obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
122 |
4. Check minimum number of eventsNone |
122 |
5. Include endpointsNone |
122 |
6. Filter based on genotype QC (FinnGen only) |
121 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other or unspecified common variable immunodeficiency
based on the number of shared cases.
Similar with more cases:
- Common variable immunodeficiency
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: unknown.
No upset table: unknown.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 443 | 255 | 186 |
| Only index persons | 415 | 243 | 172 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.95 | 48.76 | 44.63 |
| Only index persons | 45.68 | 47.31 | 43.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 121 | 77 | 44 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 47.72 | 49.04 | 45.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 122
- Matched controls
- 1220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
122.4
96
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
80.3
68
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
78.9
67
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
65.7
57
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
29.1
50.7
37
18
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
44.5
40
*
ZX120
NOMESCO Finland
Intravenous
14.4
44.5
51
58
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
32.8
30
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.5
31.7
63
136
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.8
31.1
46
71
6BA02, ,
NOMESCO Finland
+∞
30.5
28
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
29.4
27
*
J01MA14
ATC
moxifloxacin; systemic
10.0
28.6
40
57
J01MA12
ATC
levofloxacin; systemic
7.7
27.6
55
117
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
11.9
26.8
31
34
TDM10
NOMESCO Finland
Puncture of maxillary antrum
12.0
25.5
29
31
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.6
24.6
67
190
TPH04
NOMESCO Finland
Cathetrisation of vein
6.6
24.2
60
156
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
23.7
22
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
22.6
21
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
9.3
22.3
31
43
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
9.6
22.3
30
40
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
10.1
21.8
28
35
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.4
21.7
86
332
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
8.1
21.7
35
58
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
32.5
21.6
28
11
Z01.8
ICD-10 Finland
Other specified special examinations
5.9
21.1
57
157
J47
ICD-10 Finland
Bronchiectasis
44.3
20.8
25
7
H02AB06
ATC
prednisolone; systemic
5.9
18.5
91
404
R50.9
ICD-10 Finland
Fever, unspecified
6.0
18.1
41
95
J45.1
ICD-10 Finland
Nonallergic asthma
8.0
18.0
28
44
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.8
17.2
32
61
UGC12
NOMESCO Finland
Flexible bronchoscopy
13.6
16.0
28
26
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.4
15.3
25
41
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
14.0
15.2
26
23
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
14.9
14
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
6.5
13.9
26
49
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
24.7
13.8
19
9
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.1
13.6
27
54
J01FA06
ATC
roxithromycin; oral
4.2
13.5
75
338
J01FA15
ATC
telithromycin; oral
5.8
13.1
28
60
J01FF01
ATC
clindamycin; systemic
4.1
13.0
57
217
UJF32
NOMESCO Finland
Coloscopy
4.2
12.8
48
163
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
12.6
61
248
SPAT1262
SPAT
Handing over of treatment supplies
4.7
12.5
36
100
J45.9
ICD-10 Finland
Asthma, unspecified
4.5
12.4
39
116
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.8
12.3
21
36
TGC00
NOMESCO Finland
Bronchial lavation
18.9
12.1
18
11
H02AB04
ATC
methylprednisolone; systemic
4.7
11.6
33
90
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
11.6
11
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.1
11.6
43
144
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
39.1
11.5
14
*
GD1AD
NOMESCO Finland
Thorax CT examination
11.3
11.3
21
22
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.6
11.1
32
88
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
10.1
11.1
22
26
C03CA01
ATC
furosemide; systemic
4.0
11.1
42
142
C01CA24
ATC
epinephrine; parenteral
5.7
11.0
23
48
WW200
NOMESCO Finland
Immunization
16.2
10.9
17
12
R03BB04
ATC
tiotropium bromide; inhalant
6.3
10.8
20
37
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
10.6
10
*
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
10.6
10
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.0
10.5
38
124
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.5
10.3
56
239
H02AB07
ATC
prednisone; oral
4.5
10.2
29
79
Z31.5
ICD-10 Finland
Genetic counselling
5.8
10.0
20
40
J45.8
ICD-10 Finland
Mixed asthma
13.0
9.9
17
15
UJF30
NOMESCO Finland
Ileoscopy through colon
4.6
9.9
27
71
Z3231
NOMESCO Finland
Registered nurse
3.4
9.9
52
217
UJF92
NOMESCO Finland
Capsular endoscopy
16.9
9.8
15
10
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.2
9.5
21
30
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
9.5
9
*
A10AB05
ATC
insulin aspart; parenteral
5.3
9.5
21
46
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
17.4
9.3
14
9
WZC00
NOMESCO Finland
Treatment plan or consultation
3.2
9.1
66
330
XQ800
NOMESCO Finland
Prick test
5.1
9.0
21
48
J01MA02
ATC
ciprofloxacin; systemic
3.2
8.9
59
279
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
3.5
8.9
89
534
SPAT1255
SPAT
Intravenous administration of medicine
7.8
8.8
20
30
C03DA01
ATC
spironolactone; oral
5.0
8.8
21
49
R03DA04
ATC
theophylline; systemic, rectal
12.0
8.6
15
14
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
96.4
8.5
9
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
8.4
8
*
WZC30
NOMESCO Finland
Teaching
3.6
8.3
33
113
J05AB11
ATC
valaciclovir; oral
3.6
8.3
34
119
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.4
8.3
37
137
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.4
8.2
23
61
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
8.2
30
97
D70.89
ICD-10 Finland
Neutropenic splenomegaly
36.0
8.2
10
*
A07EA06
ATC
budesonide; oral, local oral
7.9
8.1
18
26
C10AC01
ATC
colestyramine; oral
10.5
8.0
15
16
Z2221
NOMESCO Finland
Medical doctor
3.1
7.9
48
213
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
48.1
7.8
9
*
B29
ICPC
Lymph/immune mech sympt/complt other
48.1
7.8
9
*
P01AB01
ATC
metronidazole; oral, rectal
2.9
7.7
66
354
B99
ICPC
Blood/lymph/spleen disease other
85.0
7.5
8
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
12.0
7.5
13
12
132
Kela drug reimbursment
Sarcoidosis
+∞
7.4
7
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
7.4
7
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
8.8
7.4
15
19
JN4AD
NOMESCO Finland
Body CT examination
4.4
7.3
20
52
A07AA09
ATC
vancomycin; oral
32.1
7.3
9
*
XW000
NOMESCO Finland
Bone marrow biopsy
11.0
7.2
13
13
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.0
7.2
86
542
R03AC12
ATC
salmeterol; inhalant
8.4
7.1
15
20
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
14.9
7.0
11
8
J32.4
ICD-10 Finland
Chronic pansinusitis
14.9
7.0
11
8
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
7.0
24
74
XG410
NOMESCO Finland
Flow-volume spirometry
11.9
7.0
12
11
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
7.0
43
191
M05BA04
ATC
alendronic acid; oral
6.2
6.9
18
33
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
8.6
6.8
14
18
J01AA02
ATC
doxycycline; systemic
3.7
6.8
104
742
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.4
6.7
18
46
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
10.9
6.7
12
12
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
8.2
6.6
14
19
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
6.6
17
42
R01AD09
ATC
mometasone; nasal
2.7
6.6
75
453
R03AC02
ATC
salbutamol; inhalant
2.8
6.6
82
518
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
6.5
32
124
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
8.9
6.5
13
16
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
73.5
6.5
7
*
1XC02, ,
NOMESCO Finland
73.5
6.5
7
*
ZXA10
NOMESCO Finland
Bilateral
3.1
6.4
32
125
J01DA06
ATC
[U] cefuroxime
3.3
6.4
28
101
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
7.0
6.4
15
24
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.4
6.4
26
90
J01DA08
ATC
[U] cefaclor
3.3
6.3
27
96
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
28.3
6.3
8
*
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
+∞
6.3
6
*
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
6.3
6
*
R03AK07
ATC
formoterol and budesonide; inhalant
2.9
6.2
35
147
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
6.1
24
81
WX002
NOMESCO Finland
Sedation and analgesia
3.0
6.1
32
129
J01FA09
ATC
clarithromycin; systemic
2.6
6.1
52
271
R01AD05
ATC
budesonide; nasal
4.2
6.0
17
45
J02AC01
ATC
fluconazole; systemic
2.5
6.0
64
369
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
6
138.96
49.41
2.3
1.3
—
—
—
0
0
34
5
93.05
31.82
5.6
1.4
881.85
1493.20
u/ml
—
34
5
38
58
9.06
25.53
2.7
1.6
—
—
—
0
0
50
133
5.68
19.02
2.8
2.0
—
—
—
0
0
46
114
5.87
18.93
6.4
7.3
1.03
1.06
mmol/l
0.32
46
108
25
12
25.79
18.20
2.0
1.4
634.52
516.67
e6/l
0.40
25
12
43
105
5.78
17.88
2.8
2.6
17.57
24.24
%
2.28
37
89
28
45
7.78
17.61
2.9
1.4
—
—
—
0
0
61
209
4.84
16.78
2.9
2.0
3.14
3.15
mg/l
0.01
56
184
25
18
17.11
15.88
3.3
2.4
—
—
—
0
0
27
25
13.53
15.47
1.9
1.2
—
—
—
0
0
96
492
5.46
15.07
11.1
6.3
10.59
10.39
umol/l
0.05
96
464
114
740
9.24
14.63
21.9
7.2
94.56
76.63
u/l
3.11
114
687
87
420
4.73
14.60
11.8
8.1
1.21
1.22
mmol/l
0.49
81
363
37
97
5.04
13.87
2.1
1.6
—
—
—
0
0
23
22
12.60
12.93
1.4
1.9
—
—
—
0
0
22
20
13.14
12.66
1.5
1.9
—
—
—
0
0
36
103
4.54
11.98
2.7
2.3
332.61
373.24
nmol/l
0.59
36
96
17
10
19.49
11.58
2.8
1.0
—
—
—
0
0
17
10
19.49
11.58
2.8
1.0
—
—
—
0
0
75
377
3.57
10.72
12.0
10.1
1.05
1.18
inr
1.81
26
125
33
98
4.25
10.35
2.3
1.7
—
—
—
0
0
17
14
13.88
10.22
1.5
1.6
—
—
—
0
0
17
14
13.88
10.22
1.5
1.6
—
—
—
0
0
65
310
3.35
9.91
4.7
3.1
—
—
—
0
0
16
13
13.95
9.68
1.5
1.8
—
—
—
0
0
14
10
15.61
8.94
3.1
1.8
—
—
—
0
0
16
16
11.31
8.84
1.5
2.0
—
—
—
0
0
14
12
12.99
8.31
1.6
1.8
—
—
—
0
0
12
8
16.45
7.89
1.3
1.4
—
—
—
0
0
12
8
16.45
7.89
1.3
1.4
—
—
—
0
0
20
49
4.69
7.89
5.7
3.6
1.88
0.94
mmol/l
0.52
13
34
13
11
13.05
7.78
3.3
1.7
—
—
—
0
0
12
9
14.61
7.56
1.3
2.0
—
—
—
0
0
11
7
17.08
7.38
1.5
2.0
—
—
—
0
0
50
235
2.91
7.36
1.4
1.3
3.09
2.44
u/ml
—
10
53
63
335
2.82
7.35
2.4
1.9
92.09
97.76
pmol/l
0.30
39
166
12
10
13.14
7.25
1.4
1.9
—
—
—
0
0
79
481
2.82
6.97
6.2
4.7
0.00
0.00
estimate
-0.00
23
99
12
11
11.94
6.97
1.3
1.8
—
—
—
0
0
14
18
8.63
6.83
1.5
1.4
—
—
—
0
0
13
15
9.55
6.74
1.4
1.3
—
—
—
0
0
79
487
2.77
6.70
4.8
3.4
0.00
0.00
estimate
-0.00
24
93
79
489
2.75
6.61
4.9
3.3
0.00
0.00
estimate
-0.00
24
103
13
16
8.94
6.52
9.2
2.6
3.26
3.86
e9/l
0.43
13
16
13
16
8.94
6.52
9.6
2.9
52.92
51.56
%
0.14
13
16
13
17
8.41
6.31
1.4
1.4
—
—
—
0
0
16
29
6.18
6.25
3.7
1.5
—
—
—
0
0
49
247
2.64
6.12
3.9
3.0
0.57
0.39
e6/l
0.24
41
182
16
30
5.97
6.10
3.6
2.7
—
—
—
0
0
16
31
5.78
5.95
4.8
2.4
—
—
—
0
0
16
41
4.34
5.93
2.1
1.7
—
—
—
0
0
13
19
7.52
5.91
4.2
1.7
—
—
—
0
0
13
20
7.14
5.73
4.2
1.7
—
—
—
0
0
13
20
7.14
5.73
4.2
1.7
—
—
—
0
0
13
20
7.14
5.73
4.2
1.7
—
—
—
0
0
13
20
7.14
5.73
4.2
1.7
—
—
—
0
0
13
20
7.14
5.73
4.2
1.7
—
—
—
0
0
35
153
2.81
5.72
8.4
4.1
0.77
0.82
mmol/l
1.84
35
148
10
11
9.78
5.40
1.5
2.1
—
—
—
0
0
9
8
12.02
5.38
1.4
1.8
—
—
—
0
0
9
8
12.02
5.38
1.4
1.8
—
—
—
0
0
9
8
12.02
5.38
1.4
1.8
—
—
—
0
0
48
255
2.45
5.23
5.1
3.5
0.00
0.00
estimate
-0.00
23
92
72
458
2.40
5.23
3.1
2.6
—
—
—
0
0
16
37
4.82
5.16
1.6
1.5
—
—
—
0
0
13
24
5.93
5.08
2.5
2.1
—
—
—
0
0
19
63
3.39
4.92
5.6
3.6
1.21
1.23
mmol/l
0.68
19
57
9
10
9.60
4.87
1.3
1.2
—
—
—
0
0
13
26
5.46
4.79
1.3
1.3
—
—
—
0
0
61
378
2.23
4.51
5.1
3.2
—
—
—
0
0
24
97
2.84
4.47
9.6
7.1
104.21
104.21
mmol/l
0.00
24
97
14
35
4.38
4.26
1.4
3.4
—
—
—
0
0
38
197
2.35
4.26
3.2
2.4
847.12
791.38
ng/l
0.05
33
158
23
94
2.78
4.19
8.3
12.5
0.19
1.72
mmol/l
0.98
16
72
53
319
2.17
4.13
4.4
3.0
20.54
38.27
ng/l
0.59
37
183
9
14
6.84
4.06
2.6
1.4
—
—
—
0
0
14
43
3.55
4.05
2.7
3.5
25.16
24.99
mmol/l
0.07
14
43
7
8
9.19
3.82
1.1
1.0
—
—
—
0
0
6
5
12.52
3.80
1.5
1.0
—
—
—
0
0
13
35
4.03
3.72
2.9
1.3
—
—
—
0
0
111
936
3.06
3.35
31.5
10.8
88.84
88.07
ml/min/173m2
0.12
100
768
43
256
2.05
3.32
3.3
2.5
7249.51
5805.71
umol/l
0.07
43
229
39
226
2.07
3.23
3.3
2.1
—
—
—
0
0
6
8
7.81
3.09
1.0
1.6
—
—
—
0
0
6
8
7.81
3.09
1.5
2.3
—
—
—
0
0
40
239
