vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
225 |
4. Check minimum number of eventsNone |
225 |
5. Include endpointsNone |
225 |
6. Filter based on genotype QC (FinnGen only) |
192 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_STRICT
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia vascularis subito incipiens
Similar endpoints
↥List of similar endpoints to
Vascular dementia (sudden onset)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 192 | 56 | 136 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | 78.23 | 80.15 | 77.44 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 203
- Matched controls
- 2030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
290.6
202
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
555.3
100.6
92
*
F03
ICD-10 Finland
Unspecified dementia
150.9
62.0
63
6
N05AX08
ATC
risperidone; systemic
12.3
49.0
56
61
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
+∞
25.6
24
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
25.6
24
*
N05AH04
ATC
quetiapine; oral
6.0
21.8
44
89
N06DX01
ATC
memantine; oral
67.6
21.4
24
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.8
21.2
61
168
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
20.1
19
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
61.3
19.3
22
*
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
19.1
18
*
N06DA02
ATC
donepezil; oral
38.8
17.0
21
6
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
+∞
15.8
15
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.1
14.1
33
75
N06DA03
ATC
rivastigmine; oral, transdermal
43.2
13.4
16
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.3
13.1
67
267
F01
ICD-10 Finland
Vascular dementia
+∞
12.6
12
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
5.9
12.1
23
43
N05BA04
ATC
oxazepam; oral
3.1
12.0
65
266
N05AD01
ATC
haloperidol; systemic
6.0
11.4
21
38
G30.8
ICD-10 Finland
Other Alzheimer disease
115.7
10.5
11
*
N06DA04
ATC
galantamine; oral
115.7
10.5
11
*
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
+∞
10.5
10
*
WYA20
NOMESCO Finland
Home visit
9.5
10.0
20
23
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.2
9.9
28
74
R41.0
ICD-10 Finland
Disorientation, unspecified
8.2
9.7
21
28
N06AB04
ATC
citalopram; systemic
3.0
9.7
54
222
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
104.7
9.5
10
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
9.1
54
229
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
52.3
8.8
10
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.5
8.6
33
108
Z75.5
ICD-10 Finland
Holiday relief care
9.5
8.2
16
18
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.2
8.0
36
130
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
46.8
7.8
9
*
N30.0
ICD-10 Finland
Acute cystitis
2.9
7.8
40
156
A28
ICPC
Limited function/disability NOS
2.5
7.8
61
296
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
7.6
98
589
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.4
7.6
19
32
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.3
7.5
20
50
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.5
7.5
19
46
N05AH03
ATC
olanzapine; systemic
12.7
7.2
12
10
N06AB10
ATC
escitalopram; oral
3.3
6.6
26
86
R53
ICD-10 Finland
Malaise and fatigue
2.3
6.6
61
316
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
+∞
6.3
6
*
F01.14
ICD-10 Finland
Multi-infarct dementia's other mixed symptoms of mixed type
+∞
6.3
6
*
G04BD07
ATC
tolterodine; oral
3.5
6.2
22
68
B01AC07
ATC
dipyridamole; systemic
2.5
6.1
42
189
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
256
0.28
4.07
2.3
2.1
1.18
1.21
mmol/l
—
8
207
54
800
0.56
3.34
4.9
5.9
2.20
2.33
mmol/l
0.65
54
711
52
773
0.56
3.22
4.3
5.0
1.29
1.38
mmol/l
0.85
52
687
58
798
0.62
2.46
5.3
5.8
6.25
6.20
mmol/l
0.12
52
702
5
8
6.37
2.38
1.6
1.6
—
—
—
0
0
14
62
2.35
2.13
3.0
1.7
—
—
—
0
0
15
71
2.20
1.98
1.3
1.4
—
—
—
0
0
0
50
0.00
1.91
0.0
2.6
—
1.01
—
0
37
9
195
0.44
1.84
3.3
2.6
21.46
21.82
%
—
9
185
44
608
0.65
1.78
3.3
3.9
14.99
15.27
pmol/l
0.26
44
537
0
46
0.00
1.73
0.0
2.7
—
0.00
—
0
36
12
55
2.26
1.71
3.1
1.5
—
—
—
0
0
10
208
0.45
1.68
3.1
2.6
2.07
2.18
g/l
—
10
198
0
44
0.00
1.53
0.0
2.7
—
0.00
—
0
34
12
58
2.14
1.52
3.3
4.0
1.52
1.55
%
0.04
12
53
14
243
0.54
1.39
2.9
3.2
0.75
1.05
ug/l
—
9
167
0
41
0.00
1.32
0.0
2.9
—
0.00
—
0
34
29
408
0.66
1.24
3.0
3.2
100.69
145.08
ug/l
1.02
29
379
24
349
0.65
1.20
5.2
4.9
20.18
23.22
%
—
9
194
5
112
0.43
1.17
10.6
9.6
—
—
—
0
0
23
335
0.65
1.16
4.0
4.1
16.16
12.81
mg/mmol
0.16
16
221
16
253
0.60
1.14
1.7
1.9
462.69
456.21
pmol/l
0.04
16
214
53
658
0.74
1.11
31.6
28.2
14.21
14.29
%
0.13
53
646
78
905
0.78
0.97
39.5
29.7
100.83
94.01
umol/l
0.32
78
884
42
525
0.75
0.90
7.2
7.9
4.99
4.41
e9/l
0.65
36
454
10
166
0.58
0.88
3.8
5.7
105.20
104.09
mmol/l
—
10
166
79
902
0.80
0.82
37.5
27.2
138.86
139.29
mmol/l
0.57
79
875
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
6
33
1.84
0.79
1.0
1.5
—
—
—
0
0
6
33
1.84
0.79
1.0
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.3
—
—
—
0
0
40
494
0.76
0.78
4.1
4.6
33.29
33.58
g/l
0.13
35
455
80
907
0.81
0.77
41.1
32.2
91.29
92.05
fl
0.58
80
886
39
479
0.77
0.73
6.6
4.8
0.00
0.00
estimate
—
7
117
40
481
0.79
0.63
6.9
4.9
0.00
13.65
estimate
—
7
119
41
487
0.80
0.58
6.9
4.9
0.00
0.00
estimate
—
6
112
0
23
0.00
0.58
0.0
2.6
—
83.17
—
0
23
5
88
0.56
0.57
2.2
2.4
27.80
33.30
u/l
—
5
70
6
40
1.51
0.52
1.5
1.4
—
—
—
0
0
80
877
0.86
0.48
32.2
21.9
29.11
31.84
mg/l
0.42
75
774
5
33
1.53
0.41
2.8
3.8
26.60
31.06
mg/l
—
5
27
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
4.0
—
786.50
—
0
16
32
368
0.85
0.34
7.1
5.1
0.00
0.08
estimate
—
6
92
27
233
1.18
0.29
2.6
1.9
—
—
—
0
0
45
410
1.13
0.25
3.3
3.9
—
—
—
0
0
30
337
0.87
0.24
2.6
2.5
3.53
3.18
mg/l
0.21
25
298
6
81
0.73
0.24
3.7
1.6
—
—
—
0
0
34
306
1.13
0.23
3.3
2.4
54.58
54.75
u/l
0.02
34
273
10
79
1.28
0.22
2.8
1.5
430.20
439.72
nmol/l
—
10
69
0
11
0.00
0.21
0.0
1.5
—
2.86
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
10
122
0.81
0.19
2.7
5.6
113.00
115.63
g/l
—
10
117
14
162
0.85
0.17
1.8
1.8
—
—
—
0
0
24
266
0.89
0.17
6.5
4.4
0.00
0.03
estimate
—
5
75
53
560
0.93
0.15
5.2
5.1
12.79
13.58
umol/l
0.24
53
530
15
169
0.88
0.13
1.9
1.8
—
—
—
0
0
38
401
0.94
0.10
2.1
2.5
71.06
81.45
nmol/l
1.43
33
345
29
274
1.07
0.08
3.2
2.7
34.31
36.60
u/l
0.09
29
265
9
84
1.07
0.07
2.3
1.7
—
—
—
0
0
42
436
0.95
0.06
2.3
3.2
—
—
estimate
—
0
0
47
485
0.96
0.05
2.4
2.5
92.56
90.82
pmol/l
0.09
33
265
10
90
1.12
0.05
3.8
4.9
24.16
24.14
mmol/l
—
10
85
15
139
1.09
0.05
4.2
3.2
2.54
1.96
mmol/l
—
9
112
45
463
0.96
0.04
6.4
5.2
41.53
191.04
ng/l
0.63
36
393
35
340
1.04
0.03
3.6
2.2
—
—
—
0
0
10
93
1.08
0.02
2.5
3.4
77.30
97.81
ng/l
—
10
80
10
106
0.94
0.01
3.6
5.3
36.70
32.89
%
—
10
65
16
164
0.97
0.00
2.5
4.9
10.61
11.10
kpa
0.21
16
157
67
668
1.00
0.00
35.8
30.3
328.76
329.30
g/l
0.16
67
656
16
163
0.98
0.00
2.5
5.0
4.88
5.25
kpa
0.74
16
155
26
255
1.02
0.00
1.7
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
113.50
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
11
110
1.00
-0.00
5.5
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.84
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.7
—
0.89
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
9.85
—
0
6
0
7
0.00
-0.00
0.0
3.0
—
4.61
—
0
7
0
7
0.00
-0.00
0.0
3.0
—
10.53
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: VD_SO – Vascular dementia (sudden onset)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).