Carcinoma in situ of anus and anal canal

CD2_INSITU_ANUS_ANAL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions not C3_ANUS_ANALCANAL	557526
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D01.3& Hospital discharge: ICD-9 — 230[5-6] Cause of death: ICD-10 — D01.3& Cause of death: ICD-9 — 230[5-6] Cancer registry: Topography ICD-O-3 — C21 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	53
4. Check minimum number of events None	53
5. Include endpoints None	53
6. Filter based on genotype QC (FinnGen only)	45

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D01
Name in latin: Carcinoma in situ laryngis

NAME	CD2_INSITU_ANUS_ANAL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_ANUS_ANALCANAL
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D013
HD_ICD_9	230[5-6]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D013
COD_ICD_9	230[5-6]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C21
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of anus and anal canal based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	45	27	18
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.72	61.38	59.74

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

11.53

16.03

1.8

1.2

—

(3022145) Colonoscopy Study observation

7.87

11.40

3.6

1.4

—

(4035726) Immunohistochemistry procedure

7.66

7.32

1.5

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

4.92

6.26

2.9

3.1

4.42

1.87

e6/l

0.39

(40758558) Short blood count panel - Blood

130

4.62

6.13

13.1

7.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.59

4.40

3.1

2.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

148

3.51

4.20

4.9

3.2

—

(40768804) Tissue Pathology biopsy report

165

3.58

4.20

5.0

1.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

3.61

4.06

3.2

3.0

0.55

1.14

e6/l

0.79

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.66

4.02

7.4

8.5

106.41

104.13

mmol/l

1.44

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.73

3.99

3.7

3.8

—

(3030467) Casts [#/volume] in Urine by Automated count

122

3.24

3.80

5.2

2.8

0.86

0.28

e6/l

0.60

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

11.20

3.60

2.2

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

134

3.10

3.54

3.6

2.4

—

(36304419) Bacteria [Presence] in Urine

111

3.10

3.50

5.4

2.9

—

estimate

—

(3021589) Normoblasts [#/volume] in Blood

169

3.14

3.48

24.2

13.7

0.00

e9/l

-0.00

138

(3001604) Monocytes [#/volume] in Blood

216

3.43

3.46

13.3

6.9

0.59

0.58

e9/l

0.12

188

(3006315) Basophils [#/volume] in Blood

218

3.37

3.36

13.3

6.9

0.03

0.04

e9/l

2.25

190

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.46

3.36

2.9

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.24

3.35

3.4

2.1

—

(40768443) Skin Pathology biopsy report

6.18

3.35

1.5

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.27

3.30

3.7

1.9

—

(42870588) Differential panel, method unspecified - Blood

139

2.95

3.24

12.1

5.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

192

3.09

3.23

3.6

2.8

—

estimate

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

8.38

3.15

1.0

1.1

—

(3044889) 12 lead EKG panel

285

3.70

3.13

5.3

3.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.44

3.12

2.8

2.0

—

(3042936) Bacteria identified in Isolate by Culture

3.03

3.02

2.4

—

(3002582) Erythrocytes [#/volume] in Urine

144

2.80

2.97

5.2

3.3

19.78

41.30

e6/l

0.69

114

(3000991) Gas panel - Venous blood

3.57

2.89

8.5

9.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.67

2.84

2.0

1.9

—

(3032080) INR in Blood by Coagulation assay

201

2.86

2.82

20.3

12.5

1.27

1.22

inr

0.18

160

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

9.12

2.81

1.6

2.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

9.12

2.81

1.6

2.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.21

2.81

2.5

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

6.69

2.79

2.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

6.69

2.79

1.0

1.2

—

(3018095) Leukocytes [#/volume] in Urine

158

2.67

2.70

6.2

3.8

106.63

34.89

e6/l

0.46

117

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.07

2.63

2.8

1.9

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.57

2.54

6.2

11.2

1.44

1.12

mmol/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.69

2.54

2.9

4.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

5.12

2.35

2.3

2.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

6.06

2.27

2.4

2.0

—

(3031040) Bacteria [#/volume] in Urine by Automated count

267

2.81

2.23

7.6

4.6

—

96.00

—

(3026008) Bacteria identified in Urine by Culture

126

2.40

2.19

4.0

3.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.49

2.13

1.6

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.44

2.12

1.0

1.4

—

(3023368) Bacteria identified in Blood by Culture

112

2.37

2.07

10.7

4.8

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

3.88

1.90

2.0

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.11

1.89

9.1

9.3

23.06

24.87

mmol/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.52

1.87

2.2

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

278

2.56

1.86

6.8

4.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.36

1.79

3.9

2.0

16.25

14.16

umol/l

0.70

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

4.17

1.76

1.4

1.6

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

321

2.65

1.73

5.8

4.4

13.03

11.22

mm/h

0.33

301

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

3.46

1.72

5.5

1.8

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.68

1.72

7.2

7.6

232.80

249.47

u/l

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.31

1.65

3.9

2.0

2.16

2.32

g/l

0.54

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

185

2.08

1.61

1.9

2.1

94.41

96.89

pmol/l

0.12

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.86

1.58

1.4

1.5

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.60

1.56

1.4

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.97

1.48

5.2

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

3.37

1.47

6.0

1.8

—

(3019977) pH of Arterial blood

2.35

1.47

8.6

8.2

7.40

7.42

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.31

1.41

1.9

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.16

1.39

2.2

1.8

—

(3025941) Bacteria identified in Stool by Culture

2.98

1.32

1.4

1.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.49

1.23

8.0

2.5

22.68

24.25

mmol/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.49

1.23

9.8

12.3

23.00

24.95

mmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.47

1.16

6.7

1.7

—

(3003694) ABO and Rh group [Type] in Blood

109

1.88

1.14

1.4

1.3

—

(4024509) Urine culture

2.54

1.12

1.2

1.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.17

1.05

7.4

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.96

1.04

1.6

1.5

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.00

1.01

0.0

2.1

—

2.97

—

(3015736) pH of Urine

172

1.66

0.88

2.9

3.9

6.07

6.18

0.17

(3014007) Fractional oxyhemoglobin in Arterial blood

2.07

0.88

9.3

11.7

95.85

94.13

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.00

0.85

3.8

1.6

1.07

1.09

g/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

242

1.66

0.84

3.1

3.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.90

0.82

2.9

1.8

—

(36660697) Celiac disease serology panel - Serum

1.93

0.82

1.0

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.72

0.81

5.5

7.9

—

(3000494) Fungus identified in Specimen by Culture

1.82

0.81

1.8

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.99

0.78

8.1

2.0

12.37

9.06

g/l

—

(1002224) Polysomnography panel

2.12

0.75

1.6

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.95

0.70

1.0

2.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.59

0.63

2.4

1.4

1.70

2.21

g/l

—

(40768797) Stomach Pathology biopsy report

1.61

0.62

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.62

0.0

1.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.87

0.61

9.3

10.8

2.02

1.41

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.87

0.61

9.3

10.7

0.70

0.66

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.82

0.60

1.0

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

137

1.51

0.59

6.9

3.3

22.29

8.37

mg/mmol

—

(40761536) Microorganisms panel - Urine sediment

1.68

0.44

9.8

3.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.52

0.43

2.1

1.4

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.42

0.0

1.2

—

309.84

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

165

1.37

0.41

3.8

4.2

0.00

estimate

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.60

0.39

1.0

1.7

485.60

531.00

pmol/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

391

1.70

0.39

7.7

6.2

40.62

39.19

mmol/mol

0.44

370

(3035350) Ketones [Presence] in Urine by Test strip

215

1.35

0.39

4.4

4.1

196.14

0.00

estimate

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

303

0.74

0.37

4.4

3.1

65.59

49.34

u/l

0.46

290

(3021601) Nitrite [Presence] in Urine by Test strip

216

1.34

0.37

4.2

4.0

0.00

estimate

—

(3017732) Neutrophils [#/volume] in Blood

1.28

0.29

2.5

3.7

3.61

7.96

e9/l

—

(3009261) Glucose [Presence] in Urine by Test strip

222

1.27

0.27

4.4

4.0

0.00

estimate

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.35

0.24

2.0

1.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

4.7

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.21

0.0

1.6

—

10.17

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

71.21

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

142

0.79

0.21

2.8

2.3

133.00

139.28

u/l

0.06

137

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.1

—

(3000492) Spirometry study

1.23

0.21

1.3

1.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

114

1.19

0.13

5.1

2.8

434.85

338.39

umol/l

1.51

100

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

404

0.93

0.08

6.0

5.3

4.71

4.57

mmol/l

0.36

378

(3029937) Albumin [Presence] in Urine by Test strip

119

1.13

0.07

4.9

4.5

0.00

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

114

1.07

0.01

3.5

4.8

16.22

22.86

—

(3013512) EKG study

149

1.01

0.00

5.0

3.6

—

(1761868) Lipid panel - Serum or Plasma

157

1.03

0.00

2.6

3.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.6

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

20.08

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.3

—

175.67

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

-0.00

0.0

1.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

1.8

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.3

—

107.88

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.6

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

14.22

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.3

—

4.06

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.3

—

1.22

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

1.45

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

182.76

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.7

—

10.77

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_ANUS_ANAL – Carcinoma in situ of anus and anal canal

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of anus and anal canal

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Carcinoma in situ of anus and anal canal (CD2_INSITU_ANUS_ANAL)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Relationships between endpoints