2.00
3.03
4.4
3.9
6.67
15.15
mg/mmol
0.81
30
150
5
5
10.35
3.00
2.0
2.0
—
—
—
0
0
5
5
10.35
3.00
2.0
2.0
—
—
—
0
0
5
5
10.35
3.00
2.6
1.2
44.20
79.80
ug/l
—
5
5
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
5
10.35
3.00
1.0
1.2
—
—
—
0
0
5
5
10.35
3.00
2.0
2.0
—
—
—
0
0
5
5
10.35
3.00
2.2
3.8
—
—
—
0
0
5
5
10.35
3.00
2.0
2.0
—
—
—
0
0
5
5
10.35
3.00
1.2
1.0
—
—
—
0
0
5
5
10.35
3.00
2.2
3.8
—
—
—
0
0
11
32
3.67
2.98
1.9
1.1
—
—
—
0
0
11
32
3.67
2.98
1.9
1.1
—
—
—
0
0
7
13
5.64
2.91
1.0
1.2
—
—
—
0
0
5
6
8.62
2.77
1.0
1.2
3.20
2.97
mg/l
—
5
6
5
6
8.62
2.77
1.8
2.0
—
—
—
0
0
5
6
8.62
2.77
1.6
1.3
48.40
54.83
u/l
—
5
6
5
6
8.62
2.77
1.8
2.0
—
—
—
0
0
7
14
5.23
2.77
1.0
1.1
—
—
—
0
0
96
783
2.06
2.73
4.3
4.0
14.77
14.71
pmol/l
0.08
91
728
12
42
3.06
2.63
4.3
3.1
46.32
52.67
%
0.27
12
42
5
7
7.38
2.57
7.2
3.1
—
—
—
0
0
5
7
7.38
2.57
3.0
1.1
—
—
—
0
0
14
59
2.55
2.39
1.7
1.2
—
—
—
0
0
17
79
2.34
2.38
3.6
3.1
—
—
—
0
0
39
249
1.83
2.36
1.6
1.6
—
—
—
0
0
106
915
2.21
2.32
42.8
14.5
14.85
14.48
%
0.35
106
905
6
13
4.79
2.30
1.2
1.3
—
—
—
0
0
7
18
4.06
2.29
1.3
1.3
—
—
—
0
0
10
35
3.02
2.27
1.7
7.3
24.53
24.39
mmol/l
—
10
35
5
9
5.74
2.23
1.2
1.3
—
—
—
0
0
8
25
3.35
2.13
1.5
1.6
—
—
—
0
0
10
39
2.70
1.99
1.9
3.6
0.58
0.65
%
—
10
39
30
189
1.78
1.86
1.4
1.3
21.73
45.52
iu/ml
—
6
65
6
17
3.65
1.86
1.5
1.2
—
—
—
0
0
13
60
2.31
1.85
2.4
3.0
4.66
4.73
pmol/l
0.10
13
54
5
12
4.29
1.84
1.0
1.2
—
—
—
0
0
14
68
2.20
1.78
2.7
2.6
82.86
70.90
ml/min/173m2
—
7
29
91
772
1.70
1.77
4.0
3.4
—
—
—
0
0
8
30
2.78
1.76
1.1
1.1
—
—
—
0
0
10
40
2.63
1.71
1.9
3.5
1.66
1.15
%
—
10
40
5
14
3.68
1.63
1.2
1.1
264.00
337.93
pmol/l
—
5
14
27
172
1.73
1.61
4.8
3.2
16.74
131.44
ng/l
1.05
16
110
23
140
1.79
1.59
2.7
2.8
1.64
3.16
e6/l
0.73
11
72
30
198
1.68
1.58
1.4
1.3
1.09
8.35
u/ml
1.77
12
82
5
15
3.43
1.54
2.2
1.3
—
—
—
0
0
12
62
2.04
1.33
5.9
1.9
72.92
120.02
ng/l
0.78
12
54
33
233
1.57
1.32
1.7
1.8
0.75
0.64
mg/l
0.18
26
175
5
21
2.44
1.10
1.2
1.5
—
—
—
0
0
5
21
2.44
1.10
1.2
1.5
—
—
—
0
0
13
80
1.70
0.88
1.9
1.3
11.32
130.21
iu/ml
—
6
33
21
150
1.48
0.80
2.3
2.7
2.09
0.77
e6/l
—
9
82
0
25
0.00
0.80
0.0
1.3
—
—
—
0
0
7
40
1.79
0.72
1.6
1.2
—
—
—
0
0
5
28
1.82
0.67
1.4
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
6
38
1.61
0.55
1.2
1.7
—
—
—
0
0
6
38
1.61
0.55
1.7
1.5
—
—
—
0
0
13
93
1.45
0.50
2.6
2.0
—
—
—
0
0
11
79
1.43
0.42
2.5
1.9
—
—
—
0
0
5
79
0.62
0.37
1.6
1.5
—
—
—
0
0
5
39
1.29
0.23
1.4
1.4
—
—
—
0
0
5
39
1.29
0.23
1.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
20
176
1.16
0.19
3.0
2.2
—
—
—
0
0
19
167
1.16
0.18
3.1
2.0
—
—
—
0
0
13
113
1.17
0.13
8.5
6.5
—
—
—
0
0
19
210
0.89
0.13
1.4
1.4
—
—
—
0
0
102
1005
1.09
0.08
4.3
4.5
2.66
2.84
mmol/l
1.02
97
943
19
176
1.09
0.08
3.2
3.9
25.61
24.45
%
—
9
72
11
104
1.06
0.01
4.5
4.1
31.45
31.25
%
0.02
11
68
6
62
0.97
-0.00
1.2
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
10.17
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_CVIDNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CVIDNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CVIDNAS – Other or unspecified common variable immunodeficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data