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Acquired ichthyosis

L12_ACQICTHY

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L85.0
  • Hospital discharge: ICD-9 7011B
  • Hospital discharge: ICD-8 70115
  • Cause of death: ICD-10 L85.0
  • Cause of death: ICD-9 7011B
  • Cause of death: ICD-8 70115

2 out of 7 registries used, show all original rules.

28

4. Check minimum number of events

None

28

5. Include endpoints

None

28

6. Filter based on genotype QC (FinnGen only)

26

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L85
Name in latin
Ichthyosis acquisita

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 250 91 152
Only index persons 202 75 127
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 38.42 46.93 32.72
Only index persons 31.90 39.07 27.66

-FinnGen-

Key figures

All Female Male
Number of individuals 26 11 15
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 52.91 53.44 52.52

-FinRegistry-

Age distribution of first events

01020304050607080900510152025303540AgeIndividuals

-FinnGen-

Age distribution of first events

020608090012345678910AgeIndividuals

-FinRegistry-

Year distribution of first events

19751980198519902000200520102015202020220510152025303540YearIndividuals

-FinnGen-

Year distribution of first events

1970198019901995201020152025012345678YearIndividuals

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
7
17
5.11
2.55
1.4
1.6
—
—
—
0
0
7
20
4.30
2.22
16.7
2.9
—
—
—
0
0
7
22
3.88
2.03
1.6
1.5
—
—
—
0
0
5
14
4.10
1.69
1.0
1.6
—
—
—
0
0
6
20
3.52
1.68
1.5
1.6
—
—
—
0
0
13
71
2.55
1.52
6.8
2.6
368.62
9736.03
umol/l
0.78
13
58
5
17
3.34
1.42
10.8
2.9
11.58
8.20
mmol/l
—
5
17
5
17
3.34
1.42
1.6
1.9
—
—
—
0
0
14
82
2.41
1.39
2.1
2.0
—
—
—
0
0
20
142
2.42
1.33
4.4
3.9
6.37
6.86
mmol/l
0.57
20
131
7
30
2.77
1.23
2.0
1.1
—
—
—
0
0
6
28
2.45
0.98
2.5
2.5
5.67
11.69
umol/l
—
6
22
14
93
2.01
0.93
1.6
1.7
106.71
97.42
pmol/l
—
8
44
16
113
1.97
0.89
13.4
7.2
15.31
11.39
umol/l
0.55
16
108
0
24
0.00
0.84
0.0
1.4
—
—
—
0
0
7
38
2.12
0.81
2.6
1.5
1006.61
1453.29
nmol/l
—
7
28
21
170
1.94
0.80
10.3
4.0
16.14
11.72
mm/h
0.56
21
154
10
62
1.95
0.78
7.5
4.0
—
—
—
0
0
5
26
2.12
0.75
5.8
1.6
25.88
23.04
%
—
5
21
5
28
1.95
0.70
1.2
1.4
—
260.00
—
0
6
8
52
1.75
0.67
21.3
6.5
—
—
—
0
0
0
19
0.00
0.63
0.0
1.3
—
—
—
0
0
14
103
1.72
0.62
13.6
5.7
1.40
1.81
e9/l
1.51
14
91
6
37
1.79
0.60
1.2
1.2
—
—
—
0
0
13
95
1.69
0.58
12.5
5.5
59.85
58.41
%
0.11
13
84
13
95
1.69
0.58
15.5
5.8
25.69
26.79
%
0.11
13
85
10
68
1.73
0.57
3.0
3.9
—
—
—
0
0
14
105
1.67
0.56
24.3
11.7
1.20
1.13
inr
—
6
29
6
90
0.58
0.54
8.8
3.4
26.50
61.39
ng/l
—
6
60
13
97
1.64
0.52
21.2
4.8
1.22
1.22
mmol/l
0.02
13
86
8
56
1.60
0.48
1.1
1.3
—
—
—
0
0
5
30
1.81
0.47
2.6
1.5
—
—
—
0
0
12
90
1.58
0.46
15.4
5.3
0.92
0.72
%
0.45
12
80
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
13
101
1.54
0.42
14.5
5.7
0.56
0.61
e9/l
0.48
13
86
0
17
0.00
0.42
0.0
1.4
—
—
—
0
0
15
121
1.52
0.40
18.1
11.5
3.83
4.51
e9/l
0.56
15
104
18
152
1.52
0.38
4.9
4.3
—
—
—
0
0
13
103
1.49
0.37
14.5
5.6
0.05
0.04
e9/l
0.20
13
87
12
94
1.48
0.36
16.7
5.6
2.42
2.89
%
0.58
12
84
21
227
0.70
0.34
22.8
13.4
—
—
—
0
0
10
76
1.49
0.34
3.3
2.4
—
—
—
0
0
12
95
1.46
0.34
18.0
6.2
7.75
8.15
%
0.18
12
85
8
64
1.35
0.31
1.3
3.3
—
—
—
0
0
9
71
1.39
0.30
3.3
2.5
—
—
—
0
0
6
83
0.65
0.29
5.7
3.9
—
5.94
—
0
8
13
108
1.38
0.27
18.2
5.7
0.16
0.21
e9/l
0.70
13
96
12
99
1.37
0.25
22.1
6.1
—
—
—
0
0
6
49
1.28
0.22
3.3
3.7
—
—
—
0
0
0
11
0.00
0.22
0.0
1.8
—
—
—
0
0
0
11
0.00
0.22
0.0
7.9
—
24.72
—
0
11
0
11
0.00
0.22
0.0
3.1
—
146.00
—
0
11
0
10
0.00
0.22
0.0
3.6
—
0.95
—
0
10
0
10
0.00
0.22
0.0
1.0
—
—
—
0
0
0
10
0.00
0.22
0.0
1.5
—
—
—
0
0
6
50
1.25
0.21
1.3
1.7
18.47
23.75
nmol/l
—
6
39
23
235
0.88
0.10
32.7
16.8
105.70
78.15
umol/l
0.69
23
235
22
227
0.86
0.10
7.5
5.0
4.57
4.67
mmol/l
0.16
22
212
22
227
0.86
0.10
32.1
13.4
34.91
23.54
mg/l
0.30
17
176
15
162
0.84
0.09
5.9
4.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.6
—
0.78
—
0
9
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
338.40
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
56.00
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
1.04
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
5.67
—
0
6
0
5
0.00
-0.00
0.0
2.8
—
6.30
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
230.80
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
1.64
—
0
5
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
22.40
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
1.36
—
0
5

Mortality – FinRegistry

Association

Association between endpoint L12_ACQICTHY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACQICTHY.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ACQICTHY – Acquired ichthyosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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