Airway disease due to specific organic dust

J10_AIRWDISDUST

byssinosis: An occupational lung disorder caused by exposure to cotton dust. It occurs more commonly in workers in the textile industry. Signs and symptoms include chest tightness, cough and wheezing. The symptoms tend to get worse at the beginning of the week and subside by the end of the week.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J66 Hospital discharge: ICD-9 — 504 Cause of death: ICD-10 — J66 Cause of death: ICD-9 — 504 2 out of 7 registries used, show all original rules.	100
4. Check minimum number of events None	100
5. Include endpoints None	100
6. Filter based on genotype QC (FinnGen only)	92

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Morbus viarum respiratoriarum e pulvere organico specifico

NAME	J10_AIRWDISDUST
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J66
HD_ICD_9	504
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J66
COD_ICD_9	504
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Airway disease due to specific organic dust based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	675	305	364
Only index persons	584	272	312
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.30	44.90	45.45
Only index persons	44.00	44.43	43.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	92	49	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	44.98	40.60	49.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
950

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J66.8

ICD-10 Finland

Airway disease due to other specific organic dusts

+∞

92.3

J45.0

ICD-10 Finland

Predominantly allergic asthma

9.7

21.8

J45.9

ICD-10 Finland

Asthma, unspecified

6.7

18.7

109

R03AC03

ATC

terbutaline; inhalant

5.2

10.5

J66.0

ICD-10 Finland

Byssinosis

+∞

9.5

J45.1

ICD-10 Finland

Nonallergic asthma

5.5

8.8

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

4.0

8.7

112

J67.0

ICD-10 Finland

Farmer lung

+∞

8.5

XG410

NOMESCO Finland

Flow-volume spirometry

24.6

8.2

R03AC02

ATC

salbutamol; inhalant

3.8

7.9

405

H02AB06

ATC

prednisolone; systemic

3.4

7.7

319

R03DC03

ATC

montelukast; oral

4.0

7.3

J45

ICD-10 Finland

Asthma

4.4

7.1

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

13.6

6.8

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

4.4

6.8

XQ800

NOMESCO Finland

Prick test

6.2

6.5

R06.0

ICD-10 Finland

Dyspnoea

3.1

6.4

168

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3015665) Acarus siro IgE Ab [Units/volume] in Serum

+∞

5.25

1.0

0.0

0.48

—

u/ml

—

(3000510) Lepidoglyphus destructor IgE Ab [Units/volume] in Serum

+∞

5.25

1.0

0.0

1.84

—

u/ml

—

(3017414) Tyrophagus putrescentiae IgE Ab [Units/volume] in Serum

+∞

5.25

1.0

0.0

0.76

—

u/ml

—

(3005322) IgE [Units/volume] in Serum or Plasma

3.35

4.85

1.8

1.3

82.58

169.25

u/ml

0.84

(4062490) Immunoglobulin typing, IgG

7.46

2.58

1.4

1.3

—

(3006504) Eosinophils/Leukocytes in Blood

399

1.90

2.39

11.3

5.6

2.93

2.89

0.04

380

(3022096) Basophils/Leukocytes in Blood

399

1.90

2.39

11.3

5.6

0.62

0.70

0.53

377

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

4.11

2.30

1.1

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

222

1.91

2.27

4.5

4.8

—

(3011288) Drugs identified in Urine by Screen method Nominal

3.54

2.23

1.4

1.1

—

(3018010) Neutrophils/Leukocytes in Blood

398

1.83

2.15

11.0

5.7

57.14

57.76

0.18

383

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.40

2.15

2.4

2.7

—

(3019069) Monocytes/Leukocytes in Blood

400

1.81

2.10

11.0

5.6

8.36

8.45

0.10

382

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.69

2.10

2.9

2.3

11.09

9.18

mg/l

—

(3002030) Lymphocytes/Leukocytes in Blood

404

1.78

2.00

11.2

5.7

27.50

27.56

0.01

389

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

3.93

1.97

1.0

1.1

—

(42870588) Differential panel, method unspecified - Blood

269

1.76

1.88

10.1

5.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.28

1.87

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.69

1.87

1.2

1.6

—

(3000494) Fungus identified in Specimen by Culture

2.03

1.76

2.4

1.5

—

(3045424) Erythrocytes [Presence] in Urine

2.55

1.58

3.8

2.1

—

0.00

estimate

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

127

1.84

1.53

2.7

1.9

—

(3002179) Metamyelocytes/Leukocytes in Blood

2.05

1.48

5.6

4.4

2.20

0.55

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

147

1.74

1.40

1.6

1.4

6.57

17.17

u/ml

0.79

(3019977) pH of Arterial blood

1.89

1.35

3.8

7.7

7.44

7.43

0.26

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.21

1.34

9.7

2.2

1.18

0.99

mmol/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.60

1.32

3.2

1.5

—

(3023419) Bacteria identified in Sputum by Culture

2.87

1.30

6.4

1.7

—

(3000492) Spirometry study

1.84

1.20

2.5

1.4

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

2.58

1.16

1.0

2.3

—

2.17

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.07

1.16

1.9

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.07

1.16

1.3

1.2

—

(3022313) Gas panel - Capillary blood

2.28

1.10

12.1

2.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

123

1.68

1.10

2.7

2.6

2.41

2.38

g/l

0.08

117

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.10

1.08

2.8

7.8

24.07

23.86

mmol/l

—

(3022145) Colonoscopy Study observation

1.74

1.08

1.3

1.4

—

(3026361) Erythrocytes [#/volume] in Blood

903

0.50

1.06

34.0

22.2

4.51

4.54

e12/l

0.26

883

(3035941) MCH [Entitic mass]

903

0.50

1.06

33.6

22.1

30.38

30.36

0.04

895

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

903

0.50

1.06

34.1

22.5

40.69

40.88

0.11

895

(3024731) MCV [Entitic mean volume] in Red Blood Cells

903

0.50

1.06

33.6

22.1

91.45

90.92

0.49

895

(3010813) Leukocytes [#/volume] in Blood

903

0.50

1.06

34.3

22.4

6.91

6.72

e9/l

0.39

884

(3000963) Hemoglobin [Mass/volume] in Blood

903

0.50

1.06

34.2

22.4

136.27

137.01

g/l

0.18

896

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.34

1.04

1.0

1.1

—

(3007461) Platelets [#/volume] in Blood

902

0.51

1.04

34.3

22.2

257.27

251.66

e9/l

0.42

886

(3019060) Gas panel - Arterial blood

1.88

1.00

3.3

4.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.88

1.00

2.8

6.6

25.43

24.79

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.71

0.97

2.7

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.96

0.96

2.6

1.5

—

(3042936) Bacteria identified in Isolate by Culture

120

1.62

0.94

1.7

2.1

—

(1761868) Lipid panel - Serum or Plasma

394

0.68

0.93

2.9

3.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.99

0.91

1.0

1.1

—

(4024509) Urine culture

2.14

0.91

4.0

1.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

130

1.58

0.90

2.4

2.7

12.43

14.10

umol/l

0.50

125

(3032080) INR in Blood by Coagulation assay

380

1.41

0.86

16.7

11.6

1.17

1.18

inr

0.02

312

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

167

1.50

0.84

1.5

1.4

12.97

24.51

iu/ml

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

876

0.58

0.83

16.3

11.5

30.13

26.91

u/l

0.74

860

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

1.73

0.81

1.1

—

0.66

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.80

0.0

1.8

—

186.33

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.24

0.77

1.2

1.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.24

0.77

1.8

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.14

0.75

1.8

1.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.05

0.74

1.2

0.21

0.25

g/l

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

119

1.52

0.73

2.5

2.6

22.63

23.87

0.18

113

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

530

1.36

0.69

3.0

3.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

137

0.62

0.67

2.3

1.6

—

(40761511) CBC panel - Blood by Automated count

854

0.65

0.66

19.3

13.6

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.69

0.64

1.1

1.36

1.55

g/l

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.65

0.63

1.1

0.73

0.90

g/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.59

0.0

1.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.76

0.59

1.0

1.2

—

(3008898) HLA-B27 [Presence]

1.76

0.59

1.0

1.1

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

842

0.68

0.57

22.3

16.6

140.00

139.72

mmol/l

0.67

829

(3023103) Potassium [Moles/volume] in Serum or Plasma

842

0.68

0.57

22.3

16.7

3.99

3.96

mmol/l

0.50

825

(3000764) Benzodiazepines [Presence] in Urine

1.62

0.55

1.3

1.2

—

(3028300) Cannabinoids [Presence] in Urine

1.57

0.54

1.3

1.2

—

(3027008) Opiates [Presence] in Urine

1.57

0.54

1.3

1.2

—

(3003694) ABO and Rh group [Type] in Blood

253

0.73

0.54

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

101

1.45

0.53

2.0

2.2

184.56

120.26

ug/g

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

101

1.45

0.53

2.5

1.9

—

(4035726) Immunohistochemistry procedure

1.42

0.52

1.1

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

107

0.63

0.52

1.6

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

345

1.28

0.50

2.3

2.0

94.69

99.12

pmol/l

0.31

162

(3025941) Bacteria identified in Stool by Culture

1.60

0.50

1.1

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

166

1.34

0.49

4.1

3.9

137.67

157.07

ng/l

0.05

122

(3001019) Free T4 and TSH panel - Serum or Plasma

1.53

0.49

1.9

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

251

1.29

0.47

2.5

2.2

—

(3023368) Bacteria identified in Blood by Culture

223

1.29

0.47

4.1

4.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.61

0.44

4.2

7.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.41

0.0

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.50

0.41

2.4

1.3

—

(3018418) pH of Serum or Plasma

227

1.26

0.41

3.3

4.1

7.40

7.39

0.39

152

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.39

0.0

1.4

—

(3026782) Osmolality of Urine

156

0.74

0.38

2.4

481.33

499.04

mosm/kgh2o

0.10

134

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

842

0.74

0.38

5.3

5.9

2.67

2.75

mmol/l

0.35

794

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.39

0.35

1.2

21.18

26.37

iu/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

279

0.81

0.33

4.9

2.8

0.00

estimate

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

195

1.24

0.32

1.4

1.2

0.47

1.38

u/ml

—

(40761535) Cells panel - Urine sediment

1.37

0.32

5.7

2.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.27

0.30

1.3

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

379

0.84

0.30

2.9

2.8

—

estimate

—

(3015736) pH of Urine

342

1.19

0.29

3.7

3.1

6.11

6.16

0.12

197

(3021589) Normoblasts [#/volume] in Blood

383

1.17

0.28

13.0

12.0

0.00

e9/l

0.29

313

(3029937) Albumin [Presence] in Urine by Test strip

238

1.19

0.26

4.8

3.6

0.00

0.03

estimate

—

(40768797) Stomach Pathology biopsy report

116

1.24

0.23

1.1

1.2

—

(3027944) Amphetamines [Presence] in Urine

1.33

0.23

1.4

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

219

0.83

0.23

4.4

4.3

16.69

21.44

1.07

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.72

0.23

7.9

4.9

2.64

83.71

ug/l

—

(3020891) Body temperature

1.30

0.23

3.2

4.1

37.04

36.95

°c

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

260

1.17

0.23

2.7

2.2

106.14

254.16

u/l

1.36

248

(40758558) Short blood count panel - Blood

241

1.17

0.22

10.0

6.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

438

1.14

0.22

4.7

3.4

0.00

estimate

-0.00

100

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

3.37

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

2.0

—

32.20

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

2.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

110

0.80

0.21

1.9

1.5

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

1.5

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.21

0.0

1.2

—

9.06

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.20

0.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

349

0.87

0.20

4.8

3.3

0.00

0.07

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

443

1.12

0.17

4.7

3.4

0.00

estimate

-0.00

104

(3002032) Base excess in Venous blood by calculation

0.76

0.16

3.8

3.0

0.67

1.29

mmol/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.19

0.16

3.4

5.7

1.51

1.23

mmol/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

375

0.89

0.16

1.7

1.9

1.37

1.36

mmol/l

0.01

322

(3007164) IgA [Mass/volume] in Serum or Plasma

179

1.15

0.16

1.9

1.3

1.90

2.69

g/l

1.12

109

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

636

1.12

0.15

5.1

4.3

14.93

14.75

pmol/l

0.23

591

(3020564) Creatinine [Moles/volume] in Serum or Plasma

870

0.88

0.15

25.3

18.7

83.63

76.01

umol/l

0.72

859

(21494755) Public health laboratory ask at order entry panel

0.79

0.14

1.3

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

169

0.87

0.14

1.3

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

114

1.16

0.12

1.2

1.5

—

(3000850) Epithelial cells [#/volume] in Urine

182

1.13

0.12

3.9

2.4

2.46

6.32

e6/l

1.53

164

(3002582) Erythrocytes [#/volume] in Urine

269

0.90

0.11

5.0

2.8

22.43

307.74

e6/l

0.60

200

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

331

1.09

0.11

4.3

3.3

91.03

26.24

ng/l

0.56

221

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.16

0.11

1.8

1.7

325.55

367.46

nmol/l

0.30

(3020682) Albumin/Creatinine [Ratio] in Urine

257

0.91

0.10

6.2

4.3

6.08

8.84

mg/mmol

0.24

164

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

826

1.15

0.09

22.8

14.1

23.17

23.28

mg/l

0.01

678

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

287

0.92

0.09

5.5

2.9

—

(3009261) Glucose [Presence] in Urine by Test strip

452

1.08

0.09

4.7

3.5

0.00

estimate

-0.00

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.15

0.09

2.8

2.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.12

0.09

4.5

7.6

0.80

0.64

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.10

0.09

4.5

7.1

1.88

1.56

—

(36660697) Celiac disease serology panel - Serum

0.81

0.08

1.4

1.2

—

(40768804) Tissue Pathology biopsy report

314

1.08

0.08

2.0

1.9

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.12

0.08

1.4

1.3

—

32.90

—

(3000991) Gas panel - Venous blood

0.83

0.08

3.8

6.4

—

(40761536) Microorganisms panel - Urine sediment

0.81

0.08

3.8

3.0

—

(3026008) Bacteria identified in Urine by Culture

224

0.92

0.07

3.1

2.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.04

0.07

2.3

1.8

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.87

0.07

3.6

3.1

5.81

5.60

kpa

—

(3002256) Pathology report gross observation

100

0.89

0.06

1.3

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

273

0.93

0.06

4.4

3.4

8.05

8.36

mmol/l

0.10

235

(3014576) Chloride [Moles/volume] in Serum or Plasma

111

1.09

0.04

3.5

5.7

106.00

104.67

mmol/l

0.62

111

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

128

0.93

0.03

4.9

2.7

0.40

0.98

e6/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

182

1.05

0.02

3.0

2.2

—

(36304419) Bacteria [Presence] in Urine

217

1.02

0.00

3.4

2.6

—

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

233

0.98

0.00

3.7

2.7

0.28

0.31

e6/l

0.05

164

(3012516) Albumin [Mass/volume] in Urine

253

0.98

0.00

4.5

3.6

25.13

54.28

mg/l

0.98

171

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

765

0.97

0.00

6.1

5.2

1.70

1.90

mu/l

1.01

709

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

205

1.03

0.00

1.7

1.6

0.91

1.27

mg/l

0.40

175

(3019150) Specific gravity of Urine by Refractometry

184

0.97

0.00

5.3

3.5

1.02

kg/l

0.01

118

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

284

0.98

0.00

5.3

5.0

4.54

1.87

ug/l

0.42

259

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

116

1.04

0.00

4.3

2.9

2.00

4.23

e6/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

159

1.01

0.00

2.1

1.9

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

3.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.3

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.0

—

50.50

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.3

—

(3017704) Immunofixation for Urine

0.00

0.0

1.0

—

(44806420) Estimation of glomerular filtration rate

0.00

0.0

1.7

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

10.2

—

666.20

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

61.60

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.6

—

27.40

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(4211845) Urine protein measurement

0.00

0.0

1.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

0.0

1.1

—

176.14

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.97

0.00

2.3

3.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

229.05

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.7

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

0.0

1.0

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

0.0

1.3

—

1.16

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

174.14

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

48.06

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

100

1.00

-0.00

2.2

2.3

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

49.33

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

5.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

2.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

6.6

—

128.97

—

(3018095) Leukocytes [#/volume] in Urine

300

1.00

-0.00

5.1

3.6

36.93

139.13

e6/l

0.91

212

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.1

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

-0.00

0.0

2.8

—

0.45

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

99.50

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

9.67

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.98

-0.00

1.8

2.2

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.3

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.0

—

9.00

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.89

-0.00

3.7

2.4

4.97

4.49

kpa

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

2.3

—

1.50

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

790

1.00

-0.00

4.1

4.5

1.37

1.29

mmol/l

0.35

740

Mortality – FinRegistry

↥

Association

Association between endpoint J10_AIRWDISDUST and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_AIRWDISDUST.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: J10_AIRWDISDUST – Airway disease due to specific organic dust

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Airway disease due to specific organic dust

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints