Complications of anaesthesia during pregnancy

O15_PREG_ANESTH_COMPL

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule only females	313377
2. Check conditions None	313377
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O29 Cause of death: ICD-10 — O29 2 out of 7 registries used, show all original rules.	91
4. Check minimum number of events None	91
5. Include endpoints None	91
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: O15_PREG_OTHER_MAT_DISORD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF3
Parent code in ICD-10: O20-O29
Name in latin: Complicationes anaesthesiae in graviditate

NAME	O15_PREG_ANESTH_COMPL
CONTROL_EXCLUDE	O15_PREG_OTHER_MAT_DISORD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O29
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O29
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Complications of anaesthesia during pregnancy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	550	550	-
Only index persons	550	550	-
Unadjusted period prevalence (%)
Whole population	0.02	0.02	-
Only index persons	0.02	0.02	-
Median age at first event (years)
Whole population	-	30.03	-
Only index persons	-	30.03	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	80	-
Unadjusted period prevalence (%)	0.03	0.03	-
Median age at first event (years)	29.85	29.85	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
83: Matched controls
830

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O29.4

ICD-10 Finland

Spinal and epidural anaesthesia-induced headache during pregnancy

+∞

65.5

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

88.5

33.7

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

103.6

26.8

O29.9

ICD-10 Finland

Complication of anaesthesia during pregnancy, unspecified

+∞

15.0

O24.9

ICD-10 Finland

Diabetes mellitus in pregnancy, unspecified

+∞

13.9

O29.0

ICD-10 Finland

Pulmonary complications of anaesthesia during pregnancy

+∞

10.6

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

4.3

9.8

224

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

20.7

9.8

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

5.4

9.3

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

4.1

9.1

240

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

4.0

8.8

237

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

4.1

8.6

121

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

4.1

8.1

101

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

4.4

8.0

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

3.8

7.4

107

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

+∞

7.4

SPAT1196

SPAT

Monitoring of normal pregnancy

3.9

7.2

ZXD05

NOMESCO Finland

Urgent procedure

3.4

7.1

198

Z39.2

ICD-10 Finland

Routine postpartum follow-up

3.3

6.8

225

O20.0

ICD-10 Finland

Threatened abortion

24.9

6.8

Z30.2

ICD-10 Finland

Sterilization

4.5

6.8

SPAT1197

SPAT

Extensive health check-up of expecting family

3.3

6.7

219

TPH04

NOMESCO Finland

Cathetrisation of vein

3.9

6.6

W85

ICPC

Gestational diabetes

19.9

6.4

O99.0

ICD-10 Finland

Anaemia complicating pregnancy, childbirth and the puerperium

29.1

6.4

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

4.1

6.3

O82.0

ICD-10 Finland

Delivery by elective caesarean section

6.1

WX306

NOMESCO Finland

Lumbar epidural anesthesy

3.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019150) Specific gravity of Urine by Refractometry

151

3.28

6.30

2.9

2.5

1.02

kg/l

0.77

(3009261) Glucose [Presence] in Urine by Test strip

370

3.24

5.60

3.3

3.1

0.00

estimate

-0.00

(3035350) Ketones [Presence] in Urine by Test strip

364

3.15

5.43

3.2

3.1

0.00

21.23

estimate

0.49

(3021601) Nitrite [Presence] in Urine by Test strip

362

3.00

5.09

3.2

3.1

0.00

estimate

-0.00

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

3.70

4.80

2.0

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

268

2.48

4.00

3.2

2.6

0.00

0.05

estimate

0.49

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

3.15

3.97

1.9

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

153

2.50

3.66

1.9

2.7

7.73

12.63

ng/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

493

2.86

3.64

5.2

3.9

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

6.19

3.43

2.0

1.7

7.53

6.81

mmol/l

—

(3032080) INR in Blood by Coagulation assay

174

2.37

3.36

3.3

6.2

1.01

1.06

inr

0.80

147

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

10.52

3.01

2.0

1.6

5.04

5.34

mmol/l

—

(3015736) pH of Urine

299

2.10

2.78

2.7

2.8

6.57

6.33

0.78

157

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

118

2.31

2.69

2.3

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

217

2.06

2.55

2.6

2.3

0.00

0.07

estimate

0.68

(3020682) Albumin/Creatinine [Ratio] in Urine

2.36

2.39

3.3

4.5

2.61

14.13

mg/mmol

—

(3029937) Albumin [Presence] in Urine by Test strip

181

2.03

2.32

3.7

3.0

0.00

0.01

estimate

0.49

(3026008) Bacteria identified in Urine by Culture

181

2.03

2.32

3.5

1.8

—

(3020891) Body temperature

5.83

2.24

3.8

4.7

37.00

37.03

°c

—

(3012516) Albumin [Mass/volume] in Urine

2.28

2.21

3.3

3.7

9.09

95.33

mg/l

1.57

(3000850) Epithelial cells [#/volume] in Urine

105

2.19

3.6

2.8

8.03

9.33

e6/l

0.15

(3023511) Choriogonadotropin [Units/volume] in Urine

2.47

2.15

1.6

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.58

2.06

1.4

59.51

64.69

ug/l

0.24

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

267

1.87

2.04

1.6

1.8

95.83

95.74

pmol/l

0.00

155

(3013826) Glucose [Moles/volume] in Serum or Plasma

332

1.86

2.03

4.3

3.7

6.41

5.98

mmol/l

0.60

286

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

680

2.83

2.03

13.6

12.4

13.24

13.21

0.10

675

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.95

1.97

2.2

1.9

0.60

0.63

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.76

1.97

1.2

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.72

1.87

2.2

1.8

2.23

1.11

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

368

1.81

1.84

2.8

2.5

—

estimate

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

286

1.77

1.75

2.2

1.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.84

1.62

2.4

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.14

1.60

1.8

1.3

—

(3023368) Bacteria identified in Blood by Culture

118

1.92

1.60

3.4

2.9

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.48

1.54

1.0

1.1

—

(3018418) pH of Serum or Plasma

144

1.83

1.53

2.5

3.6

7.40

0.41

100

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.60

1.53

3.9

5.8

104.22

106.24

mmol/l

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

657

2.16

1.52

10.7

8.1

139.18

139.45

mmol/l

0.54

637

(3000991) Gas panel - Venous blood

2.63

1.49

1.7

6.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

180

1.74

1.46

4.9

3.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.04

1.45

1.1

2.0

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

644

2.11

1.40

9.1

7.9

100.00

98.16

ml/min/173m2

0.44

560

(4024509) Urine culture

2.73

1.39

2.0

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

174

1.72

1.38

4.4

2.8

25.73

74.56

e6/l

0.67

121

(40758558) Short blood count panel - Blood

175

1.71

1.35

6.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

228

1.66

1.35

4.4

3.9

36.88

37.64

g/l

0.36

221

(40761535) Cells panel - Urine sediment

2.61

1.33

3.8

3.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

239

1.63

1.30

1.6

1.2

0.74

2.13

u/ml

0.45

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.91

1.29

3.5

2.3

0.92

0.73

e6/l

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.18

1.28

1.3

1.1

—

(1002224) Polysomnography panel

2.28

1.25

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.14

1.22

1.1

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.14

1.22

1.1

2.0

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

105

1.78

1.17

3.4

2.0

22411.10

8428.47

u/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.10

1.15

1.1

1.4

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

533

1.65

1.13

3.9

3.4

8.06

8.01

mm/h

0.02

507

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.87

1.10

2.3

2.2

2.41

g/l

0.01

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

100

1.74

1.06

1.3

1.4

82.87

179.35

u/ml

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

296

1.52

1.06

2.1

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

213

1.56

1.05

1.6

1.3

1.85

2.15

g/l

1.01

133

(3042936) Bacteria identified in Isolate by Culture

1.78

1.02

1.8

2.0

—

(1761868) Lipid panel - Serum or Plasma

337

1.50

1.00

1.7

2.0

—

(3021589) Normoblasts [#/volume] in Blood

318

1.50

1.00

8.8

8.1

0.00

e9/l

-0.00

255

(3011397) Hemoglobin [Presence] in Urine by Test strip

162

1.58

0.98

3.3

3.1

—

(36304419) Bacteria [Presence] in Urine

145

1.60

0.97

4.3

2.8

—

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

145

1.60

0.97

4.7

2.8

0.05

0.37

e6/l

1.28

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.95

0.90

1.8

2.6

0.23

g/l

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.67

0.89

1.5

395.73

438.17

pmol/l

0.53

(3019832) Treponema pallidum Ab [Presence] in Serum

278

1.45

0.85

1.9

1.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.80

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.80

0.0

1.2

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.80

0.0

1.1

—

3.85

—

(40761536) Microorganisms panel - Urine sediment

1.79

0.80

3.7

3.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.74

0.80

1.1

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

685

1.74

0.78

5.0

4.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.06

0.74

1.2

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.06

0.74

1.2

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

209

1.43

0.73

4.7

4.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.98

0.72

1.2

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.98

0.72

1.2

1.1

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

1.90

0.69

1.6

1.5

2.76

7.12

umol/l

—

(3018095) Leukocytes [#/volume] in Urine

230

1.40

0.69

4.5

3.6

24.72

46.13

e6/l

0.43

128

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

728

1.80

0.67

13.7

9.8

16.14

18.49

mg/l

0.33

542

(36660697) Celiac disease serology panel - Serum

1.61

0.67

1.3

1.1

—

(3000492) Spirometry study

1.61

0.67

1.6

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.64

0.67

2.3

2.5

—

(3025941) Bacteria identified in Stool by Culture

1.70

0.64

1.8

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.61

0.0

2.0

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.59

0.0

1.1

—

0.07

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.53

0.56

1.7

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

106

0.63

0.53

1.9

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.42

0.43

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.6

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

107

1.37

0.40

1.4

10.74

19.91

iu/l

0.97

(42870588) Differential panel, method unspecified - Blood

219

1.27

0.40

4.5

5.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.38

0.40

1.4

1.5

148.64

130.00

u/ml

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

0.00

0.39

0.0

1.4

—

(3018010) Neutrophils/Leukocytes in Blood

356

1.24

0.38

5.2

5.6

59.93

56.26

2.30

342

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.68

0.35

1.5

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.66

0.35

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

116

0.75

0.30

1.8

1.5

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.34

0.30

2.0

1.4

448.27

305.51

mu/l

0.42

(3022145) Colonoscopy Study observation

1.26

0.28

1.4

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.70

0.27

1.8

3.1

30.20

32.79

—

(3044640) Blood type and Crossmatch panel - Blood

238

1.20

0.27

1.9

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

366

1.18

0.26

2.2

2.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.37

0.24

2.0

2.1

—

(3028707) Methadone [Presence] in Urine by Screen method

1.30

0.23

1.6

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

164

1.21

0.23

1.2

12.90

4.52

u/ml

—

(3003694) ABO and Rh group [Type] in Blood

300

1.17

0.23

2.0

1.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.23

0.22

1.0

1.58

1.65

g/l

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.23

0.22

1.0

2.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.23

0.22

1.0

0.82

0.84

g/l

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.4

—

(3020874) Milk IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

0.26

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

15.95

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.1

—

3.79

—

(3014599) Egg white IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

0.61

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.1

—

2.83

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.1

—

5.40

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

14.65

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.1

—

6.76

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

175

0.83

0.21

2.0

1.6

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.26

0.20

1.4

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

176

1.18

0.20

2.0

1.8

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.18

0.18

1.4

1.7

—

(3000494) Fungus identified in Specimen by Culture

1.25

0.18

1.0

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

181

0.86

0.16

2.1

1.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

212

1.12

0.12

2.5

2.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.12

0.10

1.4

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

1.07

0.09

2.0

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

195

0.90

0.09

2.0

1.6

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.08

0.09

1.3

—

(3008898) HLA-B27 [Presence]

0.81

0.08

1.0

—

(3027008) Opiates [Presence] in Urine

0.86

0.07

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

0.84

0.07

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.84

0.07

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.84

0.07

1.4

—

(3002256) Pathology report gross observation

1.07

0.07

1.3

1.1

—

(3017732) Neutrophils [#/volume] in Blood

0.85

0.07

1.9

2.9

4.20

7.30

e9/l

—

(40768804) Tissue Pathology biopsy report

292

0.94

0.05

1.8

1.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

139

0.92

0.04

1.3

1.8

3.45

3.10

ratio

—

102

(3013512) EKG study

142

1.07

0.02

2.2

2.5

—

(3037522) Nuclear Ab [Titer] in Serum

124

1.06

0.01

1.5

726.67

775.56

titre

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

174

1.04

0.00

1.4

1.3

12.53

13.85

iu/ml

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

282

0.99

0.00

2.5

2.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

301

0.99

0.00

2.6

2.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

115

1.05

0.00

1.8

1.4

—

(21494755) Public health laboratory ask at order entry panel

115

1.05

0.00

1.3

1.2

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

109

1.01

0.00

1.4

1.6

3.74

3.28

mmol/l

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.01

0.00

1.5

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

276

1.02

0.00

1.7

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.5

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.0

1.1

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

109.50

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

8.50

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

0.0

2.1

—

45.80

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.93

-0.00

2.0

2.1

—

11.25

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

4.7

—

330.00

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

123.16

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

0.96

-0.00

6.0

6.8

1.08

1.04

mmol/l

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.96

-0.00

1.4

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40768797) Stomach Pathology biopsy report

0.96

-0.00

1.1

1.2

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

0.92

-0.00

1.5

3.4

77.67

230.52

ng/l

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

2.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3026250) Tacrolimus [Mass/volume] in Blood

0.00

-0.00

0.0

38.4

—

6.30

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.8

—

1.18

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3006270) Folate [Moles/volume] in Blood

0.00

-0.00

0.0

1.2

—

488.60

—

(3016879) Cocaine [Presence] in Urine

0.89

-0.00

1.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.8

—

104.60

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.0

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

2.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

2.8

—

4.00

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.94

-0.00

1.2

10.56

7.78

u/l

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.6

—

46.20

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_PREG_ANESTH_COMPL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREG_ANESTH_COMPL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_PREG_ANESTH_COMPL – Complications of anaesthesia during pregnancy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Complications of anaesthesia during pregnancy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints