No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
91 |
4. Check minimum number of eventsNone |
91 |
5. Include endpointsNone |
91 |
6. Filter based on genotype QC (FinnGen only) |
78 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of mineral metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 666 | 410 | 245 |
| Only index persons | 511 | 317 | 194 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.70 | 57.04 | 49.92 |
| Only index persons | 49.20 | 51.04 | 46.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 78 | 45 | 33 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 45.50 | 42.63 | 49.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 84
- Matched controls
- 840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.9
ICD-10 Finland
Disorder of mineral metabolism, unspecified
+∞
61.1
51
*
E83.8
ICD-10 Finland
Other disorders of mineral metabolism
+∞
21.8
20
*
A11CC03
ATC
alfacalcidol; systemic
137.9
20.6
21
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
113.0
17.3
18
*
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
17.3
16
*
V03AG01
ATC
sodium cellulose phosphate; systemic
+∞
13.9
13
*
A12AA04
ATC
calcium carbonate; oral
75.8
12.0
13
*
E83.50
ICD-10 Finland
Hypercalcemia
75.8
12.0
13
*
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
10.6
10
*
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
9.5
9
*
27340
ICD-8 Finland
Other and unspecified congenital disorders of metabolism, Other disorders involving metabolism of minerals
+∞
7.4
7
*
E83.51
ICD-10 Finland
Hypocalcemia
+∞
7.4
7
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
7.3
20
53
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
43.7
6.9
8
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
24.9
6.8
9
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.9
6.4
9
5
Z3231
NOMESCO Finland
Registered nurse
3.4
6.4
31
123
E21.2
ICD-10 Finland
Other hyperparathyroidism
+∞
6.3
6
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
6.3
6
*
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
+∞
6.3
6
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
+∞
6.3
6
*
2759X
ICD-9 Finland
Disorders of mineral metabolism, Unspecified disorder of mineral metabolism
+∞
6.3
6
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
308
6.33
12.68
20.4
8.3
1.21
1.22
mmol/l
0.22
60
262
10
6
18.65
6.93
2.5
1.2
70.80
87.67
pmol/l
—
10
6
23
81
3.53
5.63
1.7
1.6
—
—
—
0
0
43
224
2.88
5.38
5.0
2.8
—
—
—
0
0
9
9
11.02
5.16
6.1
1.6
8.91
5.69
pmol/l
—
9
9
13
29
5.10
4.47
3.9
4.2
23.67
24.58
mmol/l
0.26
13
29
7
7
10.76
4.09
1.3
1.0
—
—
—
0
0
7
7
10.76
4.09
1.3
1.0
—
—
—
0
0
35
184
2.55
4.06
4.9
2.5
0.75
0.27
e6/l
0.65
25
133
25
111
2.78
4.05
1.8
1.9
—
—
—
0
0
10
19
5.82
3.97
3.5
1.8
26.97
26.83
mmol/l
—
10
19
20
80
2.97
3.90
1.8
1.7
—
—
—
0
0
14
47
3.37
3.61
7.1
2.3
43.56
61.00
ml/min/173m2
—
9
15
19
77
2.90
3.61
15.5
9.4
101.26
103.94
mmol/l
1.15
19
77
24
111
2.63
3.56
4.5
2.2
1.03
1.12
e6/l
0.07
16
62
11
29
4.20
3.33
8.8
2.6
1.47
1.50
%
0.02
11
29
11
29
4.20
3.33
8.7
2.6
0.61
0.68
%
0.37
11
29
20
93
2.51
2.90
4.3
2.4
5.04
3.22
e6/l
—
10
44
15
61
2.78
2.80
3.0
2.8
—
—
—
0
0
6
10
6.36
2.74
4.5
2.6
17.97
17.43
%
—
6
10
15
62
2.73
2.72
2.9
2.4
393.47
397.95
nmol/l
0.05
15
56
5
7
7.50
2.58
6.0
2.9
—
—
—
0
0
7
18
4.14
2.30
11.7
1.1
0.00
0.00
g/l
—
7
18
44
309
1.89
2.14
5.9
3.1
2.64
0.02
estimate
0.56
11
65
37
247
1.89
2.09
4.2
3.5
58.57
25.80
ng/l
0.44
28
155
53
403
1.85
1.94
6.0
3.1
0.00
0.00
estimate
—
9
75
53
405
1.84
1.89
6.0
3.2
0.00
0.00
estimate
-0.00
11
76
9
35
2.76
1.86
1.3
2.0
—
—
—
0
0
43
314
1.76
1.74
2.7
3.1
—
—
estimate
—
0
0
53
412
1.78
1.72
6.0
3.2
0.00
0.00
estimate
-0.00
11
75
8
31
2.74
1.71
2.1
1.2
—
—
—
0
0
6
19
3.32
1.69
1.5
1.3
—
—
—
0
0
52
404
1.75
1.67
13.8
11.1
4.34
3.85
e9/l
0.89
45
361
5
15
3.47
1.54
1.2
1.3
—
—
—
0
0
27
181
1.72
1.43
1.3
1.3
0.46
1.66
u/ml
—
7
41
5
17
3.06
1.38
2.8
1.4
—
—
—
0
0
31
220
1.65
1.32
5.3
2.5
4.25
0.00
estimate
0.48
12
61
5
18
2.89
1.30
1.0
1.6
—
—
—
0
0
24
161
1.69
1.25
2.7
2.8
—
—
—
0
0
10
51
2.09
1.17
3.6
1.6
—
—
—
0
0
28
204
1.56
1.04
5.3
3.2
39.52
5.33
mg/mmol
0.79
22
123
25
181
1.54
0.95
4.4
3.3
1.02
1.02
kg/l
0.02
12
110
25
182
1.53
0.92
3.3
3.0
3355.40
978.22
ng/l
0.59
20
149
8
45
1.86
0.87
1.3
2.8
23.02
58.85
u/ml
—
8
45
29
221
1.48
0.86
7.2
3.5
0.00
0.00
estimate
—
10
72
17
116
1.58
0.82
2.2
1.5
1523.82
1160.08
nmol/l
0.29
11
92
0
25
0.00
0.80
0.0
1.4
—
—
—
0
0
76
713
1.69
0.71
33.8
16.1
139.36
139.93
mmol/l
1.04
76
699
5
27
1.90
0.69
1.2
1.2
—
—
—
0
0
35
287
1.38
0.68
2.6
1.9
105.85
96.91
pmol/l
0.35
17
151
75
702
1.64
0.68
25.8
14.5
25.14
24.23
mg/l
0.08
63
556
5
28
1.83
0.67
1.4
1.5
—
—
—
0
0
8
54
1.53
0.59
2.5
2.1
—
—
—
0
0
75
711
1.51
0.48
35.4
16.3
3.93
3.93
mmol/l
0.01
75
694
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
6.43
—
0
7
0
16
0.00
0.41
0.0
1.5
—
40.64
—
0
16
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
1.71
—
0
7
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
11
84
1.36
0.32
9.6
6.5
—
—
—
0
0
15
122
1.28
0.29
1.5
1.4
—
—
—
0
0
8
62
1.32
0.29
2.9
2.2
—
—
—
0
0
76
775
0.80
0.28
40.3
21.6
133.61
136.81
g/l
1.18
76
766
76
775
0.80
0.28
40.5
22.0
40.21
40.93
%
0.80
76
765
76
775
0.80
0.28
39.6
21.4
91.37
90.63
fl
0.69
76
766
0
10
0.00
0.21
0.0
4.3
—
14.37
—
0
10
0
10
0.00
0.21
0.0
1.0
—
13.30
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1.58
—
0
5
16
137
1.21
0.20
1.8
1.6
—
—
—
0
0
13
109
1.23
0.20
3.5
1.9
—
—
—
0
0
47
494
0.89
0.16
4.0
3.2
—
—
—
0
0
62
600
1.13
0.13
29.0
16.9
13.68
13.48
%
0.54
62
590
16
178
0.88
0.13
4.1
5.1
0.89
1.79
ug/l
2.82
16
159
5
48
1.04
0.09
3.2
1.3
—
—
—
0
0
16
146
1.12
0.09
1.3
1.3
1.64
8.77
u/ml
—
5
48
13
121
1.09
0.04
4.2
2.1
—
—
—
0
0
68
689
0.93
0.03
4.9
4.6
5.78
5.80
mmol/l
0.04
62
637
17
166
1.03
0.00
1.5
1.3
9.20
23.00
iu/ml
—
5
48
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
6.04
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
101.00
—
0
5
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
1.71
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
3.93
—
0
6
6
68
0.87
-0.00
1.7
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
59.29
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
0.32
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
103.83
—
0
6
76
753
1.10
-0.00
36.1
17.6
86.08
74.29
umol/l
1.33
76
742
Mortality – FinRegistry
↥Association
Association between endpoint E4_MINERAL_METNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_METNAS | 2.427 [1.76, 3.35] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.434 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 288 females with E4_MINERAL_METNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_METNAS | 2.509 [1.54, 4.09] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 165 males with E4_MINERAL_METNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MINERAL_METNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.324% | 0.54% |
| 5 | 1.49% | 3.009% |
| 10 | 3.687% | 7.367% |
| 15 | 6.926% | 14.128% |
| 20 | 11.9% | 23.356% |
Relationships between endpoints
↥Index endpoint: E4_MINERAL_METNAS – Disorder of mineral metabolism, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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