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Organ-limited amyloidosis

DOID EFO Endpoint Browser PheWeb

E4_AMYL_ORGAN

amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E85.4
  • Cause of death: ICD-10 — E85.4

2 out of 7 registries used, show all original rules.

191

4. Check minimum number of events

None

191

5. Include endpoints

None

191

6. Filter based on genotype QC (FinnGen only)

187

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E85
Name in latin
Amyloidosis in uno organo

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1581 719 850
Only index persons 1221 545 676
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 83.24 84.01 82.64
Only index persons 83.19 84.14 82.43

-FinnGen-

Key figures

All Female Male
Number of individuals 187 69 118
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 78.02 72.46 81.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
191
Matched controls
1910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
276.4
191
*
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
51.4
47
*
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
+∞
41.1
38
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.0
19.3
82
301
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
18.2
68
227
I50.9
ICD-10 Finland
Heart failure, unspecified
3.8
17.5
77
287
E85.89
ICD-10 Finland
Other amyloidosis
+∞
16.9
16
*
C03DA01
ATC
spironolactone; oral
4.4
16.7
51
146
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.8
16.4
33
66
I50.0
ICD-10 Finland
Congestive heart failure
4.4
15.8
48
136
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
14.9
128
708
C03CA01
ATC
furosemide; systemic
3.2
13.9
117
629
WX892
NOMESCO Finland
Monitored bed care
4.9
13.0
31
72
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
12.6
12
*
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
69.3
11.8
13
*
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
11.6
11
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
127.4
11.6
12
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
37.5
11.4
14
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.8
10.9
21
40
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
10.8
41
134
I68.0*E85.9
ICD-10 Finland
Cerebral amyloid angiopathy
+∞
10.5
10
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.8
10.2
76
368
E85.3
ICD-10 Finland
Secondary systemic amyloidosis
+∞
9.4
9
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
13.4
9.0
15
12
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
9.0
56
245
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.6
8.2
20
47
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.6
8.1
63
306
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.8
8.1
19
43
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
13.8
8.0
13
10
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
7.9
85
479
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.5
7.4
56
268
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
4.8
7.3
17
38
N08.4
ICD-10 Finland
Glomerular disorders in other endocrine, nutritional and metabolic diseases
+∞
7.3
7
*
C10AA01
ATC
simvastatin; oral
2.3
7.3
104
655
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
31.3
7.2
9
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.6
7.2
52
243
207
Kela drug reimbursment
Chronic arrhythmias
2.5
7.1
56
272
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
8.0
7.0
15
20
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.2
6.7
13
15
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
6.6
60
309
TFJ02
NOMESCO Finland
Muscle biopsy of heart
72.2
6.5
7
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.7
6.4
40
173
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.2
6.3
76
440
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.8
6.3
36
148
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
18.8
6.3
9
5
E85.0
ICD-10 Finland
Non-neuropathic heredofamilial amyloidosis
+∞
6.3
6
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
6.3
33
130
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
6.3
23
73
TFP20
NOMESCO Finland
Cardiodefibrillation
3.0
6.2
29
107
AA1AD
NOMESCO Finland
CT of head and brain
2.2
6.1
74
428
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
6.1
51
252
X59
ICD-10 Finland
Exposure to unspecified factor
2.6
6.1
40
177
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.0
6.1
18
49

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Cardiac amyloidosis
I43.1*E85.9 (2000502511)
Amyloidosis, unspecified
E85.9 (45571695)
Other amyloidosis
E85.89 (2000501545)
Organ-limited amyloidosis
E85.4 (45557143)
Intracerebral haemorrhage in hemisphere, cortical
I61.1 (45562360)
Thorax X-ray examination outside radiological department
GD1UA (2001303652)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Basophils [#/volume] in Blood
26444-0 (3006315)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Pneumonia, unspecified
J18.9 (45601123)
Fall on same level from slipping, tripping and stumbling
W01 (45756243)
Emergency Room Visit
ER (9203)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Congestive heart failure
I50.0 (45567179)
Heart failure, unspecified
I50.9 (45576879)
Supine thorax X-ray examination
GD1QA (2001303648)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
INR in Blood by Coagulation assay
34714-6 (3032080)
Phosphate [Moles/volume] in Serum or Plasma
14879-1 (3003458)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Hematology
82 (38004501)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Thorax X-ray examination
GD1AA (2001303617)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Platelets [#/volume] in Blood
26515-7 (3007461)
MCH [Entitic mass]
28539-5 (3035941)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
Outpatient Visit
OP (9202)
CBC panel - Blood by Automated count
58410-2 (40761511)
Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
34487-9 (3044938)
Blood type and Crossmatch panel - Blood
34531-4 (3044640)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Emergency Room and Inpatient Visit
ERIP (262)
Troponin T.cardiac [Mass/volume] in Serum or Plasma
6598-7 (3019800)
Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
33762-6 (3029187)
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
14804-9 (3022250)
Kappa light chains/Lambda light chains [Mass Ratio] in Serum
15189-4 (3007778)
Kappa light chains.free [Mass/volume] in Serum
36916-5 (3034860)
Lambda light chains.free [Mass/volume] in Serum or Plasma
33944-0 (3047169)
Immunoglobulin light chains.free panel - Serum
57778-3 (40760888)
Bacteria identified in Blood by Culture
600-7 (3023368)
Inpatient Hospital
21 (8717)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
oxycodone; oral, parenteral
N02AA05 (21604260)
Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
2157-6 (3007220)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Outpatient Hospital
22 (8756)
General Practice
1 (38004446)
IgM [Mass/volume] in Serum or Plasma
2472-9 (3028026)
Laboratory Visit
OMOP4822461 (32036)
Internal Medicine
11 (38004456)
Amylase [Enzymatic activity/volume] in Serum or Plasma
1798-8 (3016771)
Blood group antibody screen [Presence] in Serum or Plasma
890-4 (3001079)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
pH of Serum or Plasma
2753-2 (3018418)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
Nephrology
39 (38004479)
Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
95941-1 (36031861)
spironolactone; oral
C03DA01 (21601534)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Inpatient Visit
IP (9201)
Emergency Medicine
93 (38004510)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30248-9 (3015399)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Cardiology
6 (38004451)
Atherosclerotic heart disease
I25.1 (45596196)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Neurology
13 (38004458)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Casts [#/volume] in Urine by Automated count
51483-6 (3030467)
potassium chloride; oral
A12BA01 (21600877)
Protein electrophoresis panel - Serum or Plasma
24351-9 (3004588)
SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
94500-6 (706163)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
furosemide; oral, parenteral
C03CA01 (21601518)
Calcium [Moles/volume] in Serum or Plasma
2000-8 (3015377)
IgG [Mass/volume] in Serum or Plasma
2465-3 (3005719)
Protein [Mass/volume] in Serum or Plasma
2885-2 (3020630)
Bacteria [#/volume] in Urine by Automated count
51480-2 (3031040)
EKG study
11524-6 (3013512)
Immunohistochemistry procedure
117617002 (4035726)
Home Visit
OMOP4822459 (581476)
Urea [Moles/volume] in Serum or Plasma
22664-7 (3020779)
Case Management Agency
251B00000X (38004193)
Urinalysis macro (dipstick) panel - Urine
24357-6 (3037467)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
IgA [Mass/volume] in Serum or Plasma
2458-8 (3007164)
aPTT in Platelet poor plasma by Coagulation assay
14979-9 (3018677)
prednisolone
A07EA01 (21600653)
prednisolone; oral, parenteral
H02AB06 (21602734)
Bacteria identified in Isolate by Culture
43409-2 (3042936)
Protein electrophoresis panel - 24 hour Urine
81231-3 (21494890)
Essential (primary) hypertension
I10 (45591453)
pantoprazole; oral, parenteral
A02BC02 (21600097)
Magnesium [Moles/volume] in Serum or Plasma
2601-3 (3012095)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
Immunofixation for Serum or Plasma
25700-6 (3037756)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
ABO and Rh group [Type] in Blood by Confirmatory method
77397-8 (46236098)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
43
19.41
66.95
5.4
2.0
1.21
1.53
ratio
0.95
37
21
59
46
18.11
64.46
5.9
2.4
35.92
181.57
mg/l
0.54
47
37
59
46
18.11
64.46
5.8
2.4
59.73
34.10
mg/l
0.95
47
38
60
120
6.83
30.88
4.1
1.7
—
—
—
0
0
37
43
10.43
30.33
1.7
1.2
—
—
—
0
0
30
14
25.13
21.61
2.3
1.2
—
—
—
0
0
26
13
22.90
18.32
2.9
2.2
1.05
1.40
g/24h
—
20
6
110
591
3.03
12.76
7.1
3.3
4828.44
1657.19
ng/l
6.02
100
509
57
230
3.11
10.74
2.2
3.0
1.84
1.72
%
0.32
49
206
10
0
+∞
10.51
2.7
0.0
—
—
—
0
0
41
137
3.54
10.47
1.4
1.3
—
—
—
0
0
127
790
2.81
10.39
24.1
18.8
1.45
1.39
inr
0.57
109
657
110
643
2.68
10.08
7.9
4.2
76.54
48.41
ng/l
1.20
96
507
90
477
2.68
10.06
6.4
4.6
—
—
—
0
0
121
746
2.70
9.88
7.8
5.8
0.16
0.19
e9/l
1.06
110
651
119
728
2.68
9.87
7.6
5.6
0.03
0.04
e9/l
0.56
110
626
119
732
2.66
9.69
7.8
5.7
1.49
1.72
e9/l
2.49
111
647
118
723
2.65
9.69
7.7
5.6
0.63
0.62
e9/l
0.23
109
620
46
175
3.15
9.48
2.0
3.1
71.27
64.15
e9/l
0.53
35
134
115
704
2.59
9.33
9.1
4.1
33.31
34.36
g/l
0.97
107
651
54
229
2.89
9.18
3.1
1.4
2.59
3.15
g/l
0.56
43
123
112
681
2.56
9.16
8.4
5.7
9.09
9.12
%
0.03
107
638
54
231
2.86
9.02
2.6
1.9
29.69
29.71
s
0.01
54
220
30
91
3.72
8.78
1.7
2.4
1.33
1.61
g/l
0.84
23
86
125
812
2.56
8.71
16.1
5.7
1.20
1.21
mmol/l
0.63
113
678
115
728
2.46
8.34
14.2
5.5
1.20
1.21
mmol/l
0.04
110
651
18
25
7.83
8.18
1.2
1.5
—
—
—
0
0
31
101
3.47
8.14
8.7
3.2
161.08
95.03
ng/l
1.68
24
83
87
495
2.39
7.91
7.2
5.5
—
—
—
0
0
58
274
2.60
7.88
5.0
2.3
10.29
12.13
umol/l
1.22
53
248
122
813
2.39
7.60
11.0
9.3
4.84
4.28
e9/l
1.10
113
711
68
353
2.44
7.52
1.9
1.7
995.80
1170.89
nmol/l
0.97
47
270
26
81
3.56
7.28
5.5
3.9
—
—
—
0
0
69
367
2.38
7.18
4.6
2.6
415.06
360.23
umol/l
2.38
62
310
13
13
10.63
7.15
1.8
1.4
347.38
652.69
mg
0.29
13
13
38
152
2.87
7.06
6.7
3.4
7.38
7.39
ph
0.28
28
92
37
150
2.82
6.69
7.0
3.4
2.14
1.95
mmol/l
0.12
32
126
6
0
+∞
6.28
1.2
0.0
—
—
—
0
0
15
25
6.41
6.14
2.9
2.7
—
—
—
0
0
17
45
4.05
5.96
3.4
2.1
117.55
123.00
g/l
0.36
11
39
29
110
2.93
5.89
2.5
1.4
—
—
—
0
0
14
23
6.48
5.81
1.2
1.5
3193.40
43334.23
e6/l
—
5
13
31
123
2.81
5.81
2.4
1.4
—
—
—
0
0
36
155
2.63
5.77
2.7
1.7
—
—
—
0
0
13
20
6.89
5.66
1.1
1.3
—
—
—
0
0
16
43
3.97
5.49
2.6
2.7
8.16
8.00
kpa
0.13
16
43
14
25
5.95
5.49
1.2
1.4
636.56
900.89
e6/l
—
9
18
8
5
16.60
5.46
1.4
1.4
1622.50
1958.00
ml
—
8
5
22
76
3.14
5.23
2.2
1.2
—
—
—
0
0
18
55
3.51
5.17
3.2
2.6
24.16
25.85
mmol/l
1.08
18
55
18
55
3.51
5.17
2.2
3.6
312.20
178.33
mg/l
—
10
18
31
132
2.61
5.06
15.1
8.1
—
—
—
0
0
70
422
2.04
5.04
5.1
3.2
0.65
0.46
e6/l
0.38
57
313
15
33
4.84
4.99
2.7
3.0
88.85
89.75
%
0.11
15
33
15
33
4.84
4.99
2.9
1.2
0.21
0.23
g/l
0.28
15
33
73
451
2.00
4.89
2.6
2.2
3.21
3.19
mg/l
0.02
62
390
76
479
1.97
4.79
3.3
2.9
—
—
—
0
0
15
35
4.56
4.75
2.9
1.3
1.16
1.12
g/l
0.18
15
35
77
493
1.94
4.60
5.2
3.4
55.91
224.11
e6/l
0.65
64
379
83
545
1.92
4.60
6.1
3.8
67.82
110.89
e6/l
0.56
65
390
13
29
4.73
4.33
1.9
1.5
—
—
—
0
0
9
13
7.20
4.21
1.2
1.2
—
—
—
0
0
74
479
1.89
4.20
10.0
3.7
7.39
7.40
ph
0.29
62
351
89
612
1.85
4.17
4.7
2.7
157.54
160.07
ug/l
0.04
80
547
43
231
2.11
4.13
3.3
2.0
—
—
—
0
0
82
552
1.85
4.10
2.3
2.3
—
—
—
0
0
33
162
2.25
3.95
7.6
3.4
7.36
7.36
ph
0.06
28
107
56
337
1.94
3.92
4.2
2.7
3.34
4.41
e6/l
0.82
56
306
7
8
9.02
3.80
2.4
2.5
—
—
—
0
0
7
9
8.02
3.59
2.0
1.0
—
—
—
0
0
12
31
4.06
3.56
1.4
1.1
—
—
—
0
0
31
155
2.19
3.55
1.5
1.3
432.00
565.52
titre
—
5
29
12
32
3.93
3.45
3.3
2.0
2.37
2.46
mmol/l
—
7
15
91
657
1.74
3.44
3.4
3.2
—
—
estimate
—
0
0
9
18
5.19
3.41
4.7
1.7
11.91
6.80
pmol/l
—
9
18
158
1343
2.02
3.39
37.6
18.2
26.96
28.31
mg/l
0.23
145
1149
29
145
2.18
3.32
2.8
1.6
—
—
—
0
0
73
500
1.74
3.30
2.7
3.0
5.94
7.13
mmol/l
1.81
62
408
6
7
8.80
3.28
1.0
1.4
108.17
111.29
