Adrenomedullary hyperfunction

E4_ADREMEDHYPER

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E27.5 Hospital discharge: ICD-9 — 2556 Cause of death: ICD-10 — E27.5 Cause of death: ICD-9 — 2556 2 out of 7 registries used, show all original rules.	121
4. Check minimum number of events None	121
5. Include endpoints None	121
6. Filter based on genotype QC (FinnGen only)	109

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E27
Name in latin: Hyperfunctio medullae glandulae suprarenalis

NAME	E4_ADREMEDHYPER
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E275
HD_ICD_9	2556
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E275
COD_ICD_9	2556
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Adrenomedullary hyperfunction based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	589	326	256
Only index persons	521	296	225
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.31	57.45	57.21
Only index persons	56.12	56.57	55.53

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	109	56	53
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	54.58	50.74	58.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1110

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E27.5

ICD-10 Finland

Adrenomedullary hyperfunction

+∞

140.4

103

D44.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Adrenal gland

852.6

78.3

BCA31

NOMESCO Finland

Endoscopic unilateral adrenalectomy

+∞

77.4

D35.0

ICD-10 Finland

Benign neoplasm: Adrenal gland

142.2

52.8

C74.1

ICD-10 Finland

Malignant neoplasm: Medulla of adrenal gland

+∞

29.5

TPH07

NOMESCO Finland

Cathetrisation of artery

10.6

28.8

8700/3-C74.1

ICD-O-3

Pheochromocytoma, NOS, of medulla of adrenal gland

+∞

26.1

8700/3-C74.9

ICD-O-3

Pheochromocytoma, NOS, of adrenal gland, NOS

+∞

26.1

BCA30

NOMESCO Finland

Unilateral adrenalectomy

+∞

23.8

H02AB09

ATC

hydrocortisone; systemic

41.8

21.3

C74.9

ICD-10 Finland

Malignant neoplasm: Adrenal gland, unspecified

+∞

20.4

C74.0

ICD-10 Finland

Malignant neoplasm: Cortex of adrenal gland

+∞

17.1

ZXE10

NOMESCO Finland

More than one and less than three hours

4.5

13.9

266

BC1CD

NOMESCO Finland

Very extensive CT of adrenal glands

52.9

12.2

BC1AD

NOMESCO Finland

CT of adrenal glands

31.7

11.0

BC5AQ

NOMESCO Finland

Chromaffine tissue SPECT with low dose CT

+∞

10.6

105

Kela drug reimbursment

Adrenal cortical hypofunction

+∞

9.5

E34.9

ICD-10 Finland

Endocrine disorder, unspecified

+∞

9.5

C04AX02

ATC

phenoxybenzamine; oral

+∞

8.4

D35.59

ICD-10 Finland

Other paragangliom

+∞

8.4

JN3BD

NOMESCO Finland

Extensive abdominal CT

4.7

8.3

E27.1

ICD-10 Finland

Primary adrenocortical insufficiency

+∞

7.4

E27.0

ICD-10 Finland

Other adrenocortical overactivity

+∞

7.4

WX302

NOMESCO Finland

Thoracal epidural anesthesy

7.6

7.1

C07AB07

ATC

bisoprolol; oral

2.9

6.9

418

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

9.6

6.8

H02AA02

ATC

fludrocortisone; oral

73.9

6.5

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.3

6.4

I15.2

ICD-10 Finland

Hypertension secondary to endocrine disorders

+∞

6.3

ZXE20

NOMESCO Finland

More than three and less than five hours

3.4

6.3

JN4BD

NOMESCO Finland

Extensive body CT

3.8

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

103.58

123.17

7.1

1.2

0.52

—

nmol/l

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

129.29

121.88

6.4

1.1

—

nmol/l

—

(4035726) Immunohistochemistry procedure

100

6.89

21.25

1.4

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

39.71

20.31

1.2

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

30.12

18.26

1.9

1.4

89.18

25.36

ng/l

—

(3018418) pH of Serum or Plasma

289

3.34

9.03

6.9

4.5

7.40

0.04

198

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

462

3.32

7.91

10.2

7.8

1.20

1.21

mmol/l

0.36

403

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

4.27

7.79

7.7

3.5

1.23

1.22

mmol/l

0.37

(3010421) pH of Blood

6.25

5.59

5.2

2.0

7.40

7.42

0.73

