testicular disease: A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleonly males |
226725 |
2. Check conditionsNone |
226725 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
206 |
4. Check minimum number of eventsNone |
206 |
5. Include endpointsNone |
206 |
6. Filter based on genotype QC (FinnGen only) |
199 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Testicular dysfunction, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Testicular dysfunction
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1111 | - | 1111 |
| Only index persons | 1058 | - | 1058 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | - | 0.03 |
| Only index persons | 0.04 | - | 0.04 |
| Median age at first event (years) | |||
| Whole population | - | - | 39.11 |
| Only index persons | - | - | 39.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 199 | - | 199 |
| Unadjusted period prevalence (%) | 0.09 | - | 0.09 |
| Median age at first event (years) | 51.48 | - | 51.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 206
- Matched controls
- 2060
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
E29.9 (45552393)
E29.8 (45586155)
1 (38004446)
50373000 (4177340)
60621009 (4245997)
KF8AE (2001306187)
G04BE08 (21602653)
10501-5 (3009214)
2 (38004447)
34 (38004474)
46 (38004485)
N40 (45563015)
OMOP4822013 (45756826)
ER (9203)
G03BA03 (21602510)
14913-8 (3017446)
A14AA01 (21600917)
G03BB02 (21602513)
13967-5 (3004248)
96559-0 (36032269)
OMOP4822462 (581458)
251B00000X (38004193)
12841-3 (3001784)
OP (9202)
2857-1 (3013603)
58410-2 (40761511)
G04BE03 (21602648)
G47.3 (45562094)
OMOP4822461 (32036)
30428-7 (3024731)
718-7 (3000963)
26515-7 (3007461)
28539-5 (3035941)
26453-1 (3026361)
20570-8 (3009542)
26464-8 (3010813)
30385-9 (3002385)
OMOP5117446 (33004)
3016-3 (3009201)
1988-5 (3020460)
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint E4_TESTICDYSNAS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_TESTICDYSNAS | 1.564 [1.05, 2.32] | 0.026 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 694 males with E4_TESTICDYSNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_TESTICDYSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.294% |
| 5 | No data | 1.847% |
| 10 | No data | 4.324% |
| 15 | No data | 8.11% |
| 20 | No data | 13.644% |
Relationships between endpoints
↥Index endpoint: E4_TESTICDYSNAS – Testicular dysfunction, other/unspecified
GWS hits: -