Sequelae of malnutrition and other nutritional deficiencies

E4_SEQUMAL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E64 Cause of death: ICD-10 — E64 2 out of 7 registries used, show all original rules.	100
4. Check minimum number of events None	100
5. Include endpoints None	100
6. Filter based on genotype QC (FinnGen only)	81

Control definitions (FinnGen only)

Control exclude: E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E50-E64
Name in latin: Sequelae malnutritionis et aliarum deficientiarum nutritionalium

NAME	E4_SEQUMAL
CONTROL_EXCLUDE	E4_NUTRIDEF
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E64
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E64
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Sequelae of malnutrition and other nutritional deficiencies based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1025	566	443
Only index persons	738	414	324
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	73.60	76.42	70.18
Only index persons	72.79	75.38	69.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	81	38	43
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	68.74	62.28	74.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
84: Matched controls
840

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E64.9

ICD-10 Finland

Sequelae of unspecified nutritional deficiency

+∞

82.3

D64.9

ICD-10 Finland

Anaemia, unspecified

9.8

24.4

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.7

7.8

161

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

5.2

7.4

E64.3

ICD-10 Finland

Sequelae of rickets

+∞

6.3

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

6.0

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

180

3.03

5.73

3.6

2.2

2.62

2.77

mg/l

0.18

156

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.56

2.91

14.9

5.1

1.14

1.03

mmol/l

0.68

(3023520) Reticulocytes [#/volume] in Blood

2.67

2.88

7.8

2.9

63.43

67.96

e9/l

0.18

(40760892) CBC W Ordered Manual Differential panel - Blood

122

2.35

2.87

3.8

6.3

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

8.75

2.78

5.2

3.5

8.88

10.60

mg/l

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

4.54

2.75

1.1

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.67

2.53

1.3

1.1

—

(1616796) Gas panel - Central venous blood

4.39

2.41

2.9

2.6

—

(3019977) pH of Arterial blood

2.41

2.38

3.1

9.1

7.41

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

4.88

2.31

3.0

1.4

33.00

31.46

—

(21494890) Protein electrophoresis panel - 24 hour Urine

5.82

2.24

1.6

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.37

2.19

4.6

3.9

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

4.53

2.19

1.2

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.52

2.10

3.7

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

247

1.89

2.09

6.0

3.5

—

(3006315) Basophils [#/volume] in Blood

305

1.84

1.99

7.6

6.8

0.03

0.04

e9/l

0.98

263

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

4.76

1.97

2.6

1.5

9.52

9.23

pmol/l

—

(3010421) pH of Blood

3.22

1.84

5.0

2.9

7.37

7.42

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.02

1.74

1.2

1.4

—

(3027315) Oxygen [Partial pressure] in Blood

3.32

1.69

5.3

2.4

6.77

8.40

kpa

—

(3012501) Base excess in Blood by calculation

3.32

1.69

5.3

2.4

1.60

1.79

mmol/l

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.32

1.69

5.3

2.4

5.35

4.94

kpa

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.96

1.69

1.4

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

149

1.86

1.65

2.0

1.9

1.32

1.67

mg/l

0.37

126

(3013115) Eosinophils [#/volume] in Blood

309

1.72

1.62

8.4

7.0

0.13

0.16

e9/l

1.16

270

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.57

1.58

1.3

1.0

—

(3037756) Immunofixation for Serum or Plasma

3.47

1.54

1.0

1.5

—

(3001604) Monocytes [#/volume] in Blood

305

1.67

1.49

7.9

6.7

0.50

0.61

e9/l

2.04

263

(3023368) Bacteria identified in Blood by Culture

205

1.72

1.49

7.2

5.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.63

1.48

3.3

3.2

—

(3000991) Gas panel - Venous blood

2.17

1.46

13.8

12.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.96

1.45

2.6

2.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

140

1.77

1.38

2.1

1.7

1282.88

1249.74

nmol/l

0.03

112

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.06

1.30

6.0

9.7

1.28

1.41

mmol/l

0.17

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.89

1.30

1.2

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.11

1.29

7.5

7.6

24.62

24.91

mmol/l

0.09

(36304419) Bacteria [Presence] in Urine

195

1.65

1.27

6.5

3.4

—

estimate

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.50

1.26

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.41

1.21

3.3

2.8

—

(3042936) Bacteria identified in Isolate by Culture

