Cutaneous autosensitization

L12_CUT_AUTOSENS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L30.2
  • Cause of death: ICD-10 L30.2

2 out of 7 registries used, show all original rules.

60

4. Check minimum number of events

None

60

5. Include endpoints

None

60

6. Filter based on genotype QC (FinnGen only)

52

Control definitions (FinnGen only)

Control exclude
L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L30
Name in latin
Reactio "id"

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 378 203 172
Only index persons 355 197 158
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 45.42 45.51 45.03
Only index persons 45.42 46.08 44.60

-FinnGen-

Key figures

All Female Male
Number of individuals 52 32 20
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 49.65 49.61 49.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
54
Matched controls
540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L30.2
ICD-10 Finland
Cutaneous autosensitization
+∞
77.3
54
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
18.5
27.4
35
49
D07AC13
ATC
mometasone; topical
9.8
16.5
31
65
E0000UV, ,
ATC
10.4
15.0
41
126
D07AD01
ATC
clobetasol; topical
10.2
15.0
22
34
L30.3
ICD-10 Finland
Infective dermatitis
48.2
14.5
17
5
XQ802
NOMESCO Finland
Epicutan test
92.3
13.3
14
*
D07AC01
ATC
betamethasone; topical
7.0
11.6
35
112
L20.0
ICD-10 Finland
Besnier prurigo
+∞
9.7
9
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
12.5
8.5
15
16
B86
ICD-10 Finland
Scabies
92.2
7.6
8
*
D02AE01
ATC
carbamide; topical
19.2
7.6
11
7
B35.3
ICD-10 Finland
Tinea pedis
20.0
7.0
10
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.7
6.6
13
17

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
6
15.32
5.26
1.5
1.0
—
—
—
0
0
9
14
7.46
4.18
1.2
1.0
—
—
—
0
0
15
51
3.69
3.95
1.9
1.4
—
—
—
0
0
15
58
3.20
3.20
2.1
1.3
—
—
—
0
0
17
75
2.85
2.88
1.6
1.4
9.76
15.18
u/ml
—
8
27
30
179
2.52
2.77
2.2
1.9
111.14
100.84
pmol/l
0.44
12
99
20
102
2.53
2.53
1.5
1.4
2.84
2.37
g/l
0.25
13
56
5
9
5.99
2.26
1.4
1.0
—
—
—
0
0
7
19
4.07
2.23
5.3
5.9
0.40
0.75
%
—
7
19
20
109
2.33
2.15
1.6
1.2
1.05
2.09
u/ml
—
6
25
32
215
2.20
2.06
7.3
5.4
55.82
57.64
%
0.45
32
203
7
21
3.67
2.04
5.3
5.6
1.67
2.25
%
—
7
21
9
34
2.97
1.97
2.3
7.8
0.98
1.06
mmol/l
—
9
28
7
22
3.50
1.95
5.3
5.4
93.01
91.00
%
—
7
22
13
62
2.44
1.83
2.0
1.8
—
—
—
0
0
32
222
2.08
1.82
7.6
5.4
30.18
27.94
%
0.61
32
208
6
18
3.61
1.80
1.7
1.3
0.24
0.26
g/l
—
6
18
18
101
2.17
1.76
4.3
3.6
—
—
—
0
0
5
13
4.12
1.75
2.2
1.9
—
—
—
0
0
31
215
2.04
1.74
7.8
5.6
0.56
0.70
%
0.95
31
196
31
216
2.02
1.70
7.8
5.5
2.88
2.69
%
0.16
31
197
24
153
2.02
1.68
2.7
2.0
—
—
—
0
0
31
217
2.01
1.67
7.8
5.6
8.10
8.41
%
0.28
31
200
6
20
3.24
1.63
1.3
1.1
—
—
—
0
0
34
253
1.93
1.46
6.7
4.4
6.68
6.60
mmol/l
0.08
34
231
9
42
2.37
1.42
1.2
1.1
—
—
—
0
0
8
34
2.58
1.36
2.3
3.7
—
—
—
0
0
19
119
1.92
1.35
4.3
4.2
—
—
—
0
0
5
18
2.95
1.31
13.2
6.5
—
—
—
0
0
5
18
2.95
1.31
1.8
1.3
1.28
1.28
g/l
—
5
18
24
166
1.80
1.25
2.3
2.8
9.03
19.28
ng/l
3.09
19
106
16
98
1.90
1.20
6.6
3.4
96.06
96.08
%
0.00
16
98
5
21
2.52
1.11
1.6
3.2
4.88
4.85
kpa
—
5
21
42
354
1.84
1.02
4.6
4.6
14.23
14.69
pmol/l
0.64
36
326
6
27
2.37
0.97
1.7
1.8
—
—
—
0
0
24
176
1.65
0.97
2.3
1.9
—
—
—
0
0
28
215
1.63
0.93
3.0
2.6
—
—
estimate
—
0
0
6
30
2.12
0.90
1.2
3.0
70.98
84.10
e9/l
—
6
22
38
317
1.67
0.89
5.1
4.2
—
—
—
0
0
15
99
1.71
0.87
2.1
2.2
—
—
—
0
0
20
144
1.62
0.85
1.2
1.6
—
—
—
0
0
6
32
1.98
0.84
5.3
4.9
—
—
—
0
0
6
33
1.92
0.82
5.2
4.3
2.27
1.24
mmol/l
—
6
33
21
155
1.58
0.80
9.3
5.5
—
—
—
0
0
18
128
1.61
0.79
3.0
3.3
7.40
7.39
ph
0.09
12
90
17
123
1.56
0.69
3.1
2.9
—
—
—
0
0
8
51
1.67
0.64
1.5
1.4
—
—
—
0
0
8
53
1.60
0.62
1.5
1.7
—
—
—
0
0
0
19
0.00
0.61
0.0
1.6
—
—
—
0
0
46
425
1.55
0.53
6.2
5.3
1.88
1.82
mu/l
0.13
41
400
8
55
1.53
0.46
5.4
4.9
104.25
104.29
mmol/l
—
8
55
19
152
1.39
0.45
2.3
3.6
2.35
2.36
mmol/l
0.11
19
142
49
508
0.62
0.43
35.7
19.9
267.55
252.75
e9/l
0.68
49
502
49
508
0.62
0.43
35.6
19.9
4.57
4.55
e12/l
0.10
49
497
49
508
0.62
0.43
35.9
20.0
7.10
6.62
e9/l
0.78
49
497
0
15
0.00
0.42
0.0
5.4
—
—
—
0
0
9
65
1.46
0.42
3.8
2.7
0.85
0.81
mmol/l
—
9
60
5
34
1.52
0.41
5.4
3.0
0.22
0.24
g/l
—
5
34
0
17
0.00
0.41
0.0
3.4
—
15.26
—
0
17
0
18
0.00
0.40
0.0
1.5
—
1.21
—
0
13
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
9
69
1.36
0.40
1.9
2.0
178.44
83.23
ug/g
—
9
60
16
127
1.37
0.39
3.4
3.4
20.74
67.55
mg/l
—
10
81
15
118
1.38
0.39
4.1
3.1
1.02
1.02
kg/l
—
10
66
6
44
1.41
0.36
1.3
1.5
—
—
—
0
0
12
152
0.73
0.35
3.0
3.0
—
—
—
0
0
17
203
0.76
0.34
2.2
2.9
—
—
—
0
0
7
56
1.29
0.31
1.3
2.1
—
—
—
0
0
23
201
1.25
0.28
1.9
1.9
1.25
1.42
mmol/l
0.66
17
169
23
205
1.21
0.22
5.7
3.4
6.27
6.32
ph
0.07
13
117
0
10
0.00
0.21
0.0
2.6
—
1.78
—
0
10
0
10
0.00
0.21
0.0
2.6
—
56.60
—
0
10
5
46
1.10
0.10
3.0
1.5
—
0.00
estimate
—
0
8
5
61
0.80
0.09
1.0
1.2
—
—
—
0
0
8
76
1.06
0.08
1.8
1.9
—
—
—
0
0
47
461
1.15
0.07
22.6
13.8
3.89
3.95
mmol/l
1.16
47
453
22
233
0.91
0.07
11.2
9.0
0.00
0.00
e9/l
0.50
16
184
15
146
1.04
0.00
9.9
5.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
237.88
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
55
0.90
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
34.40
—
0
5
0
7
0.00
-0.00
0.0
6.9
—
2.01
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
12.08
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
222.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
49
486
1.09
-0.00
25.7
15.9
70.06
73.49
umol/l
1.48
49
481
0
7
0.00
-0.00
0.0
2.9
—
4.24
—
0
7
0
6
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
0.48
—
0
5
48
481
0.98
-0.00
20.0
11.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
105.43
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
56
0.88
-0.00
1.4
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
39.34
—
0
5
0
7
0.00
-0.00
0.0
2.9
—
1.18
—
0
7
0
9
0.00
-0.00
0.0
2.8
—
9.37
—
0
9

Mortality – FinRegistry

Association

Association between endpoint L12_CUT_AUTOSENS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_CUT_AUTOSENS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_CUT_AUTOSENS – Cutaneous autosensitization

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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