Fracture of spine, level unspecified

ST19_FRACT_SPINE_LEVEL_UNSPE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T08 Cause of death: ICD-10 — T08 2 out of 7 registries used, show all original rules.	82
4. Check minimum number of events None	82
5. Include endpoints None	82
6. Filter based on genotype QC (FinnGen only)	74

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T0[8-9]|T1[0-4]
Name in latin: Fractura columnae vertebralis, regione non specificata

NAME	ST19_FRACT_SPINE_LEVEL_UNSPE
CONTROL_EXCLUDE	ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T08
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T08
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fracture of spine, level unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	738	368	366
Only index persons	637	305	332
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	68.87	77.70	59.99
Only index persons	66.68	76.11	58.01

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	74	32	42
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	67.46	65.02	69.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
78: Matched controls
780

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T08

ICD-10 Finland

Fracture of spine, level unspecified

+∞

112.2

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

10.2

20.8

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

19.8

16.5

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

5.5

12.7

176

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

20.8

12.4

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

24.7

11.7

W19

ICD-10 Finland

Unspecified fall

6.7

11.6

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

26.0

11.2

X59

ICD-10 Finland

Exposure to unspecified factor

4.9

9.6

W17

ICD-10 Finland

Other fall from one level to another

17.0

8.6

S06.0

ICD-10 Finland

Concussion

5.4

8.5

M54.5

ICD-10 Finland

Low back pain

3.4

6.6

184

NA2AD

NOMESCO Finland

Thoracic spine CT examination

75.8

6.5

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.1

6.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

291

3.00

5.15

2.8

2.5

75.63

74.42

nmol/l

0.09

255

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.94

4.14

2.1

1.6

—

(3032080) INR in Blood by Coagulation assay

351

2.75

4.14

27.0

16.7

1.48

1.29

inr

1.14

293

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

351

2.75

4.14

15.7

6.5

1.21

mmol/l

0.13

303

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

125

2.62

3.62

2.5

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

318

2.45

3.55

3.0

2.0

90.39

92.30

pmol/l

0.12

153

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.75

3.19

9.3

6.6

26.22

24.84

mmol/l

0.53

(3023368) Bacteria identified in Blood by Culture

212

2.30

3.16

5.5

4.0

—

(3000991) Gas panel - Venous blood

2.96

3.09

7.8

7.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.12

2.98

1.8

1.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

5.79

2.94

5.9

1.5

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.80

2.81

2.2

1.9

25.53

24.35

mmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.53

2.79

2.2

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

7.53

2.58

11.6

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.20

2.54

2.6

1.9

—

(3022313) Gas panel - Capillary blood

3.20

2.54

6.9

2.9

—

(3016879) Cocaine [Presence] in Urine

4.69

2.54

9.7

1.4

—

(3018418) pH of Serum or Plasma

211

2.08

2.50

6.6

4.3

7.40

0.33

152

(3012544) pH of Venous blood

2.47

2.0

3.3

7.39

—

(3011288) Drugs identified in Urine by Screen method Nominal

5.31

2.45

1.8

1.6

—

(3027008) Opiates [Presence] in Urine

4.41

2.42

9.6

1.5

—

(3028300) Cannabinoids [Presence] in Urine

4.41

2.42

9.7

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

4.41

2.42

9.7

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.22

2.38

5.7

5.9

16.50

16.62

—

(3026008) Bacteria identified in Urine by Culture

230

1.95

2.13

7.0

3.3

—

(1616796) Gas panel - Central venous blood

5.26

2.10

4.6

3.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.97

0.0

1.3

—

(3039000) Anion gap in Blood by calculation

4.77

1.97

9.8

4.1

10.00

10.27

mmol/l

—

(3018572) Chloride [Moles/volume] in Blood

4.77

1.97

9.8

4.1

104.00

104.82

mmol/l

—

(42870588) Differential panel, method unspecified - Blood

237

1.86

1.90

6.6

5.2

—

(3027944) Amphetamines [Presence] in Urine

3.73

1.87

11.2

1.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.52

1.78

1.0

2.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.32

1.77

2.4

2.2

1.52

1.79

0.57

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.45

1.73

2.7

3.9

1.21

1.23

mmol/l

0.98

(3018010) Neutrophils/Leukocytes in Blood

321

1.76

1.62

7.9

5.4

59.48

58.73

0.14

305

(3019309) Folate [Moles/volume] in Red Blood Cells

143

1.86

1.59

1.8

1.6

770.33

1141.61

nmol/l

1.76

113

(3019977) pH of Arterial blood

2.03

1.56

10.0

5.2

7.40

7.42

—

(3037756) Immunofixation for Serum or Plasma

3.49

1.55

1.4

1.3

—

(3024928) Oxygen saturation in Venous blood

3.49

1.55

1.6

2.9

49.80

53.65

—

(3030467) Casts [#/volume] in Urine by Automated count

213

1.76

1.54

5.0

3.1

0.35

0.53

e6/l

0.33

156

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

171

1.78

1.49

2.9

2.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.26

1.46

1.0

1.3

—

(3015736) pH of Urine

292

1.67

1.40

4.4

3.5

6.11

6.18

0.16

159

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.29

1.39

2.2

1.5

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.62

1.33

9.2

4.1

3.61

4.11

ratio

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.62

1.33

1.0

1.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

466

1.72

1.30

8.5

4.7

—

343.91

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

366

1.63

1.25

2.8

2.7

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.00

1.21

2.3

3.0

4.55

4.29

kpa

0.16

(3007853) Bacteria identified in Skin by Aerobe culture

1.97

1.16

2.6

1.9

—

(3019198) Lymphocytes [#/volume] in Blood

351

1.58

1.15

6.2

5.7

1.78

1.79

e9/l

0.02

306

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

624

1.92

1.14

27.0

17.6

75.15

76.92

ml/min/173m2

0.24

584

(3041096) Erythrocytes [Presence] in Urine by Automated

201

1.61

1.14

5.0

3.4

0.00

estimate

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.38

1.13

1.3

1.8

52.29

42.85

u/l

—

(3002582) Erythrocytes [#/volume] in Urine

247

1.58

1.13

5.0

3.3

21.15

302.97

e6/l

0.55

188

(3001604) Monocytes [#/volume] in Blood

343

1.57

1.11

6.3

5.7

0.62

0.60

e9/l

0.16

294

(3018095) Leukocytes [#/volume] in Urine

278

1.55

1.06

5.4

4.0

101.17

137.75

e6/l

0.20

197

(3006315) Basophils [#/volume] in Blood

346

1.54

1.05

6.3

5.7

0.04

e9/l

0.04

295

(3037467) Urinalysis macro (dipstick) panel - Urine

460

1.57

1.00

8.7

4.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

652

1.99

0.99

31.7

16.7

22.89

24.38

mg/l

0.18

542

(40768797) Stomach Pathology biopsy report

103

1.70

0.97

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

239

1.49

0.89

3.5

2.1

—

(3013115) Eosinophils [#/volume] in Blood

355

1.47

0.88

6.5

5.7

0.20

0.18

e9/l

0.39

305

(3019150) Specific gravity of Urine by Refractometry

158

1.55

0.87

5.2

4.0

1.02

kg/l

0.01

101

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.73

0.84

4.0

3.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.78

0.83

12.2

7.0

93.91

94.16

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

108

1.61

0.81

3.5

5.5

104.00

103.65

mmol/l

0.08

108

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.07

0.74

2.4

2.5

—

(3012516) Albumin [Mass/volume] in Urine

238

1.42

0.73

3.8

3.2

44.47

50.91

mg/l

0.14

161

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.98

0.72

2.4

2.8

—

(3025941) Bacteria identified in Stool by Culture

1.69

0.69

1.4

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

396

1.39

0.69

11.6

9.3

4.65

4.09

e9/l

0.83

338

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.84

0.67

1.4

1.1

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.84

0.67

3.4

2.7

82.40

97.37

u/ml

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

299

1.38

0.66

5.8

4.3

56.39

44.70

ng/l

0.15

240

(3019060) Gas panel - Arterial blood

1.70

0.64

6.5

2.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.59

0.64

1.8

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.67

0.64

12.2

6.6

0.74

0.65

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.60

0.62

12.2

6.5

1.71

1.40

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.61

0.0

1.7

—

222.00

—

(3021601) Nitrite [Presence] in Urine by Test strip

371

1.35

0.61

6.2

3.8

0.00

estimate

—

(3000492) Spirometry study

1.59

0.60

1.5

—

(36660697) Celiac disease serology panel - Serum

1.54

0.59

1.4

—

(40768443) Skin Pathology biopsy report

0.00

0.59

0.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

275

1.35

0.58

6.1

3.8

0.00

estimate

—

(3003694) ABO and Rh group [Type] in Blood

181

1.38

0.57

1.5

1.3

—

(3002256) Pathology report gross observation

0.59

0.56

1.2

1.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

683

1.70

0.56

16.9

12.1

26.64

24.61

u/l

0.36

669

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

267

1.34

0.55

6.3

3.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.54

0.53

3.0

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

327

1.32

0.52

3.9

2.6

—

estimate

—

(3022145) Colonoscopy Study observation

1.50

0.48

1.2

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.57

0.48

8.8

8.3

—

(3009261) Glucose [Presence] in Urine by Test strip

381

1.29

0.46

6.3

3.9

0.00

0.05

estimate

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.48

0.46

2.4

1.7

—

(1761868) Lipid panel - Serum or Plasma

235

0.75

0.46

4.3

3.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.42

0.43

3.3

2.6

—

(3042936) Bacteria identified in Isolate by Culture

1.41

0.43

2.5

1.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.41

0.0

1.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.41

0.0

1.2

—

(40761511) CBC panel - Blood by Automated count

669

1.45

0.41

26.0

15.6

—

(3035350) Ketones [Presence] in Urine by Test strip

375

1.26

0.41

6.3

3.9

0.00

18.45

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.43

0.40

2.7

1.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.40

0.0

1.3

—

(40768793) Breast Pathology biopsy report

0.00

0.40

0.0

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

614

1.35

0.38

4.7

4.4

1.25

mmol/l

0.01

557

(3020682) Albumin/Creatinine [Ratio] in Urine

240

1.26

0.38

4.6

3.9

4.30

9.02

mg/mmol

1.00

158

(40768804) Tissue Pathology biopsy report

281

0.79

0.37

1.7

2.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

504

1.23

0.31

4.3

4.0

15.08

15.02

pmol/l

0.06

460

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

123

1.27

0.28

5.9

3.4

1.69

3.05

e6/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

133

1.26

0.27

5.4

3.1

0.59

1.03

e6/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

262

0.83

0.26

2.3

1.9

1.33

1.31

mmol/l

0.04

210

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

636

1.25

0.22

5.3

5.2

1.40

1.44

mmol/l

0.24

579

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.21

0.0

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.3

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.21

0.0

1.4

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.21

0.0

1.4

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.5

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.21

0.0

1.4

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.5

—

32.17

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

3.2

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.20

0.0

2.4

—

2.75

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.20

0.0

4.6

—

66.21

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.20

0.0

1.4

—

(3044889) 12 lead EKG panel

453

1.15

0.20

5.1

4.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.14

0.17

1.4

2.5

9.48

13.28

nmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.14

0.16

1.2

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.12

0.10

2.2

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

216

0.90

0.10

7.9

3.7

0.00

estimate

—

(40761536) Microorganisms panel - Urine sediment

0.79

0.08

9.4

3.0

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.10

0.08

1.4

1.3

—

(3013512) EKG study

265

1.09

0.08

6.8

3.8

—

(4035726) Immunohistochemistry procedure

1.07

0.08

1.3

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.11

0.08

1.3

1.5

—

(3021589) Normoblasts [#/volume] in Blood

306

1.08

0.07

20.0

11.5

0.00

e9/l

0.50

252

(40758558) Short blood count panel - Blood

203

0.92

0.07

5.3

6.8

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

293

1.04

0.01

5.3

6.0

1.56

2.09

ug/l

1.16

251

(40760892) CBC W Ordered Manual Differential panel - Blood

132

0.98

0.00

8.7

5.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.06

0.00

2.9

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

231

0.99

0.00

5.0

5.1

27.21

20.71

0.56

125

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.4

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

10.21

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.5

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

2.4

—

29.04

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.0

—

1.83

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.5

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

-0.00

0.0

1.3

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

2.0

—

75.43

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.5

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

187.83

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint ST19_FRACT_SPINE_LEVEL_UNSPE and mortality.

Females

Parameter	HR [95% CI]	p-value
ST19_FRACT_SPINE_LEVEL_UNSPE	1.876 [1.28, 2.74]	0.001
Birth year	0.995 [0.99, 1.0]	0.263

During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 271 females with ST19_FRACT_SPINE_LEVEL_UNSPE died.

Males

Parameter	HR [95% CI]	p-value
ST19_FRACT_SPINE_LEVEL_UNSPE	2.304 [1.4, 3.78]	0.001
Birth year	0.988 [0.98, 1.0]	0.014

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 280 males with ST19_FRACT_SPINE_LEVEL_UNSPE died.

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_SPINE_LEVEL_UNSPE.

N-year risk	Females	Males
1	0.23%	0.388%
5	1.078%	2.665%
10	2.559%	6.877%
15	5.06%	12.868%
20	8.965%	21.156%

Relationships between endpoints

↥

Index endpoint: ST19_FRACT_SPINE_LEVEL_UNSPE – Fracture of spine, level unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fracture of spine, level unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints