No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpointsNone |
89 |
6. Filter based on genotype QC (FinnGen only) |
74 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Cyclic neutropenia
based on the number of shared cases.
Similar with more cases:
- Agranulocytosis
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 74 | 48 | 26 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 53.36 | 52.41 | 55.11 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 75
- Matched controls
- 750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D70.81
ICD-10 Finland
Neutropenia congenital
+∞
107.8
75
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
172.1
31.5
31
*
L03AA02
ATC
filgrastim; parenteral
35.3
22.6
29
13
A49.9
ICD-10 Finland
Bacterial infection, unspecified
10.9
19.1
25
33
R50.9
ICD-10 Finland
Fever, unspecified
7.2
15.7
33
74
L03AA13
ATC
pegfilgrastim; parenteral
17.0
15.0
24
20
H02AB02
ATC
dexamethasone; systemic
6.2
11.8
26
59
XW000
NOMESCO Finland
Bone marrow biopsy
17.9
11.1
17
12
1501
Kela drug reimbursment
Palbociclib
127.0
10.7
11
*
L01XE33
ATC
[U] palbociclib
+∞
10.7
10
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
63.5
9.9
11
*
A41.9
ICD-10 Finland
Sepsis, unspecified
25.7
9.7
13
6
394
Kela drug reimbursment
Palbociclib
113.8
9.7
10
*
115
Kela drug reimbursment
Breast cancer
5.6
8.8
20
46
A03FA01
ATC
metoclopramide; systemic, rectal
4.3
8.7
35
128
TPX10
NOMESCO Finland
Implantation of vascular injection port
17.1
8.6
13
9
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
8.5
8
*
JN4BD
NOMESCO Finland
Extensive body CT
5.6
8.5
19
43
ZX120
NOMESCO Finland
Intravenous
5.8
8.4
18
39
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
25.3
8.3
11
5
L02BA03
ATC
fulvestrant; parenteral
50.4
7.9
9
*
A04AA55
ATC
palonosetron, combinations; systemic
10.1
7.8
15
18
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
7.7
50
250
192
Kela drug reimbursment
Fulvestrant
88.5
7.6
8
*
X76
ICPC
Malignant neoplasm breast female
14.0
6.8
11
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
6.5
18
48
R4110
NOMESCO Finland
Physiotherapy
3.5
6.4
33
138
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
11.5
6.3
11
11
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
8.5
6.2
13
18
HAC20
NOMESCO Finland
Total mastectomy
9.3
6.1
12
15
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
83
4.02
6.87
2.4
1.6
—
—
—
0
0
14
19
8.78
6.78
12.8
3.5
39.07
18.37
u/ml
0.99
14
19
28
107
3.58
6.21
2.8
1.9
—
—
—
0
0
22
78
3.58
5.38
2.8
1.6
—
—
—
0
0
25
98
3.33
5.23
2.8
2.8
7.89
2.98
e6/l
0.50
12
53
16
50
3.80
4.65
1.6
1.5
—
—
—
0
0
14
36
4.54
4.28
2.9
1.7
—
—
—
0
0
47
289
2.68
4.08
4.6
4.8
36.35
36.46
g/l
0.04
42
276
24
106
2.86
3.99
2.9
2.8
1.55
0.88
e6/l
0.43
11
59
11
30
4.11
3.24
1.2
1.2
—
—
—
0
0
29
156
2.40
3.16
2.1
2.1
0.73
1.52
mg/l
0.93
24
120
12
37
3.66
3.11
7.1
2.9
18.33
43.74
u/ml
0.50
12
37
22
105
2.55
3.08
2.5
2.0
14.59
13.07
umol/l
0.56
22
98
6
9
7.13
2.92
2.0
3.1
—
—
—
0
0
6
10
6.41
2.75
1.3
1.8
—
—
—
0
0
38
241
2.17
2.72
3.1
3.4
14.15
19.22
ng/l
1.00
27
147
42
285
2.08
2.45
2.0
2.0
90.29
95.89
pmol/l
0.37
26
147
7
17
4.43
2.42
1.7
1.9
—
—
—
0
0
30
182
2.08
2.34
3.1
3.0
0.73
0.39
e6/l
0.44
21
135
8
24
3.60
2.25
2.3
3.8
24.61
25.11
mmol/l
—
8
24
34
221
1.98
2.16
3.1
3.2
—
—
—
0
0
23
130
2.11
2.13
2.5
3.7
65.06
104.60
ng/l
0.29
17
87
5
10
5.27
2.10
1.2
1.3
—
—
—
0
0
10
39
2.80
2.03
2.6
8.4
24.79
25.69
mmol/l
—
10
39
7
21
3.56
2.02
1.7
1.8
—
—
—
0
0
6
17
3.74
1.88
1.2
1.4
—
—
—
0
0
5
12
4.38
1.85
1.0
1.0
—
—
—
0
0
7
23
3.25
1.85
1.1
1.3
—
—
—
0
0
32
216
1.84
1.74
2.4
2.6
48.84
55.10
u/l
0.40
32
199
7
25
2.98
1.69
1.7
1.2
—
—
—
0
0
8
33
2.59
1.59
1.5
4.1
24.13
24.65
mmol/l
—
8
33
6
21
3.01
1.54
1.3
3.2
0.00
0.00
g/l
—
6
21
6
21
3.01
1.54
1.3
3.2
0.00
0.00
g/l
—
6
21
6
21
3.01
1.54
1.8
1.8
—
—
—
0
0
24
158
1.76
1.37
3.2
2.7
—
—
—
0
0
6
25
2.52
1.27
1.2
1.2
—
—
—
0
0
41
319
1.63
1.24
3.8
2.9
—
—
estimate
—
0
0
13
76
1.86
1.07
4.3
8.3
104.77
104.45
mmol/l
0.07
13
76
20
280
0.61
1.05
1.8
1.9
1.19
1.35
mmol/l
0.64
20
235
5
22
2.36
1.05
1.2
1.2
—
—
—
0
0
5
22
2.36
1.05
1.2
1.2
—
—
—
0
0
0
29
0.00
1.00
0.0
1.5
—
2.74
—
0
20
54
463
1.59
0.98
3.3
3.3
—
—
—
0
0
6
33
1.89
0.81
5.0
18.8
0.80
1.30
%
—
6
33
6
33
1.89
0.81
5.0
18.7
0.48
0.62
%
—
6
33
0
27
0.00
0.79
0.0
1.3
—
—
—
0
0
5
28
1.84
0.67
2.6
4.1
47.82
42.02
%
—
5
28
22
273
0.73
0.56
3.7
3.5
0.00
0.00
estimate
—
5
60
6
38
1.63
0.56
2.2
2.2
13.72
13.75
nmol/l
—
6
38
10
67
1.57
0.53
1.8
2.0
328.00
394.02
nmol/l
—
10
61
5
32
1.60
0.43
1.2
1.7
—
275.94
—
0
17
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
10
76
1.36
0.30
1.9
2.9
0.49
0.80
ug/l
—
5
50
8
62
1.32
0.29
2.9
3.7
—
—
—
0
0
39
356
1.20
0.28
3.7
3.6
0.00
0.00
estimate
—
6
71
39
358
1.19
0.25
3.7
3.7
0.00
0.00
estimate
—
6
71
15
125
1.25
0.25
1.8
1.5
—
—
—
0
0
7
90
0.76
0.24
2.4
2.4
—
—
—
0
0
5
38
1.34
0.24
1.6
1.7
—
—
—
0
0
5
39
1.30
0.23
1.2
1.3
—
—
—
0
0
18
207
0.83
0.23
4.1
3.2
0.00
0.00
estimate
—
5
59
0
11
0.00
0.21
0.0
1.7
—
13.36
—
0
11
0
10
0.00
0.21
0.0
1.3
—
54.39
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
39
362
1.16
0.21
3.7
3.7
0.00
22.25
estimate
—
5
73
18
160
1.16
0.16
2.1
1.5
—
—
—
0
0
11
94
1.20
0.14
2.2
5.4
21.42
23.75
%
—
5
48
5
44
1.15
0.10
1.2
1.0
—
—
—
0
0
6
54
1.12
0.09
1.0
1.4
—
—
—
0
0
62
633
0.88
0.09
4.8
4.9
5.77
5.83
mmol/l
0.15
62
586
11
123
0.88
0.08
2.8
1.7
608.18
454.10
pmol/l
0.35
11
101
7
82
0.84
0.07
1.7
2.3
—
—
—
0
0
19
200
0.93
0.04
3.8
3.6
0.00
0.00
estimate
—
6
67
13
134
0.96
0.00
1.2
1.3
21.00
35.27
iu/ml
—
5
47
0
5
0.00
-0.00
0.0
1.4
—
11.00
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
565.20
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
49
1.02
-0.00
4.4
5.0
1.21
1.23
mmol/l
—
5
41
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
1.6
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
14.04
—
0
7
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: D3_CYCLIC_NEUTROPENIA – Cyclic neutropenia
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).