obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
137 |
4. Check minimum number of eventsNone |
137 |
5. Include endpointsNone |
137 |
6. Filter based on genotype QC (FinnGen only) |
123 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other or unspecified common variable immunodeficiency
based on the number of shared cases.
Similar with more cases:
- Common variable immunodeficiency
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 443 | 255 | 186 |
| Only index persons | 415 | 243 | 172 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.95 | 48.76 | 44.63 |
| Only index persons | 45.68 | 47.31 | 43.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 123 | 78 | 45 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 47.64 | 48.90 | 45.46 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 124
- Matched controls
- 1240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
125.1
98
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
85.6
72
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
81.5
69
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
66.8
58
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
30.4
60.1
44
22
ZX120
NOMESCO Finland
Intravenous
14.2
44.9
52
60
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
44.5
40
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
32.8
30
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.6
32.0
49
79
6BA02, ,
NOMESCO Finland
+∞
30.5
28
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
29.3
27
*
J01MA14
ATC
moxifloxacin; systemic
9.7
29.2
42
62
UGC12
NOMESCO Finland
Flexible bronchoscopy
14.3
28.6
29
26
J18.9
ICD-10 Finland
Pneumonia, unspecified
7.1
27.1
65
166
TDM10
NOMESCO Finland
Puncture of maxillary antrum
12.4
27.0
30
31
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
10.5
26.5
34
43
J01MA12
ATC
levofloxacin; systemic
7.2
26.1
55
123
TPH04
NOMESCO Finland
Cathetrisation of vein
6.9
25.9
63
162
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
23.7
22
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
23.7
22
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.3
23.7
68
201
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
10.5
23.3
29
35
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
8.2
23.1
37
61
J47
ICD-10 Finland
Bronchiectasis
48.7
22.8
27
7
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
9.2
22.8
32
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.8
22.0
93
379
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.8
22.0
32
47
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
28.6
21.6
29
13
Z01.8
ICD-10 Finland
Other specified special examinations
5.8
20.8
59
169
GD1AD
NOMESCO Finland
Thorax CT examination
10.0
20.4
26
32
H02AB06
ATC
prednisolone; systemic
6.1
19.1
94
419
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.9
18.5
34
64
R50.9
ICD-10 Finland
Fever, unspecified
5.7
18.3
45
112
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.8
16.6
26
41
J45.1
ICD-10 Finland
Nonallergic asthma
7.2
16.6
28
48
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
16.0
15
*
OAB50, ,
SPAT
7.4
15.3
25
41
J45.9
ICD-10 Finland
Asthma, unspecified
4.9
14.9
44
126
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.6
14.7
23
36
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.8
14.6
26
25
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.3
14.4
28
55
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
24.6
13.8
19
9
J01FA06
ATC
roxithromycin; oral
4.1
13.3
75
340
J01FA15
ATC
telithromycin; oral
5.7
13.1
28
60
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.0
13.0
64
263
J45.0
ICD-10 Finland
Predominantly allergic asthma
5.9
12.8
26
53
J01FF01
ATC
clindamycin; systemic
3.9
12.6
57
220
H02AB04
ATC
methylprednisolone; systemic
4.8
12.5
34
90
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.2
12.5
46
154
UJF32
NOMESCO Finland
Coloscopy
4.1
12.4
48
166
SPAT1262
SPAT
Handing over of treatment supplies
4.6
12.3
36
101
R03BB04
ATC
tiotropium bromide; inhalant
6.6
11.9
21
37
TGC00
NOMESCO Finland
Bronchial lavation
17.3
11.7
18
12
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
11.6
11
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
39.1
11.5
14
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
9.8
11.4
23
28
UJF92
NOMESCO Finland
Capsular endoscopy
16.2
10.9
17
12
C03CA01
ATC
furosemide; systemic
3.9
10.8
43
150
WZC00
NOMESCO Finland
Treatment plan or consultation
3.5
10.8
73
359
Z3231
NOMESCO Finland
Registered nurse
3.5
10.6
54
222
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
10.6
10
*
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
10.6
10
*
WW200
NOMESCO Finland
Immunization
14.9
10.5
17
13
UJF30
NOMESCO Finland
Ileoscopy through colon
4.6
10.5
29
77
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.3
10.3
32
93
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.9
10.3
39
131
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.4
10.3
59
260
C01CA24
ATC
epinephrine; parenteral
5.3
10.3
23
51
H02AB07
ATC
prednisone; oral
4.5
10.1
29
79
Z31.5
ICD-10 Finland
Genetic counselling
5.5
10.0
21
44
J45.8
ICD-10 Finland
Mixed asthma
12.9
9.9
17
15
B99
ICPC
Blood/lymph/spleen disease other
107.9
9.6
10
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.2
9.5
21
30
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
9.5
9
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
15.3
9.5
15
11
J01MA02
ATC
ciprofloxacin; systemic
3.2
9.4
61
286
R03DA04
ATC
theophylline; systemic, rectal
12.9
9.4
16
14
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.5
9.2
43
165
D70.89
ICD-10 Finland
Neutropenic splenomegaly
39.9
9.2
11
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.6
9.1
24
61
XQ800
NOMESCO Finland
Prick test
5.1
9.0
21
48
A10AB05
ATC
insulin aspart; parenteral
5.0
8.8
21
49
J05AB11
ATC
valaciclovir; oral
3.6
8.6
36
128
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
96.3
8.5
9
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
8.4
8
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
13.0
8.3
14
12
C03DA01
ATC
spironolactone; oral
4.6
8.3
22
56
A07AA09
ATC
vancomycin; oral
35.9
8.2
10
*
Z2221
NOMESCO Finland
Medical doctor
3.1
8.1
49
217
SPAT1255
SPAT
Intravenous administration of medicine
6.8
8.1
20
34
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
3.3
8.1
92
578
JN4AD
NOMESCO Finland
Body CT examination
4.2
8.0
24
67
C10AC01
ATC
colestyramine; oral
10.5
8.0
15
16
H02AB09
ATC
hydrocortisone; systemic
12.0
8.0
14
13
XW000
NOMESCO Finland
Bone marrow biopsy
12.0
8.0
14
13
A07EA06
ATC
budesonide; oral, local oral
7.6
7.9
18
27
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
16.4
7.9
12
8
B29
ICPC
Lymph/immune mech sympt/complt other
48.1
7.8
9
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
48.1
7.8
9
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.3
7.6
15
18
P01AB01
ATC
metronidazole; oral, rectal
2.8
7.5
67
364
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
7.4
21
56
M05BA04
ATC
alendronic acid; oral
6.4
7.4
19
34
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
7.4
7
*
132
Kela drug reimbursment
Sarcoidosis
+∞
7.4
7
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.0
7.3
89
567
R03AC12
ATC
salmeterol; inhalant
8.4
7.1
15
20
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
8.4
7.1
15
20
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
7.1
26
84
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
7.0
31
113
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.4
6.9
29
102
ZXA10
NOMESCO Finland
Bilateral
3.2
6.8
33
127
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
24.0
6.8
9
*
WZC30
NOMESCO Finland
Teaching
3.2
6.7
33
128
XG410
NOMESCO Finland
Flow-volume spirometry
10.9
6.7
12
12
R01AD09
ATC
mometasone; nasal
2.7
6.7
77
468
WW500
NOMESCO Finland
Blood transfusion
8.2
6.6
14
19
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.7
6.6
53
269
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
6.6
43
196
J15.8
ICD-10 Finland
Other bacterial pneumonia
73.5
6.5
7
*
1XC02, ,
NOMESCO Finland
73.5
6.5
7
*
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
73.5
6.5
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
6.5
33
131
J32.4
ICD-10 Finland
Chronic pansinusitis
11.9
6.4
11
10
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
7.7
6.4
14
20
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.4
6.4
17
43
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
7.0
6.4
15
24
R03AC02
ATC
salbutamol; inhalant
2.7
6.4
84
540
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
28.3
6.3
8
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
28.3
6.3
8
*
TAB00
NOMESCO Finland
Lumbar puncture
4.6
6.3
16
39
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
6.3
6
*
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
+∞
6.3
6
*
K90.8
ICD-10 Finland
Other intestinal malabsorption
+∞
6.3
6
*
R03BA02
ATC
budesonide; inhalant
2.9
6.3
37
159
ZY010
NOMESCO Finland
Hospital outpatient
4.3
6.2
17
44
J01DA08
ATC
[U] cefaclor
3.3
6.2
27
97
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
9.4
6.2
12
14
J01DA06
ATC
[U] cefuroxime
3.2
6.2
28
103
R03AK07
ATC
formoterol and budesonide; inhalant
2.9
6.2
37
160
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.5
6.2
10
8
J01AA02
ATC
doxycycline; systemic
3.5
6.2
106
777
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
6.0
25
87
J01FA09
ATC
clarithromycin; systemic
2.6
6.0
53
279
J02AC01
ATC
fluconazole; systemic
2.5
6.0
65
377
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
6
151.79
52.94
2.4
1.5
—
—
—
0
0
39
5
112.25
37.40
6.2
1.4
866.44
1493.20
u/ml
—
39
5
40
14
41.40
32.36
2.8
1.2
452.31
874.56
e6/l
—
32
9
30
31
12.45
27.01
1.9
1.3
—
—
—
0
0
42
69
8.69
26.56
3.3
1.6
—
—
—
0
0
28
27
13.10
26.33
3.4
2.7
—
—
—
0
0
26
30
10.70
21.47
2.1
1.7
—
—
—
0
0
32
49
8.45
21.18
2.8
1.5
—
—
—
0
0
27
13
26.13
19.66
2.5
1.4
0.61
0.58
e9/l
0.09
27
13
55
155
5.58
19.61
3.4
2.0
—
—
—
0
0
46
123
5.36
17.16
2.6
1.7
—
—
—
0
0
49
142
5.05
16.54
7.9
6.8
1.03
1.07
mmol/l
0.56
49
131
52
160
4.88
16.27
3.1
2.6
156.68
119.85
ug/g
0.32
47
128
15
0
+∞
15.97
1.9
0.0
1.13
—
iu/ml
—
9
0
66
262
4.25
14.43
3.7
2.1
3.18
2.91
mg/l
0.44
61
231
101
552
5.47
14.06
14.0
6.7
10.61
10.47
umol/l
0.04
101
523
42
121
4.74
14.03
2.8
2.3
340.86
377.44
nmol/l
0.59
42
114
26
28
11.44
13.82
2.2
1.7
—
—
—
0
0
23
22
12.56
12.92
1.6
1.5
—
—
—
0
0
116
797
8.05
12.69
27.5
8.0
95.58
77.36
u/l
3.19
116
751
92
501
4.24
12.04
14.4
8.0
1.21
1.21
mmol/l
0.36
87
439
17
10
19.44
11.57
2.8
1.0
—
—
—
0
0
17
10
19.44
11.57
2.8
1.0
—
—
—
0
0
16
8
22.68
11.47
1.3
1.9
—
—
—
0
0
38
117
4.24
11.43
2.6
1.7
—
—
—
0
0
19
18
12.23
10.72
1.5
1.6
—
—
—
0
0
16
10
18.13
10.68
4.0
1.8
—
—
—
0
0
16
11
16.47
10.32
4.1
1.7
—
—
—
0
0
17
14
13.85
10.21
1.4
1.7
—
—
—
0
0
19
37
5.88
9.71
3.7
1.5
—
—
—
0
0
18
19
10.87
9.65
2.3
1.9
—
—
—
0
0
17
17
11.39
9.37
1.4
1.6
—
—
—
0
0
15
13
12.93
8.84
1.7
1.8
—
—
—
0
0
17
22
8.77
8.20
1.4
1.4
—
—
—
0
0
21
54
4.48
7.80
6.0
3.4
1.94
0.92
mmol/l
0.64
14
38
59
297
2.88
7.68
1.4
1.3
3.09
2.11
u/ml
—
10
64
91
586
3.08
7.31
5.4
3.5
0.00
0.00
estimate
-0.00
25
121
12
10
13.12
7.25
1.4
1.3
—
—
—
0
0
55
275
2.80
7.15
4.2
3.2
0.52
0.40
e6/l
0.16
45
195
15
20
8.37
7.15
1.4
1.5
—
—
—
0
0
11
8
14.92
7.03
2.5
1.8
—
—
—
0
0
11
8
14.92
7.03
2.5
1.8
—
—
—
0
0
11
8
14.92
7.03
2.5
1.8
—
—
—
0
0
91
593
3.01
7.02
5.6
3.5
51.00
0.00
estimate
0.49
26
121
74
435
2.74
6.94
2.6
2.1
91.02
97.78
pmol/l
0.45
44
221
91
595
2.99
6.94
5.5
3.6
0.12
0.00
estimate
0.49
26
116
16
26
6.90
6.73
1.6
1.3
362.00
311.88
ug/g
0.35
11
14
14
19
8.15
6.62
4.4
1.7
—
—
—
0
0
18
47
4.31
6.53
2.2
1.8
—
—
—
0
0
21
62
3.87
6.48
1.3
2.9
3.78
7.09
iu/ml
—
6
18
17
32
5.98
6.44
4.1
2.8
—
—
—
0
0
14
20
7.74
6.43
4.4
1.7
—
—
—
0
0
14
20
7.74
6.43
4.5
1.7
—
—
—
0
0
14
20
7.74
6.43
4.4
1.7
—
—
—
0
0
14
20
7.74
6.43
4.5
1.7
—
—
—
0
0
14
20
7.74
6.43
4.4
1.7
—
—
—
0
0
57
309
2.56
6.10
5.5
3.6
0.00
0.00
estimate
-0.00
24
112
14
22
7.03
6.06
1.4
1.4
—
—
—
0
0
17
37
5.15
5.75
1.2
1.4
—
—
—
0
0
16
33
5.41
5.67
4.9
2.5
—
—
—
0
0
14
25
6.17
5.56
2.5
2.2
—
—
—
0
0
78
505
2.47
5.51
3.5
2.9
—
—
estimate
—
0
0
27
106
2.98
5.32
7.7
12.7
-0.61
1.35
mmol/l
1.33
20
87
60
358
2.31
4.95
4.6
3.1
21.15
35.41
ng/l
0.52
40
209
11
17
6.98
4.89
1.9
1.8
—
—
—
0
0
13
27
5.25
4.65
2.5
2.3
12.00
2.29
index
—
6
14
7
5
14.71
4.63
1.4
1.0
—
—
—
0
0
37
183
2.46
4.62
10.2
3.9
0.78
0.82
mmol/l
1.62
37
175
8
8
10.58
4.59
2.5
1.5
134.13
117.25
pmol/l
—
8
8
20
72
3.12
4.54
5.7
3.6
1.21
1.23
mmol/l
0.69
20
64
118
1014
4.38
4.35
37.8
12.9
87.62
87.83
ml/min/173m2
0.03
113
939
7
6
12.25
4.33
2.9
2.0
—
—
—
0
0
7
6
12.25
4.33
2.9
2.0
—
—
—
0
0
7
6
12.25
4.33
2.9
2.0
—
—
—
0
0
7
6
12.25
4.33
2.9
2.0
—
—
—
0
0
7
6
12.25
4.33
1.1
1.0
—
—
—
0
0
44
245
2.23
4.14
3.6
2.5
987.44
791.62
ng/l
0.19
39
198
10
18
5.94
4.07
2.5
1.3
—
—
—
0
0
14
37
4.13
4.05
3.0
1.3
—
—
—
0
0
28
129
2.51
4.02
9.3
6.9
104.71
104.22
mmol/l
0.19
28
129
44
248
2.20
4.00
4.5
3.4
1.02
1.02
kg/l
0.03
33
157
6
5
12.51
3.80
2.2
2.0
—
—
—
0
0
6
5
12.51
3.80
2.2
2.0
—
—
—
0
0
6
5
12.51
3.80
2.2
2.0
—
—
—
0
0
6
5
12.51
3.80
2.3
1.0
161.50
45.22
u/l
—
6
5
6
5
12.51
3.80
2.3
1.0
51.67
22.34
u/l
—
6
5
6
5
12.51
3.80
2.2
2.0
—
—
—
0
0
66
442
2.05
3.78
5.5
3.3
0.00
0.00
estimate
-0.00
25
106
8
12
7.04
3.73
1.1
1.7
—
—
—
0
0
7
9
8.16
3.61
6.7
2.9
—
—
—
0
0
47
282
2.07
3.59
3.8
2.6
351.30
336.00
umol/l
0.42
47
255
14
47
3.23
3.54
3.0
3.4
24.94
24.90
mmol/l
0.01
14
47
6
6
10.42
3.53
1.7
1.5
45.83
54.83
u/l
—
6
6
7
10
7.34
3.41
1.1
1.2
—
—
—
0
0
5
5
10.34
3.00
1.2
1.2
78.20
554.80
mg
—
5
5
5
5
10.34
3.00
3.2
2.0
—
—
—
0
0
5
5
10.34
3.00
3.0
1.2
44.20
79.80
ug/l
—
5
5
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
5
10.34
3.00
1.0
1.2
—
—
—
0
0
5
5
10.34
3.00
3.2
2.0
—
—
—
0
0
5
5
10.34
3.00
2.2
3.8
—
—
—
0
0
5
5
10.34
3.00
3.2
2.0
—
—
—
0
0
5
5
10.34
3.00
1.2
1.0
—
—
—
0
0
5
5
10.34
3.00
2.2
3.8
—
—
—
0
0
10
27
3.93
2.95
1.4
1.6
—
—
—
0
0
11
33
3.56
2.89
1.9
1.1
—
—
—
0
0
11
33
3.56
2.89
1.9
1.1
—
—
—
0
0
42
259
1.94
2.88
4.0
2.3
—
—
—
0
0
5
6
8.61
2.77
3.2
2.3
—
—
—
0
0
7
14
5.23
2.77
1.0
1.1
—
—
—
0
0
6
10
6.24
2.73
1.5
2.1
—
—
—
0
0
7
15
4.88
2.63
1.0
1.1
—
—
—
0
0
46
301
1.84
2.59
4.5
4.1
7.76
12.08
mg/mmol
0.47
34
190
5
7
7.38
2.57
1.0
1.1
3.20
3.29
mg/l
—
5
7
5
7
7.38
2.57
1.4
1.0
—
—
—
0
0
7
17
4.30
2.39
1.9
1.3
—
—
—
0
0
49
334
1.77
2.38
5.1
3.0
0.00
0.00
estimate
-0.00
24
100
18
87
2.25
2.31
2.4
1.3
—
—
—
0
0
94
777
1.87
2.30
6.5
3.3
64.68
41.82
u/l
1.26
94
748
6
13
4.79
2.30
1.3
1.3
—
—
—
0
0
7
19
3.84
2.18
1.3
1.3
—
—
—
0
0
40
263
1.77
2.17
2.1
1.8
0.85
0.89
mg/l
0.04
33
203
18
90
2.17
2.13
3.7
3.1
—
—
—
0
0
108
943
2.13
2.13
51.2
17.4
14.04
13.47
%
3.93
108
938
14
63
2.38
2.10
1.7
1.2
—
—
—
0
0
95
801
1.80
2.02
4.3
3.5
—
—
—
0
0
5
11
4.69
1.96
3.6
3.1
2.26
3.33
nmol/l
—
5
11
5
11
4.69
1.96
1.8
1.9
—
—
—
0
0
41
279
1.70
1.95
1.7
1.6
—
—
—
0
0
26
156
1.84
1.88
2.9
3.0
1.64
3.15
e6/l
0.73
11
73
12
53
2.40
1.87
5.3
3.0
43.66
53.43
%
0.55
12
53
5
12
4.29
1.84
1.2
1.2
—
—
—
0
0
6
18
3.45
1.77
1.5
1.2
—
—
—
0
0
5
13
3.96
1.73
2.4
3.8
17.62
15.19
%
—
5
13
5
13
3.96
1.73
1.0
1.2
—
—
—
0
0
15
76
2.11
1.73
2.7
2.7
85.50
69.66
ml/min/173m2
—
8
32
5
14
3.67
1.63
1.4
1.2
0.20
0.13
nmol/l
—
5
9
12
57
2.22
1.61
1.8
5.3
25.25
24.59
mmol/l
0.45
12
57
6
21
2.95
1.52
3.0
1.9
7.82
6.23
pmol/l
—
6
21
34
236
1.61
1.46
1.5
1.3
17.73
7.75
u/ml
0.25
15
96
6
22
2.81
1.45
1.2
1.5
—
—
—
0
0
6
22
2.81
1.45
1.2
1.5
—
—
—
0
0
13
67
2.05
1.44
2.5
3.1
4.66
4.73
pmol/l
0.11
13
60
35
248
1.57
1.38
1.5
1.4
23.20
41.36
iu/ml
—
7
77
29
203
1.56
1.20
5.3
3.2
21.22
160.49
ng/l
1.45
17
129
12
65
1.94
1.18
6.4
2.1
75.75
116.43
ng/l
0.66
12
58
10
55
1.89
0.95
2.1
3.0
1.63
1.34
%
—
10
55
10
55
1.89
0.95
2.1
3.0
0.59
0.64
%
—
10
55
9
52
1.79
0.94
1.7
1.3
—
—
—
0
0
24
171
1.50
0.92
2.5
2.9
2.09
0.73
e6/l
—
9
88
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
13
87
1.55
0.66
2.2
1.3
11.32
126.91
u/ml
—
6
34
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
6
37
1.65
0.56
1.3
1.3
—
—
—
0
0
6
39
1.57
0.54
1.7
1.5
—
—
—
0
0
15
113
1.37
0.45
2.7
2.1
—
—
—
0
0
11
79
1.43
0.42
2.2
2.1
0.14
0.15
e6/l
0.08
11
74
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
13
99
1.35
0.37
2.4
2.0
—
—
—
0
0
14
112
1.28
0.30
8.7
6.8
—
—
—
0
0
19
222
0.83
0.26
1.4
1.5
—
—
—
0
0
5
39
1.29
0.23
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
5
45
1.12
0.10
1.0
1.5
—
—
—
0
0
7
68
1.03
0.08
1.1
1.0
—
—
—
0
0
21
196
1.09
0.07
3.0
2.4
—
—
—
0
0
20
187
1.08
0.07
3.0
2.2
—
—
—
0
0
21
200
1.06
0.04
3.3
4.1
23.87
24.33
%
—
10
79
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
10.17
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_CVIDNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CVIDNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CVIDNAS – Other or unspecified common variable immunodeficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data