Autoimmune hepatitis

AUTOHEP

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K75.4
  • Cause of death: ICD-10 K75.4

2 out of 7 registries used, show all original rules.

386

4. Check minimum number of events

None

386

5. Include endpoints

None

386

6. Filter based on genotype QC (FinnGen only)

346

Control definitions (FinnGen only)

Control exclude
AUTOIMMUNE

Extra metadata

First used in FinnGen datafreeze
DF11

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 346 254 92
Unadjusted period prevalence (%) 0.08 0.09 0.04
Median age at first event (years) 64.36 64.65 63.54

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
359
Matched controls
3590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
307.7
359
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
189.0
307.7
201
24
A07EA06
ATC
budesonide; oral, local oral
189.8
307.7
185
20
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
83.4
307.7
212
61
L04AX01
ATC
azathioprine; systemic
1197.0
300.3
253
7
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
4473.7
230.1
197
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
89.5
183.7
98
15
A05AA02
ATC
ursodeoxycholic acid; oral
81.7
161.1
87
14
K76.9
ICD-10 Finland
Liver disease, unspecified
84.1
147.3
79
12
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
15.7
142.9
157
169
L04AA06
ATC
mycophenolic acid; systemic
91.4
137.9
73
10
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
33.5
120.9
81
31
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
197.0
100.0
100
7
H02AB06
ATC
prednisolone; systemic
11.5
87.4
300
1102
H03AA01
ATC
levothyroxine sodium; systemic
11.5
85.7
104
123
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
8.2
83.7
252
803
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
973.3
81.8
77
*
L01BB02
ATC
mercaptopurine; oral
201.7
78.6
79
5
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
20.6
77.4
62
36
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
31.2
65.7
44
16
A07EC02
ATC
mesalazine; oral, rectal
28.8
59.7
41
16
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
48.3
179
613
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.9
47.8
109
249
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
46.9
44
*
P01BA02
ATC
hydroxychloroquine; oral
9.9
38.4
47
54
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
37.1
35
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
46.1
33.9
41
10
K51.5
ICD-10 Finland
Left sided colitis
187.2
33.3
34
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
32.8
31
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
10.7
31.7
36
37
K83.0
ICD-10 Finland
Cholangitis
42.2
30.9
38
10
104
Kela drug reimbursment
Thyroid insufficiency
10.6
29.9
34
35
A10AC01
ATC
insulin (human); parenteral
7.7
29.1
43
62
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.0
28.8
30
27
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
10.3
28.4
33
35
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.6
28.3
60
125
H02AB07
ATC
prednisone; oral
4.5
28.2
81
218
UJF30
NOMESCO Finland
Ileoscopy through colon
4.8
27.9
73
182
L04AD02
ATC
tacrolimus; systemic
50.0
27.0
32
7
ZX120
NOMESCO Finland
Intravenous
4.8
24.2
61
147
A02BC02
ATC
pantoprazole; systemic
3.9
23.5
295
1944
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
39.2
23.4
29
8
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
128.2
22.9
24
*
JJA20
NOMESCO Finland
Open biopsy of liver
81.8
20.9
23
*
L04AD01
ATC
ciclosporin; systemic
32.3
20.9
27
9
E03
ICD-10 Finland
Other hypothyroidism
18.7
20.4
31
18
R94.5
ICD-10 Finland
Abnormal results of liver function studies
15.8
19.8
32
22
K90.0
ICD-10 Finland
Coeliac disease
33.4
19.5
25
8
UJF32
NOMESCO Finland
Coloscopy
3.0
19.3
117
502
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
28.4
18.1
24
9
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
21.5
18.0
26
13
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
188.9
17.7
18
*
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
15.7
15
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
40.0
15.5
19
5
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
40.0
15.5
19
5
C03DA01
ATC
spironolactone; oral
3.4
15.1
61
204
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
59.3
14.9
17
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.1
14.6
72
271
JJC00
NOMESCO Finland
Allogenic transplantation of liver
156.1
14.6
15
*
Z94.4
ICD-10 Finland
Liver transplant status
44.4
14.2
17
*
A10AB05
ATC
insulin aspart; parenteral
4.9
13.8
32
71
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
13.6
13
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
13.6
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
13.4
99
461
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.3
12.6
26
52
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
12.6
12
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
12.6
12
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
9.5
12.5
25
28
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
12.3
186
1172
K72.9
ICD-10 Finland
Hepatic failure, unspecified
39.0
12.3
15
*
D97
ICPC
Liver disease NOS
27.8
12.1
16
6
N02AX02
ATC
tramadol; systemic, rectal
2.2
12.0
172
1057
E03.89
ICD-10 Finland
Other specified hypothyroidism
15.4
11.9
19
13
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
11.4
63
251
K51.8
ICD-10 Finland
Other ulcerative colitis
113.2
10.5
11
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
10.5
10
*
R50.9
ICD-10 Finland
Fever, unspecified
2.6
10.2
69
304
R18
ICD-10 Finland
Ascites
10.0
9.9
19
20
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.0
9.8
29
78
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
102.6
9.5
10
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
102.6
9.5
10
*
T86
ICPC
Hypothyroidism/myxoedema
12.8
9.4
16
13
5714B
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]
+∞
9.4
9
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
+∞
9.4
9
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
9.4
9
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
4.5
9.3
23
54
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.7
9.1
30
87
127
Kela drug reimbursment
Transplant complication
16.1
9.1
14
9
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.6
8.9
55
231
UJK02
NOMESCO Finland
ERCP
7.5
8.9
20
28
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
51.3
8.7
10
*
K76.89
ICD-10 Finland
Other specified diseases of liver
28.3
8.5
11
*
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
92.1
8.4
9
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
+∞
8.4
8
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
8.4
8
*
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
17.7
8.1
12
7
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
10.4
8.1
15
15
M13.9
ICD-10 Finland
Arthritis, unspecified
3.3
7.9
31
101
H02AB09
ATC
hydrocortisone; systemic
7.2
7.9
18
26
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.4
7.8
56
253
K74.0
ICD-10 Finland
Hepatic fibrosis
46.0
7.7
9
*
Z2221
NOMESCO Finland
Medical doctor
2.0
7.7
113
679
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
7.5
144
942
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.4
7.5
27
83
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
7.5
36
132
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.9
7.5
22
59
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
81.7
7.4
8
*
K51
ICD-10 Finland
Ulcerative colitis
81.7
7.4
8
*
B19.9
ICD-10 Finland
Unspecified viral hepatitis without hepatic coma
81.7
7.4
8
*
L04AX03
ATC
methotrexate; systemic
4.0
7.4
21
55
A06AD11
ATC
lactulose; oral
2.4
7.3
55
253
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
7.3
7
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
7.3
7
*
K71.2
ICD-10 Finland
Toxic liver disease with acute hepatitis
+∞
7.3
7
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
7.3
7
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.1
89
503
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
14.1
6.9
11
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
6.9
60
295
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
6.3
6.9
17
28
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
40.8
6.8
8
*
D94
ICPC
Chronic enteritis/ulcerative colitis
40.8
6.8
8
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
40.8
6.8
8
*
ZXE00
NOMESCO Finland
One hour or less
1.8
6.7
145
980
JN4AD
NOMESCO Finland
Body CT examination
2.4
6.5
49
226
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
71.1
6.4
7
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
6.4
59
296
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
6.3
6
*
K75.8
ICD-10 Finland
Other specified inflammatory liver diseases
+∞
6.3
6
*
0709X
ICD-9 Finland
Viral hepatitis, Unspecified viral hepatitis without mention of hepatic coma
+∞
6.3
6
*
L04AB02
ATC
infliximab; parenteral
+∞
6.3
6
*
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
+∞
6.3
6
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
27.2
6.3
8
*
H02AB04
ATC
methylprednisolone; systemic
2.2
6.2
55
271
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.1
132
884
WX402
NOMESCO Finland
General anaesthesia
1.9
6.0
93
562

