Other specific arthropathies

M13_OTERSPECARTHR

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M12.8
  • Hospital discharge: ICD-9 7164
  • Cause of death: ICD-10 M12.8
  • Cause of death: ICD-9 7164

2 out of 7 registries used, show all original rules.

80

4. Check minimum number of events

None

80

5. Include endpoints

None

80

6. Filter based on genotype QC (FinnGen only)

72

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M12
Name in latin
Aliae arthropathiae specificae non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 538 264 268
Only index persons 487 239 248
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 43.11 48.62 37.31
Only index persons 39.19 46.04 32.59

-FinnGen-

Key figures

All Female Male
Number of individuals 72 41 31
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 49.25 51.96 45.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
74
Matched controls
740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.8
ICD-10 Finland
Other specific arthropathies, not elsewhere classified
+∞
75.4
59
*
7164A
ICD-9 Finland
Other and unspecified arthropathies, Transient arthropathy
+∞
16.2
15
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
38.8
14.7
18
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
21.9
14.5
21
13
M13.9
ICD-10 Finland
Arthritis, unspecified
61.7
13.4
15
*
L04AX03
ATC
methotrexate; systemic
19.3
12.1
18
12
A07EC01
ATC
sulfasalazine; oral, rectal
26.3
11.2
15
7
M25.5
ICD-10 Finland
Pain in joint
5.3
11.0
32
93
P01BA02
ATC
hydroxychloroquine; oral
28.2
10.7
14
6
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
10.7
10
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
20.5
10.4
15
9
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
31.0
10.2
13
5
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
57.0
8.9
10
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
57.0
8.9
10
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
15.3
8.8
14
11
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
31.8
8.8
11
*
L01BA01
ATC
methotrexate; systemic
101.1
8.6
9
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
8.5
8
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
38.0
8.3
10
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
+∞
7.4
7
*
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
+∞
7.4
7
*
L88
ICPC
Rheumatoid/seropositive arthritis
44.2
6.9
8
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
10.8
6.6
12
13
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
76.1
6.5
7
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
76.1
6.5
7
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
6.3
6
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
+∞
6.3
6
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
6.3
6
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
9.3
6.1
12
15

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
86
4.63
8.76
1.4
1.2
25.26
1.18
u/ml
—
9
40
24
65
4.98
8.76
1.6
1.3
440.00
351.11
titre
—
6
9
27
91
4.10
7.33
1.4
1.2
16.37
13.81
iu/ml
—
7
23
17
61
3.32
4.01
1.8
4.2
4.29
4.98
e9/l
0.59
17
56
15
51
3.43
3.83
1.1
1.3
—
—
—
0
0
9
17
5.86
3.64
1.1
1.1
0.26
0.27
g/l
—
9
17
9
18
5.53
3.49
1.1
1.1
1.26
1.25
g/l
—
9
18
40
258
2.20
2.77
2.9
2.9
5.92
6.19
ph
0.88
24
149
8
19
4.58
2.76
2.1
2.6
—
—
—
0
0
56
420
2.37
2.60
6.1
4.0
—
—
—
0
0
36
228
2.13
2.56
2.8
3.4
22.00
55.91
ng/l
1.23
30
156
32
198
2.09
2.38
10.8
4.7
—
—
—
0
0
47
338
2.07
2.30
3.6
3.3
0.00
0.00
estimate
—
7
69
24
139
2.08
2.09
3.6
3.1
—
—
—
0
0
6
15
4.25
2.08
1.3
1.2
—
—
—
0
0
46
339
1.94
1.99
3.7
3.3
0.00
0.00
estimate
—
6
63
41
292
1.91
1.95
11.2
5.3
25.62
27.87
%
0.66
41
279
45
333
1.90
1.88
3.8
3.2
0.00
0.00
estimate
—
7
71
5
12
4.38
1.85
1.0
1.4
—
—
—
0
0
8
30
2.86
1.78
6.5
4.0
—
—
—
0
0
38
270
1.84
1.77
10.6
12.3
1.19
1.24
inr
0.24
32
226
36
253
1.82
1.73
3.4
3.1
0.00
0.00
estimate
—
7
53
26
167
1.86
1.65
1.9
1.6
19.47
20.30
nmol/l
0.11
21
140
28
185
1.83
1.62
14.8
6.7
—
—
—
0
0
6
20
3.17
1.61
1.0
1.2
—
—
—
0
0
7
27
2.75
1.55
1.7
1.6
—
—
—
0
0
29
197
1.78
1.52
3.7
2.0
125.69
164.68
u/l
0.63
29
189
11
53
2.26
1.47
7.5
1.7
9.75
9.82
g/l
0.02
11
48
30
208
1.74
1.46
4.0
2.9
83.46
54.18
e6/l
0.21
24
155
5
17
3.08
1.38
1.2
1.5
—
—
—
0
0
35
259
1.67
1.31
2.3
2.4
—
—
estimate
—
0
0
34
252
1.65
1.26
2.4
2.1
93.82
101.06
pmol/l
0.47
21
123
41
319
1.64
1.25
9.5
8.3
1.22
1.21
mmol/l
0.12
36
266
15
89
1.86
1.18
1.3
1.6
—
—
—
0
0
24
165
1.67
1.17
5.0
3.8
—
—
—
0
0
25
176
1.63
1.11
4.1
2.9
0.24
0.69
e6/l
0.86
20
125
5
21
2.48
1.11
2.0
1.2
28.40
39.95
nmol/l
—
5
21
5
22
2.36
1.05
1.2
1.5
—
—
—
0
0
13
78
1.81
0.99
1.9
1.7
—
—
—
0
0
26
190
1.57
0.98
2.7
2.8
0.00
0.02
estimate
—
6
46
12
71
1.82
0.95
1.3
1.4
—
—
—
0
0
31
238
1.52
0.93
4.8
3.5
10.94
250.12
e6/l
0.93
24
161
27
202
1.53
0.91
4.6
3.4
—
—
—
0
0
6
31
2.02
0.86
2.3
2.4
—
—
—
0
0
8
48
1.75
0.82
1.5
1.8
—
—
—
0
0
8
48
1.75
0.82
2.0
11.4
1.24
1.44
mmol/l
—
8
48
0
27
0.00
0.79
0.0
1.6
—
279.35
—
0
17
9
54
1.76
0.78
1.3
1.7
—
—
—
0
0
11
68
1.73
0.77
2.1
1.6
—
—
—
0
0
7
43
1.69
0.69
1.7
1.1
—
—
—
0
0
12
79
1.62
0.67
1.2
1.7
—
—
—
0
0
8
50
1.67
0.64
5.1
2.9
—
—
—
0
0
46
402
1.38
0.62
5.3
4.1
—
33.60
—
0
5
0
21
0.00
0.61
0.0
1.4
—
—
—
0
0
6
34
1.83
0.60
2.2
1.5
15.92
23.51
iu/l
—
6
28
31
258
1.35
0.55
1.8
2.1
—
—
—
0
0
26
212
1.35
0.52
3.5
3.3
208.56
54.97
mg/l
0.48
17
131
69
660
1.67
0.49
19.3
12.6
—
—
—
0
0
11
77
1.50
0.49
1.2
1.5
—
—
—
0
0
68
647
1.63
0.46
25.5
16.9
3.97
3.96
mmol/l
0.12
68
636
5
31
1.66
0.44
2.4
15.7
0.36
0.73
%
—
5
31
11
79
1.46
0.43
2.3
2.7
4.36
6.19
umol/l
0.87
11
71
5
33
1.55
0.42
1.2
1.1
—
—
—
0
0
18
143
1.34
0.42
2.4
1.5
1.85
2.55
g/l
—
8
87
0
15
0.00
0.41
0.0
3.4
—
64.15
—
0
15
5
34
1.50
0.41
1.4
1.6
—
—
—
0
0
9
65
1.44
0.41
2.9
11.3
-2.42
1.22
mmol/l
—
9
55
5
35
1.46
0.40
2.6
5.3
—
—
—
0
0
5
36
1.42
0.39
2.6
13.4
24.16
24.46
mmol/l
—
5
36
6
88
0.65
0.35
1.0
1.2
—
—
—
0
0
25
216
1.24
0.31
5.0
4.1
39.49
8.93
mg/mmol
0.60
16
130
11
86
1.33
0.28
1.3
1.2
—
—
—
0
0
21
182
1.21
0.25
2.2
2.1
—
—
—
0
0
67
646
1.39
0.24
25.7
16.7
139.37
139.77
mmol/l
0.68
67
635
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
20
175
1.20
0.21
1.2
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
67.74
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
59
1.21
0.18
4.7
1.6
—
—
—
0
0
9
82
1.11
0.15
2.9
9.8
101.33
104.35
mmol/l
—
9
82
16
143
1.15
0.13
3.9
5.6
—
—
—
0
0
24
222
1.12
0.12
2.8
2.3
58.63
94.86
u/l
0.68
24
203
19
174
1.12
0.11
3.4
3.0
—
—
—
0
0
5
44
1.15
0.10
3.4
12.6
—
—
—
0
0
6
57
1.06
0.09
2.0
1.4
—
—
—
0
0
20
190
1.07
0.04
4.3
3.3
0.00
0.00
estimate
—
5
66
27
263
1.04
0.01
3.2
3.4
—
—
—
0
0
53
528
1.01
0.00
29.5
17.8
13.47
13.60
%
0.38
53
522
12
115
1.05
0.00
4.3
3.5
0.82
0.82
mmol/l
0.01
12
115
11
114
0.96
0.00
1.4
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.2
2.6
2.94
5.54
ug/l
—
5
42
0
7
0.00
-0.00
0.0
1.6
—
15.04
—
0
7
6
62
0.96
-0.00
1.3
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
82.40
—
0
5
8
79
1.01
-0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
31.83
—
0
6
0
7
0.00
-0.00
0.0
2.6
—
12.57
—
0
7
5
58
0.85
-0.00
3.0
4.5
7.38
7.39
ph
—
5
37
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
17.9
—
1019.44
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
56
0.89
-0.00
4.2
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
8.54
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
0.86
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
12.29
—
0
7
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
154.07
—
0
7
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_OTERSPECARTHR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_OTERSPECARTHR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: M13_OTERSPECARTHR – Other specific arthropathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data