Radiodermatitis

L12_RADIODERMATITIS

A significant side effect of ionizing radiation delivered to the skin during cancer treatment as well as a result of nuclear attacks and disasters.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L58 Hospital discharge: ICD-8 — 6927 Cause of death: ICD-10 — L58 Cause of death: ICD-8 — 6927 2 out of 7 registries used, show all original rules.	89
4. Check minimum number of events None	89
5. Include endpoints None	89
6. Filter based on genotype QC (FinnGen only)	81

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L55-L59
Name in latin: Radiodermatitis

NAME	L12_RADIODERMATITIS
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L58
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	6927
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L58
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	6927
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Radiodermatitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	430	304	124
Only index persons	380	272	108
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	61.07	62.40	57.84
Only index persons	60.71	62.23	56.88

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	81	62	19
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	59.23	59.23	59.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
86: Matched controls
860

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L58.9

ICD-10 Finland

Radiodermatitis, unspecified

+∞

63.6

L58.0

ICD-10 Finland

Acute radiodermatitis

+∞

26.4

115

Kela drug reimbursment

Breast cancer

6.3

15.2

HAB40

NOMESCO Finland

Wedge excision of mammary gland

7.2

13.5

H02AB02

ATC

dexamethasone; systemic

5.1

10.9

L58.1

ICD-10 Finland

Chronic radiodermatitis

+∞

10.6

HA1AA

NOMESCO Finland

X-ray mammography

5.3

9.7

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

5.9

9.6

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

6.1

9.6

WF003

NOMESCO Finland

Adjuvant radiotherapy

10.6

8.5

L02BG04

ATC

letrozole; oral

4.7

8.3

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.0

8.2

106

A03FA01

ATC

metoclopramide; systemic, rectal

3.6

7.9

173

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

4.7

7.8

C50.40

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication

10.9

7.6

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.6

7.4

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.4

6.8

PJA12

NOMESCO Finland

Sentinel node biopsy

3.9

6.5

XX3DW

NOMESCO Finland

Time consuming IT work

3.7

6.2

L57.0

ICD-10 Finland

Actinic keratosis

6.1

L02BA01

ATC

tamoxifen; oral

5.6

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

3.98

7.64

2.4

1.4

—

(3023368) Bacteria identified in Blood by Culture

224

2.97

5.81

6.2

4.4

—

(4035726) Immunohistochemistry procedure

3.24

4.67

1.5

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

5.27

4.59

5.2

3.4

18.69

20.46

u/ml

0.09

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

468

2.95

4.34

9.6

7.0

9.15

10.74

umol/l

1.65

446

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

2.94

4.13

4.0

5.1

5.55

7.35

ug/l

0.24

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.17

3.86

1.5

1.4

—

(40768443) Skin Pathology biopsy report

3.98

3.83

1.3

1.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.24

3.68

1.9

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

2.48

3.45

2.5

1.9

—

(3013115) Eosinophils [#/volume] in Blood

423

2.38

3.38

7.6

5.9

0.21

0.18

e9/l

0.54

366

(3006315) Basophils [#/volume] in Blood

414

2.35

3.34

7.4

5.7

0.04

e9/l

0.03

351

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.57

3.31

2.0

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.76

3.27

2.3

1.3

—

(3019198) Lymphocytes [#/volume] in Blood

418

2.31

3.21

7.4

5.7

1.66

1.76

e9/l

0.39

368

(42870588) Differential panel, method unspecified - Blood

261

2.19

3.14

6.9

5.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

363

2.20

3.09

3.4

2.6

—

estimate

—

(3001604) Monocytes [#/volume] in Blood

412

2.25

3.08

7.5

5.7

0.58

0.56

e9/l

0.20

353

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

10.50

3.01

1.4

1.0

—

(3002256) Pathology report gross observation

106

2.45

2.96

1.7

1.2

—

(40768804) Tissue Pathology biopsy report

318

2.05

2.70

3.1

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

256

2.05

2.67

3.1

2.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

4.98

2.65

6.6

4.3

72.46

34.25

u/ml

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.30

2.64

2.6

2.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

175

2.10

2.54

3.3

2.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.09

2.53

4.1

2.0

—

(1616796) Gas panel - Central venous blood

5.28

2.44

5.5

4.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.38

2.41

1.3

2.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

409

1.96

2.27

11.1

6.3

1.20

1.22

mmol/l

0.73

350

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.23

2.22

1.4

2.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

421

1.95

2.22

3.2

2.7

—

(3010421) pH of Blood

4.52

2.19

2.8

5.6

7.44

7.43

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.21

2.07

1.3

2.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.95

1.97

1.3

1.9

—

(3017181) Myelocytes/Leukocytes in Blood

2.30

1.88

5.9

3.3

1.33

0.78

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

4.35

1.85

1.2

2.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

4.35

1.85

1.2

1.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

4.35

1.85

3.2

4.3

5.28

4.74

kpa

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

4.35

1.85

1.2

1.1

—

(3027315) Oxygen [Partial pressure] in Blood

4.35

1.85

3.2

4.3

7.50

8.96

kpa

—

(3012501) Base excess in Blood by calculation

4.35

1.85

3.2

4.3

3.60

2.80

mmol/l

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

376

1.79

1.84

10.8

5.7

1.20

1.22

mmol/l

0.61

348

(3022313) Gas panel - Capillary blood

3.22

1.84

7.3

2.2

—

(3021440) Promyelocytes/Leukocytes in Blood

2.29

1.76

6.2

3.4

0.17

0.15

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

4.01

1.74

1.4

3.5

1.22

1.20

mmol/l

—

(3035285) Chloride [Moles/volume] in Venous blood

4.01

1.74

1.4

3.5

107.00

106.54

mmol/l

—

(3041354) Potassium [Moles/volume] in Venous blood

4.01

1.74

1.4

3.5

3.82

3.90

mmol/l

—

(3002179) Metamyelocytes/Leukocytes in Blood

2.25

1.70

5.3

3.2

1.17

0.76

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.44

1.62

14.2

6.3

24.83

25.75

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.10

1.54

4.9

4.0

—

(3037756) Immunofixation for Serum or Plasma

2.99

1.53

3.5

1.8

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.99

1.53

2.2

4.9

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.99

1.53

1.0

1.4

—

(40768793) Breast Pathology biopsy report

2.60

1.53

1.6

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.38

1.53

1.6

2.5

0.63

0.60

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

104

1.92

1.51

1.6

1.8

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.46

1.48

4.3

1.6

39.22

40.34

u/l

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.33

1.46

2.0

2.4

127.90

131.28

g/l

—

(3035715) Granulocytes [#/volume] in Blood

3.25

1.46

6.4

1.4

3.99

5.42

e9/l

—

(3026008) Bacteria identified in Urine by Culture

260

1.66

1.44

4.0

3.1

—

(3019060) Gas panel - Arterial blood

2.28

1.40

4.1

4.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.28

1.40

1.6

2.5

0.71

1.38

—

(3038515) Glucose [Moles/volume] in Venous blood

3.06

1.38

2.2

3.5

7.34

7.68

mmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

1.87

1.36

1.6

1.9

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.23

1.33

16.6

8.2

94.68

94.50

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.34

1.28

2.4

2.8

24.80

24.39

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

304

1.59

1.28

4.3

4.4

40.85

54.49

e6/l

0.28

221

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.50

1.26

1.0

1.1

—

(3035933) Granulocytes/Leukocytes in Blood

2.50

1.26

6.2

1.3

59.33

61.96

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

277

1.59

1.25

4.3

3.6

26.19

28.20

u/l

0.40

264

(3025159) Blasts/Leukocytes in Blood

2.02

1.25

6.3

3.6

0.20

0.07

—

(3000494) Fungus identified in Specimen by Culture

105

1.77

1.17

1.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.02

1.06

2.4

3.4

57.50

49.39

—

(3019977) pH of Arterial blood

100

1.74

1.06

12.2

6.2

7.42

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.80

1.05

12.4

7.5

—

(3008037) Lactate [Moles/volume] in Venous blood

2.35

1.05

2.2

3.3

1.46

1.62

mmol/l

—

(3000991) Gas panel - Venous blood

1.92

1.04

13.8

6.2

—

(3015736) pH of Urine

335

1.50

1.02

4.5

3.6

6.38

6.20

0.47

197

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.79

0.98

2.0

3.0

5.65

5.84

kpa

0.37

(3027801) Oxygen [Partial pressure] in Arterial blood

103

1.68

0.96

12.2

5.9

15.13

12.73

kpa

0.78

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

103

1.68

0.96

12.3

5.9

5.06

5.24

kpa

0.35

(3002582) Erythrocytes [#/volume] in Urine

272

1.48

0.95

3.6

14.81

28.61

e6/l

1.33

212

(40760892) CBC W Ordered Manual Differential panel - Blood

190

1.53

0.94

7.1

4.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

302

1.46

0.92

6.6

3.9

16.21

37.00

ng/l

0.99

218

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

1.82

0.91

2.9

3.1

15.18

32.67

u/ml

0.61

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

156

1.55

0.91

1.3

66.14

37.39

iu/ml

—

(3012544) pH of Venous blood

1.71

0.87

2.0

3.0

7.41

7.39

—

(3022621) pH of Urine by Test strip

1.69

0.84

2.4

2.8

6.25

6.19

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.82

0.83

5.0

2.9

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.74

0.79

2.0

2.7

5.00

4.26

kpa

0.68

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.86

0.74

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

283

1.40

0.74

4.2

3.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.62

0.74

1.6

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.77

0.72

1.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.77

0.72

1.9

1.3

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.98

0.72

2.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

112

1.53

0.70

1.9

2.0

—

(3012516) Albumin [Mass/volume] in Urine

258

1.38

0.68

3.2

3.1

41.10

46.59

mg/l

0.07

159

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

139

1.47

0.68

3.4

3.1

0.87

0.78

e6/l

0.05

(1761868) Lipid panel - Serum or Plasma

301

0.72

0.64

4.2

3.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

377

1.34

0.63

2.8

2.6

73.89

78.68

nmol/l

0.50

342

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.59

0.0

1.3

—

296.27

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

126

1.44

0.57

1.2

1.4

—

(3020891) Body temperature

1.67

0.57

5.2

36.93

36.91

°c

—

(40758558) Short blood count panel - Blood

265

1.33

0.56

11.7

6.9

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

145

1.40

0.55

1.3

34.67

12.15

u/ml

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

278

1.30

0.51

5.7

2.7

1659.99

1003.93

ng/l

0.44

232

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

129

1.40

0.51

3.4

3.3

3.25

3.05

e6/l

0.03

(3035350) Ketones [Presence] in Urine by Test strip

418

1.27

0.47

5.3

4.1

0.00

18.88

estimate

—

(3020682) Albumin/Creatinine [Ratio] in Urine

263

1.28

0.45

3.7

3.8

7.83

9.42

mg/mmol

0.12

152

(3009261) Glucose [Presence] in Urine by Test strip

420

1.26

0.44

5.4

4.2

0.00

estimate

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

349

0.78

0.44

1.8

2.0

1.29

1.31

mmol/l

0.11

286

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.45

0.43

1.8

2.6

23.45

31.46

u/l

0.99

(3018418) pH of Serum or Plasma

274

1.27

0.43

7.6

4.0

7.40

0.19

193

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

161

1.32

0.42

4.7

3.8

36.92

299.59

ng/l

0.85

128

(3029937) Albumin [Presence] in Urine by Test strip

227

1.28

0.42

5.9

4.1

0.00

estimate

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.41

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.9

—

49.12

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.1

—

9.94

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.43

0.40

3.1

2.2

11.37

5.30

ug/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.41

0.40

1.6

3.2

380.33

200.09

ng/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

257

1.26

0.40

2.5

2.1

103.43

140.92

u/l

0.52

244

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.41

0.39

1.0

1.3

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

640

1.30

0.38

29.1

20.9

13.83

0.00

631

(3021601) Nitrite [Presence] in Urine by Test strip

416

1.23

0.37

5.4

4.1

0.00

estimate

—

(40761511) CBC panel - Blood by Automated count

772

1.52

0.35

24.0

14.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

111

1.31

0.32

13.0

5.8

104.36

104.38

mmol/l

0.01

111

(3025941) Bacteria identified in Stool by Culture

1.38

0.32

1.4

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.38

0.32

1.3

1.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.32

0.29

9.1

4.8

1.23

mmol/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.30

0.27

1.3

—

(40768797) Stomach Pathology biopsy report

111

0.79

0.21

1.1

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.0

—

(3014037) CD3+CD4+ (T4 helper) cells/cells in Blood

0.00

0.21

0.0

2.6

—

47.00

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.3

—

31.83

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.30

0.21

1.2

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.30

0.21

1.2

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.20

0.0

1.3

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.20

0.0

1.7

—

10.50

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.20

0.0

2.6

—

3.24

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

101

1.22

0.17

1.5

—

(21494755) Public health laboratory ask at order entry panel

0.74

0.17

1.2

1.3

—

(3000492) Spirometry study

1.14

0.16

1.0

1.5

—

(3003694) ABO and Rh group [Type] in Blood

219

1.13

0.15

1.5

1.4

—

(3022145) Colonoscopy Study observation

106

0.83

0.14

1.0

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

766

0.84

0.14

5.8

6.1

2.82

2.72

mmol/l

0.46

709

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

755

0.86

0.12

5.0

5.2

1.57

1.55

mmol/l

0.14

692

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

322

1.09

0.10

5.6

3.9

0.00

estimate

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.09

0.10

1.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.04

0.08

1.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.04

0.08

5.5

3.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

138

1.11

0.07

1.4

—

(3021589) Normoblasts [#/volume] in Blood

356

1.07

0.07

19.8

11.9

0.00

e9/l

-0.00

283

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

760

0.90

0.05

5.1

5.4

4.86

4.73

mmol/l

0.53

704

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

720

0.92

0.05

4.2

4.4

1.36

1.27

mmol/l

0.45

658

(3007164) IgA [Mass/volume] in Serum or Plasma

170

1.07

0.04

1.5

1.3

2.11

2.36

g/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

238

0.95

0.02

4.0

3.5

0.00

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

363

1.03

0.01

2.7

2.1

90.53

97.91

pmol/l

0.62

169

(3037522) Nuclear Ab [Titer] in Serum

118

1.02

0.00

1.4

1.3

608.00

612.00

titre

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.0

—

(44806420) Estimation of glomerular filtration rate

0.00

0.0

2.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

59.43

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.2

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

0.33

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

59.40

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

33.80

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.3

—

11.44

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.3

—

4.58

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

2.6

—

45.20

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.6

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

57.60

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

1.9

—

37.79

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

1.2

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(36660697) Celiac disease serology panel - Serum

0.87

-0.00

1.0

1.2

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

4.60

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

23.00

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.4

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.1

—

11.53

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

5.95

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.0

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

12.60

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_RADIODERMATITIS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_RADIODERMATITIS	1.892 [1.32, 2.71]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.171

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 262 females with L12_RADIODERMATITIS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_RADIODERMATITIS.

N-year risk	Females	Males
1	0.18%	No data
5	1.015%	No data
10	2.571%	No data
15	5.165%	No data
20	9.201%	No data

Relationships between endpoints

↥

Index endpoint: L12_RADIODERMATITIS – Radiodermatitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Radiodermatitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints