obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
206 |
4. Check minimum number of eventsNone |
206 |
5. Include endpointsNone |
206 |
6. Filter based on genotype QC (FinnGen only) |
184 |
Control definitions (FinnGen only)
- Control exclude
- E4_OBESITY_HYPER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E65-E68
- Name in latin
- Obesitas localisata
Similar endpoints
↥List of similar endpoints to
Localized adiposity
based on the number of shared cases.
Similar with more cases:
- Obesity and other hyperalimentation
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1024 | 788 | 230 |
| Only index persons | 989 | 768 | 221 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.98 | 47.00 | 55.93 |
| Only index persons | 48.80 | 46.87 | 55.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 184 | 152 | 32 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.01 |
| Median age at first event (years) | 49.94 | 48.71 | 55.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 194
- Matched controls
- 1940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E65
ICD-10 Finland
Localized adiposity
4503599627370496.0
272.2
192
*
E66.8
ICD-10 Finland
Other obesity
69.4
98.1
55
11
E66.01
ICD-10 Finland
Obesity due to excess calories
21.2
85.1
75
56
QBJ30
NOMESCO Finland
Correction of abdominal apron
+∞
50.2
46
*
QBJ00
NOMESCO Finland
Liposuction in trunk
113.2
41.8
44
5
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
22.3
21
*
E66.9
ICD-10 Finland
Obesity, unspecified
51.9
19.7
23
5
QDJ00
NOMESCO Finland
Liposuction in lower extremity
209.4
18.9
19
*
E66.00
ICD-10 Finland
Metabolic syndrome
17.7
18.7
29
19
E66
ICD-10 Finland
Obesity
7.1
17.8
29
47
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.6
15.9
33
68
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.9
14.6
24
39
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
6.1
12.9
24
44
A10BA02
ATC
metformin; oral
3.1
12.0
66
273
N02AX02
ATC
tramadol; systemic, rectal
2.9
11.6
110
610
N06AX12
ATC
bupropion; oral
4.4
10.9
30
78
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.7
10.7
39
124
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.1
10.7
55
218
A10BH01
ATC
sitagliptin; oral
4.6
10.5
27
66
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.0
10.5
57
233
R60.9
ICD-10 Finland
Oedema, unspecified
5.1
10.3
23
50
C03CA01
ATC
furosemide; systemic
2.9
10.2
62
269
T82
ICPC
Obesity
8.1
10.0
22
30
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.4
9.6
39
133
103
Kela drug reimbursment
Diabetes, insulin-treated
2.9
9.5
57
244
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
9.4
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
9.3
72
352
WX002
NOMESCO Finland
Sedation and analgesia
2.8
8.5
50
211
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
8.2
52
228
WX402
NOMESCO Finland
General anaesthesia
2.6
8.1
59
277
T90
ICPC
Diabetes non-insulin dependent
2.7
8.0
52
231
A10BJ06
ATC
semaglutide; parenteral
4.6
7.7
19
45
N06AX21
ATC
duloxetine; oral
2.9
7.6
40
158
N03AX16
ATC
[U] pregabalin
2.5
7.5
62
308
N06AB03
ATC
fluoxetine; oral
3.0
7.5
38
147
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
7.3
34
125
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
7.2
71
381
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.4
7.2
27
87
A02BC02
ATC
pantoprazole; systemic
2.6
7.2
151
1117
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
7.2
110
711
R03BA05
ATC
fluticasone; inhalant
2.6
7.1
52
243
N05CF01
ATC
zopiclone; oral
2.3
7.0
77
432
N02BE01
ATC
paracetamol; systemic, rectal
4.9
7.0
186
1603
J01DB01
ATC
cefalexin; oral
3.7
7.0
177
1430
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.8
6.7
39
162
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.4
6.7
17
41
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.5
6.7
24
75
J45
ICD-10 Finland
Asthma
3.0
6.6
33
126
QBA00
NOMESCO Finland
Puncture of skin of trunk
72.1
6.5
7
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
6.4
103
668
UJF32
NOMESCO Finland
Coloscopy
2.3
6.3
58
300
QBJ05
NOMESCO Finland
Other correction of loose or redundant skin of trunk
+∞
6.3
6
*
SPAT1255
SPAT
Intravenous administration of medicine
4.0
6.2
18
48
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.2
88
542
AA1AD
NOMESCO Finland
CT of head and brain
2.3
6.2
60
317
K92.1
ICD-10 Finland
Melaena
5.5
6.2
17
33
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
6.1
68
380
J01MA02
ATC
ciprofloxacin; systemic
2.1
6.1
79
470
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
113
707
2.43
8.38
3.0
1.9
92.63
99.46
pmol/l
1.03
72
336
53
233
2.75
8.33
2.4
1.6
1186.01
1241.19
nmol/l
0.18
45
173
121
809
2.32
7.32
3.7
2.4
75.10
78.13
nmol/l
0.56
114
744
56
275
2.46
6.90
4.0
3.4
0.82
0.82
mmol/l
0.29
56
263
61
315
2.37
6.70
3.2
3.5
32.62
379.67
ng/l
1.05
37
226
71
395
2.26
6.53
3.3
2.1
3.23
2.87
mg/l
0.35
65
339
81
486
2.14
6.10
3.9
3.7
8.44
7.82
mg/mmol
0.06
48
272
119
828
2.13
6.04
9.4
7.3
1.22
1.22
mmol/l
0.16
112
707
132
962
2.16
5.86
7.7
6.4
10.37
10.36
umol/l
0.01
127
916
72
419
2.14
5.81
2.3
1.7
0.98
1.12
mg/l
0.21
55
332
80
488
2.09
5.69
2.1
1.6
26.46
22.96
nmol/l
0.92
75
420
97
640
2.03
5.52
5.0
3.4
2.35
2.36
mmol/l
0.45
91
585
114
797
2.04
5.52
3.3
2.8
—
—
estimate
—
0
0
46
228
2.33
5.45
2.4
2.4
22.68
23.29
%
0.10
41
217
37
179
2.32
4.59
3.4
2.5
29.03
30.76
u/l
0.30
29
149
23
92
2.70
4.23
9.4
8.9
0.58
0.63
%
0.26
23
92
133
1036
1.90
4.14
13.8
10.3
4.24
3.90
e9/l
0.79
118
914
71
458
1.87
4.03
4.2
3.1
664.52
970.34
ng/l
0.77
63
387
24
101
2.57
4.00
2.2
1.7
—
—
—
0
0
64
403
1.88
3.90
1.5
1.3
4.74
6.55
u/ml
0.18
29
157
22
90
2.63
3.88
9.6
9.2
93.78
94.41
%
0.33
22
90
36
187
2.14
3.75
16.9
6.9
104.53
104.44
mmol/l
0.05
36
187
22
92
2.57
3.72
9.6
9.0
1.17
1.35
%
0.65
22
92
43
241
2.01
3.66
6.3
2.7
4.28
3.16
e6/l
0.30
18
108
167
1435
2.18
3.55
5.9
4.7
14.50
14.57
pmol/l
0.14
160
1344
46
268
1.94
3.50
6.0
2.5
0.68
0.84
e6/l
0.31
22
134
65
430
1.77
3.30
1.5
1.3
35.85
29.37
iu/ml
0.12
25
145
31
160
2.12
3.28
1.2
1.2
116.41
177.40
u/ml
—
9
68
68
459
1.74
3.20
6.8
2.8
0.55
0.43
e6/l
0.23
49
322
69
469
1.73
3.17
1.4
1.2
0.58
2.41
u/ml
1.09
17
127
41
238
1.92
3.14
2.0
1.8
—
—
—
0
0
19
82
2.46
3.02
6.7
14.4
16.59
16.04
%
0.44
19
77
31
166
2.03
2.98
2.2
1.7
—
—
—
0
0
27
139
2.09
2.87
8.4
11.1
121.33
120.60
g/l
0.07
27
134
60
402
1.71
2.86
2.5
2.4
—
—
—
0
0
29
155
2.02
2.80
9.1
10.3
5.35
5.16
kpa
0.33
29
148
29
155
2.02
2.80
9.1
10.3
11.20
12.49
kpa
0.92
29
149
186
1728
2.85
2.75
27.3
13.6
20.76
19.82
mg/l
0.17
167
1352
11
35
3.27
2.69
6.4
2.2
7.61
7.94
kpa
0.19
11
35
119
960
1.62
2.68
4.6
3.7
0.00
0.02
estimate
0.50
18
199
10
30
3.46
2.64
1.8
1.3
—
—
—
0
0
10
30
3.46
2.64
1.8
1.3
—
—
—
0
0
12
44
2.84
2.60
9.9
2.9
24.38
25.31
mmol/l
0.20
12
44
28
154
1.96
2.50
1.8
1.3
25.47
29.03
iu/l
0.27
28
130
117
953
1.57
2.42
4.6
3.7
0.00
0.00
estimate
-0.00
19
209
18
85
2.23
2.37
18.6
3.3
23.86
24.34
mmol/l
0.33
18
85
20
100
2.11
2.30
1.2
1.1
—
—
—
0
0
194
1881
+∞
2.29
39.4
21.8
39.99
40.40
%
0.50
194
1868
194
1880
+∞
2.29
37.2
21.4
91.69
91.07
fl
0.94
194
1868
5
9
5.67
2.22
1.0
1.1
—
—
—
0
0
100
798
1.52
2.19
2.1
1.9
1.39
1.37
mmol/l
0.13
90
698
194
1882
+∞
2.08
37.3
21.6
133.65
134.67
g/l
0.50
194
1868
16
77
2.17
2.03
2.2
1.5
—
—
—
0
0
114
945
1.50
2.02
4.6
3.7
0.00
0.00
estimate
-0.00
19
208
7
21
3.42
1.98
1.0
1.1
—
—
—
0
0
5
11
4.63
1.95
1.6
1.3
—
—
—
0
0
29
176
1.76
1.93
2.3
1.6
—
—
—
0
0
180
1670
2.08
1.92
24.2
13.5
87.59
84.00
ml/min/173m2
1.75
173
1560
7
23
3.12
1.81
1.3
1.3
—
—
—
0
0
21
118
1.87
1.78
2.2
1.6
—
—
—
0
0
9
36
2.57
1.76
1.6
1.5
—
—
—
0
0
180
1680
1.99
1.72
6.1
4.7
6.02
5.76
mmol/l
1.91
175
1570
26
159
1.73
1.70
5.1
3.0
—
—
—
0
0
8
31
2.65
1.68
1.1
1.7
—
—
—
0
0
11
51
2.23
1.53
1.1
1.1
—
2.75
—
0
10
14
72
2.02
1.53
1.4
1.3
—
—
—
0
0
7
27
2.65
1.53
2.6
1.6
—
—
—
0
0
53
400
1.45
1.43
4.3
3.7
1.02
1.02
kg/l
0.14
39
268
5
17
2.99
1.36
1.8
1.1
—
—
—
0
0
176
1652
1.70
1.34
5.1
4.2
1.39
1.24
mmol/l
2.06
171
1536
16
91
1.83
1.33
19.9
2.4
0.64
0.60
%
0.24
16
91
6
24
2.55
1.31
1.7
1.3
—
—
—
0
0
16
93
1.79
1.25
4.0
5.9
24.54
25.56
mmol/l
0.37
16
93
6
26
2.35
1.19
2.0
1.2
—
—
—
0
0
6
26
2.35
1.19
1.8
1.2
—
—
—
0
0
6
26
2.35
1.19
1.8
1.2
—
—
—
0
0
32
228
1.48
1.15
2.0
1.8
—
—
—
0
0
161
1495
1.45
1.14
32.6
17.3
13.89
13.50
%
2.74
161
1482
23
154
1.56
1.10
1.7
2.6
75.86
67.01
ml/min/173m2
—
7
67
7
32
2.23
1.09
1.7
1.3
—
—
—
0
0
75
626
1.32
1.08
4.4
3.5
18.53
24.92
ng/l
0.72
48
411
7
33
2.16
1.06
2.0
2.5
—
—
—
0
0
7
33
2.16
1.06
1.3
1.5
—
—
—
0
0
182
1740
1.74
1.05
6.0
4.9
1.38
1.56
mmol/l
7.32
177
1633
7
34
2.10
1.04
2.6
1.5
—
—
—
0
0
7
35
2.04
1.01
1.0
1.0
—
—
—
0
0
15
92
1.68
1.00
21.0
2.4
1.18
1.20
%
0.02
15
92
85
728
1.30
1.00
3.7
3.5
0.00
0.02
estimate
0.74
14
173
182
1744
1.70
0.98
6.1
5.0
4.60
4.87
mmol/l
3.06
182
1643
5
23
2.20
0.98
1.2
1.1
—
—
—
0
0
21
143
1.53
0.94
1.3
1.3
—
25.69
—
0
8
10
55
1.86
0.94
2.1
2.1
—
—
—
0
0
6
28
2.18
0.92
1.8
1.2
—
—
—
0
0
8
47
1.73
0.81
1.0
1.1
4.15
3.80
mmol/l
—
8
42
8
47
1.73
0.81
1.5
1.3
—
—
—
0
0
15
99
1.56
0.78
2.4
1.5
—
—
—
0
0
6
34
1.79
0.77
1.5
1.3
—
—
—
0
0
9
53
1.73
0.76
1.9
2.5
—
—
—
0
0
7
38
1.87
0.74
1.7
1.6
—
—
—
0
0
9
56
1.64
0.73
1.6
1.3
—
—
—
0
0
9
56
1.64
0.73
1.7
1.4
—
—
—
0
0
5
25
2.03
0.73
2.6
1.8
—
—
—
0
0
5
25
2.03
0.73
1.2
1.7
—
—
—
0
0
7
40
1.78
0.72
1.1
1.3
—
—
—
0
0
5
94
0.52
0.68
1.8
1.5
—
—
—
0
0
64
554
1.23
0.65
3.5
3.0
0.00
0.01
estimate
0.50
14
165
5
29
1.74
0.64
1.2
1.9
—
—
—
0
0
126
1171
1.22
0.62
3.9
3.4
—
—
—
0
0
8
53
1.53
0.59
1.0
1.2
—
—
—
0
0
18
133
1.39
0.57
1.4
1.4
—
—
—
0
0
6
37
1.64
0.56
1.2
1.6
—
—
—
0
0
6
38
1.60
0.55
1.7
1.4
10.18
35.67
u/l
—
6
31
6
39
1.56
0.53
11.0
3.4
3.83
3.88
mmol/l
—
6
39
26
207
1.30
0.53
1.8
1.7
—
—
—
0
0
59
518
1.20
0.52
4.0
3.8
0.00
0.00
estimate
-0.00
19
197
12
87
1.40
0.43
16.9
11.6
24.32
25.09
mmol/l
0.16
12
82
10
70
1.45
0.42
1.6
1.4
—
3.22
—
0
10
10
70
1.45
0.42
1.6
1.4
—
8.21
—
0
15
5
34
1.48
0.40
1.0
2.3
6.26
7.19
pmol/l
—
5
34
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
9
71
1.28
0.36
1.0
1.7
—
—
—
0
0
7
52
1.36
0.31
2.6
1.8
—
—
—
0
0
7
54
1.31
0.30
1.0
1.2
—
—
—
0
0
44
395
1.15
0.30
1.7
1.5
—
—
—
0
0
16
194
0.81
0.29
7.8
6.0
—
—
—
0
0
14
172
0.80
0.28
2.4
2.7
0.66
0.76
ug/l
—
8
92
8
62
1.30
0.28
1.6
1.3
—
—
—
0
0
12
98
1.24
0.22
1.6
1.4
—
—
—
0
0
5
42
1.20
0.21
1.2
1.7
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
21
184
1.16
0.20
4.9
4.5
6.06
7.02
ug/l
0.08
15
144
11
132
0.82
0.19
4.2
3.6
1.23
1.23
mmol/l
0.02
11
118
8
68
1.18
0.17
8.5
1.7
—
—
—
0
0
5
44
1.14
0.10
1.2
1.8
—
—
—
0
0
5
46
1.09
0.09
5.6
3.1
44.20
36.68
u/ml
—
5
46
10
87
1.16
0.09
1.1
1.4
—
—
—
0
0
37
386
0.95
0.07
1.7
1.6
—
—
—
0
0
21
217
0.96
0.01
2.8
4.4
19.77
22.74
%
—
6
92
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
2451.86
—
0
7
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
9
93
0.97
-0.00
1.0
1.2
1.60
1.60
g/l
—
9
93
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
0.29
—
0
7
9
95
0.94
-0.00
1.0
1.2
0.88
0.91
g/l
—
9
95
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
7.45
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
21.50
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint E4_LOCALADIP and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_LOCALADIP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_LOCALADIP – Localized adiposity
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data