Sweet's syndrome

L12_SWEET_SDR

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L98.2
  • Cause of death: ICD-10 L98.2

2 out of 7 registries used, show all original rules.

62

4. Check minimum number of events

None

62

5. Include endpoints

None

62

6. Filter based on genotype QC (FinnGen only)

52

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 272 141 130
Only index persons 252 130 122
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 58.60 57.94 59.42
Only index persons 57.46 55.77 59.27

-FinnGen-

Key figures

All Female Male
Number of individuals 52 34 18
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 61.03 60.89 61.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
54
Matched controls
540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.2
ICD-10 Finland
Febrile neutrophilic dermatosis [Sweet]
+∞
77.3
54
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
13.8
20.7
26
34
L30.9
ICD-10 Finland
Dermatitis, unspecified
9.7
16.3
33
75
R50.9
ICD-10 Finland
Fever, unspecified
10.0
16.2
27
49
A49.9
ICD-10 Finland
Bacterial infection, unspecified
10.8
10.8
22
32
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.8
9.4
19
40
H02AB06
ATC
prednisolone; systemic
6.0
8.0
42
198
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
14.9
6.9
11
9
L04AX01
ATC
azathioprine; systemic
26.4
6.9
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.8
6.3
41
213

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
30
12.50
12.08
1.7
1.2
—
—
—
0
0
21
41
7.75
11.40
6.4
1.4
—
—
—
0
0
41
164
7.23
10.28
19.1
5.4
—
—
—
0
0
20
42
6.97
10.01
11.8
7.0
0.09
0.08
%
0.04
11
13
20
44
6.63
9.52
11.8
6.8
0.82
0.60
%
0.28
11
15
35
140
5.26
8.23
11.9
4.4
—
—
—
0
0
18
41
6.09
8.16
12.3
6.9
0.50
0.08
%
—
10
13
18
42
5.93
7.93
12.6
8.3
0.44
0.00
%
—
9
11
30
110
4.89
7.77
2.3
1.4
2.97
2.80
g/l
0.09
22
63
21
60
5.09
7.33
2.9
1.5
—
—
—
0
0
22
71
4.54
6.52
3.6
2.4
—
—
—
0
0
23
77
4.46
6.50
1.7
1.4
274.29
594.00
titre
—
7
20
25
94
4.09
5.97
2.8
3.3
516.82
515.88
mosm/kgh2o
0.01
25
85
9
8
13.17
5.52
7.0
8.4
—
—
—
0
0
5
0
+∞
5.28
1.4
0.0
—
—
—
0
0
9
9
11.69
5.25
1.4
1.2
—
—
—
0
0
19
64
4.04
5.19
8.4
4.8
1.13
1.01
mmol/l
0.51
19
58
9
10
10.51
5.00
5.2
1.2
—
—
—
0
0
18
62
3.85
4.72
1.4
1.5
—
—
—
0
0
11
20
6.61
4.58
1.5
1.0
—
—
—
0
0
8
9
10.18
4.44
1.1
1.2
—
—
—
0
0
7
6
13.13
4.41
1.1
1.2
—
—
—
0
0
9
13
8.05
4.36
1.4
1.0
—
—
—
0
0
25
114
3.22
4.20
3.2
3.1
7.17
4.55
e6/l
0.88
25
108
25
116
3.15
4.05
13.9
6.3
—
—
—
0
0
17
62
3.54
4.05
1.5
1.5
—
—
—
0
0
8
11
8.30
4.02
4.1
1.4
4.76
5.72
e9/l
—
8
11
14
45
3.85
3.99
4.7
4.0
—
—
—
0
0
9
16
6.51
3.84
5.4
1.5
60.56
61.59
%
—
9
16
8
12
7.60
3.82
1.5
1.6
14.10
10.70
mg/l
—
8
12
12
31
4.67
3.78
1.4
1.4
—
—
—
0
0
12
35
4.11
3.37
1.8
1.2
—
—
—
0
0
28
151
2.77
3.32
5.0
4.2
0.00
0.00
estimate
-0.00
15
54
28
152
2.75
3.27
3.0
2.9
—
—
—
0
0
38
242
2.92
3.24
13.2
6.6
1.20
1.22
mmol/l
1.00
32
212
27
145
2.72
3.20
3.6
3.2
—
—
estimate
—
0
0
8
16
5.67
3.19
2.0
1.3
1.06
1.17
g/l
—
8
16
14
53
3.22
3.08
1.4
1.5
—
—
—
0
0
17
74
2.89
2.95
1.8
1.6
—
—
—
0
0
7
14
5.57
2.83
1.4
2.3
24.97
25.16
mmol/l
—
7
14
5
6
9.01
2.80
1.0
1.2
—
—
—
0
0
32
196
2.55
2.80
2.3
1.9
—
—
—
0
0
5
7
7.72
2.60
5.6
1.0
—
—
—
0
0
44
324
2.93
2.50
6.5
4.6
—
105.67
—
0
6
5
8
6.74
2.42
3.6
1.9
31.00
31.75
pg
—
5
8
19
97
2.48
2.38
1.7
1.3
28.91
4.39
u/ml
—
7
37
27
162
2.33
2.37
3.6
2.2
143.56
161.66
u/l
0.12
27
154
27
162
2.33
2.37
8.0
4.3
7.42
7.40
ph
1.22
21
111
26
154
2.33
2.34
4.1
3.2
0.00
0.00
estimate
-0.00
13
48
6
13
5.04
2.34
2.0
4.9
7.42
7.42
ph
—
6
13
38
270
2.38
2.18
4.7
3.9
0.00
0.00
estimate
-0.00
16
56
5
10
5.38
2.12
3.0
3.0
—
—
—
0
0
17
87
2.39
2.09
1.7
1.7
—
—
—
0
0
38
274
2.31
2.04
4.7
4.0
0.00
0.00
estimate
-0.00
15
54
38
274
2.31
2.04
4.7
3.9
0.00
0.00
estimate
-0.00
16
59
30
198
2.16
2.00
4.5
3.8
0.00
0.00
estimate
-0.00
13
44
5
11
4.88
1.98
2.6
2.8
—
—
—
0
0
5
11
4.88
1.98
1.8
3.4
16.52
15.68
%
—
5
11
31
214
2.05
1.77
3.3
3.5
6.03
6.21
ph
0.45
17
114
5
14
3.82
1.65
1.0
1.2
—
—
—
0
0
0
43
0.00
1.61
0.0
1.2
—
—
—
0
0
20
126
1.93
1.41
1.5
1.3
2.15
1.76
u/ml
—
6
39
22
145
1.87
1.35
21.5
6.6
—
—
—
0
0
5
19
2.79
1.24
3.2
1.9
—
—
—
0
0
7
31
2.44
1.15
6.6
3.7
—
—
—
0
0
30
226
1.74
1.14
2.8
2.1
88.83
98.73
pmol/l
0.64
20
103
5
21
2.52
1.11
6.8
4.7
—
—
—
0
0
17
109
1.82
1.11
2.0
1.3
12.16
35.23
iu/ml
—
9
41
24
172
1.71
1.07
10.8
2.3
—
—
—
0
0
13
78
1.88
1.03
1.5
1.2
—
—
—
0
0
27
202
1.67
1.02
6.4
4.3
46.08
27.01
ng/l
0.77
21
140
10
55
2.00
1.00
15.3
6.9
1.74
0.73
mmol/l
—
10
49
10
56
1.96
0.95
15.3
6.6
95.09
96.29
%
—
10
56
6
30
2.12
0.90
19.3
8.2
24.80
24.38
mmol/l
—
6
30
6
30
2.12
0.90
18.8
8.1
23.90
24.92
mmol/l
—
6
30
10
58
1.89
0.86
15.3
6.4
11.24
12.83
kpa
—
10
58
10
58
1.89
0.86
15.3
6.4
5.20
5.11
kpa
—
10
58
0
27
0.00
0.80
0.0
1.9
—
—
—
0
0
9
55
1.76
0.79
1.0
1.5
—
—
—
0
0
45
482
0.60
0.74
4.5
5.4
4.73
4.64
mmol/l
0.16
40
453
5
26
2.01
0.72
1.4
1.2
—
—
—
0
0
0
20
0.00
0.62
0.0
1.3
—
—
—
0
0
0
19
0.00
0.61
0.0
1.0
—
—
—
0
0
0
22
0.00
0.61
0.0
1.0
—
—
—
0
0
45
477
0.66
0.56
4.4
5.3
1.40
1.52
mmol/l
0.91
40
445
10
67
1.60
0.54
1.2
1.2
—
—
—
0
0
46
485
0.65
0.46
5.2
6.2
2.65
2.68
mmol/l
0.09
41
451
29
249
1.36
0.45
9.3
2.7
—
—
estimate
—
0
0
5
33
1.57
0.42
12.0
4.2
4.44
4.27
pmol/l
—
5
33
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
10
73
1.45
0.38
19.5
5.4
103.20
103.89
mmol/l
—
10
73
21
177
1.31
0.35
3.8
3.6
—
—
—
0
0
7
55
1.31
0.31
20.6
6.4
103.71
121.24
g/l
—
7
55
5
41
1.24
0.22
1.6
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
53.08
—
0
10
6
47
1.31
0.21
7.5
3.5
7.39
7.26
ph
—
6
35
0
12
0.00
0.21
0.0
2.4
—
7.40
—
0
12
0
13
0.00
0.21
0.0
3.1
—
20.46
—
0
13
6
49
1.25
0.21
19.7
7.3
—
—
—
0
0
5
44
1.15
0.10
1.0
1.1
—
—
—
0
0
14
154
0.88
0.09
1.5
1.5
—
—
—
0
0
12
121
0.99
0.00
4.0
4.0
—
—
—
0
0
21
205
1.04
0.00
2.3
3.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
10.25
—
0
8
0
8
0.00
0.00
0.0
3.0
—
—
—
0
0
6
62
0.96
0.00
2.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
8.93
—
0
6
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
257.86
—
0
7
0
5
0.00
-0.00
0.0
3.2
—
4.76
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
53.20
—
0
5

Mortality – FinRegistry

Association

Association between endpoint L12_SWEET_SDR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SWEET_SDR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_SWEET_SDR – Sweet's syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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