(3014576) Chloride [Moles/volume] in Serum or Plasma

136

2.78

5.04

7.7

7.9

104.81

104.15

mmol/l

0.38

136

(3000850) Epithelial cells [#/volume] in Urine

231

2.50

4.98

2.5

5.19

4.79

e6/l

0.09

219

(3023368) Bacteria identified in Blood by Culture

258

2.43

4.80

5.9

4.7

—

(3044640) Blood type and Crossmatch panel - Blood

325

2.37

4.75

2.1

2.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.00

4.67

4.9

2.7

—

(3019977) pH of Arterial blood

109

2.81

4.57

7.2

9.3

7.42

7.43

0.18

(40768804) Tissue Pathology biopsy report

378

2.28

4.36

2.1

2.0

—

(3021589) Normoblasts [#/volume] in Blood

454

2.29

4.26

20.6

11.0

0.00

e9/l

0.39

371

(1616796) Gas panel - Central venous blood

7.42

4.25

4.3

2.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

3.28

4.22

5.6

3.7

4.38

4.52

pmol/l

0.22

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.85

4.00

5.9

8.9

1.08

1.24

mmol/l

0.50

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

446

2.18

3.88

2.9

2.8

—

estimate

—

(3000991) Gas panel - Venous blood

2.67

3.70

5.7

9.4

—

(3032080) INR in Blood by Coagulation assay

430

2.08

3.48

7.8

12.0

1.10

1.20

inr

1.19

349

(3002256) Pathology report gross observation

118

2.44

3.43

1.4

1.2

—

(3021901) Oxygen saturation in Capillary blood

6.06

3.40

3.6

1.9

89.69

91.06

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

134

2.34

3.32

7.0

6.2

1.06

mmol/l

0.05

124

(3013826) Glucose [Moles/volume] in Serum or Plasma

563

2.11

3.28

7.5

5.0

6.44

6.62

mmol/l

0.35

526

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

230

2.07

3.13

2.8

2.1

2.96

2.72

mg/l

0.33

204

(40758558) Short blood count panel - Blood

299

1.99

3.05

6.0

6.2

—

(3018095) Leukocytes [#/volume] in Urine

392

1.93

2.92

3.5

4.0

146.97

31.02

e6/l

0.56

274

(3020891) Body temperature

3.32

2.88

7.3

3.9

36.86

36.90

°c

0.14

(3026782) Osmolality of Urine

201

2.00

2.66

2.8

588.00

550.04

mosm/kgh2o

0.40

181

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.54

2.63

5.3

8.2

25.03

24.66

mmol/l

0.18

(3028626) Oxygen [Partial pressure] in Capillary blood

4.22

2.62

3.6

1.8

7.63

8.49

kpa

—

(3042631) Mycobacterium sp identified in Specimen

5.69

2.58

2.0

1.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.69

2.58

1.7

1.0

—

(3052851) Hemolysis interference index of Serum or Plasma

3.67

2.54

4.6

2.9

0.90

3.08

index

—

(3030467) Casts [#/volume] in Urine by Automated count

297

1.87

2.53

3.1

3.2

0.54

0.33

e6/l

0.51

216

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.08

2.29

1.0

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

350

1.78

2.27

3.2

57.65

213.23

e6/l

0.39

266

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

188

1.90

2.22

4.0

3.3

157.39

285.49

ng/l

0.28

145

(3022948) Iron [Moles/volume] in Serum or Plasma

159

1.92

2.10

3.5

2.5

11.34

13.70

umol/l

1.15

150

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

738

1.93

2.08

11.5

8.8

109.67

79.68

u/l

0.58

698

(40768797) Stomach Pathology biopsy report

145

1.93

2.03

1.6

1.3

—

(3019060) Gas panel - Arterial blood

2.52

2.03

6.2

4.6

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.67

1.86

3.2

2.2

5.25

4.92

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

3.67

1.86

3.2

2.2

8.07

8.72

kpa

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

3.46

1.77

1.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

573

1.66

1.77

12.5

10.9

4.10

4.02

e9/l

0.14

502

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.92

1.68

1.6

1.5

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.17

1.61

1.3

85.71

108.10

u/ml

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

133

1.82

1.57

1.2

1.8

—

(42870588) Differential panel, method unspecified - Blood

341

1.60

1.56

5.8

5.9

—

(3026008) Bacteria identified in Urine by Culture

278

1.62

1.55

2.3

3.1

—

(3029937) Albumin [Presence] in Urine by Test strip

289

1.60

1.50

3.6

4.0

0.00

estimate

-0.00

101

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

127

1.81

1.50

1.2

1.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

177

1.69

1.47

4.7

2.8

0.81

mmol/l

0.03

167

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.82

1.45

1.3

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

230

1.62

1.43

1.7

2.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.51

1.41

3.4

1.9

23.74

24.57

mmol/l

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.86

1.30

1.2

1.3

—

(3013115) Eosinophils [#/volume] in Blood

528

1.50

1.27

8.4

6.8

0.19

e9/l

0.07

464

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.48

1.26

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

159

1.65

1.25

1.9

1.7

—

(40761536) Microorganisms panel - Urine sediment

1.86

1.19

3.9

4.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.42

1.14

1.7

180.29

178.47

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

172

1.59

1.13

1.7

1.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.44

1.10

1.2

1.7

—

(3019198) Lymphocytes [#/volume] in Blood

518

1.45

1.10

7.2

6.8

1.75

1.76

e9/l

0.04

459

(3023103) Potassium [Moles/volume] in Serum or Plasma

104

979

1.99

1.07

29.0

17.9

4.03

3.96

mmol/l

1.92

104

959

(3017143) Hepatitis C virus Ab [Presence] in Serum

124

1.64

1.05

1.9

1.7

—

(3006315) Basophils [#/volume] in Blood

511

1.43

1.05

7.3

6.7

0.04

e9/l

0.18

439

(3001604) Monocytes [#/volume] in Blood

511

1.43

1.05

7.2

6.6

0.60

0.58

e9/l

0.31

442

(3006184) Hemoglobin [Mass/volume] in Capillary blood

2.33

1.04

4.2

2.0

118.80

135.00

g/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.07

1.02

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

409

1.40

0.96

1.9

2.1

83.85

94.81

pmol/l

0.88

196

(3019550) Sodium [Moles/volume] in Serum or Plasma

104

980

1.97

0.95

28.8

17.7

139.21

139.76

mmol/l

1.04

104

964

(3021960) Folate [Moles/volume] in Serum or Plasma

270

1.43

0.92

1.9

1.7

19.00

21.97

nmol/l

0.53

229

(3049717) Cytology report of Urine Cyto stain

2.13

0.91

3.2

2.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

290

1.41

0.89

3.2

3.3

5756.94

1074.09

ng/l

0.89

240

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.06

0.88

1.3

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.76

0.82

1.6

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.86

0.80

1.5

1.6

104.17

98.70

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

195

1.44

0.79

1.8

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

401

1.35

0.78

3.3

3.8

0.00

0.01

estimate

0.50

(21494755) Public health laboratory ask at order entry panel

106

0.54

0.77

1.7

1.4

—

(3003694) ABO and Rh group [Type] in Blood

269

1.38

0.77

1.6

1.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.23

0.77

1.4

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.62

0.76

1.8

1.7

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.90

0.75

1.4

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

374

1.34

0.75

6.1

3.9

37.55

35.68

ng/l

0.05

259

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.85

0.74

1.6

1.3

19.30

31.99

iu/l

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.05

0.73

1.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

190

0.64

0.73

1.3

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

244

1.38

0.72

5.2

5.8

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

1.97

0.71

1.0

2.0

—

3.25

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.89

0.69

8.6

1.5

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.82

0.67

2.2

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.61

0.65

1.7

1.6

—

(3007566) Smooth muscle Ab [Titer] in Serum

1.76

0.64

1.2

—

58.00

—

(4094501) Cardiovascular stress test using bicycle ergometer

1.76

0.64

1.0

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.70

0.62

1.4

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

1.70

0.62

1.4

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.61

0.62

1.4

2.4

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.60

0.0

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.60

0.0

3.2

—

49.48

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

1.75

0.59

1.5

1.7

—

0.12

—

(3014051) Protein [Presence] in Urine by Test strip

299

0.75

0.56

2.7

3.1

—

0.22

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.49

0.55

2.1

3.3

23.80

24.78

mmol/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.42

0.52

3.9

3.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.42

0.46

1.5

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

252

1.26

0.44

1.6

3.1

333.12

352.14

umol/l

0.50

223

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.38

0.42

4.0

2.6

0.73

0.65

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.54

0.42

1.2

1.7

—

(1761868) Lipid panel - Serum or Plasma

408

1.22

0.42

3.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3000492) Spirometry study

105

0.64

0.41

1.1

1.5

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.34

0.40

3.0

2.6

1.01

1.30

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.40

0.0

1.7

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.40

0.0

1.7

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.40

0.0

1.7

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.40

0.0

1.7

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.35

0.39

2.8

1.3

293.58

381.63

u/ml

—

(3037522) Nuclear Ab [Titer] in Serum

135

1.31

0.38

1.6

1.5

346.67

590.67

titre

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.49

0.36

1.7

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

299

1.20

0.33

3.0

3.2

0.00

estimate

-0.00

(3035350) Ketones [Presence] in Urine by Test strip

547

1.17

0.30

3.6

3.8

0.00

estimate

-0.00

110

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

189

1.20

0.27

2.9

3.1

0.31

0.87

e6/l

2.21

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

142

1.23

0.26

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

963

1.26

0.25

23.7

15.2

25.37

22.96

mg/l

0.31

780

(3021601) Nitrite [Presence] in Urine by Test strip

543

1.14

0.25

3.6

3.9

0.00

estimate

-0.00

108

(3020564) Creatinine [Moles/volume] in Serum or Plasma

104

1015

1.39

0.23

31.5

19.9

83.62

77.07

umol/l

0.61

104

1004

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.30

0.23

1.2

1.1

1.63

1.52

g/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

240

1.17

0.23

1.4

0.84

0.91

u/ml

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.26

0.23

1.2

1.1

0.97

0.86

g/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

100

0.78

0.22

16.0

6.8

—

(3000494) Fungus identified in Specimen by Culture

123

0.79

0.21

1.4

1.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.9

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.3

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.9

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.8

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

2.5

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.21

0.0

1.8

—

9.68

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.4

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.7

—

(4024509) Urine culture

1.26

0.20

1.5

1.6

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.19

0.20

1.0

1.1

—

(3015736) pH of Urine

449

1.12

0.19

3.9

3.5

6.16

6.20

0.10

241

(3009261) Glucose [Presence] in Urine by Test strip

550

1.11

0.18

3.6

3.9

0.00

estimate

-0.00

104

(3000963) Hemoglobin [Mass/volume] in Blood

104

1049

0.86

0.18

38.1

23.7

133.89

136.93

g/l

1.12

104

1041

(3024731) MCV [Entitic mean volume] in Red Blood Cells

104

1048

0.88

0.17

37.6

23.5

89.86

91.05

2.30

104

1040

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

104

1048

0.88

0.17

38.3

24.1

40.40

40.91

0.54

104

1039

(3035941) MCH [Entitic mass]

104

1048

0.88

0.17

37.5

23.5

29.80

30.38

2.65

104

1039

(3019225) pH of Specimen

1.12

0.16

3.6

4.6

7.22

7.36

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

119

0.82

0.16

1.2

1.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.12

0.15

1.1

1.6

—

(40761511) CBC panel - Blood by Automated count

102

1001

1.23

0.13

24.7

13.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

318

1.10

0.13

3.4

4.1

14.35

7.69

mg/mmol

0.25

199

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

172

1.13

0.12

3.0

3.2

6.98

2.15

e6/l

0.56

(3019832) Treponema pallidum Ab [Presence] in Serum

1.18

0.12

1.2

1.9

—

(3012516) Albumin [Mass/volume] in Urine

311

1.09

0.10

2.5

3.4

135.52

47.19

mg/l

0.39

201

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

114

0.87

0.10

1.3

2.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.09

0.10

2.8

1.4

34.60

47.33

nmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.14

0.09

1.0

1.9

—

(1002224) Polysomnography panel

1.10

0.09

1.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.08

0.09

1.0

1.9

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.03

0.07

3.6

2.5

10.11

10.30

g/l

—

(36660697) Celiac disease serology panel - Serum

0.87

0.07

1.1

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

103

0.86

0.06

1.3

2.0

—

(3022145) Colonoscopy Study observation

120

1.09

0.05

1.8

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

190

0.94

0.04

1.2

1.3

61.49

25.43

iu/ml

—

(3042936) Bacteria identified in Isolate by Culture

142

1.07

0.02

1.7

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

649

0.97

0.02

2.9

3.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

262

1.04

0.02

4.0

4.8

23.49

23.04

0.03

128

(3019150) Specific gravity of Urine by Refractometry

227

0.96

0.01

4.9

3.8

1.02

kg/l

0.92

146

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

454

1.02

0.00

1.9

1.53

1.41

mmol/l

0.60

386

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

112

0.98

0.00

2.0

2.2

3.91

3.41

ratio

0.47

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

207

1.02

0.00

3.3

3.0

1.02

0.76

ug/l

0.48

135

(3013512) EKG study

345

0.98

0.00

3.5

3.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

105

1.05

0.00

2.8

1.7

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.2

—

132.52

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.9

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.5

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

50.33

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

117.40

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.5

—

1.48

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

1.8

—

1.08

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.90

-0.00

1.5

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3025941) Bacteria identified in Stool by Culture

0.92

-0.00

1.8

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.87

-0.00

1.4

2.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

2.2

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.9

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.3

—

6.47

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

-0.00

0.0

1.0

—

0.23

—

(4198724) Urine methamphetamine measurement

0.00

-0.00

0.0

1.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.4

—

4.56

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3008898) HLA-B27 [Presence]

0.90

-0.00

1.0

1.1

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

86.40

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

3.80

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.8

—

7.70

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

220

1.00

-0.00

2.3

1.4

5.32

2.61

g/l

0.56

131

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.8

—

0.62

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

102

1013

1.09

-0.00

14.8

12.1

28.70

27.81

u/l

0.10

102

982

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

8.6

—

7.04

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.9

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3015956) Eosinophils/Leukocytes in Blood by Manual count

0.00

-0.00

0.0

3.2

—

2.40

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

5.74

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3026250) Tacrolimus [Mass/volume] in Blood

0.00

-0.00

0.0

25.8

—

5.77

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

1.8

—

1.04

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

2.0

—

13.69

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.4

—

9.78

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.3

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

2.6

—

194.80

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ADREMEDHYPER and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_ADREMEDHYPER	2.134 [1.49, 3.05]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.122

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 254 females with E4_ADREMEDHYPER died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ADREMEDHYPER.

N-year risk	Females	Males
1	0.217%	No data
5	1.264%	No data
10	2.879%	No data
15	5.587%	No data
20	9.629%	No data

Relationships between endpoints

↥

Index endpoint: E4_ADREMEDHYPER – Adrenomedullary hyperfunction

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Adrenomedullary hyperfunction

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints