Gangrene and necrosis of lung

J10_LUNGNECROSIS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J85.0 Cause of death: ICD-10 — J85.0 2 out of 7 registries used, show all original rules.	11
4. Check minimum number of events None	11
5. Include endpoints None	11
6. Filter based on genotype QC (FinnGen only)	9

Control definitions (FinnGen only)

Control exclude: J10_NECROTIC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J85
Name in latin: Necrosis pulmonis

NAME	J10_LUNGNECROSIS
CONTROL_EXCLUDE	J10_NECROTIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J850
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J850
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Gangrene and necrosis of lung based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	263	84	175
Only index persons	158	58	100
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	61.42	64.70	59.89
Only index persons	58.09	56.91	58.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	9	-	6
Unadjusted period prevalence (%)	0.00	-	0.00
Median age at first event (years)	58.83	-	69.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

5.30

1.91

3.3

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.80

1.65

3.4

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.19

1.47

3.4

1.6

—

(3033658) Prothrombin time (PT) actual/Normal

2.95

0.88

5.0

4.3

79.80

78.25

—

(42870588) Differential panel, method unspecified - Blood

2.67

0.83

2.4

2.3

—

(3023368) Bacteria identified in Blood by Culture

2.66

0.76

7.3

4.9

—

(3044640) Blood type and Crossmatch panel - Blood

2.21

0.53

3.0

2.3

—

(3018418) pH of Serum or Plasma

2.11

0.52

4.4

7.3

7.38

7.39

—

(3026008) Bacteria identified in Urine by Culture

1.93

0.50

3.0

2.5

—

(3021589) Normoblasts [#/volume] in Blood

1.66

0.28

15.5

12.2

0.00

e9/l

—

(3000991) Gas panel - Venous blood

0.00

0.22

0.0

13.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.22

0.0

2.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.22

0.0

5.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.00

0.22

0.0

2.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.22

0.0

2.7

—

(40761535) Cells panel - Urine sediment

0.00

0.22

0.0

4.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.22

0.0

1.7

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

2.3

—

0.18

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

9.2

—

1.20

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

10.7

—

0.47

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

4.2

—

0.54

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

10.7

—

0.80

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

4.2

—

1.24

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

16.86

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

2.0

—

57.14

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

6.6

—

93.63

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

-0.00

0.0

1.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

-0.00

0.0

2.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

-0.00

0.0

3.5

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

-0.00

0.0

6.7

—

22.53

—

(3025941) Bacteria identified in Stool by Culture

0.00

-0.00

0.0

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

-0.00

0.0

11.8

—

95.63

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

-0.00

0.0

3.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

-0.00

0.0

3.1

—

(36660697) Celiac disease serology panel - Serum

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

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Association

Association between endpoint J10_LUNGNECROSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_LUNGNECROSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: J10_LUNGNECROSIS – Gangrene and necrosis of lung

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Gangrene and necrosis of lung

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints