No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
141 |
4. Check minimum number of eventsNone |
141 |
5. Include endpointsNone |
141 |
6. Filter based on genotype QC (FinnGen only) |
131 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80
- Name in latin
- Hypogammaglobulinaemia hereditaria
Similar endpoints
↥List of similar endpoints to
Hereditary hypogammaglobulinemia
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 605 | 359 | 244 |
| Only index persons | 530 | 325 | 205 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.72 | 45.82 | 38.04 |
| Only index persons | 42.31 | 45.45 | 37.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 131 | 81 | 50 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 47.00 | 46.63 | 47.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 133
- Matched controls
- 1330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
171.7
125
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
79.3
68
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
78.0
67
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
76.6
66
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
26.2
62.3
49
29
ZX120
NOMESCO Finland
Intravenous
15.1
53.8
63
75
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
49.0
44
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
12.7
43.5
54
68
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
41.9
38
*
J01MA12
ATC
levofloxacin; systemic
9.7
39.5
71
140
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
16.6
37.3
35
28
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
37.2
34
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
15.5
35.8
35
30
UGC12
NOMESCO Finland
Flexible bronchoscopy
14.6
35.3
36
33
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
15.0
35.1
35
31
TPH04
NOMESCO Finland
Cathetrisation of vein
8.5
34.9
77
186
J01MA14
ATC
moxifloxacin; systemic
10.3
34.4
48
69
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
12.8
31.8
35
36
C01CA24
ATC
epinephrine; parenteral
10.5
31.2
41
54
WW200
NOMESCO Finland
Immunization
37.4
28.5
36
13
H02AB07
ATC
prednisone; oral
8.0
28.0
49
90
J45.9
ICD-10 Finland
Asthma, unspecified
6.7
25.9
59
141
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.1
25.7
37
54
H02AB06
ATC
prednisolone; systemic
8.1
25.0
107
449
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
24.8
23
*
R50.9
ICD-10 Finland
Fever, unspecified
6.6
24.2
53
121
J45.1
ICD-10 Finland
Nonallergic asthma
9.2
24.1
34
48
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
34.7
23.5
30
11
J47
ICD-10 Finland
Bronchiectasis
43.8
23.1
28
8
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.0
23.0
103
438
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.0
23.0
37
61
6BA02, ,
NOMESCO Finland
+∞
22.5
21
*
R03BB04
ATC
tiotropium bromide; inhalant
8.6
21.9
32
47
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.7
21.4
31
45
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.3
20.9
72
241
H02AB04
ATC
methylprednisolone; systemic
6.1
20.4
46
106
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
20.3
19
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
7.7
20.1
33
55
Z01.8
ICD-10 Finland
Other specified special examinations
5.2
19.2
60
183
