Disorders of muscle in diseases classified elsewhere

M13_MUSCLEINOTH

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M63 Cause of death: ICD-10 — M63 2 out of 7 registries used, show all original rules.	46
4. Check minimum number of events None	46
5. Include endpoints None	46
6. Filter based on genotype QC (FinnGen only)	45

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M60-M63
Name in latin: Morbositates musculorum in morbis alibi classificatis

NAME	M13_MUSCLEINOTH
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M63
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M63
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Disorders of muscle in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	333	191	142
Only index persons	304	183	121
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	-	47.83	39.78
Only index persons	44.87	47.58	40.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	45	31	14
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	54.70	47.40	70.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

+∞

7.48

6.7

0.0

6170.00

—

u/ml

—

(3013512) EKG study

106

2.81

2.85

3.3

4.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

9.14

2.82

1.2

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

9.14

2.82

1.2

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

167

2.73

2.72

10.2

6.5

—

(3035350) Ketones [Presence] in Urine by Test strip

181

2.63

2.50

5.7

3.7

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

182

2.61

2.46

5.7

3.7

0.00

estimate

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

5.13

2.35

8.3

1.8

3.35

3.65

mg/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.07

2.27

1.6

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

6.07

2.27

1.2

1.1

—

(3022145) Colonoscopy Study observation

3.35

2.22

1.2

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.55

2.21

2.1

1.8

4.06

3.44

mg/l

0.27

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

5.45

2.12

1.4

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

181

2.40

2.12

7.4

4.9

0.00

estimate

—

(3015736) pH of Urine

146

2.35

2.07

3.0

3.1

—

5.88

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.74

2.06

1.4

1.6

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.89

1.90

2.2

5.5

25.70

23.47

mmol/l

—

(3019225) pH of Specimen

3.12

1.89

4.0

5.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

169

2.24

1.87

2.1

2.3

—

(3003694) ABO and Rh group [Type] in Blood

109

2.27

1.83

1.2

1.3

—

(3022313) Gas panel - Capillary blood

3.67

1.81

4.5

5.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.37

1.80

2.8

3.3

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

4.17

1.76

2.6

2.2

187.20

239.54

ug/l

—

(3037522) Nuclear Ab [Titer] in Serum

2.69

1.72

1.8

1.4

336.00

280.00

titre

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.69

1.72

1.6

1.4

—

(3026782) Osmolality of Urine

2.30

1.69

7.6

3.1

626.33

526.33

mosm/kgh2o

1.05

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.87

1.66

2.6

2.2

—

(3045414) Leukocytes [Presence] in Urine

3.87

1.66

2.6

1.7

—

(3025941) Bacteria identified in Stool by Culture

3.29

1.64

1.3

1.4

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.72

1.63

2.4

4.5

5.67

5.78

kpa

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.47

1.60

3.5

2.6

2.83

2.84

e6/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

3.60

1.56

2.2

13.2

22.66

24.52

mmol/l

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.76

1.52

5.9

4.7

4.73

5.15

kpa

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

3.37

1.48

4.8

6.1

23.06

25.31

mmol/l

—

(40758558) Short blood count panel - Blood

109

2.07

1.47

13.0

6.7

—

(3023368) Bacteria identified in Blood by Culture

2.02

1.32

7.9

3.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

113

1.97

1.32

3.6

3.3

13.33

9.40

mg/mmol

0.12

(3026008) Bacteria identified in Urine by Culture

113

1.97

1.32

4.7

2.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.57

1.18

2.1

3.3

4.60

4.40

kpa

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.68

1.18

1.0

1.2

—

(3000991) Gas panel - Venous blood

2.68

1.18

1.8

13.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

135

1.85

1.16

7.0

4.9

43.00

33.92

ng/l

0.14

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.54

1.12

3.4

7.6

25.54

25.50

mmol/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.42

1.06

3.0

10.0

1.54

1.15

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

121

1.80

1.04

2.3

2.2

—

(3000850) Epithelial cells [#/volume] in Urine

1.88

1.02

6.4

2.4

10.96

4.07

e6/l

0.64

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.11

1.02

2.1

1.6

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.40

0.97

6.2

1.8

646.83

164.45

ng/l

—

(3042936) Bacteria identified in Isolate by Culture

2.00

0.97

4.4

2.4

—

(36304419) Bacteria [Presence] in Urine

107

1.76

0.92

6.8

2.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.96

0.92

3.3

2.2

0.24

2.05

e6/l

—

(4200892) Spirometry reversibility

2.15

0.90

1.8

1.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

211

1.68

0.88

5.4

4.9

7.97

6.83

mmol/l

1.19

195

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.89

0.88

5.0

4.8

34.75

37.61

—

(3041096) Erythrocytes [Presence] in Urine by Automated

109

1.72

0.86

6.6

3.6

—

(3000492) Spirometry study

1.94

0.82

2.7

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

265

1.68

0.80

6.8

3.8

—

(3009508) Creatinine [Moles/volume] in Urine

111

1.68

0.80

3.4

2.7

6.82

7.72

mmol/l

0.35

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.74

0.80

2.2

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

148

1.62

0.78

6.6

3.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.99

0.78

2.1

1.8

—

(40768804) Tissue Pathology biopsy report

167

1.61

0.78

2.7

2.1

—

(3012516) Albumin [Mass/volume] in Urine

103

1.68

0.78

3.5

3.0

93.10

79.68

mg/l

—

(3000494) Fungus identified in Specimen by Culture

1.88

0.75

3.4

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.68

0.75

2.9

1.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

160

1.57

0.72

19.2

14.5

1.53

1.25

inr

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

134

1.56

0.67

7.2

2.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.76

0.67

6.6

5.9

1.15

1.11

mmol/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.62

0.0

1.5

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.62

0.0

1.5

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.58

0.61

1.4

2.1

30.49

29.47

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

157

1.48

0.57

5.6

4.0

35.01

35.96

g/l

0.31

152

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.57

0.54

6.2

4.3

—

(3044889) 12 lead EKG panel

260

1.44

0.49

5.2

3.7

—

(3016502) Oxygen saturation in Arterial blood

1.58

0.43

2.6

8.1

96.72

95.36

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.42

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.42

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.42

0.0

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.53

0.42

2.6

7.9

106.20

104.68

mmol/l

—

(40761536) Microorganisms panel - Urine sediment

1.53

0.42

7.0

3.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.41

0.0

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

226

1.35

0.37

3.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

373

1.55

0.37

24.7

13.6

21.39

25.44

mg/l

0.43

280

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.35

0.24

6.6

7.3

—

(1761868) Lipid panel - Serum or Plasma

133

0.77

0.23

2.1

2.9

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.2

—

(3002256) Pathology report gross observation

1.29

0.21

1.0

1.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.6

—

21.31

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.20

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

391

1.18

0.08

25.7

15.6

83.28

77.62

umol/l

0.20

391

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.08

0.08

2.0

1.4

—

(40768797) Stomach Pathology biopsy report

0.98

0.00

1.2

1.3

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.98

-0.00

1.2

1.9

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

2.0

—

31.65

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.3

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

-0.00

0.0

3.7

—

1.72

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.94

-0.00

1.1

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

2.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(3003181) Sodium [Moles/volume] in Urine

0.00

-0.00

0.0

3.0

—

49.60

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

-0.00

0.0

1.4

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

-0.00

0.0

1.1

—

135.29

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

3.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

4.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

13.57

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.3

—

7.00

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

3.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.5

—

180.12

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.5

—

6.20

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

-0.00

0.0

4.2

—

5.54

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.90

-0.00

4.1

5.1

91.05

2.11

ug/l

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

2.2

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3049717) Cytology report of Urine Cyto stain

0.00

-0.00

0.0

2.1

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

11.06

—

(3011288) Drugs identified in Urine by Screen method

0.00

-0.00

0.0

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

3.0

—

92.18

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

-0.00

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.8

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.4

—

87.20

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_MUSCLEINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_MUSCLEINOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: M13_MUSCLEINOTH – Disorders of muscle in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Disorders of muscle in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints