.9
*
291
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
9.9
71
329
N05AH02
ATC
clozapine; systemic
8.4
9.8
21
27
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
57.2
9.7
11
*
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
57.2
9.7
11
*
RL140, ,
NOMESCO Finland
15.8
9.6
15
10
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
9.6
70
326
N03AX15
ATC
zonisamide; oral
31.3
9.5
12
*
Q99.8
ICD-10 Finland
Other specified chromosome abnormalities
103.8
9.5
10
*
3046, ,
Kela drug reimbursment
+∞
9.4
9
*
N03AX24
ATC
cannabidiol; oral
+∞
9.4
9
*
31209
ICD-8 Finland
Moderate mental retardation, Following infections and intoxications, Unspecified
+∞
9.4
9
*
199
Kela drug reimbursment
Rufinamide
+∞
9.4
9
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
14.4
9.3
15
11
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
9.3
33
102
M01AB05
ATC
diclofenac; systemic, rectal
0.4
9.0
53
1033
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.0
9.0
20
43
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
9.0
49
196
H50.31
ICD-10 Finland
Intermittent exotropia
9.1
9.0
18
21
R33
ICD-10 Finland
Retention of urine
4.4
8.9
23
56
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
14.7
8.8
14
10
XA800
NOMESCO Finland
Neuropsychological investigation
3.7
8.8
29
85
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.8
8.8
20
44
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.5
8.6
70
341
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
8.6
90
491
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.1
8.6
20
30
N05AD03
ATC
melperone; systemic
28.6
8.6
11
*
N05AF05
ATC
zuclopenthixol; systemic
20.9
8.6
12
6
N05CD07
ATC
temazepam; oral
3.6
8.5
29
87
H50.30
ICD-10 Finland
Intermittent esotropy
11.3
8.4
15
14
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
8.4
37
131
Q85.1
ICD-10 Finland
Tuberous sclerosis
+∞
8.4
8
*
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
+∞
8.4
8
*
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.1
8.3
*
255
R11
ICD-10 Finland
Nausea and vomiting
3.1
8.2
38
138
34599
ICD-8 Finland
Epilepsy, Other and unspecified
34.6
8.1
10
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
34.6
8.1
10
*
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
34.6
8.1
10
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
7.7
8.1
18
25
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
7.9
62
296
RS222, ,
NOMESCO Finland
11.3
7.9
14
13
Z50.5
ICD-10 Finland
Speech therapy
4.6
7.8
19
44
N06AB04
ATC
citalopram; systemic
2.6
7.8
50
217
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
46.4
7.8
9
*
AA1AD
NOMESCO Finland
CT of head and brain
2.4
7.7
63
307
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
2.3
7.7
68
343
RT490, ,
NOMESCO Finland
25.9
7.6
10
*
F84.0
ICD-10 Finland
Childhood autism
25.9
7.6
10
*
OAA62, ,
SPAT
0.0
7.6
*
182
N05BA04
ATC
oxazepam; oral
2.3
7.5
68
346
K59.09
ICD-10 Finland
Constipation, unspecified
3.6
7.5
26
79
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
82.4
7.5
8
*
N05AC01
ATC
periciazine; systemic
82.4
7.5
8
*
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
+∞
7.3
7
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
7.3
7
*
3170B
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,JOSSA KÄYTÄYTYM.HÄIRI]
+∞
7.3
7
*
31199
ICD-8 Finland
Mild mental retardation, Other and unspecified
+∞
7.3
7
*
1530, ,
Kela drug reimbursment
+∞
7.3
7
*
F72.9
ICD-10 Finland
Severe mental retardation, without mention of impairment of behaviour
+∞
7.3
7
*
3180B
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS JA KÄYTÄYT.HÄIR]
+∞
7.3
7
*
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
4.2
7.3
20
51
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.1
7.2
*
271
N03AB02
ATC
phenytoin; systemic
12.5
7.2
12
10
WX892
NOMESCO Finland
Monitored bed care
3.3
7.0
27
88
JDB10
NOMESCO Finland
Percutaneous gastrostomy
14.3
7.0
11
8
WYA50
NOMESCO Finland
Student oral health check consistent with decree to assess need for oral health guidance and services
0.0
6.9
*
198
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
6.9
37
146
U04
ICPC
Incontinence urine
4.5
6.9
17
40
SCA02
NOMESCO Finland
Preventive oral health care
2.2
6.8
71
381
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
17.3
6.8
10
6
G40.30
ICD-10 Finland
Benign myoclonic eplilepsy in infancy
41.2
6.8
8
*
SPAT1325
SPAT
Vaccination
2.0
6.8
98
597
N05BE01
ATC
buspirone; oral
6.8
6.8
16
25
N05AB03
ATC
perphenazine; systemic, rectal
6.2
6.7
17
29
Z02.4
ICD-10 Finland
Examination for driving licence
0.2
6.7
8
334
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.2
6.7
14
18
RT150, ,
NOMESCO Finland
12.7
6.6
11
9
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.5
6.6
45
200
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
7.2
6.6
15
22
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.9
6.6
20
55
U07
ICPC
Urine symptom/complaint other
3.1
6.6
28
97
EBA00
NOMESCO Finland
Extraction of tooth
2.0
6.5
124
829
7834D
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[LAPSEN NORMAALIN KEHITTYMISEN HIDASTUMINEN]
71.6
6.5
7
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
71.6
6.5
7
*
3459X
ICD-9 Finland
Epilepsy, unspecified
71.6
6.5
7
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
71.6
6.5
7
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
6.4
26
87
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
6.3
23
72
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
18.6
6.3
9
5
OAA80, ,
SPAT
0.1
6.3
*
205
F70
ICD-10 Finland
Mild mental retardation
+∞
6.3
6
*
N03AD01
ATC
ethosuximide; oral
27.4
6.3
8
*
4451
FHL
Guitar cutting
4.0
6.2
18
48
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.4
6.1
17
33
E86
ICD-10 Finland
Volume depletion
8.9
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
155
972
2.54
11.56
11.4
10.2
1.21
1.21
mmol/l
0.18
141
863
14
5
29.49
10.84
3.2
2.0
27.43
11.48
umol/l
—
14
5
141
895
2.30
9.58
10.4
10.2
1.21
1.22
mmol/l
0.02
133
846
68
321
2.53
9.00
2.1
2.0
—
—
—
0
0
61
284
2.51
8.26
4.8
9.5
1.17
1.74
mmol/l
0.80
52
231
54
242
2.57
7.89
2.1
1.8
—
—
—
0
0
50
218
2.61
7.72
8.4
6.0
1.64
1.43
mmol/l
0.14
37
163
45
194
2.61
7.08
7.8
14.4
2.86
0.90
mmol/l
3.36
37
162
51
237
2.44
6.85
2.2
1.9
—
—
—
0
0
53
255
2.36
6.58
5.8
11.7
103.87
104.68
mmol/l
0.37
53
255
15
25
6.31
6.10
17.6
14.4
927.00
788.36
nmol/l
0.40
15
25
46
215
2.39
6.07
1.6
1.5
1061.90
1250.69
nmol/l
0.89
39
172
36
679
0.45
4.77
1.9
1.8
—
—
—
0
0
24
93
2.75
4.62
1.8
1.3
—
—
—
0
0
183
1499
1.80
4.18
8.0
7.4
88.18
87.77
u/l
0.03
176
1423
133
998
1.70
4.17
6.6
6.9
8.88
12.43
umol/l
3.99
128
945
16
52
3.22
4.16
1.7
1.5
—
—
—
0
0
0
100
0.00
3.94
0.0
1.1
—
1.53
—
0
100
23
96
2.54
3.85
1.6
1.6
—
—
—
0
0
14
45
3.23
3.71
1.1
1.5
—
—
—
0
0
24
482
0.45
3.62
3.5
2.5
—
—
—
0
0
15
366
0.37
3.62
1.3
1.3
37.46
23.93
iu/ml
—
5
106
9
17
5.45
3.54
5.8
2.0
13.33
11.29
mmol/l
—
9
17
22
448
0.44
3.43
3.5
2.4
—
—
—
0
0
9
18
5.14
3.40
12.3
11.6
0.65
0.57
mmol/l
—
9
18
138
1092
1.58
3.19
5.3
3.6
0.00
0.00
estimate
-0.00
29
192
137
1084
1.58
3.15
5.2
3.6
0.03
7.85
estimate
0.49
31
207
136
1076
1.57
3.12
5.2
3.5
0.00
0.00
estimate
-0.00
30
205
50
308
1.78
3.08
1.7
1.6
513.68
457.50
pmol/l
0.64
44
263
88
632
1.60
3.04
3.4
3.3
46.14
32.97
ng/l
0.30
66
402
27
135
2.12
3.04
2.0
2.0
—
—
—
0
0
119
919
1.56
3.00
3.3
3.1
79.79
70.61
nmol/l
2.59
112
857
75
524
1.61
2.89
5.6
3.1
1.02
1.02
kg/l
0.08
55
330
67
456
1.64
2.86
1.7
1.6
22.85
22.04
nmol/l
0.14
60
397
23
111
2.18
2.83
3.0
9.3
0.67
0.59
%
0.62
23
111
97
728
1.54
2.72
1.9
1.9
105.93
95.93
pmol/l
0.79
51
374
12
44
2.81
2.58
1.2
2.4
—
—
—
0
0
77
563
1.53
2.39
5.2
3.7
0.00
0.01
estimate
0.50
26
193
169
1899
0.67
2.28
5.5
4.8
2.54
2.73
mmol/l
2.88
164
1789
155
1769
0.68
2.25
4.1
3.8
1.36
1.25
mmol/l
1.10
150
1654
23
401
0.53
2.24
4.0
3.7
22.68
21.01
%
—
5
151
22
117
1.96
2.14
2.9
4.2
68.41
66.02
g/l
0.72
22
111
16
305
0.49
2.05
1.8
2.7
0.92
0.67
ug/l
—
7
166
5
11
4.61
1.95
9.8
2.6
—
—
—
0
0
168
1872
0.69
1.94
4.7
4.3
1.28
1.41
mmol/l
4.42
163
1755
50
349
1.54
1.89
3.9
3.8
338.78
430.04
ng/l
0.11
37
248
7
22
3.24
1.89
1.7
4.4
2.31
3.43
nmol/l
—
7
22
184
1639
1.45
1.86
5.1
4.1
14.51
14.72
pmol/l
0.48
178
1517
101
812
1.41
1.85
5.4
3.3
0.00
0.01
estimate
0.50
23
172
14
263
0.50
1.73
2.9
2.5
—
—
—
0
0
11
48
2.35
1.73
1.6
1.5
—
—
—
0
0
154
1339
1.38
1.73
17.6
11.2
4.13
3.94
e9/l
0.48
137
1150
8
171
0.45
1.65
1.4
1.5
—
—
—
0
0
20
329
0.57
1.60
1.3
1.3
15.19
6.98
u/ml
—
8
117
5
16
3.17
1.44
1.0
1.1
—
—
—
0
0
6
22
2.77
1.44
2.5
1.5
—
—
—
0
0
59
451
1.40
1.41
3.5
4.2
890.26
1087.54
ng/l
0.30
50
375
12
60
2.05
1.40
2.8
2.2
—
—
—
0
0
65
508
1.38
1.37
3.9
4.1
7.43
11.37
mg/mmol
0.54
46
346
11
56
2.01
1.24
3.0
2.1
—
—
—
0
0
14
78
1.84
1.24
1.4
1.7
—
—
—
0
0
8
38
2.14
1.19
1.9
1.8
—
—
—
0
0
5
20
2.53
1.15
1.4
1.8
—
—
—
0
0
5
20
2.53
1.15
1.4
1.8
—
—
—
0
0
5
20
2.53
1.15
1.4
1.8
—
—
—
0
0
5
20
2.53
1.15
1.4
1.8
—
—
—
0
0
25
168
1.54
1.15
5.7
6.3
—
—
—
0
0
14
81
1.77
1.11
1.5
1.9
—
—
—
0
0
203
1899
1.35
1.10
6.4
4.9
2.03
1.88
mu/l
1.03
196
1777
5
21
2.41
1.09
1.4
1.8
—
—
—
0
0
5
21
2.41
1.09
1.4
1.8
—
—
—
0
0
7
32
2.22
1.09
1.4
1.7
—
—
—
0
0
11
60
1.87
1.04
1.7
1.5
—
—
—
0
0
36
267
1.41
1.04
4.1
4.9
5.43
8.45
umol/l
1.05
28
241
14
224
0.60
1.03
2.7
2.4
—
—
—
0
0
18
268
0.65
0.99
1.3
1.5
—
—
—
0
0
230
2371
0.67
0.95
37.1
20.6
4.50
4.63
e12/l
3.76
225
2309
8
42
1.93
0.89
8.1
5.8
6.55
7.35
pmol/l
—
8
42
22
153
1.48
0.89
5.5
3.3
—
—
—
0
0
39
303
1.34
0.86
2.1
2.8
2.45
2.44
mmol/l
0.16
34
270
13
81
1.64
0.83
1.5
1.9
1.43
1.29
g/l
0.27
13
73
69
586
1.24
0.79
4.9
3.4
0.34
0.27
e6/l
0.17
53
423
9
55
1.66
0.74
1.6
2.9
128.33
132.24
g/l
—
9
42
52
431
1.26
0.73
2.3
3.0
1.34
1.13
mg/l
0.20
47
333
7
40
1.77
0.72
1.7
1.5
—
—
—
0
0
28
215
1.34
0.69
3.6
5.2
209.86
259.92
u/l
2.20
28
208
7
43
1.65
0.67
2.0
1.3
—
—
—
0
0
10
153
0.64
0.65
1.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
4.4
—
—
—
0
0
7
111
0.62
0.59
1.9
1.6
—
—
—
0
0
61
530
1.20
0.56
2.3
3.0
2.42
2.59
mg/l
0.33
56
466
41
344
1.23
0.53
3.9
3.3
3.10
1.85
e6/l
0.30
21
172
6
99
0.60
0.53
1.0
1.3
—
—
—
0
0
6
40
1.51
0.52
1.0
1.8
—
—
—
0
0
97
1056
0.87
0.49
3.6
3.4
106.82
90.43
ug/l
0.62
90
1004
15
111
1.37
0.48
3.4
8.3
99.27
93.99
%
0.43
15
111
10
68
1.49
0.47
2.2
1.9
—
—
—
0
0
13
94
1.40
0.47
3.8
6.4
176.54
178.01
%
0.03
13
94
7
49
1.44
0.46
1.0
1.2
—
—
—
0
0
7
49
1.44
0.46
3.4
2.4
—
—
—
0
0
7
49
1.44
0.46
1.0
1.2
—
—
—
0
0
189
1814
1.17
0.46
16.8
11.8
101.46
91.40
ml/min/173m2
4.87
166
1585
8
58
1.39
0.42
2.3
3.0
413.50
272.98
e6/l
—
8
43
8
58
1.39
0.42
2.1
2.9
3.87
5.76
e6/l
—
8
41
0
15
0.00
0.41
0.0
1.4
—
11.56
—
0
15
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
73
802
0.87
0.41
2.1
2.0
1.49
1.38
mmol/l
0.46
66
706
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.5
—
11.82
—
0
17
0
18
0.00
0.40
0.0
6.9
—
39.40
—
0
5
67
605
1.15
0.39
4.7
3.1
0.00
0.00
estimate
-0.00
22
163
8
111
0.71
0.38
2.3
2.1
—
—
—
0
0
5
78
0.63
0.36
1.0
1.7
40.60
38.34
u/l
—
5
69
26
219
1.21
0.34
1.9
2.2
25.20
29.55
u/l
0.64
20
176
6
44
1.37
0.34
1.2
1.8
—
—
—
0
0
166
1720
0.90
0.31
3.8
3.6
—
—
—
0
0
95
889
1.11
0.31
3.3
3.0
—
—
estimate
—
0
0
53
479
1.13
0.31
3.2
2.8
—
—
—
0
0
7
100
0.69
0.31
1.0
1.2
—
5.29
—
0
10
8
63
1.28
0.28
1.3
1.5
—
—
—
0
0
8
65
1.24
0.27
1.0
1.1
—
14.49
—
0
8
76
713
1.09
0.24
1.6
1.6
0.37
2.17
u/ml
2.63
18
180
5
42
1.19
0.21
1.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
1846.64
—
0
11
0
11
0.00
0.21
0.0
2.8
—
114.73
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
403.24
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
141
1456
0.93
0.21
4.6
3.7
46.94
40.66
u/l
0.64
136
1399
187
1828
1.09
0.20
5.3
4.1
6.07
5.78
mmol/l
1.09
180
1693
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
16
138
1.17
0.18
3.2
2.7
76.86
75.51
ml/min/173m2
—
7
51
6
77
0.77
0.16
1.0
1.1
—
—
—
0
0
6
78
0.76
0.16
1.0
1.1
—
—
—
0
0
39
366
1.08
0.12
3.6
3.1
0.43
0.81
e6/l
0.82
18
193
5
47
1.07
0.09
1.6
1.3
—
—
—
0
0
20
187
1.08
0.06
1.0
1.0
—
—
—
0
0
10
109
0.91
0.04
1.4
1.4
—
—
—
0
0
10
94
1.07
0.01
1.5
1.8
—
—
—
0
0
13
128
1.02
0.00
2.1
1.7
0.14
0.29
mg/l
—
6
62
16
159
1.01
0.00
1.1
1.2
44.05
128.61
u/ml
—
6
53
212
2121
1.00
0.00
22.4
13.7
26.09
22.91
mg/l
0.85
185
1648
18
177
1.02
0.00
4.3
4.2
34.83
31.13
%
0.79
12
122
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
7.47
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
19.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.4
—
6.00
—
0
9
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
43.82
—
0
6
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
8.26
—
0
5
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.2
—
35.00
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_MODRET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MODRET | 6.615 [5.16, 8.48] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 265 out of 1858 females with F5_MODRET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MODRET | 3.444 [2.87, 4.13] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 284 out of 2621 males with F5_MODRET died.
Mortality risk
Mortality risk for people of age
years, who have F5_MODRET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.543% | 0.549% |
| 5 | 3.359% | 3.302% |
| 10 | 8.41% | 8.733% |
| 15 | 16.665% | 16.144% |
| 20 | 26.975% | 26.716% |
Relationships between endpoints
↥Index endpoint: F5_MODRET – Moderate mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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