keratosis: A skin disorder consisting of hypertrophy of the stratum corneum of the skin.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
103 |
4. Check minimum number of eventsNone |
103 |
5. Include endpointsNone |
103 |
6. Filter based on genotype QC (FinnGen only) |
91 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Alkalosis
Similar endpoints
↥List of similar endpoints to
Alkalosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 798 | 411 | 378 |
| Only index persons | 681 | 363 | 318 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.60 | 64.07 | 58.89 |
| Only index persons | 61.83 | 64.41 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 91 | 48 | 43 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 57.91 | 54.56 | 61.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 94
- Matched controls
- 940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.3
ICD-10 Finland
Alkalosis
+∞
129.8
92
*
E87.6
ICD-10 Finland
Hypokalaemia
229.9
49.3
47
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
144.5
29.7
30
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
7.5
19.6
38
78
JN3AD
NOMESCO Finland
Abdominal CT examination
8.3
19.4
32
55
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.5
18.1
33
63
R11
ICD-10 Finland
Nausea and vomiting
7.7
14.7
24
40
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
7.3
14.0
24
42
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.0
13.5
48
163
A10AE04
ATC
insulin glargine; parenteral
6.6
12.3
23
44
AA1AD
NOMESCO Finland
CT of head and brain
4.7
12.2
44
149
TPH07
NOMESCO Finland
Cathetrisation of artery
6.6
11.5
21
39
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
11.4
61
274
WX892
NOMESCO Finland
Monitored bed care
10.5
10.8
21
25
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.0
10.2
50
207
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.1
10.1
43
161
N17.9
ICD-10 Finland
Acute renal failure, unspecified
29.8
10.1
13
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.9
9.8
20
41
C03CA01
ATC
furosemide; systemic
4.0
9.8
42
158
WX882
NOMESCO Finland
High dependency care
33.9
9.7
12
*
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
+∞
9.5
9
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.8
9.2
46
190
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.1
9.1
34
115
C03DA01
ATC
spironolactone; oral
5.1
8.7
21
50
K92.0
ICD-10 Finland
Haematemesis
14.7
8.7
14
11
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.9
8.6
22
55
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
8.6
31
102
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
8.6
19
42
N05AH04
ATC
quetiapine; oral
4.2
8.5
28
86
A10AB05
ATC
insulin aspart; parenteral
7.9
8.4
19
29
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
8.1
22
58
103
Kela drug reimbursment
Diabetes, insulin-treated
3.6
8.0
36
137
N05BA04
ATC
oxazepam; oral
3.6
8.0
36
137
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.2
7.9
25
74
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
20.5
7.8
11
6
A10AE06
ATC
insulin degludec; parenteral
20.5
7.8
11
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.1
7.6
18
42
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.2
7.6
24
71
N17.8
ICD-10 Finland
Other acute renal failure
86.6
7.5
8
*
A46
ICD-10 Finland
Erysipelas
4.5
7.4
21
57
E87.5
ICD-10 Finland
Hyperkalaemia
+∞
7.4
7
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
11.4
7.3
13
13
A11CC03
ATC
alfacalcidol; systemic
32.8
7.3
9
*
E86
ICD-10 Finland
Volume depletion
32.8
7.3
9
*
JN4AD
NOMESCO Finland
Body CT examination
4.5
7.3
20
53
Z3229
NOMESCO Finland
Other healthcare associate professional
5.0
7.1
17
40
TKC20
NOMESCO Finland
Catheterisation of bladder
7.5
7.0
16
25
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.2
7.0
44
204
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
43.3
6.9
8
*
H04AA01
ATC
glucagon; nasal, parenteral
43.3
6.9
8
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
6.7
23
72
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.3
6.6
19
52
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.6
6.5
26
90
N05CF01
ATC
zopiclone; oral
3.1
6.5
40
181
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
74.7
6.5
7
*
E83.51
ICD-10 Finland
Hypocalcemia
74.7
6.5
7
*
T89
ICPC
Diabetes insulin dependent
10.4
6.5
12
13
N07BB01
ATC
disulfiram; oral
8.0
6.5
14
20
N05BA01
ATC
diazepam; systemic, rectal
4.0
6.5
21
63
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
28.8
6.3
8
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
28.8
6.3
8
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
+∞
6.3
6
*
A10AC01
ATC
insulin (human); parenteral
5.9
6.3
17
34
F10.24
ICD-10 Finland
Alcohol depence active use
13.8
6.2
10
8
ZXD05
NOMESCO Finland
Urgent procedure
3.0
6.2
40
185
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.6
6.2
16
40
A02BC02
ATC
pantoprazole; systemic
3.5
6.2
74
483
I50.0
ICD-10 Finland
Congestive heart failure
6.7
6.1
15
26
N05CF02
ATC
zolpidem; oral
3.5
6.1
25
88
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
65
11.85
31.58
15.6
3.3
4.74
1.69
mmol/l
1.91
39
55
47
86
9.93
27.99
20.1
6.4
99.00
104.91
mmol/l
4.68
47
86
29
33
12.26
24.69
14.8
5.1
26.72
24.45
mmol/l
1.53
29
33
25
34
9.65
18.35
18.2
6.6
28.40
24.44
mmol/l
2.09
25
34
26
40
8.60
17.21
20.5
8.4
0.72
0.60
%
0.76
26
40
26
41
8.38
16.83
20.4
8.4
93.95
94.34
%
0.11
26
41
26
42
8.18
16.46
20.4
7.6
1.46
1.45
%
0.01
26
42
27
48
7.49
15.65
2.1
1.6
—
—
—
0
0
41
114
5.61
14.92
2.2
1.7
1293.95
1216.00
nmol/l
0.20
34
83
23
37
7.91
14.51
19.5
8.4
27.90
24.08
mmol/l
2.18
23
37
52
181
5.19
14.38
4.1
2.0
2.96
2.84
mg/l
0.15
47
159
74
345
6.38
14.22
26.1
6.4
1.18
1.21
mmol/l
2.95
69
299
40
120
5.06
13.08
2.5
1.9
—
—
—
0
0
58
249
4.47
11.61
6.2
3.0
2.31
2.35
mmol/l
0.97
52
220
44
163
4.19
10.60
5.2
2.8
—
—
—
0
0
19
38
6.01
9.56
13.3
1.9
1.33
1.17
%
0.30
19
38
19
39
5.85
9.30
13.3
1.9
0.65
0.63
%
0.10
19
39
29
86
4.43
9.27
2.3
1.8
—
—
—
0
0
25
66
4.80
9.24
7.1
3.0
25.10
26.41
u/l
0.12
20
54
64
329
3.96
9.22
5.3
2.1
70.60
74.24
nmol/l
0.41
58
293
52
236
3.69
9.00
9.9
3.2
45.38
27.57
u/l
1.79
47
221
29
88
4.32
8.98
2.3
1.8
—
—
—
0
0
54
254
3.65
8.79
8.8
3.5
48.42
46.12
ng/l
0.05
41
179
37
137
3.80
8.65
4.8
3.0
2.47
2.46
mmol/l
0.09
29
117
18
38
5.62
8.52
1.7
1.4
—
—
—
0
0
20
48
5.02
8.21
3.1
1.7
53.88
68.37
ml/min/173m2
—
8
16
30
100
3.94
8.10
3.5
1.9
1.71
1.32
%
2.31
25
86
60
318
3.45
7.79
3.4
2.0
90.60
98.95
pmol/l
0.61
40
165
45
201
3.38
7.73
5.0
3.0
0.29
0.42
e6/l
0.28
38
146
71
419
3.84
7.73
20.2
10.6
4.84
3.99
e9/l
2.18
65
362
19
34
6.73
7.57
1.7
1.6
—
—
—
0
0
36
153
3.19
6.53
3.3
1.7
1.08
1.48
mg/l
0.36
30
117
13
17
8.68
6.37
6.3
1.4
1.80
1.43
mg/l
0.61
13
11
11
11
11.14
6.22
1.2
1.1
—
—
—
0
0
45
225
2.92
6.05
7.6
3.7
60.45
8.14
mg/mmol
0.98
33
142
12
18
7.47
5.45
14.6
3.7
30.74
24.72
mmol/l
1.44
12
18
30
126
3.03
5.44
3.5
2.7
2.46
0.72
e6/l
0.38
14
72
11
16
7.62
5.12
1.8
1.7
—
—
—
0
0
12
21
6.38
4.94
9.3
3.7
1.54
1.15
mmol/l
0.48
12
21
55
329
2.62
4.94
5.2
3.1
—
—
estimate
—
0
0
33
155
2.74
4.81
1.7
1.2
0.82
0.68
u/ml
0.46
13
30
27
114
2.92
4.79
3.7
2.9
7.74
1.83
e6/l
0.44
11
60
30
135
2.80
4.73
2.8
1.8
662.04
475.14
pmol/l
0.52
24
115
7
5
14.96
4.65
1.3
1.0
—
—
—
0
0
10
17
6.44
4.26
11.0
4.4
3.65
3.96
mmol/l
—
10
17
11
25
4.84
3.76
2.5
1.2
—
—
—
0
0
7
9
8.29
3.62
1.0
1.0
—
—
—
0
0
58
397
2.20
3.36
5.3
3.1
0.00
0.00
estimate
-0.00
14
90
58
401
2.17
3.23
5.3
3.1
0.00
0.00
estimate
-0.00
11
85
57
393
2.14
3.17
5.4
3.0
0.00
0.00
estimate
-0.00
14
89
7
13
5.72
2.92
3.0
1.3
7.86
4.80
pmol/l
—
7
13
8
18
4.75
2.86
2.0
1.8
—
—
—
0
0
9
24
4.03
2.75
3.4
2.6
—
—
—
0
0
9
24
4.03
2.75
1.1
1.5
—
16.07
—
0
6
9
25
3.87
2.65
2.0
2.7
10.68
10.13
g/l
—
9
25
8
20
4.27
2.63
3.7
2.3
—
—
—
0
0
8
20
4.27
2.63
1.1
1.3
—
—
—
0
0
8
20
4.27
2.63
1.0
1.6
—
20.50
—
0
5
6
11
5.74
2.58
1.0
2.1
—
—
—
0
0
5
7
7.46
2.58
1.0
1.3
—
—
—
0
0
7
16
4.63
2.52
1.0
1.9
—
—
—
0
0
9
27
3.57
2.46
2.0
2.6
6.93
7.57
g/l
—
9
27
9
27
3.57
2.46
2.0
2.6
4.02
4.52
g/l
—
9
27
16
74
2.40
2.30
4.1
3.6
—
—
—
0
0
86
751
2.70
2.26
58.0
14.4
27.23
23.16
mg/l
0.67
81
594
5
9
5.79
2.24
1.6
2.0
—
—
—
0
0
5
9
5.79
2.24
1.6
2.0
—
—
—
0
0
5
9
5.79
2.24
1.6
2.0
—
—
—
0
0
5
9
5.79
2.24
1.0
1.3
—
—
—
0
0
5
9
5.79
2.24
1.0
1.2
0.30
0.49
nmol/l
—
5
9
7
19
3.89
2.19
1.9
1.2
—
—
—
0
0
7
19
3.89
2.19
1.9
1.2
—
—
—
0
0
8
26
3.26
2.06
2.0
2.7
2.89
3.07
g/l
—
8
26
8
27
3.14
1.98
2.1
2.6
3.68
3.67
g/l
—
8
27
6
16
3.93
1.97
3.5
1.8
—
—
—
0
0
6
16
3.93
1.97
3.5
1.8
—
—
—
0
0
7
22
3.35
1.92
1.6
1.5
—
—
—
0
0
6
17
3.69
1.87
1.0
1.2
—
—
—
0
0
6
17
3.69
1.87
1.8
1.3
—
—
—
0
0
6
17
3.69
1.87
7.7
2.1
245.83
166.41
%
—
6
17
7
23
3.20
1.84
2.1
2.8
0.00
0.00
g/l
—
7
23
7
24
3.07
1.76
1.6
1.2
—
—
—
0
0
7
24
3.07
1.76
2.1
2.8
0.00
0.00
g/l
—
7
24
33
225
1.72
1.62
7.1
3.3
0.00
0.00
estimate
-0.00
12
80
6
20
3.13
1.61
1.7
1.6
—
—
—
0
0
73
619
1.80
1.56
60.4
18.0
14.57
13.57
%
5.07
73
614
6
21
2.98
1.53
7.5
1.4
93.83
94.48
%
—
6
21
9
38
2.51
1.50
1.7
1.4
—
—
—
0
0
6
22
2.84
1.46
2.8
2.2
—
—
—
0
0
86
782
2.17
1.42
78.7
15.6
138.07
139.89
mmol/l
5.90
86
764
86
783
2.15
1.41
78.2
15.7
3.86
3.97
mmol/l
2.82
86
764
39
303
1.49
1.05
6.2
3.0
0.00
0.00
estimate
-0.00
14
73
0
32
0.00
0.97
0.0
1.4
—
239.26
—
0
15
20
140
1.54
0.86
1.3
1.3
45.98
33.88
iu/ml
—
9
45
0
24
0.00
0.80
0.0
1.8
—
—
—
0
0
55
474
1.39
0.78
3.0
3.3
—
—
—
0
0
9
141
0.60
0.77
1.4
1.4
—
—
—
0
0
5
24
2.14
0.76
1.2
2.4
—
—
—
0
0
86
813
1.68
0.70
73.1
17.8
96.48
75.03
umol/l
1.76
86
803
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
80
750
1.45
0.57
5.8
4.6
4.30
4.67
mmol/l
2.78
75
698
22
174
1.35
0.51
7.1
3.0
1.02
1.02
kg/l
0.07
14
107
79
744
1.39
0.49
5.9
4.5
1.47
1.46
mmol/l
0.05
74
688
17
131
1.36
0.46
1.2
1.3
1.73
11.21
u/ml
—
8
43
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
75
712
1.26
0.34
5.5
3.8
1.26
1.30
mmol/l
0.25
70
655
86
835
1.35
0.31
82.4
21.5
38.29
40.78
%
5.00
86
824
86
835
1.35
0.31
77.4
21.1
90.99
91.01
fl
0.01
86
825
9
75
1.22
0.26
1.9
2.1
—
—
—
0
0
86
837
1.32
0.22
78.8
21.3
125.10
136.31
g/l
7.93
86
828
5
41
1.23
0.22
1.2
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
23
205
1.16
0.19
5.9
4.5
20.77
22.03
%
—
8
94
29
313
0.89
0.15
2.6
1.8
1.29
1.42
mmol/l
0.32
23
262
6
53
1.14
0.09
2.5
1.3
—
—
—
0
0
9
84
1.08
0.07
1.9
2.3
—
—
—
0
0
9
86
1.05
0.07
20.0
5.8
—
—
—
0
0
75
741
1.06
0.03
6.8
4.7
6.57
5.88
mmol/l
1.93
68
682
23
222
1.05
0.02
5.1
2.8
0.00
0.01
estimate
0.49
12
69
14
146
0.95
0.00
1.5
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
29.05
—
0
6
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_ALKALOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ALKALOSIS | 3.225 [1.93, 5.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 300 females with E4_ALKALOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ALKALOSIS | 4.629 [2.28, 9.39] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 246 males with E4_ALKALOSIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ALKALOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.279% | 1.062% |
| 5 | 1.763% | 5.621% |
| 10 | 4.404% | 13.68% |
| 15 | 8.305% | 24.568% |
| 20 | 13.736% | 38.647% |
Relationships between endpoints
↥Index endpoint: E4_ALKALOSIS – Alkalosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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