1.82

1.21

1.9

2.2

—

(3026008) Bacteria identified in Urine by Culture

217

1.59

1.16

4.7

3.6

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.45

1.15

7.4

3.6

1.87

2.28

mmol/l

—

(3019060) Gas panel - Arterial blood

2.05

1.12

2.1

4.0

—

(3029937) Albumin [Presence] in Urine by Test strip

192

1.60

1.12

5.0

4.2

0.00

estimate

—

(3018418) pH of Serum or Plasma

219

1.58

1.12

10.9

4.1

7.39

7.40

0.37

160

(42870588) Differential panel, method unspecified - Blood

219

1.58

1.12

9.5

6.2

—

(3037522) Nuclear Ab [Titer] in Serum

1.82

1.09

1.3

1.4

—

301.67

—

(3002582) Erythrocytes [#/volume] in Urine

240

1.54

1.05

6.7

3.6

15.46

315.10

e6/l

0.58

184

(3024928) Oxygen saturation in Venous blood

2.35

1.05

6.8

2.7

49.74

62.84

—

(3015736) pH of Urine

269

1.52

1.02

4.9

3.9

6.13

6.24

0.17

149

(40761535) Cells panel - Urine sediment

1.89

1.00

3.0

3.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

1.00

0.0

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.89

0.99

1.1

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

197

1.55

0.99

3.6

2.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.81

0.95

2.3

1.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.15

0.91

2.3

2.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

284

1.47

0.91

2.8

2.3

83.06

93.00

pmol/l

0.73

145

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.95

0.90

2.0

1.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

122

1.61

0.89

5.1

3.3

0.78

0.81

mmol/l

0.33

113

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

323

1.46

0.89

18.1

7.3

1.20

1.21

mmol/l

0.50

275

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

258

1.46

0.87

4.9

4.4

0.00

estimate

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.82

0.85

2.6

1.7

—

(40761536) Microorganisms panel - Urine sediment

1.82

0.84

5.4

4.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.82

0.84

3.2

2.4

0.04

0.22

e6/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

349

1.41

0.78

3.9

3.2

95.62

55.45

u/l

0.53

326

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.76

0.76

1.5

1.6

—

(3023420) DNA double strand Ab [Units/volume] in Serum

1.90

0.69

1.6

—

11.02

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

139

1.47

0.68

3.5

2.9

—

(40768797) Stomach Pathology biopsy report

1.61

0.67

1.5

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

231

1.39

0.67

5.4

3.5

6111.46

1948.36

ng/l

0.46

198

(3022145) Colonoscopy Study observation

1.64

0.62

1.2

1.3

—

(3019150) Specific gravity of Urine by Refractometry

151

1.43

0.61

4.1

4.4

1.02

kg/l

0.24

108

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

490

0.75

0.60

4.2

4.5

1.29

1.19

mmol/l

0.35

438

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.61

0.58

8.6

4.3

1.24

1.21

mmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.61

0.58

2.1

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.62

0.55

1.5

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

345

1.30

0.53

6.6

4.3

0.00

estimate

-0.00

(3000494) Fungus identified in Specimen by Culture

1.56

0.52

1.8

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

268

1.31

0.52

3.4

3.0

—

estimate

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

221

1.33

0.51

3.4

3.1

2.33

2.36

mmol/l

0.40

200

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.51

0.51

2.2

4.5

10.55

67.39

ug/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.57

0.50

1.6

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

130

1.39

0.49

1.8

1.3

2.97

2.61

g/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.50

0.48

14.4

4.5

23.71

23.97

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

171

0.72

0.45

3.0

3.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

538

0.79

0.45

4.7

5.4

6.11

5.97

mmol/l

0.17

473

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

518

0.79

0.44

4.7

5.4

4.29

4.36

mmol/l

0.18

467

(3049717) Cytology report of Urine Cyto stain

1.65

0.44

2.2

2.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

106

1.38

0.42

2.6

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.41

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.50

0.41

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.41

0.0

1.4

—

(3016879) Cocaine [Presence] in Urine

0.00

0.41

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

456

0.80

0.40

54.2

25.9

14.31

13.87

1.05

451

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.39

0.0

1.4

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.39

0.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

191

1.28

0.39

4.6

3.8

0.00

estimate

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.37

0.38

2.7

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

333