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
187
28
138.31
307.65
1.5
1.3
—
—
—
0
0
219
64
86.18
307.65
2.1
1.2
384.69
100.00
titre
—
64
6
206
66
71.89
307.65
1.8
1.2
708.50
—
titre
—
20
0
231
155
39.99
289.74
2.4
1.6
1.50
1.49
g/l
0.00
226
142
264
267
34.59
266.46
7.1
2.1
0.20
0.22
g/l
1.88
256
253
106
17
88.06
197.72
1.2
1.0
—
—
—
0
0
113
26
62.97
196.97
2.0
1.3
—
—
titre
—
0
0
97
13
101.87
185.41
1.2
1.0
—
—
—
0
0
243
375
17.96
176.53
2.4
1.2
843.72
331.25
titre
5.07
129
64
104
46
31.42
148.55
1.1
1.0
—
—
—
0
0
104
49
29.47
144.90
1.2
1.1
—
—
—
0
0
200
368
11.01
119.60
7.1
3.2
17.87
8.27
umol/l
2.66
194
321
181
314
10.61
112.88
1.5
1.4
—
—
—
0
0
251
637
10.77
111.48
2.4
1.4
2.90
2.29
g/l
4.89
225
382
84
45
24.06
109.91
1.3
1.6
270.00
220.08
u/ml
0.46
40
24
85
53
20.70
103.58
1.3
1.5
—
—
—
0
0
204
446
9.28
102.34
1.6
1.6
—
—
—
0
0
352
1628
60.51
100.58
24.4
6.5
16.66
11.08
umol/l
3.74
352
1545
97
92
14.08
93.27
1.4
1.5
—
—
—
0
0
76
47
20.24
92.62
1.3
1.5
145.71
152.13
au/ml
0.10
15
17
279
940
9.83
89.07
19.8
4.7
—
—
—
0
0
178
413
7.56
81.48
2.3
2.0
2.43
2.37
g/l
0.70
173
383
181
434
7.39
79.93
2.5
2.1
17.09
13.65
umol/l
3.92
175
402
338
1506
22.27
78.50
23.3
4.5
0.04
0.04
e9/l
1.19
310
1244
337
1501
21.32
78.12
23.3
4.5
0.54
0.56
e9/l
0.83
312
1245
338
1538
21.47
75.74
23.4
4.5
1.71
1.91
e9/l
2.12
317
1320
87
96
11.64
74.85
2.7
1.2
8.26
4.35
iu/ml
0.61
25
18
338
1567
20.78
73.31
23.8
4.9
0.17
0.18
e9/l
1.19
317
1331
312
1344
11.09
72.15
17.6
11.4
1.14
1.17
inr
0.70
279
1094
133
271
7.21
67.80
1.4
1.4
—
—
—
0
0
64
51
15.05
67.56
1.1
1.2
—
—
—
0
0
110
191
7.86
65.08
1.3
1.3
—
—
—
0
0
338
1742
17.07
60.10
26.5
8.5
3.55
4.04
e9/l
3.87
316
1475
298
1390
7.73
57.72
4.7
2.3
76.41
77.97
nmol/l
0.47
291
1239
46
26
20.15
57.71
1.3
1.2
—
—
—
0
0
353
2373
30.16
50.20
37.7
6.9
101.12
79.96
u/l
7.46
353
2227
63
77
9.71
49.48
1.7
1.2
14.46
3.65
u/ml
—
17
10
103
217
6.25
49.42
7.8
3.5
0.26
0.82
%
1.89
42
57
200
744
4.81
48.54
1.6
1.3
1.14
0.86
u/ml
0.47
53
207
226
924
4.90
48.43
4.6
3.5
7.40
7.40
ph
0.59
166
630
106
235
5.98
48.07
8.5
3.5
0.49
1.02
%
1.58
47
64
62
77
9.52
48.05
1.6
1.2
12.95
2.43
u/ml
—
15
8
80
137
7.23
47.04
1.6
1.5
0.13
0.37
mg/l
2.99
20
57
103
230
5.88
46.21
8.9
3.9
0.02
0.06
%
0.33
41
48
116
302
5.20
43.47
4.1
2.3
39.51
30.75
u/l
2.27
103
251
289
1524
5.60
42.22
8.8
6.4
1.21
1.21
mmol/l
0.26
260
1321
276
1414
5.12
41.60
31.1
9.1
0.00
0.00
e9/l
0.60
241
1114
97
225
5.54
41.39
9.0
3.6
0.03
0.18
%
1.28
37
55
63
97
7.66
40.59
2.1
1.1
3.84
—
iu/ml
—
7
0
216
962
4.13
38.58
5.1
2.3
68.06
67.37
u/l
0.03
211
888
335
2122
9.66
36.16
11.3
3.1
103.38
45.53
u/l
11.70
330
1992
56
87
7.44
35.64
2.1
1.1
—
—
—
0
0
170
699
3.72
32.93
3.8
2.0
2.73
2.79
mg/l
0.13
153
589
343
2300
12.02
32.59
11.7
3.4
19.00
11.40
mm/h
12.71
336
2117
255
1380
3.93
31.91
7.2
5.7
1.21
1.22
mmol/l
0.99
249
1267
115
375
4.04
31.13
3.9
1.3
188.45
91.29
ug/g
1.85
104
283
161
679
3.49
29.28
12.1
3.2
—
—
—
0
0
62
145
4.96
25.53
3.9
3.1
1058.56
1353.06
u/ml
0.08
54
125
189
963
3.03
23.71
14.9
6.0
—
—
—
0
0
48
96
5.62
23.53
1.8
1.5
1.28
1.39
g/l
0.27
41
84
195
1033
2.94
22.42
2.8
2.3
—
—
—
0
0
28
34
8.85
21.67
5.3
2.2
3.76
5.17
e9/l
1.17
28
34
125
537
3.04
20.81
1.7
1.9
—
—
—
0
0
269
1786
3.02
18.85
7.2
4.4
6.45
6.43
mmol/l
0.05
258
1678
236
1488
2.71
17.83
3.0
2.6
—
—
estimate
—
0
0
151
772
2.65
17.52
6.3
3.9
—
—
—
0
0
71
243
3.40
17.04
1.3
1.2
—
—
—
0
0
57
169
3.82
16.98
1.6
2.7
—
—
—
0
0
89
351
3.04
16.84
3.7
4.2
3.21
10.40
ug/l
2.90
62
287
31
56
5.96
16.79
5.2
2.2
56.74
59.54
%
0.47
31
56
100
423
2.89
16.66
1.2
1.2
—
—
—
0
0
150
787
2.56
16.24
2.3
2.2
—
—
—
0
0
22
9
25.92
16.20
2.0
2.2
4.55
4.32
ug/l
—
22
9
28
24
12.55
15.84
1.7
1.1
—
—
—
0
0
80
312
3.01
15.33
1.7
1.2
—
—
—
0
0
111
518
2.65
15.14
3.3
2.6
2.29
2.99
e6/l
0.23
55
220
175
1013
2.42
15.00
3.9
2.9
16.12
106.35
e6/l
0.75
135
740
26
23
12.09
14.53
1.8
1.1
—
—
—
0
0
37
90
4.47
14.31
1.6
2.4
15.38
10.38
g/l
3.68
37
84
353
3099
9.32
14.01
38.5
12.9
14.98
23.67
mg/l
11.36
334
2451
156
882
2.36
13.83
3.8
2.9
0.16
0.53
e6/l
2.98
115
606
114
563
2.50
13.63
3.3
2.6
0.97
0.97
e6/l
0.00
59
266
92
411
2.67
13.53
7.2
6.5
104.25
104.30
mmol/l
0.04
92
411
242
1663
2.40
13.42
5.1
3.6
0.00
0.00
estimate
0.50
63
320
188
1165
2.29
13.27
5.0
3.5
33.38
65.87
e6/l
1.24
140
783
73
293
2.87
13.16
3.3
3.9
2.30
1.75
mmol/l
0.62
63
245
242
1675
2.36
13.02
5.1
3.6
0.00
10.91
estimate
0.80
63
321
74
308
2.77
12.41
3.4
3.9
7.39
7.39
ph
0.01
43
176
242
1697
2.31
12.29
5.3
3.6
0.00
0.01
estimate
0.50
58
307
86
391
2.58
12.08
2.0
1.9
—
—
—
0
0
110
573
2.33
11.40
3.1
2.6
511.76
526.50
mosm/kgh2o
0.28
104
499
23
27
9.02
11.21
1.0
1.1
—
—
—
0
0
18
14
13.46
10.76
2.0
1.8
11.17
10.87
umol/l
0.09
18
14
54
207
2.89
10.48
2.8
2.4
70.41
75.97
e9/l
0.48
40
147
63
264
2.68
10.34
7.9
7.5
—
—
—
0
0
352
3177