pmol/l
—
6
7
9
19
4.91
3.28
1.4
1.5
—
—
—
0
0
72
494
1.73
3.22
3.0
3.1
129.36
46.92
mg/l
1.56
54
324
13
40
3.41
3.21
4.0
1.6
2.68
1.60
mg/l
1.89
13
32
74
513
1.72
3.18
3.6
3.7
35.05
8.53
mg/mmol
1.83
53
318
77
551
1.67
2.89
4.3
2.9
2.35
2.34
mmol/l
0.04
71
494
40
238
1.86
2.84
4.5
3.1
2.15
1.66
e6/l
0.13
20
126
36
207
1.91
2.83
9.9
6.8
1.04
1.30
mmol/l
0.15
31
165
163
1429
1.96
2.78
45.0
24.0
111.06
83.94
umol/l
4.62
157
1406
71
502
1.66
2.77
3.6
3.3
—
—
—
0
0
30
164
1.98
2.73
1.8
1.5
—
—
—
0
0
161
1410
1.90
2.70
45.5
21.6
4.02
4.02
mmol/l
0.07
155
1370
161
1410
1.90
2.70
44.6
21.5
138.95
139.74
mmol/l
2.58
155
1371
160
1405
1.86
2.57
16.9
12.1
22.51
23.40
u/l
0.51
152
1350
6
11
5.59
2.56
1.2
1.3
—
—
—
0
0
49
320
1.71
2.54
2.0
1.6
1.90
1.57
mg/l
0.29
35
251
53
357
1.67
2.45
2.7
3.0
2.49
2.45
mmol/l
1.00
45
318
17
78
2.29
2.39
1.9
3.1
—
—
—
0
0
5
8
6.38
2.38
1.4
1.4
—
—
—
0
0
162
1439
1.83
2.35
51.3
27.4
235.07
236.64
e9/l
0.11
156
1403
162
1439
1.83
2.35
51.3
27.4
4.23
4.38
e12/l
2.88
154
1393
162
1439
1.83
2.35
51.6
27.4
7.08
6.77
e9/l
1.02
154
1392
35
213
1.79
2.31
10.2
6.7
7.43
7.42
ph
0.39
21
137
0
60
0.00
2.29
0.0
2.0
—
—
—
0
0
93
729
1.54
2.24
2.3
2.1
86.55
96.14
pmol/l
1.15
58
382
78
589
1.55
2.22
23.9
12.3
0.00
0.01
e9/l
0.66
66
480
58
410
1.60
2.20
7.6
6.1
—
—
—
0
0
10
36
2.87
2.17
1.5
2.1
1.08
0.83
%
—
10
24
8
25
3.29
2.12
1.3
1.3
—
—
—
0
0
32
196
1.76
2.07
10.9
6.8
96.28
94.83
%
1.12
32
188
154
1364
1.67
2.06
34.8
16.4
—
—
—
0
0
21
116
1.91
1.87
5.3
3.9
—
—
—
0
0
145
1277
1.56
1.87
5.9
6.8
41.28
40.06
mmol/mol
0.87
127
1163
5
12
4.25
1.83
1.4
1.4
—
—
—
0
0
54
391
1.53
1.81
2.6
3.3
0.67
0.88
ug/l
1.27
39
269
8
29
2.83
1.81
2.0
1.2
—
—
—
0
0
43
296
1.58
1.80
7.1
5.5
—
—
—
0
0
24
141
1.80
1.78
7.2
3.8
0.23
0.95
%
2.74
15
53
23
134
1.81
1.76
7.4
3.9
0.00
0.17
%
1.72
14
46
115
974
1.45
1.73
6.6
4.6
—
0.40
—
0
5
28
175
1.70
1.70
12.1
7.4
123.39
120.85
g/l
0.24
28
170
148
1321
1.53
1.68
5.2
5.9
2.40
2.57
mmol/l
1.32
131
1178
8
31
2.65
1.68
1.3
1.2
—
—
—
0
0
7
25
2.87
1.66
2.0
2.6
—
—
—
0
0
147
1313
1.52
1.63
5.1
5.6
5.92
6.06
mmol/l
0.88
132
1162
139
1230
1.48
1.60
4.8
5.0
2.31
2.03
mu/l
1.23
121
1085
7
26
2.75
1.59
1.1
1.2
—
—
—
0
0
34
228
1.60
1.58
12.9
5.9
103.68
104.42
mmol/l
0.43
34
228
5
15
3.39
1.53
1.2
1.3
0.22
0.22
nmol/l
—
5
9
32
214
1.60
1.51
1.3
1.3
37.35
42.14
iu/ml
0.09
11
67
23
141
1.72
1.50
7.8
3.4
1.20
1.22
mmol/l
0.58
23
118
19
110
1.81
1.49
16.5
9.1
94.73
93.77
%
0.48
19
110
7
28
2.56
1.46
1.6
1.3
—
114.00
—
0
5
6
22
2.78
1.44
1.0
1.1
—
—
—
0
0
22
136
1.70
1.40
7.7
4.2
0.00
0.33
%
0.91
13
43
16
90
1.85
1.38
17.3
8.5
15.64
15.69
%
0.02
16
84
92
771
1.37
1.35
4.5
4.1
0.00
1.86
estimate
0.50
27
161
137
1227
1.41
1.33
4.5
4.3
1.27
1.22
mmol/l
0.35
120
1086
15
85
1.83
1.27
1.1
1.1
—
—
—
0
0
30
208
1.52
1.22
1.2
1.4
—
—
—
0
0
21
134
1.64
1.20
7.6
3.7
0.08
0.46
%
2.01
12
46
5
20
2.54
1.16
1.4
1.1
—
—
—
0
0
7
30
2.38
1.13
1.4
1.2
—
—
—
0
0
113
996
1.33
1.12
3.8
4.0
15.12
15.15
pmol/l
0.03
100
881
5
21
2.42
1.09
1.0
2.4
—
—
—
0
0
7
32
2.23
1.09
4.9
2.7
59.29
60.12
%
—
7
32
141
1290
1.36
1.05
5.0
5.1
4.28
4.47
mmol/l
1.13
126
1165
5
23
2.20
0.98
6.0
2.6
5.53
4.60
e9/l
—
5
23
79
673
1.30
0.96
5.1
6.1
3.56
5.18
ug/l
0.44
70
581
9
51
1.80
0.96
1.2
1.2
39.47
446.47
u/ml
—
9
46
12
70
1.76
0.95
1.2
1.5
—
—
—
0
0
19
127
1.55
0.93
2.8
3.9
—
—
—
0
0
139
1281
1.31
0.90
4.9
5.0
1.39
1.46
mmol/l
1.03
123
1140
87
757
1.27
0.88
4.5
4.0
0.00
0.00
estimate
-0.00
28
163
8
46
1.77
0.83
1.1
1.4
—
—
—
0
0
27
200
1.41
0.82
1.3
1.3
3.78
17.44
u/ml
1.07
11
72
44
354
1.32
0.81
1.6
2.0
488.13
433.69
pmol/l
0.58
38
285
27
202
1.39
0.78
1.5
1.2
—
—
—
0
0
87
768
1.24
0.76
4.6
4.0
0.00
0.00
estimate
-0.00
29
169
5
24
2.11
0.75
1.2
1.1
—
—
—
0
0
13
84
1.59
0.74
2.8
4.1
37.01
36.91
°c
1.28
13
84
7
39
1.82
0.73
1.1
1.1
—
—
—
0
0
43
353
1.28
0.68
3.7
3.1
—
0.00
—
0
15
11
70
1.61
0.66
1.1
1.3
—
—
—
0
0
5
29
1.74
0.64
1.0
1.2
—
—
—
0
0
15
107
1.44
0.57
1.3
1.4
—
—
—
0
0
39
324
1.26
0.57
4.0
4.1
—
0.00
—
0
5
66
590
1.18
0.47
3.8
3.7
6.22
6.27
ph
0.14
34
335
11
79
1.42
0.41
4.4
3.6
0.79
0.97
%
0.95
11
71
0
16
0.00
0.41
0.0
1.5
—
8.75
—
0
16
5
34
1.48
0.40
5.2
1.4
63.20
59.44
%
—
5
34
12
89
1.37
0.39
3.8
2.2
0.75
0.63
%
0.46
12
89
12
89
1.37
0.39
3.8
2.2
1.07
1.10
%
0.10
12
89
16
126
1.29
0.36
2.6
2.3
155.63
140.05
ug/g
0.12
16
105
40
351
1.18
0.36
1.3
1.3
—
—
—
0
0
10
73
1.39
0.35
1.1
1.3
—
—
—
0
0
47
419
1.16
0.35
5.0
3.6
0.09
0.22
estimate
0.26
23
122
15
122
1.25
0.28
4.2
2.7
0.38
0.22
e6/l
0.49
15
116
30
339
0.86
0.26
4.3
4.5
1.01
1.02
kg/l
1.37
22
229
15
123
1.24
0.26
4.9
6.0
24.27
24.56
mmol/l
0.10
15
115
29
257
1.15
0.24
1.2
1.2
0.97
2.57
u/ml
—
6
58
5
37
1.36
0.23
2.8
4.6
104.00
104.94
mmol/l
—
5
32
5
37
1.36
0.23
2.8
4.6
11.40
11.06
mmol/l
—
5
32
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
400.40
—
0
10
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
46.47
—
0
14
6
50
1.21
0.20
2.7
4.9
1.25
1.25
mmol/l
—
6
43
18
159
1.15
0.15
2.4
2.8
3.87
5.80
e9/l
0.58
11
132
18
161
1.13
0.13
1.2
1.3
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
48
461
1.06
0.08
4.9
4.2
0.05
0.00
estimate
0.48
20
141
7
81
0.86
0.07
6.3
4.5
1.02
1.02
ratio
—
7
75
54
523
1.05
0.07
1.8
1.7
22.39
20.86
nmol/l
0.24
46
425
10
92
1.09
0.03
2.3
2.5
—
—
—
0
0
40
408
0.98
0.01
2.8
3.3
—
—
—
0
0
59
589
1.00
0.00
5.0
4.2
0.08
0.01
estimate
0.36
26
137
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
126.25
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
189.43
—
0
7
7
72
0.97
-0.00
1.1
1.3
—
50.30
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
16.52
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
324.80
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint E4_AMYL_ORGAN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_AMYL_ORGAN.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: E4_AMYL_ORGAN – Organ-limited amyloidosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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