0.80

0.37

3.9

2.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.43

0.36

1.2

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

349

1.22

0.34

6.7

4.4

0.00

estimate

-0.00

(40758558) Short blood count panel - Blood

195

1.25

0.33

10.3

6.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

371

1.21

0.32

9.6

5.7

6.87

6.74

mmol/l

0.18

355

(3024731) MCV [Entitic mean volume] in Red Blood Cells

605

0.82

0.30

56.1

28.7

92.10

91.66

0.27

595

(3000963) Hemoglobin [Mass/volume] in Blood

605

0.82

0.30

56.7

29.0

120.93

131.88

g/l

5.23

594

(3035941) MCH [Entitic mass]

605

0.82

0.30

55.9

28.6

30.42

30.43

0.02

595

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

605

0.82

0.30

57.1

29.4

36.32

39.50

3.11

594

(36660697) Celiac disease serology panel - Serum

1.34

0.29

1.4

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

354

1.19

0.28

6.9

4.4

0.00

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

179

0.80

0.26

5.7

4.9

26.74

22.22

—

103

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

229

1.20

0.26

2.8

2.2

105.04

279.06

u/l

1.46

218

(40768804) Tissue Pathology biopsy report

239

0.84

0.23

2.2

2.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

519

0.87

0.21

6.7

7.0

40.71

40.55

mmol/mol

0.04

478

(3023419) Bacteria identified in Sputum by Culture

0.00

0.20

0.0

3.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

518

0.87

0.20

4.2

5.2

1.48

1.45

mmol/l

0.20

461

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.27

0.20

2.2

1.6

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

525

0.88

0.17

40.2

20.2

72.33

75.33

ml/min/173m2

0.28

494

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

446

1.12

0.16

5.9

4.6

18.76

14.08

mm/h

1.10

402

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

533

0.89

0.15

5.7

5.4

2.22

1.95

mu/l

0.42

468

(40761511) CBC panel - Blood by Automated count

567

0.91

0.10

32.1

17.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

537

0.92

0.10

4.7

6.1

2.42

2.49

mmol/l

0.24

485

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.04

0.09

1.8

2.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.09

2.6

2.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

137

1.12

0.08

3.5

1.9

—

(3045414) Leukocytes [Presence] in Urine

1.05

0.08

3.9

2.3

—

0.00

estimate

—

(3003694) ABO and Rh group [Type] in Blood

148

1.10

0.07

2.1

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

559

0.95

0.03

40.6

19.8

33.86

26.28

mg/l

0.82

474

(3012516) Albumin [Mass/volume] in Urine

198

1.01

0.00

4.3

3.1

135.62

37.16

mg/l

0.82

123

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.00

0.00

2.3

1.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.89

0.00

15.8

9.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.3

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

4.80

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(4268621) Lupus anticoagulant assay

0.00

-0.00

0.0

1.7

—

(3002256) Pathology report gross observation

0.90

-0.00

1.0

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.2

—

1.00

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

46.90

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.2

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

43.08

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

5.67

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

1.50

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(4035726) Immunohistochemistry procedure

1.02

-0.00

1.2

1.3

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.7

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

6.7

—

90.00

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.6

—

17.32

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.4

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

10.63

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

0.90

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_SEQUMAL and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_SEQUMAL	2.544 [1.9, 3.41]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.426

During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 483 females with E4_SEQUMAL died.

Males

Parameter	HR [95% CI]	p-value
E4_SEQUMAL	3.135 [2.06, 4.76]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 380 males with E4_SEQUMAL died.

Mortality risk

Mortality risk for people of age

years, who have E4_SEQUMAL.

N-year risk	Females	Males
1	0.212%	0.748%
5	1.486%	4.033%
10	3.966%	9.774%
15	7.901%	17.424%
20	13.061%	28.764%

Relationships between endpoints

↥

Index endpoint: E4_SEQUMAL – Sequelae of malnutrition and other nutritional deficiencies

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Sequelae of malnutrition and other nutritional deficiencies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints