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Carcinoma in situ of skin of lip

DOID Endpoint Browser PheWeb

CD2_INSITU_SKIN_LIP

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D04.0&
  • Hospital discharge: ICD-9 — 2320
  • Cause of death: ICD-10 — D04.0&
  • Cause of death: ICD-9 — 2320

2 out of 7 registries used, show all original rules.

121

4. Check minimum number of events

None

121

5. Include endpoints

None

121

6. Filter based on genotype QC (FinnGen only)

106

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D04
Name in latin
Carcinoma in situ cutis labii (oris)

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 106 42 64
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 73.51 73.96 73.21

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
110
Matched controls
1100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
+∞
158.7
110
*
TQW99
NOMESCO Finland
Other minor procedure on skin
25.8
61.4
52
37
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
21.2
58.5
58
55
L57.0
ICD-10 Finland
Actinic keratosis
19.9
58.2
76
111
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
10.0
31.5
50
85
EAA10
NOMESCO Finland
Excision of lesion of lip
203.6
30.3
30
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
33.0
25.4
33
14
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
30.8
24.9
33
15
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
36.8
23.8
30
11
R23.8
ICD-10 Finland
Other and unspecified skin changes
6.9
23.3
58
153
ZXC20
NOMESCO Finland
Use of chemical agents
31.1
22.8
30
13
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
7.8
22.7
41
78
D06BB10
ATC
imiquimod; topical
10.9
22.0
27
32
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
8.2
21.0
34
57
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
20.4
19
*
ZQZ00
NOMESCO Finland
Treatment of several skin areas
113.7
18.2
19
*
Z2221
NOMESCO Finland
Medical doctor
5.1
16.3
56
186
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
+∞
16.0
15
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
16.0
15
*
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
45.3
16.0
19
5
ZZR00
NOMESCO Finland
Flap of skin
21.9
14.0
20
11
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
13.0
13.6
24
23
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
6.8
13.0
23
41
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
23.6
13.0
18
9
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
13.4
12.7
22
20
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
48.7
11.2
13
*
R4110
NOMESCO Finland
Physiotherapy
3.8
11.0
54
221
ZXD10
NOMESCO Finland
Scheduled procedure
3.8
10.8
64
295
XF400
NOMESCO Finland
ECG with 12 standard connections
4.0
10.4
39
132
ZXC10
NOMESCO Finland
Use of laser
15.4
10.0
16
12
S18
ICPC
Laceration/cut
3.8
9.8
76
410
S29
ICPC
Skin symptom/complaint other
3.7
9.5
41
151
ZXC50
NOMESCO Finland
Cryotherapy
8.9
8.2
17
22
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
36.3
8.2
10
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
4.1
8.0
25
73
Z3231
NOMESCO Finland
Registered nurse
3.1
7.6
51
242
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
17.3
7.4
11
7
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
+∞
7.4
7
*
ZXE00
NOMESCO Finland
One hour or less
2.9
7.2
57
295
ZXA05
NOMESCO Finland
Left side
3.0
7.1
46
212
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
7.1
32
119
Z3226
NOMESCO Finland
Physiotherapist
3.3
7.1
34
132
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
42.8
6.8
8
*
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
74.0
6.5
7
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
10.2
6.5
12
13
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
7.1
6.4
15
24
D07AB08
ATC
desonide; topical
3.8
6.4
22
68
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
28.5
6.3
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.9
6.3
38
167
8070/3-C00.1
ICD-O-3
Squamous cell carcinoma, NOS, of external lower lip
+∞
6.3
6
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
6.3
52
271