6.54
10.15
33.2
15.5
138.91
139.83
mmol/l
8.91
352
3103
158
990
2.06
10.03
3.6
3.1
—
—
—
0
0
352
3181
6.46
9.97
33.3
15.6
3.88
3.95
mmol/l
6.65
352
3096
15
9
17.31
9.96
1.1
1.1
—
—
—
0
0
64
278
2.58
9.75
2.5
2.2
0.07
0.00
estimate
0.47
14
56
148
927
2.01
9.22
3.6
2.9
—
0.13
—
0
16
22
50
4.62
9.21
1.2
2.3
—
—
—
0
0
116
667
2.09
9.12
3.0
2.4
9.43
7.07
e6/l
0.47
111
607
303
2466
2.47
9.08
5.6
3.1
15.03
14.60
pmol/l
2.62
288
2246
125
741
2.05
9.04
3.3
2.7
323.14
328.80
umol/l
0.27
118
660
13
8
16.79
8.61
5.2
1.5
0.56
0.58
mmol/l
—
13
8
186
1306
1.88
7.90
2.4
2.0
96.59
97.79
pmol/l
0.13
108
625
27
81
3.52
7.82
3.2
3.1
0.79
2.65
index
1.38
14
43
95
535
2.05
7.74
1.4
1.3
12.95
3.66
u/ml
0.84
33
196
126
785
1.93
7.69
4.8
3.3
—
0.14
—
0
7
101
589
1.99
7.44
3.9
3.4
160.26
207.52
ng/l
0.21
76
431
186
1325
1.84
7.38
4.3
3.3
6.34
6.21
ph
0.90
104
732
144
957
1.84
7.08
1.7
1.5
—
—
—
0
0
132
854
1.86
7.07
2.0
1.6
17.51
21.19
nmol/l
2.49
124
704
18
44
4.25
6.90
1.7
2.1
—
—
—
0
0
100
596
1.94
6.85
1.4
1.3
20.33
22.90
iu/ml
0.24
43
177
13
14
9.59
6.84
2.5
5.4
1500.15
806.21
u/ml
0.81
13
14
353
3291
5.34
6.63
45.2
10.3
39.97
26.03
u/l
15.43
353
3191
10
7
14.64
6.43
2.1
1.0
—
—
—
0
0
23
71
3.39
6.39
1.3
3.7
1.10
2.24
ratio
0.77
17
39
157
1098
1.76
6.34
4.3
3.4
2.35
2.37
mmol/l
1.02
151
1003
11
10
11.30
6.34
1.5
2.6
0.69
0.39
e9/l
—
11
10
50
236
2.30
6.28
2.5
2.2
0.65
0.26
e6/l
0.51
50
218
353
3297
5.23
6.28
46.3
17.0
70.99
72.18
umol/l
0.59
353
3249
13
17
7.89
6.17
1.1
1.0
—
—
—
0
0
9
6
15.33
5.93
1.1
1.8
—
—
—
0
0
16
31
5.35
5.77
1.6
1.2
—
—
—
0
0
178
1315
1.70
5.73
2.4
2.0
—
—
—
0
0
9
7
13.14
5.61
3.9
3.1
64.11
38.71
u/l
—
9
7
22
72
3.19
5.59
1.7
1.7
2.67
2.54
iu/l
—
10
29
8
6
13.59
5.10
1.0
1.3
—
—
—
0
0
8
6
13.59
5.10
1.0
1.0
—
—
—
0
0
10
12
8.53
5.09
1.4
6.7
52.19
37.62
%
—
10
12
168
1260
1.63
4.85
5.1
3.5
0.00
0.04
estimate
1.39
45
253
9
10
9.19
4.81
2.4
1.2
—
—
—
0
0
44
221
2.13
4.76
2.3
3.1
74.05
76.66
ng/l
0.08
36
194
7
5
14.24
4.59
1.1
1.0
—
—
—
0
0
8
8
10.19
4.54
1.8
2.1
51.62
125.75
e6/l
—
8
8
12
23
5.36
4.49
2.5
2.3
—
—
—
0
0
9
12
7.66
4.38
1.2
6.2
7.11
12.92
%
—
9
12
9
12
7.66
4.38
1.3
6.2
85.78
66.58
%
—
9
12
38
187
2.15
4.33
1.3
1.2
213.39
88.64
u/ml
0.80
15
61
55
312
1.90
4.25
9.8
7.3
7.43
7.41
ph
1.06
31
162
138
1016
1.58
4.14
2.8
2.9
6.89
7.55
mmol/l
0.99
122
864
257
2183
1.62
4.11
4.1
3.9
—
0.00
—
0
5
54
308
1.89
4.11
9.9
7.3
0.72
0.87
mmol/l
0.09
44
267
12
26
4.74
4.09
1.2
1.1
—
—
—
0
0
125
907
1.58
3.96
4.1
3.0
0.00
0.01
estimate
0.50
45
245
32
153
2.20
3.92
2.7
1.9
—
—
—
0
0
62
375
1.79
3.91
1.6
1.4
—
—
—
0
0
31
147
2.21
3.88
3.5
3.2
4.34
4.61
pmol/l
0.72
31
138
12
28
4.40
3.85
1.1
1.1
—
—
—
0
0
14
39
3.69
3.74
1.6
1.3
12.26
20.17
ng/l
2.78
14
39
43
235
1.94
3.71
4.2
3.3
—
—
—
0
0
45
251
1.91
3.66
3.5
2.3
5.96
6.08
ph
0.45
35
168
85
571
1.64
3.66
1.7
1.6
462.11
35010926.94
pmol/l
0.72
74
477
7
9
7.90
3.57
1.4
1.9
14.50
15.70
%
—
7
9
30
150
2.09
3.31
2.5
3.6
1.22
1.25
%
0.09
30
150
19
78
2.52
3.27
1.6
1.4
287.48
297.43
ug/g
0.10
13
42
26
125
2.16
3.17
2.4
2.2
0.00
0.00
estimate
—
10
41
11
30
3.75
3.11
1.3
1.3
—
—
—
0
0
6
8
7.60
3.06
1.2
8.0
9.33
15.00
%
—
6
8
64
418
1.65
3.06
1.8
1.6
1057.53
1226.39
nmol/l
0.93
52
300
8
17
4.79
2.93
1.0
1.5
569.50
687.53
mg
—
8
17
297
2689
1.61
2.91
49.0
17.1
331.98
332.10
g/l
0.08
297
2675
118
895
1.47
2.89
5.5
3.6
0.00
0.01
estimate
0.69
59
296
21
97
2.24
2.83
3.3
2.8
261.00
189.76
mg/l
0.27
12
38
14
53
2.71
2.83
1.6
3.2
4.96
8.13
pmol/l
1.27
14
53
25
125
2.07
2.78
1.3
1.2
—
—
—
0
0
5
6
8.43
2.75
1.6
4.2
55.00
37.67
%
—
5
6
142
1128
1.43
2.69
4.1
3.2
35.81
62.48
ng/l
0.37
100
753
8
19
4.28
2.69
1.1
1.0
—
—
—
0
0
22
106
2.15
2.69
6.3
3.7
0.95
0.86
%
0.45
22
98
12
43
2.85
2.67
1.2
1.3
17.39
16.61
u/l
0.05
12
37
11
35
3.21
2.66
1.1
1.2
—
—
—
0
0
24
121
2.05
2.62
1.1
1.1
—
—
—
0
0
34
195
1.82
2.57
12.2
8.9
1.20
1.39
%
0.77
34
195
6
11
5.53
2.55
1.2
2.0
5.72
6.82
mmol/l
—
6
11
353
3416
3.00
2.48
58.5
19.9
30.70
30.18
pg
4.91
353
3377
353
3416
3.00
2.48
58.9
20.1
6.38
6.56
e9/l
0.83
353
3331
353
3416
3.00
2.48
59.5
20.4
40.08
40.35
%
0.66
353
3373
353
3416
3.00
2.48
58.7
20.0
4.38
4.50
e12/l
5.26
353
3330
353
3415
3.01
2.48
58.8
20.0
235.80
255.07
e9/l
6.35
353
3344
353
3415
3.01
2.48
58.6
20.0
92.39
90.70
fl
7.90
353
3376
10
32
3.18
2.45
3.8
2.8
—
—
—
0
0
6
12
5.06
2.41
6.5
2.6
—
—
—
0
0
33
192
1.79
2.40
12.3
8.9
0.63
0.64
%
0.05
33
192
5
8
6.32
2.38
1.0
8.0
34.20
25.00
%
—
5
8
31
178
1.81
2.35
1.2
1.3
—
—
—
0
0
353
3418
2.96
2.34
59.2
20.2
133.04
134.98
g/l
1.85
353
3377
21
106
2.04
2.30
1.1
1.2
122.14
232.95
miu/ml
—
7
52
8
23
3.53
2.28
1.9
4.1
—
—
—
0
0
6
13
4.67
2.28
1.0
1.0
—
—
—
0
0
35
211
1.73
2.26
3.3
2.4
115.43
172.29
ng/l
1.02
30
199
5
9
5.62
2.22
5.4
3.1
—
—
—
0
0
97
744
1.42
2.17
2.3
1.8
2.24
1.21
mg/l
1.58
82
579
14
61
2.35
2.17
2.9
2.0
6.69
4.90
mmol/24h
2.04
14
54
11
42
2.67
2.16
3.3
3.2
—
—
—
0
0
6
14
4.34
2.16
1.3
2.1
64.83
50.76
ug/l
—
6
14
27
153
1.83
2.15
2.1
3.6
0.77
0.60
%
1.66
27
153
10
37
2.75
2.08
1.2
1.1
—
—
—
0
0
62
440
1.49
2.08
1.4
1.3
—
—
—
0
0
5
10
5.05
2.07
1.0
2.8
—
—
—
0
0
8
27
3.01
1.94
1.1
1.7
—
—
—
0
0
313
2935
1.52
1.90
4.6
4.0
1.24
1.26
mmol/l
0.20
299
2697
7
22
3.22
1.89
2.9
1.2
3.13
3.33
mg/l
—
7
22
9
34
2.69
1.87
3.3
4.1
2.38
2.59
nmol/l
—
9
34
8
28
2.90
1.87
1.1
1.1
—
—
—
0
0
326
3088
1.61
1.84
5.7
4.9
4.60
4.75
mmol/l
2.07
316
2875
117
949
1.35
1.84
3.5
3.6
6.18
8.27
mg/mmol
0.37
69
565
337
3221
1.75
1.81
26.8
11.6
—
—
—
0
0
5
13
3.88
1.72
1.2
1.0
—
—
—
0
0
93
737
1.35
1.69
5.7
3.7
1.02
1.02
kg/l
0.82
72
468
20
112
1.83
1.68
1.7
2.5
135.18
6271.08
u/l
—
9
48
7
25
2.83
1.65
1.3
1.4
90.27
90.01
%
—
7
25
12
56
2.18
1.63
2.3
2.0
—
—
—
0
0
8
32
2.53
1.60
2.8
1.9
8.88
10.84
mmol/l
—
8
32
14
71
2.01
1.56
3.9
4.9
4.11
3.85
mmol/l
0.81
14
71
324
3085
1.52
1.54
5.4
4.7
1.50
1.52
mmol/l
0.46
311
2856
18
303
0.57
1.52
1.1
1.4
—
—
—
0
0
27
171
1.63
1.51
3.4
3.6
7.44
7.42
ph
1.38
20
138
328
3134
1.54
1.50
6.1
5.6
2.71
2.79
mmol/l
0.94
321
2910
112
928
1.30
1.48
2.9
3.0
33.33
49.47
mg/l
0.68
67
566
9
38
2.40
1.46
1.7
2.7
—
—
—
0
0
7
28
2.53
1.46
2.4
1.7
—
—
—
0
0
10
46
2.21
1.41
8.0
5.5
10.80
10.80
mmol/l
—
10
40
10
46
2.21
1.41
8.0
5.5
103.50
106.72
mmol/l
—
10
40
9
41
2.23
1.38
1.6
1.3
—
—
—
0
0
9
41
2.23
1.38
1.6
1.3
—
—
—
0
0
9
41
2.23
1.38
1.6
1.3
—
—
—
0
0
9
41
2.23
1.38
1.6
1.3
—
—
—
0
0
11
54
2.07
1.34
1.3
1.0
—
—
—
0
0
51
382
1.39
1.31
1.5
1.5
—
—
—
0
0
6
24
2.52
1.31
2.2
2.1
—
—
—
0
0
8
34
2.38
1.30
2.0
1.8
34.63
32.18
pg
—
8
34
5
18
2.80
1.29
1.0
1.1
—
—
—
0
0
14
77
1.85
1.27
5.6
4.7
—
—
—
0
0
6
25
2.42
1.25
2.3
1.4
—
—
—
0
0
23
149
1.58
1.20
2.7
2.2
—
—
—
0
0
45
336
1.39
1.19
1.5
1.6
—
—
—
0
0
17
102
1.70
1.18
1.1
1.1
—
—
—
0
0
8
40
2.02
1.12
1.1
1.1
—
—
—
0
0
7
31
2.28
1.11
1.3
2.5
—
—
—
0
0
7
31
2.28
1.11
1.0
8.5
11.46
11.25
%
—
7
31
27
188
1.47
1.05
2.9
2.3
15.08
13.11
nmol/l
0.51
22
178
5
22
2.29
1.03
2.8
1.4
—
—
—
0
0
11
61
1.83
0.99
1.1
5.3
55.45
63.65
%
0.60
11
61
5
23
2.19
0.98
4.8
4.0
70.00
185.43
nmol/l
—
5
23
25
174
1.47
0.98
1.4
1.6
26.45
23.45
iu/l
0.20
20
141
314
3023
1.31
0.92
5.5
4.9
5.78
5.81
mmol/l
0.15
309
2773
31
234
1.36
0.81
1.1
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
6
33
1.83
0.79
3.0
2.5
4.05
3.85
mmol/l
—
6
33
6
33
1.83
0.79
3.0
2.5
104.00
106.67
mmol/l
—
6
33
6
33
1.83
0.79
3.0
2.5
1.20
1.19
mmol/l
—
6
33
14
90
1.58
0.79
1.6
2.7
—
—
—
0
0
28
369
0.74
0.79
1.9
1.6
—
—
—
0
0
5
98
0.50
0.79
14.2
8.4
—
—
—
0
0
151
1375
1.17
0.74
1.9
1.8
1.25
1.35
mmol/l
1.14
137
1153
7
40
1.76
0.71
1.4
1.2
—
—
—
0
0
8
49
1.65
0.62
1.4
1.6
—
—
—
0
0
37
301
1.26
0.60
1.5
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
99.87
—
0
23
6
35
1.73
0.58
1.3
1.1
—
—
—
0
0
6
39
1.55
0.53
1.0
2.7
—
—
—
0
0
12
84
1.44
0.50
2.5
1.9
—
—
—
0
0
15
110
1.38
0.49
2.6
1.2
0.84
0.92
g/l
0.79
15
110
7
46
1.53
0.48
2.0
1.7
—
—
—
0
0
13
94
1.40
0.46
1.2
1.2
—
—
—
0
0
36
302
1.21
0.46
1.5
1.7
—
—
—
0
0
17
131
1.31
0.43
3.6
3.5
—
—
—
0
0
28
336
0.82
0.42
2.9
3.1
0.53
0.78
ug/l
2.90
18
206
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
18.3
—
1005.71
—
0
17
10
71
1.42
0.39
1.3
2.1
—
—
—
0
0
19
151
1.27
0.39
1.0
1.1
—
—
—
0
0
9
124
0.72
0.35
1.1
1.3
—
—
—
0
0
6
45
1.34
0.34
1.3
1.4
—
—
—
0
0
133
1256
1.09
0.33
3.2
3.0
—
—
—
0
0
10
77
1.31
0.26
1.2
1.1
—
—
—
0
0
5
72
0.69
0.26
1.8
1.6
—
—
—
0
0
10
78
1.29
0.24
1.5
1.9
3.87
3.61
mmol/l
—
10
72
0
11
0.00
0.21
0.0
1.0
—
29.19
—
0
11
0
11
0.00
0.21
0.0
1.9
—
124.18
—
0
11
12
145
0.82
0.21
2.1
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
31.73
—
0
6
0
13
0.00
0.21
0.0
1.9
—
147.00
—
0
8
5
70
0.71
0.17
1.8
1.5
—
—
—
0
0
58
549
1.07
0.14
4.2
5.3
1.12
2.99
ug/l
2.25
58
495
25
271
0.92
0.12
1.4
1.9
3.21
3.47
mmol/l
0.42
14
201
6
71
0.84
0.07
1.2
1.2
—
—
—
0
0
10
89
1.13
0.07
1.6
1.9
491.00
452.27
mg/l
—
10
83
11
121
0.91
0.06
1.3
1.7
—
—
—
0
0
14
151
0.92
0.05
1.4
1.6
—
—
—
0
0
10
102
0.98
0.00
1.2
1.9
—
—
—
0
0
14
141
0.99
0.00
1.4
1.7
—
—
—
0
0
15
153
0.98
0.00
1.3
1.6
—
—
—
0
0
15
153
0.98
0.00
1.3
1.6
—
—
—
0
0
15
153
0.98
0.00
1.3
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
8.0
—
0.38
—
0
9
6
64
0.94
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
38.43
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
0.43
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
11.17
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
78.20
—
0
5
0
8
0.00
-0.00
0.0
5.9
—
0.48
—
0
8
0
7
0.00
-0.00
0.0
5.7
—
7.14
—
0
7
0
5
0.00
-0.00
0.0
2.0
—
10949.40
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
0.02
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AUTOHEP – Autoimmune hepatitis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).