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.8
18.6
43
101
Z3231
NOMESCO Finland
Registered nurse
4.7
17.9
70
253
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
17.9
58
181
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.7
17.6
71
262
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
5.0
17.3
51
147
R03AK06
ATC
salmeterol and fluticasone; inhalant
5.5
17.0
41
99
J01FA06
ATC
roxithromycin; oral
4.7
16.7
87
384
J45.0
ICD-10 Finland
Predominantly allergic asthma
6.1
16.2
33
68
R03BA02
ATC
budesonide; inhalant
4.7
16.0
51
155
2790A
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[AGAMMAGLOBULINAEMIA (BRUTON)]
+∞
15.9
15
*
Z3226
NOMESCO Finland
Physiotherapist
4.8
15.9
49
145
J01FA15
ATC
telithromycin; oral
5.7
15.8
35
78
TGC00
NOMESCO Finland
Bronchial lavation
23.6
15.7
22
11
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.5
15.4
52
165
J01MA02
ATC
ciprofloxacin; systemic
4.2
15.3
77
326
J01FF01
ATC
clindamycin; systemic
4.2
14.9
64
241
M05BA04
ATC
alendronic acid; oral
7.1
14.4
24
40
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.7
14.4
31
67
R03DC03
ATC
montelukast; oral
4.4
13.9
46
142
ZXE10
NOMESCO Finland
More than one and less than three hours
4.0
13.9
73
313
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
13.9
41
116
Z2446
NOMESCO Finland
Social worker
6.8
13.8
24
42
XF400
NOMESCO Finland
ECG with 12 standard connections
4.9
13.8
37
97
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.2
13.6
26
50
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.0
13.6
27
54
J01FA09
ATC
clarithromycin; systemic
3.9
13.4
72
312
UJF30
NOMESCO Finland
Ileoscopy through colon
5.2
13.0
31
73
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.1
12.9
21
34
XW000
NOMESCO Finland
Bone marrow biopsy
13.6
12.9
22
19
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
12.7
12
*
UJF32
NOMESCO Finland
Coloscopy
3.9
12.5
53
194
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
4.2
12.4
42
131
R4110
NOMESCO Finland
Physiotherapy
3.7
12.3
63
262
A01AB09
ATC
miconazole; local oral
5.3
12.1
28
64
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.5
12.0
26
56
A07AA02
ATC
nystatin; oral
9.8
11.9
24
29
R03AC13
ATC
formoterol; inhalant
9.8
11.9
24
29
J01DA08
ATC
[U] cefaclor
4.9
11.7
30
75
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
11.6
11
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
130.9
11.6
12
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.5
11.4
67
301
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.7
11.3
30
77
JN4BD
NOMESCO Finland
Extensive body CT
4.9
11.3
28
68
H02AB09
ATC
hydrocortisone; systemic
17.5
11.2
17
11
J01DA06
ATC
[U] cefuroxime
4.0
11.1
39
124
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
20.0
11.0
16
9
R03DA04
ATC
theophylline; systemic, rectal
14.7
11.0
18
14
J01FA10
ATC
azithromycin; systemic
4.3
11.0
108
663
J02AC01
ATC
fluconazole; systemic
3.4
10.9
80
408
ZXD20
NOMESCO Finland
Day surgery
4.4
10.9
32
89
A28
ICPC
Limited function/disability NOS
4.2
10.7
34
100
R03AK07
ATC
formoterol and budesonide; inhalant
3.6
10.7
49
186
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
10.6
10
*
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
25.8
10.5
14
6
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.6
10.4
44
159
R01AD08
ATC
fluticasone; nasal
3.3
10.3
62
278
R03AC02
ATC
salbutamol; inhalant
3.7
10.2
100
599
GD1AD
NOMESCO Finland
Thorax CT examination
8.6
10.2
22
30
A46
ICD-10 Finland
Erysipelas
4.0
10.1
35
110
N03AX16
ATC
[U] pregabalin
3.4
10.0
49
194
R01AD05
ATC
budesonide; nasal
5.3
9.9
22
48
ZXA00
NOMESCO Finland
Right side
3.3
9.8
51
209
N02AX02
ATC
tramadol; systemic, rectal
3.2
9.7
79
419
J32.4
ICD-10 Finland
Chronic pansinusitis
19.3
9.6
14
8
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
9.5
9
*
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
9.5
9
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
9.5
9
*
J31.0
ICD-10 Finland
Chronic rhinitis
4.4
9.5
27
73
R01AD09
ATC
mometasone; nasal
3.2
9.3
87
496
N03AX12
ATC
[U] gabapentin; oral
3.5
9.2
39
140
R03AC12
ATC
salmeterol; inhalant
9.7
9.1
18
21
J46
ICD-10 Finland
Status asthmaticus
13.9
9.1
15
12
WZC00
NOMESCO Finland
Treatment plan or consultation
3.0
9.1
70
357
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
9.0
34
113
Z2221
NOMESCO Finland
Medical doctor
3.1
8.9
57
261
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.6
8.8
20
30
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.8
8.8
31
98
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
8.8
36
126
ZXE00
NOMESCO Finland
One hour or less
2.9
8.7
70
364
R03BA08
ATC
ciclesonide; inhalant
4.3
8.7
25
68
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
29.7
8.6
11
*
ZX112
NOMESCO Finland
Subcutaneous
10.5
8.6
16
17
132
Kela drug reimbursment
Sarcoidosis
+∞
8.4
8
*
R03BA05
ATC
fluticasone; inhalant
3.3
8.4
41
160
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.7
8.4
21
51
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
8.3
41
161
R06AE07
ATC
cetirizine; oral
2.9
8.3
79
446
SPAT1262
SPAT
Handing over of treatment supplies
3.6
8.3
33
113
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
35.7
8.2
10
*
OAB50, ,
SPAT
5.0
8.2
19
43
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
23.8
8.2
11
5
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.1
8.1
94
587
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.5
8.0
33
115
WX002
NOMESCO Finland
Sedation and analgesia
3.3
8.0
37
139
-44
ICPC
Preventive immunization/medic
5.0
7.9
18
40
R03BA01
ATC
beclometasone; inhalant
3.5
7.8
31
106
J01DA01
ATC
[U] cefalexin
3.1
7.7
99
644
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
7.7
50
228
GD1CG
NOMESCO Finland
Extensive examination of lungs and pleura with high intensity magnet
84.6
7.5
8
*
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
84.6
7.5
8
*
R06.0
ICD-10 Finland
Dyspnoea
2.9
7.4
49
225
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.0
7.4
17
38
J01DA09
ATC
[U] cefadroxil
2.8
7.4
51
240
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.8
7.4
54
262
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
7.4
7
*
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
7.4
7
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
9.6
7.3
14
16
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.7
7.3
16
23
C03DA01
ATC
spironolactone; oral
3.9
7.2
23
67
J45.8
ICD-10 Finland
Mixed asthma
10.9
7.2
13
13
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.9
7.2
17
39
SAA04
NOMESCO Finland
Special examination of mouth
6.8
7.0
17
28
C03CA01
ATC
furosemide; systemic
2.9
7.0
42
182
UJF92
NOMESCO Finland
Capsular endoscopy
11.8
7.0
12
11
B03BA03
ATC
hydroxocobalamin; parenteral
7.9
6.9
15
21
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.8
6.9
23
69
TAB00
NOMESCO Finland
Lumbar puncture
4.5
6.9
18
45
L04AX01
ATC
azathioprine; systemic
7.5
6.7
15
22
R03AK03
ATC
[U] fenoterol and ipratropium bromide
7.5
6.7
15
22
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
6.3
6.7
17
30
R4120
NOMESCO Finland
Occupational therapy
4.2
6.6
19
51
R03BB01
ATC
ipratropium bromide; inhalant
8.1
6.6
14
19
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
6.6
32
123
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.1
6.6
17
31
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
6.5
64
355
Z50.1
ICD-10 Finland
Other physical therapy
5.6
6.5
18
36
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
6.5
30
112
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.0
6.4
20
57
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
6.4
69
398
B99
ICD-10 Finland
Other and unspecified infectious diseases
11.9
6.4
11
10
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
6.4
63
349
A07EA06
ATC
budesonide; oral, local oral
6.3
6.4
16
28
GD1DG
NOMESCO Finland
Extremely extensive MRI examination of pleura with high field magnet
+∞
6.3
6
*
S97
ICPC
Chronic ulcer skin
4.5
6.3
16
39
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.5
6.2
23
74
R03AK11
ATC
formoterol and fluticasone; inhalant
9.3
6.2
12
14
XQ800
NOMESCO Finland
Prick test
3.7
6.2
21
64
R05
ICD-10 Finland
Cough
2.7
6.1
42
194
J01AA02
ATC
doxycycline; systemic
3.8
6.1
118
900
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.4
6.1
24
81
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
5
108.99
37.20
2.9
1.6
—
—
—
0
0
37
5
101.28
34.96
2.8
1.6
13.84
8.20
%
—
37
5
31
41
9.55
23.13
2.8
1.5
—
—
—
0
0
39
73
7.14
21.46
2.8
1.8
—
—
—
0
0
52
135
5.68
20.25
3.2
1.5
—
—
—
0
0
58
170
5.28
19.53
4.2
1.8
—
—
—
0
0
25
31
9.70
19.45
2.7
1.7
—
—
—
0
0
24
32
8.93
17.58
2.9
2.8
2.36
1.69
index
0.19
11
16
46
124
5.14
16.82
3.3
1.6
—
—
—
0
0
17
6
32.13
13.33
3.5
1.0
—
—
—
0
0
17
6
32.13
13.33
3.5
1.0
—
—
—
0
0
25
28
10.73
12.95
2.9
1.8
—
—
—
0
0
25
28
10.73
12.95
1.7
1.3
—
—
—
0
0
100
549
4.31
12.91
15.4
8.6
1.20
1.21
mmol/l
0.78
95
479
50
180
3.85
12.04
4.4
2.6
10.80
13.84
umol/l
2.89
50
171
48
169
3.88
11.92
3.3
1.9
28.88
28.75
s
0.06
48
164
21
20
12.23
11.77
2.8
1.9
—
—
—
0
0
41
131
4.08
11.65
12.6
8.9
1.10
1.11
mmol/l
0.04
41
120
70
322
3.48
11.45
6.6
3.1
0.19
0.41
e6/l
0.99
58
228
17
11
17.49
11.17
5.5
3.0
—
—
—
0
0
16
9
19.97
11.03
1.8
1.9
—
—
—
0
0
42
142
3.86
10.96
13.3
8.0
104.14
104.20
mmol/l
0.03
42
142
21
25
9.76
10.53
2.4
2.5
—
—
—
0
0
106
654
4.06
10.47
12.9
5.4
7.09
6.49
mmol/l
1.43
106
616
22
47
5.41
10.19
2.2
1.3
—
—
—
0
0
15
9
18.56
10.14
4.3
2.0
—
—
—
0
0
25
65
4.50
9.18
18.6
5.6
24.57
24.03
mmol/l
0.24
25
65
60
281
3.07
9.06
2.6
1.7
0.87
1.56
mg/l
0.89
53
219
25
66
4.43
9.00
2.4
1.7
—
—
—
0
0
16
16
11.19
8.81
3.1
1.6
—
—
—
0
0
17
20
9.57
8.61
2.0
1.2
—
—
—
0
0
75
406
2.94
8.59
7.5
3.3
—
—
—
0
0
20
31
7.40
8.59
2.9
1.5
—
—
—
0
0
18
24
8.49
8.50
1.6
1.7
—
—
—
0
0
13
9
15.83
8.39
4.9
2.0
—
—
—
0
0
14
13
11.87
8.01
2.9
1.8
—
—
—
0
0
7
0
+∞
7.35
1.4
0.0
—
—
—
0
0
28
93
3.55
7.29
4.5
3.5
—
—
—
0
0
43
186
2.94
7.24
11.4
4.1
0.79
0.83
mmol/l
1.84
43
177
31
113
3.27
6.97
9.5
13.4
0.58
1.09
mmol/l
0.19
25
98
24
75
3.68
6.82
10.6
4.2
5.15
5.17
kpa
0.07
24
70
14
18
8.55
6.81
1.6
1.0
—
—
—
0
0
14
18
8.55
6.81
1.6
1.0
—
—
—
0
0
13
15
9.47
6.73
3.8
1.7
—
—
—
0
0
13
15
9.47
6.73
3.8
1.7
—
—
—
0
0
13
15
9.47
6.73
3.8
1.7
—
—
—
0
0
24
77
3.58
6.55
25.2
9.6
24.19
25.32
mmol/l
0.46
24
77
15
24
6.90
6.38
1.7
1.3
400.60
534.00
mg/l
0.81
15
24
41
185
2.76
6.29
5.8
3.0
1.60
2.82
e6/l
0.61
24
89
42
196
2.67
6.01
5.5
2.9
0.83
0.90
e6/l
0.09
24
99
12
15
8.67
5.98
4.1
1.7
—
—
—
0
0
15
27
6.12
5.89
3.6
1.5
—
—
—
0
0
15
27
6.12
5.89
3.3
1.5
—
—
—
0
0
12
16
8.12
5.77
4.1
1.6
—
—
—
0
0
12
16
8.12
5.77
4.1
1.6
—
—
—
0
0
16
43
4.09
5.55
3.6
1.7
98.00
94.84
%
0.20
16
43
83
550
2.35
5.33
4.3
3.0
—
—
estimate
—
0
0
12
20
6.48
5.04
2.0
1.2
90.20
145.57
au/ml
—
5
7
10
14
7.62
4.75
1.1
1.3
—
—
—
0
0
7
5
14.66
4.63
1.1
1.4
120.86
56.20
u/l
—
7
5
14
32
4.76
4.59
1.1
1.0
—
3.26
—
0
5
14
41
3.70
4.32
3.9
3.3
25.43
24.87
mmol/l
0.28
14
41
128
1120
4.80
4.31
39.9
13.8
86.10
85.54
ml/min/173m2
0.10
122
1025
12
25
5.17
4.30
2.6
1.6
—
—
—
0
0
22
87
2.83
4.22
5.2
5.5
72.29
81.74
ng/l
0.34
22
78
26
113
2.62
4.18
4.1
2.7
41.75
27.63
u/l
0.59
20
88
16
53
3.29
4.12
3.5
3.8
55.92
53.11
%
0.14
16
53
7
7
10.46
4.06
2.4
2.3
—
—
—
0
0
7
7
10.46
4.06
2.4
2.3
—
—
—
0
0
7
7
10.46
4.06
2.4
2.3
—
—
—
0
0
7
7
10.46
4.06
2.4
2.3
—
—
—
0
0
9
14
6.80
4.05
1.7
1.1
—
—
—
0
0
22
89
2.76
4.05
2.5
1.3
—
—
—
0
0
14
37
4.10
4.04
6.7
1.9
—
—
—
0
0
19
72
2.91
3.93
3.6
3.7
4.16
4.39
pmol/l
0.49
19
66
9
15
6.35
3.88
1.0
1.1
—
—
—
0
0
7
8
9.15
3.82
4.1
2.0
—
—
—
0
0
13
34
4.12
3.81
5.6
2.2
24.47
25.21
mmol/l
0.22
13
34
12
29
4.44
3.81
1.8
2.2
—
—
—
0
0
7
9
8.13
3.60
4.1
2.0
—
—
—
0
0
7
9
8.13
3.60
4.1
1.9
—
—
—
0
0
71
491
1.96
3.55
2.8
1.9
97.55
100.33
pmol/l
0.24
39
235
49
298
2.02
3.54
4.2
2.6
—
—
—
0
0
6
6
10.39
3.53
2.5
2.3
—
—
—
0
0
6
6
10.39
3.53
2.5
2.3
—
—
—
0
0
6
6
10.39
3.53
3.7
1.2
0.50
0.67
index
—
6
6
6
6
10.39
3.53
2.5
2.3
—
—
—
0
0
9
18
5.28
3.43
4.6
1.6
—
—
—
0
0
8
14
6.00
3.39
1.4
1.4
—
—
—
0
0
10
23
4.61
3.38
2.7
1.6
—
—
—
0
0
10
23
4.61
3.38
4.2
1.6
—
—
—
0
0
16
60
2.89
3.37
17.6
2.8
0.61
0.62
%
0.04
16
60
13
43
3.24
3.35
23.1
4.7
1.64
1.33
mg/l
0.58
13
38
6
7
8.90
3.29
1.2
1.0
—
—
—
0
0
7
11
6.64
3.23
4.4
1.8
—
—
—
0
0
7
11
6.64
3.23
2.4
2.1
—
—
—
0
0
7
11
6.64
3.23
2.4
2.1
—
—
—
0
0
7
11
6.64
3.23
2.4
2.1
—
—
—
0
0
16
62
2.80
3.18
17.7
2.8
1.97
1.21
%
0.71
16
62
12
36
3.56
3.11
1.2
1.2
—
—
—
0
0
6
8
7.78
3.08
1.5
3.0
—
—
—
0
0
6
8
7.78
3.08
1.2
1.3
—
—
—
0
0
5
5
10.32
3.00
1.4
1.0
1.69
1.67
mmol/l
—
5
5
55
365
1.86
2.98
6.2
4.0
13.42
7.76
mg/mmol
0.28
38
224
12
38
3.37
2.94
5.9
2.3
—
—
—
0
0
36
209
1.99
2.89
5.3
3.3
225.50
128.04
ng/l
0.24
24
145
5
6
8.59
2.77
2.2
1.5
94.80
127.50
pmol/l
—
5
6
16
68
2.54
2.68
11.1
12.6
0.48
0.59
%
1.29
16
68
16
68
2.54
2.68
11.4
12.3
0.89
1.27
%
1.35
16
68
10
30
3.52
2.66
1.8
4.1
1.12
4.84
ratio
—
5
13
11
36
3.24
2.63
2.4
1.1
0.00
0.00
g/l
-0.00
11
36
82
631
1.78
2.62
6.8
3.7
0.00
0.00
estimate
-0.00
19
117
6
11
5.65
2.57
1.0
1.0
—
—
—
0
0
12
45
2.83
2.53
13.9
5.3
25.13
24.30
mmol/l
0.38
12
45
5
8
6.44
2.39
1.2
1.0
—
—
—
0
0
81
631
1.73
2.39
6.8
3.6
0.00
0.00
estimate
-0.00
19
115
60
431
1.71
2.38
5.4
3.3
24.35
24.42
ng/l
0.00
47
271
115
997
2.13
2.37
60.8
17.8
14.16
13.52
%
4.38
115
989
6
13
4.78
2.30
1.0
1.0
—
—
—
0
0
6
13
4.78
2.30
2.0
1.3
—
—
—
0
0
6
14
4.43
2.17
2.0
1.3
—
—
—
0
0
47
324
1.70
2.12
1.6
1.3
0.36
1.99
u/ml
—
10
87
5
10
5.15
2.09
1.0
1.0
—
—
—
0
0
80
637
1.64
2.04
6.9
3.7
0.00
0.00
estimate
-0.00
18
112
7
21
3.46
1.99
2.0
1.3
—
—
—
0
0
5
11
4.68
1.96
1.6
1.4
—
—
—
0
0
5
11
4.68
1.96
7.2
1.5
1.34
0.71
mmol/l
—
5
11
5
11
4.68
1.96
1.0
1.0
—
—
—
0
0
7
22
3.30
1.91
1.9
1.1
—
—
—
0
0
5
12
4.28
1.84
1.6
1.4
—
—
—
0
0
5
12
4.28
1.84
1.6
1.4
—
—
—
0
0
5
13
3.95
1.73
1.6
1.4
—
—
—
0
0
5
15
3.42
1.53
7.0
3.7
16.16
16.69
%
—
5
15
5
15
3.42
1.53
1.6
1.3
—
—
—
0
0
10
45
2.32
1.50
1.5
1.3
—
—
—
0
0
6
23
2.68
1.38
1.2
1.1
—
1.05
—
0
6
6
23
2.68
1.38
3.5
1.3
8861.00
3270.47
e6/l
—
6
15
46
356
1.45
1.17
6.6
3.2
0.00
0.00
estimate
-0.00
18
92
9
46
2.02
1.06
1.3
1.3
—
—
—
0
0
30
219
1.48
1.01
1.6
1.4
—
—
—
0
0
43
340
1.39
0.95
6.4
3.7
0.00
0.02
estimate
0.50
19
109
92
825
1.37
0.90
4.3
3.3
—
—
—
0
0
14
89
1.64
0.85
3.2
3.1
100.17
67.03
ml/min/173m2
—
6
37
9
151
0.57
0.84
6.9
4.3
36.56
31.56
%
—
9
95
15
101
1.55
0.74
5.8
2.6
0.57
0.13
e6/l
0.77
15
94
7
40
1.79
0.72
1.9
1.6
—
4608.92
—
0
13
7
115
0.59
0.61
9.0
6.2
—
—
—
0
0
93
861
1.27
0.57
5.3
3.3
60.41
45.61
u/l
0.83
93
821
33
274
1.27
0.52
1.7
1.6
—
—
—
0
0
32
265
1.27
0.51
1.3
1.3
12.49
46.63
iu/ml
—
9
86
55
487
1.22
0.49
6.8
3.4
0.00
0.03
estimate
0.50
17
97
25
298
0.80
0.40
6.3
5.1
2.38
2.71
ug/l
0.11
25
267
9
69
1.33
0.38
1.6
1.8
—
—
—
0
0
19
153
1.28
0.38
1.8
2.0
1.62
1.42
%
0.36
13
138
29
249
1.21
0.34
1.2
1.3
1.20
8.72
u/ml
1.54
11
105
21
244
0.83
0.27
5.0
4.4
19.46
22.73
%
0.44
14
102
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
11.70
—
0
10
6
52
1.16
0.19
1.7
1.9
326.83
304.81
mu/l
—
6
47
5
65
0.76
0.17
1.4
1.3
—
—
—
0
0
18
158
1.16
0.17
1.8
1.8
—
—
—
0
0
6
75
0.79
0.16
1.0
1.1
—
—
—
0
0
9
81
1.12
0.15
1.9
1.8
—
—
—
0
0
16
146
1.11
0.08
1.7
1.6
—
—
—
0
0
9
83
1.09
0.07
2.2
2.4
7.62
5.10
ug/l
—
9
70
30
287
1.06
0.06
5.0
3.3
1.02
1.02
kg/l
0.01
18
186
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
30.19
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
9.14
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
13.80
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
52.07
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
0.01
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDHYPOGAMMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDHYPOGAMMA | 3.534 [2.19, 5.71] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 290 females with D3_HEREDHYPOGAMMA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have D3_HEREDHYPOGAMMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.309% | No data |
| 5 | 1.859% | No data |
| 10 | 4.472% | No data |
| 15 | 8.584% | No data |
| 20 | 14.501% | No data |
Relationships between endpoints
↥Index endpoint: D3_HEREDHYPOGAMMA – Hereditary hypogammaglobulinemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data