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
121
7.25
23.79
2.5
1.3
—
—
—
0
0
26
32
10.33
20.55
1.4
1.3
—
—
—
0
0
84
349
6.95
19.48
5.4
2.3
—
—
—
0
0
49
166
4.52
13.44
4.1
3.4
2.58
2.02
e6/l
0.12
26
88
30
88
4.31
9.60
7.7
7.8
—
—
—
0
0
26
83
3.79
7.29
1.2
1.4
—
—
—
0
0
58
301
2.96
7.28
4.7
3.4
0.61
0.38
e6/l
0.39
42
223
64
357
2.90
6.93
4.7
3.4
109.92
246.91
e6/l
0.32
50
276
21
60
4.09
6.83
5.4
3.8
24.30
24.12
mmol/l
0.05
21
60
67
385
2.89
6.82
5.8
4.3
50.65
111.54
e6/l
0.69
50
284
72
464
2.60
5.34
5.3
4.1
34.64
34.53
g/l
0.05
66
433
25
95
3.11
5.26
6.6
5.5
13.07
11.41
mmol/l
0.50
25
90
46
242
2.55
5.24
2.9
3.8
—
0.20
—
0
10
70
450
2.53
5.15
3.0
2.3
100.64
95.20
pmol/l
0.34
36
230
55
317
2.47
5.13
5.7
4.1
7.40
7.39
ph
0.39
35
226
26
106
2.90
4.83
1.7
1.3
—
—
—
0
0
89
660
2.83
4.58
37.7
25.7
14.16
14.03
%
0.35
89
651
61
382
2.34
4.57
3.0
4.1
6.70
6.33
ph
1.41
20
210
30
142
2.53
4.14
6.2
6.0
7.42
7.42
ph
0.08
12
89
46
269
2.22
3.92
8.0
7.0
—
—
—
0
0
26
119
2.55
3.83
5.2
3.6
7.38
7.39
ph
0.12
15
77
29
142
2.42
3.70
6.4
6.0
0.93
1.32
mmol/l
0.13
22
115
23
101
2.61
3.67
2.2
1.7
—
—
—
0
0
50
315
2.08
3.42
7.6
5.3
—
—
—
0
0
53
342
2.06
3.39
3.0
3.1
2.36
2.34
mmol/l
0.60
48
305
16
61
2.90
3.30
4.0
7.6
26.00
24.80
mmol/l
0.42
16
61
66
465
2.05
3.29
8.4
5.9
0.65
0.63
e9/l
0.15
55
397
48
302
2.05
3.27
3.3
2.3
—
—
—
0
0
66
466
2.04
3.26
8.3
5.9
0.03
0.04
e9/l
0.65
54
397
6
8
7.85
3.09
1.7
1.4
—
—
—
0
0
60
416
1.97
3.05
3.3
2.6
—
—
estimate
—
0
0
13
46
3.07
3.04
2.2
2.5
—
—
—
0
0
66
475
1.97
2.99
8.6
6.0
1.86
1.80
e9/l
0.15
55
416
66
476
1.97
2.96
8.5
6.1
0.15
0.19
e9/l
1.50
55
412
50
329
1.95
2.93
1.9
1.9
23.26
19.89
nmol/l
0.80
45
266
15
59
2.79
2.93
2.7
2.0
1.76
1.63
g/l
0.26
15
54
35
203
2.06
2.92
3.9
2.4
11.32
12.42
umol/l
0.43
35
186
19
86
2.46
2.83
1.4
1.6
—
—
—
0
0
21
100
2.36
2.81
3.0
2.5
5.70
10.66
umol/l
1.42
21
90
12
43
3.01
2.74
1.1
2.5
1.10
3.32
ratio
—
6
21
23
117
2.22
2.65
1.4
2.7
73.55
67.34
e9/l
0.43
11
90
68
513
1.85
2.48
12.3
9.3
4.57
4.40
e9/l
0.23
58
448
30
175
1.98
2.42
2.4
2.7
0.80
0.82
mmol/l
0.58
30
165
8
22
3.84
2.41
1.3
1.1
—
—
—
0
0
5
8
6.48
2.39
1.2
1.9
—
—
—
0
0
42
277
1.84
2.34
3.2
2.3
3.04
2.93
mg/l
0.09
36
243
29
448
0.52
2.34
3.8
4.6
24.43
49.83
ng/l
1.80
23
373
24
133
2.03
2.22
1.8
1.8
—
—
—
0
0
55
403
1.73
2.10
12.5
13.7
0.00
0.00
e9/l
0.32
45
336
5
10
5.18
2.09
1.0
2.0
7.80
10.14
%
—
5
10
40
270
1.76
2.02
3.4
2.9
403.47
367.81
umol/l
0.87
32
227
47
335
1.70
1.95
4.9
3.2
93.95
57.36
mg/l
0.27
34
234
99
877
2.29
1.87
34.9
24.0
3.97
4.02
mmol/l
1.01
99
858
99
877
2.29
1.87
34.4
23.9
138.92
139.56
mmol/l
1.41
99
858
99
884
2.20
1.72
36.9
26.7
99.61
87.20
umol/l
1.10
99
871
26
386
0.57
1.68
4.2
4.3
—
—
—
0
0
12
57
2.24
1.62
1.6
1.6
—
—
—
0
0
99
890
2.12
1.58
42.6
30.0
38.98
39.20
%
0.18
99
877
99
890
2.12
1.58
41.7
29.7
128.57
131.54
g/l
1.06
99
877
99
890
2.12
1.58
41.3
29.4
30.51
30.47
pg
0.08
99
877
99
890
2.12
1.58
41.5
29.5
92.19
92.04
fl
0.14
99
877
44
323
1.60
1.56
5.5
4.6
—
—
—
0
0
7
27
2.70
1.54
1.4
1.1
—
—
—
0
0
95
849
1.87
1.44
26.7
19.6
35.84
26.80
mg/l
1.43
81
737
12
61
2.09
1.39
2.2
2.6
0.55
0.65
%
0.59
12
61
12
61
2.09
1.39
2.2
2.6
1.03
1.15
%
0.23
12
61
32
223
1.61
1.38
1.3
1.3
—
—
—
0
0
17
265
0.58
1.27
5.1
4.0
—
—
—
0
0
45
347
1.50
1.23
5.6
3.9
19.95
9.61
mg/mmol
0.38
31
230
15
240
0.57
1.22
1.5
1.9
459.56
461.87
pmol/l
—
9
206
10
50
2.10
1.20
1.5
3.3
—
—
—
0
0
43
332
1.48
1.16
4.4
3.5
—
—
—
0
0
9
45
2.09
1.08
3.1
3.3
4.23
4.31
pmol/l
—
9
39
11
60
1.93
1.07
1.0
1.3
—
—
—
0
0
9
51
1.83
0.97
1.0
1.3
—
—
—
0
0
12
70
1.80
0.97
1.7
1.5
—
—
—
0
0
6
32
1.92
0.83
1.2
1.2
—
—
—
0
0
0
24
0.00
0.80
0.0
1.1
—
—
—
0
0
5
23
2.23
0.77
1.2
1.2
—
—
—
0
0
5
26
1.97
0.71
1.0
1.1
—
—
—
0
0
7
41
1.75
0.71
1.1
1.4
—
—
—
0
0
32
254
1.37
0.71
5.0
3.5
0.66
0.79
ug/l
0.42
22
179
20
146
1.45
0.70
1.2
1.4
14.43
35.68
iu/ml
—
7
57
91
846
1.44
0.69
18.4
17.7
—
—
—
0
0
7
44
1.63
0.66
1.1
1.2
—
—
—
0
0
14
96
1.53
0.65
1.2
2.2
—
—
—
0
0
9
61
1.52
0.55
3.3
1.9
8.23
10.77
g/l
—
9
55
5
31
1.64
0.43
1.2
1.2
—
—
—
0
0
11
79
1.44
0.42
5.7
3.7
—
—
—
0
0
20
160
1.31
0.42
1.6
1.3
2.39
2.69
g/l
—
6
83
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
2.2
—
9.95
—
0
19
9
70
1.31
0.38
1.2
1.6
—
—
—
0
0
6
82
0.72
0.25
5.7
2.5
7.39
7.42
ph
—
6
61
57
534
1.14
0.24
27.5
17.4
1.41
1.35
inr
0.31
50
455
5
41
1.23
0.22
3.6
1.8
—
—
—
0
0
16
136
1.21
0.21
1.6
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
5.03
—
0
11
0
10
0.00
0.21
0.0
4.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
15
175
0.83
0.20
6.2
5.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
51
1.19
0.20
6.2
3.9
37.15
36.99
°c
—
6
51
8
78
1.03
0.07
4.4
3.4
—
—
—
0
0
11
100
1.11
0.05
1.1
2.3
524.82
411.10
nmol/l
0.40
11
94
12
110
1.10
0.05
1.3
1.3
—
—
—
0
0
10
106
0.94
0.01
3.1
2.7
12.13
6.15
ug/l
—
10
92
0
5
0.00
0.00
0.0
2.8
—
4.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
254.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.90
-0.00
5.8
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
2114.29
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
59
1.02
-0.00
2.2
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
0.63
—
0
8
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_SKIN_LIP – Carcinoma in situ of skin of lip

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).