Pasteurella hemorrhagic septicemia: Any of several bacterial diseases, usually caused by pasteurella multocida, marked by the presence of hemorrhagic areas in the subcutaneous tissues, serous membranes, muscles, lymph glands, and throughout the internal organs. The diseases primarily affect animals and rarely humans.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
87 |
4. Check minimum number of eventsNone |
87 |
5. Include endpointsNone |
87 |
6. Filter based on genotype QC (FinnGen only) |
74 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_SEPTICHE_PNEUMONIA
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- A41
- Name in latin
- Septic(h)aemia ab Haemophilo influenzae
Similar endpoints
↥List of similar endpoints to
Haemophilus septicemia
based on the number of shared cases.
Similar with more cases:
- Pneumonia derived septicemia
- Other septicaemia
- Other septicaemia, including avohilmo
- Septicaemia
- Explicit Sepsis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 634 | 322 | 306 |
| Only index persons | 485 | 264 | 221 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.69 | 65.59 | 57.45 |
| Only index persons | 60.23 | 65.06 | 54.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 74 | 36 | 38 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 56.79 | 52.67 | 60.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 77
- Matched controls
- 770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A41.3
ICD-10 Finland
Sepsis due to Haemophilus influenzae
+∞
83.0
64
*
0384A
ICD-9 Finland
Septicaemia due to other gram-negative organisms[SEPTICHAEMIA HAEMOPHILUS INFLUENZAE]
+∞
14.0
13
*
J14
ICD-10 Finland
Pneumonia due to Haemophilus influenzae
140.1
11.8
12
*
A41.9
ICD-10 Finland
Sepsis, unspecified
19.8
10.9
16
10
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.2
8.8
40
159
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.9
7.4
19
48
J01MA12
ATC
levofloxacin; systemic
3.9
7.2
29
104
B03XA01
ATC
erythropoietin; parenteral
44.1
6.9
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.9
6.7
25
84
J01FF01
ATC
clindamycin; systemic
3.5
6.4
31
124
J01MA14
ATC
moxifloxacin; systemic
4.8
6.3
16
40
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
16.7
6.1
9
6
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
6.1
19
56
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.5
6.0
17
46
N03AX16
ATC
[U] pregabalin
3.6
6.0
26
96
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
43
5.54
8.45
19.4
5.9
23.54
23.81
mmol/l
0.12
19
43
23
72
4.13
6.82
18.7
5.5
1.34
1.17
mmol/l
0.06
23
57
26
94
3.67
6.24
3.9
1.7
—
—
—
0
0
23
89
3.26
4.86
22.0
6.4
1.16
1.06
mmol/l
0.67
23
83
23
92
3.14
4.58
4.3
1.8
—
—
—
0
0
28
127
2.89
4.47
3.9
1.9
—
—
—
0
0
16
54
3.48
4.14
3.4
1.6
—
—
—
0
0
13
33
4.52
4.03
2.9
1.8
1.37
1.65
g/l
0.53
13
28
9
15
6.63
3.94
1.8
1.1
—
—
—
0
0
9
15
6.63
3.94
1.8
1.1
—
—
—
0
0
46
283
2.55
3.88
6.0
2.9
147.70
119.28
ug/l
0.44
46
262
48
304
2.54
3.77
23.4
6.6
1.19
1.21
mmol/l
1.24
48
280
23
105
2.70
3.54
14.2
7.8
104.52
103.30
mmol/l
0.66
23
105
23
105
2.70
3.54
6.6
3.0
0.80
0.81
mmol/l
0.17
23
100
9
18
5.51
3.49
2.0
1.4
—
—
—
0
0
6
7
9.16
3.32
1.2
1.3
—
—
—
0
0
6
8
8.01
3.11
2.5
1.6
—
—
—
0
0
13
47
3.12
2.99
4.2
4.6
63.43
68.32
ml/min/173m2
—
7
22
9
22
4.49
2.99
2.6
1.2
—
—
—
0
0
6
9
7.11
2.92
2.5
1.1
—
—
—
0
0
6
9
7.11
2.92
2.5
1.6
—
—
—
0
0
10
28
3.95
2.90
2.2
1.5
—
—
—
0
0
8
18
4.83
2.88
1.6
1.8
—
—
—
0
0
5
6
8.80
2.79
1.0
1.0
—
—
—
0
0
12
41
3.28
2.77
3.3
1.4
—
—
—
0
0
12
42
3.19
2.70
14.1
5.0
0.68
0.66
%
0.02
12
42
19
92
2.41
2.54
8.8
2.8
19.42
23.40
%
0.81
19
83
50
359
2.12
2.49
12.4
6.4
9.87
12.82
umol/l
1.41
50
337
9
28
3.50
2.39
2.3
1.5
—
—
—
0
0
11
42
2.88
2.25
15.3
5.0
0.75
1.34
%
1.57
11
42
6
14
4.55
2.19
1.7
1.9
—
—
—
0
0
14
63
2.49
2.16
19.1
9.9
1.29
1.30
mmol/l
0.02
14
63
6
15
4.24
2.08
2.2
1.2
—
—
—
0
0
25
147
2.04
2.07
3.9
2.1
—
—
—
0
0
7
21
3.56
2.02
2.3
1.9
—
—
—
0
0
20
109
2.13
2.01
8.4
2.7
9.99
14.20
umol/l
2.07
20
97
0
54
0.00
1.94
0.0
2.3
—
3.46
—
0
43
37
254
1.88
1.94
2.8
2.1
90.93
96.69
pmol/l
0.41
25
123
41
295
1.83
1.82
16.7
4.7
31.80
35.45
g/l
3.13
41
281
6
18
3.52
1.78
6.7
5.2
253.50
201.50
%
—
6
18
0
46
0.00
1.77
0.0
1.1
—
111.88
—
0
12
7
24
3.10
1.77
2.4
2.2
—
—
—
0
0
14
71
2.19
1.66
6.2
2.4
20.07
27.12
u/l
0.98
14
59
0
44
0.00
1.57
0.0
2.0
—
3.48
—
0
33
45
344
1.74
1.55
5.4
4.3
308.43
22.87
estimate
—
7
71
9
41
2.35
1.42
1.7
1.3
—
—
—
0
0
6
23
2.74
1.39
1.0
1.3
—
—
—
0
0
5
17
3.07
1.38
2.6
2.1
—
—
—
0
0
11
55
2.17
1.35
20.6
3.9
154.91
83.06
ng/l
1.04
11
50
10
48
2.25
1.34
48.5
10.6
26.38
24.29
mmol/l
—
10
48
6
25
2.51
1.27
12.2
2.1
84.83
23.53
u/ml
—
6
25
18
114
1.76
1.16
9.7
3.3
0.64
1.19
e6/l
0.63
11
57
43
343
1.57
1.12
5.8
4.4
0.00
0.00
estimate
—
5
65
17
109
1.72
1.05
10.2
3.4
7.44
4.18
e6/l
—
9
52
49
407
1.56
1.04
13.2
5.2
7.16
6.62
mmol/l
1.02
49
389
42
339
1.53
1.00
5.6
4.3
0.00
0.00
estimate
—
5
69
22
155
1.59
0.95
4.5
4.2
1.02
1.02
kg/l
0.17
15
93
12
71
1.82
0.95
7.0
3.2
—
—
—
0
0
56
487
1.55
0.90
21.9
7.8
93.66
80.50
u/l
1.02
56
458
47
403
1.43
0.74
4.4
3.3
—
—
—
0
0
11
70
1.67
0.69
4.8
4.3
4.08
20.33
ug/l
1.43
11
55
63
671
0.66
0.59
68.6
24.7
37.54
40.30
%
5.06
63
666
63
671
0.66
0.59
68.6
24.1
122.59
135.25
g/l
7.76
63
665
0
23
0.00
0.59
0.0
1.5
—
32.78
—
0
23
63
670
0.67
0.57
68.1
23.9
91.24
90.68
fl
0.32
63
665
6
38
1.63
0.56
2.7
2.1
—
—
—
0
0
36
309
1.31
0.50
4.9
2.5
—
—
estimate
—
0
0
5
80
0.60
0.49
4.2
2.7
1536.40
445.59
nmol/l
—
5
74
25
207
1.31
0.44
6.4
3.8
21.63
13.58
mg/mmol
0.31
20
124
5
32
1.60
0.43
1.8
2.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
62
651
0.76
0.35
60.3
20.4
102.08
77.75
umol/l
1.45
62
644
60
631
0.78
0.32
63.7
18.5
138.83
139.68
mmol/l
2.08
60
624
7
54
1.33
0.31
2.1
2.7
4.54
5.50
ug/l
—
7
44
8
66
1.24
0.28
1.9
2.1
—
—
—
0
0
29
260
1.19
0.24
3.8
3.9
36.74
32.96
ng/l
0.10
22
191
63
653
0.81
0.22
26.7
11.9
22.51
26.16
u/l
1.65
63
640
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
18.44
—
0
12
8
68
1.20
0.17
17.9
9.5
—
—
—
0
0
8
72
1.12
0.16
2.5
2.2
—
—
—
0
0
13
118
1.12
0.07
1.6
1.8
—
—
—
0
0
58
576
1.03
0.00
43.1
15.2
75.47
80.66
ml/min/173m2
0.70
58
535
5
53
0.94
0.00
3.8
3.5
1.19
1.22
mmol/l
—
5
47
0
5
0.00
-0.00
0.0
1.6
—
68.40
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
26.11
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
62
620
1.00
-0.00
54.8
15.7
37.20
24.99
mg/l
1.93
62
522
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
55.97
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint HAEMOPHIL_SEPTICHE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HAEMOPHIL_SEPTICHE | 3.291 [1.69, 6.41] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.79 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 192 females with HAEMOPHIL_SEPTICHE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HAEMOPHIL_SEPTICHE | 3.733 [1.8, 7.73] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 182 males with HAEMOPHIL_SEPTICHE died.
Mortality risk
Mortality risk for people of age
years, who have HAEMOPHIL_SEPTICHE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.445% | 0.698% |
| 5 | 2.386% | 3.852% |
| 10 | 5.776% | 9.398% |
| 15 | 10.766% | 17.086% |
| 20 | 18.101% | 28.376% |
Relationships between endpoints
↥Index endpoint: HAEMOPHIL_SEPTICHE – Haemophilus septicemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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