No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
80 |
4. Check minimum number of eventsNone |
80 |
5. Include endpointsNone |
80 |
6. Filter based on genotype QC (FinnGen only) |
70 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
Similar endpoints
↥List of similar endpoints to
Kissing spine
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Paracetamol or NSAID medication
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 565 | 301 | 263 |
| Only index persons | 543 | 292 | 251 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.11 | 69.76 | 61.96 |
| Only index persons | 65.89 | 69.34 | 61.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 70 | 32 | 38 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 57.11 | 56.29 | 57.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.2
ICD-10 Finland
Kissing spine
+∞
83.8
63
*
M48.0
ICD-10 Finland
Spinal stenosis
177.7
41.3
40
5
N03AX16
ATC
[U] pregabalin
16.3
32.6
40
52
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
+∞
30.4
27
*
M54.4
ICD-10 Finland
Lumbago with sciatica
13.4
23.6
28
33
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
66.7
23.4
26
6
M54.5
ICD-10 Finland
Low back pain
9.5
20.9
45
109
N03AX12
ATC
[U] gabapentin; oral
9.4
18.0
28
46
N02AX02
ATC
tramadol; systemic, rectal
8.8
17.5
52
168
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
17.4
16
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
23.8
15.6
22
13
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
14.0
13
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
171.4
14.0
14
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
36.5
13.7
17
6
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
11.5
12.4
24
30
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
142.1
11.8
12
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
+∞
11.8
11
*
N06AX21
ATC
duloxetine; oral
14.8
11.4
19
17
N02BF01
ATC
gabapentin; oral
12.2
10.9
20
22
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
128.2
10.7
11
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
10.7
10
*
M43.1
ICD-10 Finland
Spondylolisthesis
114.7
9.7
10
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.6
9
*
ZXA05
NOMESCO Finland
Left side
4.8
9.5
31
98
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
101.6
8.6
9
*
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
12.3
8.5
15
15
M54.1
ICD-10 Finland
Radiculopathy
38.2
8.3
10
*
L86
ICPC
Back syndrome with radiating pain
15.6
8.3
13
10
UJF32
NOMESCO Finland
Coloscopy
4.4
8.2
30
102
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
8.1
30
103
M54.2
ICD-10 Finland
Cervicalgia
14.1
8.0
13
11
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.3
7.9
19
46
N06AX16
ATC
venlafaxine; oral
5.6
7.7
17
38
N02AJ06
ATC
codeine and paracetamol; systemic
3.8
7.2
42
195
M54.6
ICD-10 Finland
Pain in thoracic spine
12.8
7.1
12
11
WX408
NOMESCO Finland
General anesthesy, balanced
4.0
7.0
27
94
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.9
6.9
18
46
N02BF02
ATC
pregabalin; oral
10.3
6.9
13
15
M47.82
ICD-10 Finland
Other spondylosis, cervical region
44.4
6.9
8
*
M54.3
ICD-10 Finland
Sciatica
11.7
6.8
12
12
D11
ICPC
Diarrhoea
5.0
6.8
17
42
J45.9
ICD-10 Finland
Asthma, unspecified
4.4
6.8
21
62
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.7
6.7
43
210
M53.1
ICD-10 Finland
Cervicobrachial syndrome
7.1
6.6
16
28
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.9
6.6
17
43
R03DC03
ATC
montelukast; oral
4.4
6.6
20
58
A02BC02
ATC
pantoprazole; systemic
5.0
6.4
60
371
G56.0
ICD-10 Finland
Carpal tunnel syndrome
4.8
6.4
17
44
M47.9
ICD-10 Finland
Spondylosis, unspecified
+∞
6.3
6
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
6.3
6
*
7215A
ICD-9 Finland
Spondylosis and allied disorders, Kissing spine
+∞
6.3
6
*
ZXD05
NOMESCO Finland
Urgent procedure
3.6
6.2
31
127
ZXA00
NOMESCO Finland
Right side
3.6
6.1
29
115
SFA00
NOMESCO Finland
Small restoration
4.7
6.1
16
41
R52.2
ICD-10 Finland
Other chronic pain
12.7
6.0
10
9
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
280
3.66
6.05
3.7
2.8
—
—
estimate
—
0
0
46
268
3.03
4.78
3.1
2.0
95.52
99.95
pmol/l
0.17
23
138
24
101
3.08
4.42
2.2
2.4
2.22
2.29
g/l
0.25
24
93
48
303
2.80
4.02
5.3
3.8
0.00
0.00
estimate
-0.00
11
61
24
107
2.88
3.95
2.5
2.4
14.73
12.58
umol/l
0.61
24
100
27
130
2.74
3.84
1.3
1.2
3.35
2.63
u/ml
—
8
35
47
300
2.68
3.75
5.3
3.7
0.00
0.00
estimate
-0.00
11
68
22
96
2.87
3.74
2.1
2.4
27.30
22.31
%
0.87
22
89
42
261
2.49
3.44
4.4
2.9
88.10
133.59
ug/l
1.99
42
245
33
184
2.48
3.41
3.4
2.1
137.73
195.62
u/l
0.93
33
168
46
300
2.51
3.36
5.3
3.7
0.00
0.00
estimate
-0.00
11
67
25
124
2.57
3.28
4.8
3.8
1.02
1.02
kg/l
0.22
15
80
12
37
3.69
3.12
5.7
6.7
93.34
93.41
%
0.02
12
37
49
336
2.48
3.11
7.1
7.2
10.46
11.21
umol/l
0.36
49
322
21
100
2.56
2.97
2.7
1.8
—
—
—
0
0
12
41
3.31
2.79
5.7
6.1
1.15
1.43
%
0.55
12
41
12
41
3.31
2.79
5.7
6.1
0.78
0.69
%
0.21
12
41
35
215
2.24
2.77
4.4
3.2
35.37
31.22
u/l
0.34
35
203
19
89
2.55
2.76
6.8
5.5
104.26
104.22
mmol/l
0.01
19
89
6
10
6.43
2.75
1.8
1.1
—
—
—
0
0
16
69
2.70
2.72
2.9
1.6
—
—
—
0
0
29
167
2.25
2.66
5.9
3.9
0.00
0.00
estimate
—
10
66
16
70
2.66
2.65
2.9
1.7
—
—
—
0
0
27
155
2.20
2.47
2.3
2.5
—
—
—
0
0
8
22
3.96
2.44
4.5
1.1
—
—
—
0
0
38
251
2.11
2.42
6.1
3.9
105.75
35.26
ng/l
0.56
30
191
6
13
4.93
2.32
2.0
1.1
2441.83
15414.38
e6/l
—
6
8
17
82
2.41
2.30
1.6
1.3
19.96
8.68
u/ml
—
9
27
21
114
2.20
2.17
6.2
3.6
99.81
118.43
ng/l
0.08
21
93
10
38
2.89
2.10
1.4
1.6
—
—
—
0
0
6
16
3.99
1.98
1.3
1.1
0.25
0.26
g/l
—
6
16
6
17
3.75
1.88
1.3
1.4
—
—
—
0
0
6
17
3.75
1.88
2.2
3.1
152.08
646.05
ug/l
—
6
17
6
17
3.75
1.88
1.3
1.3
1.27
1.12
g/l
—
6
17
6
18
3.54
1.78
1.2
1.2
—
—
—
0
0
6
18
3.54
1.78
1.7
1.4
—
—
—
0
0
6
18
3.54
1.78
2.2
3.4
26.20
25.74
mmol/l
—
6
18
6
18
3.54
1.78
1.2
1.2
—
—
—
0
0
7
24
3.12
1.77
6.4
1.3
—
—
—
0
0
5
13
4.05
1.74
1.2
1.5
—
—
—
0
0
42
311
1.86
1.73
4.2
2.8
—
—
—
0
0
8
31
2.78
1.72
2.3
3.2
1.04
1.00
%
—
8
31
33
228
1.84
1.69
5.4
3.8
0.00
0.00
estimate
—
10
59
18
101
2.05
1.68
3.5
2.7
1.26
1.41
e6/l
—
10
54
7
27
2.76
1.56
1.1
1.0
—
—
—
0
0
13
66
2.19
1.55
1.8
1.3
—
—
—
0
0
7
29
2.56
1.43
1.1
1.3
—
—
—
0
0
5
17
3.08
1.38
2.4
1.6
—
—
—
0
0
11
55
2.18
1.36
2.1
2.0
37.36
27.60
u/l
0.68
11
45
6
26
2.42
1.21
1.2
1.3
—
—
—
0
0
16
98
1.82
1.15
3.4
2.9
0.65
4.74
e6/l
—
8
51
14
82
1.88
1.15
4.2
5.8
1.07
1.02
mmol/l
0.24
14
76
10
55
1.95
0.98
1.6
1.3
—
—
—
0
0
6
29
2.16
0.92
2.5
5.6
54.13
47.09
%
—
6
29
29
226
1.48
0.80
4.0
4.2
11.94
6.55
mg/mmol
0.27
22
148
9
55
1.73
0.77
3.8
2.7
4.86
7.37
ug/l
—
9
50
5
24
2.16
0.76
1.8
1.4
24.30
21.85
iu/l
—
5
18
9
57
1.66
0.74
1.8
2.6
0.37
0.20
e6/l
—
9
57
5
25
2.07
0.74
2.8
4.6
26.72
25.00
mmol/l
—
5
25
31
253
1.40
0.65
1.9
2.0
1.21
1.33
mmol/l
0.54
31
204
55
496
1.48
0.64
30.6
19.9
13.77
13.71
%
0.10
55
489
11
74
1.58
0.57
15.6
7.5
—
—
—
0
0
6
37
1.68
0.57
3.5
4.0
5.28
5.09
kpa
—
6
37
11
75
1.55
0.54
3.5
1.3
—
—
—
0
0
26
217
1.31
0.44
4.1
4.0
21.71
21.74
%
0.00
15
112
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
8
66
1.24
0.28
2.4
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
19
169
1.17
0.17
5.4
3.2
0.00
0.00
estimate
—
10
56
5
45
1.12
0.10
1.2
4.1
4.02
4.44
pmol/l
—
5
39
6
55
1.10
0.09
3.2
3.1
1.26
1.22
mmol/l
—
6
46
0
6
0.00
-0.00
0.0
2.7
—
4.73
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
13.31
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1.23
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
10.17
—
0
6
0
5
0.00
-0.00
0.0
3.0
—
18.74
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.2
—
709.80
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint M13_KISSING and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_KISSING.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_KISSING – Kissing spine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data