No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
132 |
4. Check minimum number of eventsNone |
132 |
5. Include endpointsNone |
132 |
6. Filter based on genotype QC (FinnGen only) |
111 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Epileptic seizures related to drugs
based on the number of shared cases.
Similar with more cases:
- Epilepsy
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 693 | 270 | 422 |
| Only index persons | 667 | 264 | 403 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 34.78 | 37.41 | 33.12 |
| Only index persons | 34.73 | 37.19 | 33.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 111 | 50 | 61 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 40.48 | 42.38 | 38.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 115
- Matched controls
- 1150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G40.52
ICD-10 Finland
Epileptic seizures related to drugs
+∞
166.0
115
*
N05AH02
ATC
clozapine; systemic
78.0
119.8
74
26
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
64.4
115.6
89
58
R56.8
ICD-10 Finland
Other and unspecified convulsions
51.4
101.7
71
35
N03AG01
ATC
valproic acid; systemic, rectal
45.4
98.2
74
44
N05AH03
ATC
olanzapine; systemic
37.6
90.8
78
61
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
45.0
77.4
51
20
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
37.0
74.2
53
26
N05AA02
ATC
levomepromazine; systemic
36.4
69.5
49
23
F29
ICD-10 Finland
Unspecified nonorganic psychosis
24.4
64.9
58
46
T36
ICD-10 Finland
Poisoning by systemic antibiotics
28.8
64.8
51
31
F20.9
ICD-10 Finland
Schizophrenia, unspecified
34.6
63.6
45
21
N05AX08
ATC
risperidone; systemic
22.0
63.2
62
58
N05AX12
ATC
aripiprazole; systemic
24.2
62.5
55
42
N03AX09
ATC
lamotrigine; oral
22.5
56.6
50
38
N05BA06
ATC
lorazepam; systemic, sublingual
25.8
55.1
44
27
N05CD07
ATC
temazepam; oral
21.0
49.7
44
33
N05AH04
ATC
quetiapine; oral
16.0
48.9
85
173
N05BA01
ATC
diazepam; systemic, rectal
14.9
48.5
61
81
P72
ICPC
Schizophrenia
23.4
44.6
36
22
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
21.4
42.7
36
24
AA1AD
NOMESCO Finland
CT of head and brain
11.0
38.5
70
143
N05AB03
ATC
perphenazine; systemic, rectal
19.7
38.1
33
23
N05AF03
ATC
chlorprothixene; systemic
46.3
33.2
40
13
G40.9
ICD-10 Finland
Epilepsy, unspecified
48.2
32.7
39
12
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
41.3
31.5
39
14
N04AA02
ATC
biperiden; systemic
79.3
31.2
34
6
N05BA04
ATC
oxazepam; oral
8.3
29.2
72
194
N06AB04
ATC
citalopram; systemic
8.3
28.7
56
118
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
10.0
27.8
39
56
N03AE01
ATC
clonazepam; systemic
12.6
26.1
29
30
N06AB06
ATC
sertraline; oral
8.0
26.1
48
94
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.4
23.4
33
47
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
8.5
20.9
32
50
A06AD11
ATC
lactulose; oral
8.5
20.4
31
48
P29
ICPC
Psychological sympt/compl other
6.9
20.0
40
83
C07AA05
ATC
propranolol; systemic
5.8
19.9
58
171
P99
ICPC
Psychological disorders other
9.6
19.5
26
34
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
7.7
19.1
32
55
N05BA12
ATC
alprazolam; oral
7.3
18.7
33
60
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
9.4
18.6
25
33
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.6
18.6
53
152
N05AD01
ATC
haloperidol; systemic
35.4
18.2
23
8
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
9.1
18.2
25
34
N05CF01
ATC
zopiclone; oral
5.3
18.1
61
201
N06AX16
ATC
venlafaxine; oral
5.7
17.7
45
116
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
8.8
17.7
25
35
N07BB01
ATC
disulfiram; oral
8.6
17.3
25
36
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.2
17.1
37
82
K08.3
ICD-10 Finland
Retained dental root
7.1
16.5
29
52
N05BE01
ATC
buspirone; oral
17.3
16.5
26
19
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.4
16.4
33
68
N06AB03
ATC
fluoxetine; oral
6.2
16.2
34
73
N06AX11
ATC
mirtazapine; oral
4.9
16.2
68
262
Z2446
NOMESCO Finland
Social worker
8.2
16.0
24
36
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
34.1
15.8
20
7
IGY02
NOMESCO Finland
Psychiatric monitoring contact
8.0
15.1
23
35
188
Kela drug reimbursment
Psychosis requiring demanding treatment
92.2
15.0
16
*
N05AA01
ATC
chlorpromazine; systemic, rectal
32.1
14.8
19
7
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
5.5
14.5
35
85
OAB43, ,
SPAT
0.1
14.3
6
434
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
21.7
14.0
20
11
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
39.4
13.9
17
5
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
24.9
13.9
19
9
B18.2
ICD-10 Finland
Chronic viral hepatitis C
24.9
13.9
19
9
N05AF05
ATC
zuclopenthixol; systemic
45.9
13.5
16
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
6.6
13.2
24
44
P19
ICPC
Drug abuse
56.9
13.2
15
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
7.3
13.0
21
34
F20.0
ICD-10 Finland
Paranoid schizophrenia
78.8
12.9
14
*
EBA00
NOMESCO Finland
Extraction of tooth
4.2
12.8
71
321
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
18.7
12.7
19
12
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
12.6
71
323
C07AB07
ATC
bisoprolol; oral
4.0
12.5
61
251
IGV01
NOMESCO Finland
Psychiatric network contact
24.6
12.4
17
8
F20
ICD-10 Finland
Schizophrenia
30.6
12.4
16
6
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.7
12.4
37
106
ZY010
NOMESCO Finland
Hospital outpatient
6.6
12.2
22
40
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
52.6
12.2
14
*
ZY000
NOMESCO Finland
Hospital inpatient
21.9
12.0
17
9
K59.09
ICD-10 Finland
Constipation, unspecified
14.0
11.9
20
17
N05AN01
ATC
lithium; oral
12.6
11.9
21
20
A28
ICPC
Limited function/disability NOS
5.7
11.3
24
51
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.9
11.3
23
47
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
48.4
11.2
13
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
31.5
11.0
14
5
AA400
NOMESCO Finland
Electroconvulsive therapy
31.5
11.0
14
5
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
24.3
11.0
15
7
N03AX16
ATC
[U] pregabalin
4.1
10.7
38
123
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.4
10.6
24
54
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
9.1
10.5
22
29
R42
ICD-10 Finland
Dizziness and giddiness
4.1
10.4
36
114
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
14.0
10.2
17
14
SPAT1240
SPAT
Therapeutic discussion
4.3
10.2
32
94
N03AF02
ATC
oxcarbazepine; oral
12.3
10.2
18
17
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
29.0
10.1
13
5
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.6
10.0
21
44
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
8.6
9.8
21
29
N05CF02
ATC
zolpidem; oral
3.9
9.6
36
120
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.1
9.6
23
54
G40
ICD-10 Finland
Epilepsy
24.2
9.6
13
6
N05AX15
ATC
cariprazine; oral
108.6
9.6
10
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.4
9.5
21
46
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
8.0
9.4
21
31
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
17.5
9.3
14
9
IEV99
NOMESCO Finland
Other psychiatric network intervention
40.1
9.2
11
*
R41.0
ICD-10 Finland
Disorientation, unspecified
26.5
9.1
12
5
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
7.5
9.0
21
33
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
8.5
8.9
19
26
R25.1
ICD-10 Finland
Tremor, unspecified
13.1
8.9
15
13
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
11.4
8.9
16
16
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
11.4
8.9
16
16
F13.29
ICD-10 Finland
Addiction caused by sedative and hypnotic UNS
54.2
8.8
10
*
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
18.1
8.8
13
8
N06AA12
ATC
doxepin; systemic
9.1
8.8
18
23
F10.25
ICD-10 Finland
Alcohol dependence continuous use
30.1
8.7
11
*
N05AE03
ATC
sertindole; oral
96.9
8.5
9
*
IFC01, ,
SPAT
96.9
8.5
9
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.4
8.4
18
38
N06AB05
ATC
paroxetine; oral
5.4
8.4
18
38
F11.24
ICD-10 Finland
Addiction-induced dependence caused by opiates active addiction
+∞
8.4
8
*
F61.0
ICD-10 Finland
Mixed personality disorders
16.1
8.4
13
9
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
16.1
8.4
13
9
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
11.3
8.3
15
15
IGY02, ,
SPAT
18.9
8.3
12
7
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
18.9
8.3
12
7
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
24.1
8.2
11
5
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.1
8.0
18
40
N05AC02
ATC
thioridazine; oral
16.5
7.9
12
8
F11.29
ICD-10 Finland
Addiction caused by opiates UNS
48.3
7.8
9
*
WYA20
NOMESCO Finland
Home visit
48.3
7.8
9
*
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
11.2
7.8
14
14
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
20.0
7.8
11
6
P98
ICPC
Psychosis NOS/other
20.0
7.8
11
6
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.6
7.8
31
107
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.5
7.7
32
113
183
Kela drug reimbursment
Lamotrigin and topiramate
27.1
7.7
10
*
N05BA02
ATC
chlordiazepoxide; systemic
27.1
7.7
10
*
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
27.1
7.7
10
*
G72.8
ICD-10 Finland
Other specified myopathies
27.1
7.7
10
*
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
27.1
7.7
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
7.6
25
75
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
7.5
26
81
F10.20
ICD-10 Finland
Alcohol dependence currently independent
12.0
7.5
13
12
N88
ICPC
Epilepsy
85.4
7.5
8
*
Z72.2
ICD-10 Finland
Drug use
85.4
7.5
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
7.5
33
121
R53
ICD-10 Finland
Malaise and fatigue
3.1
7.4
41
173
N06AX03
ATC
mianserin; oral
8.9
7.4
15
19
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
8.9
7.4
15
19
P15
ICPC
Chronic alcohol abuse
8.9
7.4
15
19
F19.24
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances active addiction
+∞
7.4
7
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
9.8
7.3
14
16
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
9.8
7.3
14
16
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.7
7.3
18
31
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
21.7
7.3
10
5
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
21.7
7.3
10
5
F10.24
ICD-10 Finland
Alcohol depence active use
13.2
7.3
12
10
N03AX14
ATC
levetiracetam; systemic
13.2
7.3
12
10
SFA30
NOMESCO Finland
Three-surface restoration
2.9
7.3
64
348
F13.22
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent but uses substitute intermittent medication
32.2
7.3
9
*
A10BA02
ATC
metformin; oral
3.2
7.1
35
137
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
10.3
7.0
13
14
K02.1
ICD-10 Finland
Caries of dentine
3.5
7.0
93
629
SFA10
NOMESCO Finland
One-surface restoration
3.2
6.9
88
577
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
7.3
6.9
16
25
SPAT1254
SPAT
Administration of medicine
3.9
6.8
23
70
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
42.6
6.8
8
*
SPAT1301
SPAT
No procedures
2.9
6.8
43
194
N06AX12
ATC
bupropion; oral
4.1
6.8
21
60
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
24.2
6.8
9
*
ICB06, ,
NOMESCO Finland
24.2
6.8
9
*
N05AX13
ATC
paliperidone; systemic
24.2
6.8
9
*
ZXY60
NOMESCO Finland
2-person team, nurses
24.2
6.8
9
*
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
9.6
6.8
13
15
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.7
6.8
24
76
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
13.3
6.7
11
9
EBA30
NOMESCO Finland
Extraction of root of tooth
6.2
6.6
17
31
N06AB10
ATC
escitalopram; oral
2.9
6.6
42
190
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.3
6.6
29
106
ICC03
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric ward
73.8
6.5
7
*
WX110
NOMESCO Finland
Infiltration anesthesia
4.0
6.5
100
721
N05AL01
ATC
sulpiride; systemic
12.0
6.4
11
10
SPAT1243
SPAT
Psychiatric/psychological examination
7.0
6.4
15
24
N03AX12
ATC
[U] gabapentin; oral
3.4
6.4
27
96
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
8.5
6.3
13
17
2959A
ICD-9 Finland
Schizophrenic psychoses, Unspecified schizophrenia[ERILAISTUMATON SKITSOFRENIA,TARKEMMIN MÄÄRITTELEMÄT]
+∞
6.3
6
*
F13.24
ICD-10 Finland
Addiction relationship caused by sedative and hypnotic active addiction
+∞
6.3
6
*
F13.21
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent but staying in a controlling environment
+∞
6.3
6
*
A46
ICD-10 Finland
Erysipelas
3.7
6.3
22
69
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.0
6.2
19
54
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
10.9
6.2
11
11
S29
ICPC
Skin symptom/complaint other
3.0
6.1
34
142
Z2445
NOMESCO Finland
Psychologist
6.0
6.1
16
30
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
8.8
6.0
12
15
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.1
6.0
*
170
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
22
66.65
105.30
27.4
22.9
1649.11
1551.86
nmol/l
0.12
65
22
92
360
8.78
24.10
7.8
7.9
1.19
1.22
mmol/l
2.99
84
340
92
401
7.47
20.11
8.7
8.9
1.20
1.21
mmol/l
1.39
82
356
39
83
6.60
18.97
4.5
3.6
3.01
2.39
mmol/l
0.40
34
70
43
107
5.82
17.60
2.2
1.5
—
—
—
0
0
40
96
5.86
16.98
1.7
1.6
1376.06
1253.88
nmol/l
0.23
35
77
24
35
8.40
16.39
1.6
1.3
—
—
—
0
0
42
109
5.49
16.27
2.3
1.5
—
—
—
0
0
49
147
5.07
15.96
2.4
1.8
—
—
—
0
0
18
5
42.17
14.94
1.8
1.8
15.71
18.24
umol/l
—
18
5
26
49
6.56
13.99
5.8
15.5
0.76
0.71
%
0.21
26
49
69
295
4.35
13.70
4.0
2.9
43.54
69.36
u/l
1.14
63
280
26
51
6.30
13.42
5.8
15.1
1.95
1.73
%
0.17
26
51
54
198
4.26
13.16
2.0
1.6
19.71
20.33
nmol/l
0.11
49
172
38
111
4.62
12.44
7.6
9.8
103.05
103.52
mmol/l
0.20
38
111
25
51
5.99
12.35
4.5
2.5
0.64
0.68
%
0.18
25
51
30
73
5.21
12.22
2.7
1.5
0.33
0.35
mg/l
0.05
17
33
71
331
3.99
12.01
2.6
1.9
97.45
96.51
pmol/l
0.07
45
171
66
296
3.89
11.75
3.1
3.5
2.33
2.35
mmol/l
1.02
59
276
24
51
5.68
11.31
6.1
15.2
91.63
93.22
%
0.46
24
51
55
231
3.65
10.57
9.2
3.2
1.02
1.02
kg/l
0.58
39
143
19
20
11.14
10.24
6.4
4.3
3.74
3.93
mmol/l
0.67
19
20
19
24
9.25
9.31
6.4
7.0
1.23
1.18
mmol/l
0.13
19
24
39
144
3.58
8.92
2.3
2.6
2.44
2.42
mmol/l
0.53
33
134
62
313
3.13
8.36
4.3
2.9
—
—
—
0
0
14
13
12.07
8.05
2.4
1.6
—
—
—
0
0
28
94
3.62
7.26
16.3
6.4
—
—
—
0
0
70
401
2.91
7.17
3.2
2.8
64.98
74.16
nmol/l
1.77
64
372
43
196
2.91
6.68
2.4
2.0
3.16
2.92
mg/l
0.32
38
167
99
733
3.52
5.61
6.6
4.4
14.11
14.64
pmol/l
1.50
93
693
17
48
3.98
5.57
2.4
1.5
—
—
—
0
0
56
317
2.49
5.44
5.8
3.2
48.64
21.01
ng/l
0.53
46
190
20
66
3.46
5.25
1.4
1.6
—
—
—
0
0
107
883
4.04
4.84
8.7
5.2
1.92
1.77
mu/l
0.38
99
838
92
683
2.73
4.62
4.3
3.9
11.85
8.11
mm/h
1.29
85
647
46
256
2.33
4.46
4.0
2.7
0.15
0.27
e6/l
0.64
35
187
10
16
6.73
4.40
1.3
1.4
—
—
—
0
0
10
16
6.73
4.40
1.3
1.4
—
—
—
0
0
38
197
2.39
4.31
2.2
1.9
1.03
0.88
mg/l
0.16
30
152
9
14
6.87
4.07
8.6
1.4
—
—
—
0
0
33
168
2.35
3.85
3.6
2.3
0.56
0.79
e6/l
0.28
16
84
8
14
6.05
3.40
1.1
1.1
—
—
—
0
0
8
15
5.64
3.25
1.1
1.1
—
—
—
0
0
33
181
2.15
3.18
3.1
3.3
593.42
757.19
ng/l
0.20
26
148
106
918
2.97
3.16
8.1
4.0
6.27
5.75
mmol/l
2.78
101
861
9
23
4.15
2.84
1.1
1.3
—
—
—
0
0
43
270
1.95
2.84
7.1
3.2
0.00
0.00
estimate
—
10
98
6
10
6.26
2.73
1.2
1.0
1122.67
1818.10
miu/ml
—
6
10
109
983
3.08
2.40
34.7
13.5
24.57
21.87
mg/l
0.52
102
775
12
48
2.67
2.27
1.4
1.4
—
—
—
0
0
26
148
1.98
2.22
4.4
2.4
1.73
3.16
e6/l
—
10
65
67
513
1.73
2.16
6.3
3.2
0.00
15.32
estimate
—
10
106
67
519
1.70
2.02
6.4
3.3
0.00
0.00
estimate
—
10
99
18
94
2.08
1.93
1.4
2.1
340.56
398.71
nmol/l
0.69
18
87
36
238
1.75
1.92
4.2
4.3
15.67
5.64
mg/mmol
0.55
27
158
7
22
3.32
1.91
1.1
1.9
—
—
—
0
0
21
117
1.97
1.90
4.4
2.7
7.63
5.61
umol/l
0.31
16
101
5
12
4.30
1.84
5.0
2.2
15.90
16.62
%
—
5
12
5
12
4.30
1.84
1.8
2.4
—
—
—
0
0
64
508
1.59
1.62
6.5
3.2
0.00
0.00
estimate
-0.00
11
105
7
26
2.80
1.61
1.4
1.3
—
—
—
0
0
25
157
1.76
1.57
4.7
3.2
13.12
104.39
ng/l
1.36
18
100
5
15
3.43
1.54
1.2
1.1
—
—
—
0
0
6
21
2.96
1.52
1.2
1.0
—
—
—
0
0
7
28
2.59
1.47
7.1
1.8
23.70
24.47
mmol/l
—
7
28
0
37
0.00
1.37
0.0
1.5
—
0.99
—
0
21
0
37
0.00
1.37
0.0
1.5
—
1.02
—
0
21
0
37
0.00
1.37
0.0
1.5
—
1.34
—
0
21
14
77
1.93
1.32
3.7
3.3
—
—
—
0
0
5
18
2.85
1.30
1.2
1.4
—
—
—
0
0
5
21
2.44
1.10
1.0
1.0
—
—
—
0
0
7
33
2.19
1.07
1.0
2.1
166.43
186.79
%
—
7
33
7
34
2.13
1.05
1.3
2.0
89.43
99.18
%
—
7
34
5
22
2.33
1.04
1.2
1.4
—
—
—
0
0
103
956
1.74
1.00
27.5
12.1
95.28
92.85
ml/min/173m2
0.49
93
877
0
30
0.00
0.99
0.0
1.4
—
—
—
0
0
49
397
1.41
0.99
6.6
3.0
0.00
0.00
estimate
—
8
89
73
818
0.71
0.97
4.0
3.6
—
—
—
0
0
6
29
2.13
0.91
1.3
1.5
—
—
—
0
0
6
31
1.99
0.85
1.3
1.5
—
—
—
0
0
34
265
1.40
0.84
1.6
1.4
1.98
2.23
u/ml
0.08
13
77
25
187
1.43
0.77
2.8
3.7
18.46
23.66
%
—
7
67
5
27
1.89
0.69
3.6
1.9
—
—
—
0
0
16
113
1.48
0.65
2.2
2.5
—
—
—
0
0
101
954
1.48
0.64
5.6
3.7
1.60
1.34
mmol/l
2.21
94
901
6
35
1.75
0.58
1.3
1.1
—
2.42
—
0
5
19
245
0.73
0.55
1.8
2.5
—
—
—
0
0
14
101
1.44
0.52
2.1
2.3
—
—
—
0
0
10
68
1.52
0.49
1.6
2.8
59.40
73.29
ml/min/173m2
—
5
28
104
1001
1.41
0.43
7.2
4.7
2.62
2.87
mmol/l
2.45
98
956
13
170
0.73
0.42
1.2
1.3
1.66
5.46
u/ml
—
5
74
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
220.43
—
0
18
0
18
0.00
0.40
0.0
1.2
—
3.89
—
0
8
6
43
1.42
0.35
1.3
1.9
7.37
2.49
mg/l
—
6
30
19
228
0.80
0.33
1.7
2.4
—
—
—
0
0
103
998
1.31
0.32
6.4
4.3
1.26
1.41
mmol/l
4.25
98
953
44
397
1.18
0.32
3.3
3.0
—
—
estimate
—
0
0
103
999
1.30
0.30
6.8
4.3
4.46
4.75
mmol/l
2.67
98
954
26
297
0.84
0.28
4.7
2.6
0.00
0.00
estimate
—
8
85
8
64
1.27
0.28
1.4
1.4
—
—
—
0
0
5
71
0.69
0.27
1.0
1.3
—
—
—
0
0
23
200
1.19
0.25
3.6
2.7
—
—
—
0
0
13
155
0.82
0.22
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
15.10
—
0
6
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
117.90
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
25
269
0.91
0.11
1.5
1.7
—
—
—
0
0
5
47
1.07
0.09
1.0
1.8
35.40
41.82
u/l
—
5
39
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
14
139
1.01
0.00
5.8
2.4
11.89
15.55
nmol/l
1.07
14
134
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
4.8
—
69.44
—
0
9
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.4
—
—
—
0
0
5
56
0.89
-0.00
2.2
1.7
—
—
—
0
0
6
64
0.93
-0.00
1.3
3.8
2.52
7.96
ug/l
—
6
52
0
6
0.00
-0.00
0.0
7.2
—
172.45
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
6.04
—
0
7
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.61
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint EPILEPTIC_SEIZU_RELATED_DRUGS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPILEPTIC_SEIZU_RELATED_DRUGS | 5.024 [2.97, 8.51] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 360 males with EPILEPTIC_SEIZU_RELATED_DRUGS died.
Mortality risk
Mortality risk for people of age
years, who have EPILEPTIC_SEIZU_RELATED_DRUGS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 1.073% |
| 5 | No data | 6.186% |
| 10 | No data | 14.248% |
| 15 | No data | 25.592% |
| 20 | No data | 40.267% |
Relationships between endpoints
↥Index endpoint: EPILEPTIC_SEIZU_RELATED_DRUGS – Epileptic seizures related to drugs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data