Haemophilus septicemia

HAEMOPHIL_SEPTICHE

Pasteurella hemorrhagic septicemia: Any of several bacterial diseases, usually caused by pasteurella multocida, marked by the presence of hemorrhagic areas in the subcutaneous tissues, serous membranes, muscles, lymph glands, and throughout the internal organs. The diseases primarily affect animals and rarely humans.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A41.3 Hospital discharge: ICD-9 — 0384A Cause of death: ICD-10 — A41.3 Cause of death: ICD-9 — 0384A 2 out of 7 registries used, show all original rules.	72
4. Check minimum number of events None	72
5. Include endpoints None	72
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Control exclude: ASTHMA_SEPTICHE_PNEUMONIA

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A41
Name in latin: Septic(h)aemia ab Haemophilo influenzae

NAME	HAEMOPHIL_SEPTICHE
CONTROL_EXCLUDE	ASTHMA_SEPTICHE_PNEUMONIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A413
HD_ICD_9	0384A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A413
COD_ICD_9	0384A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Haemophilus septicemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	634	322	306
Only index persons	485	264	221
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.69	65.59	57.45
Only index persons	60.23	65.06	54.47

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	34	36
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	56.79	52.67	60.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
720

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A41.3

ICD-10 Finland

Sepsis due to Haemophilus influenzae

+∞

76.1

0384A

ICD-9 Finland

Septicaemia due to other gram-negative organisms[SEPTICHAEMIA HAEMOPHILUS INFLUENZAE]

+∞

14.0

A41.9

ICD-10 Finland

Sepsis, unspecified

23.2

10.8

J14

ICD-10 Finland

Pneumonia due to Haemophilus influenzae

127.9

10.7

J18.9

ICD-10 Finland

Pneumonia, unspecified

4.6

9.6

140

A49.9

ICD-10 Finland

Bacterial infection, unspecified

5.5

8.0

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

33.8

7.3

J01MA12

ATC

levofloxacin; systemic

4.0

7.1

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.8

6.7

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.2

6.7

J01FF01

ATC

clindamycin; systemic

3.7

6.6

116

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

12.7

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

141

6.09

13.34

8.4

3.9

—

(3012544) pH of Venous blood

5.05

7.78

15.2

5.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.37

6.77

3.1

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.50

5.74

3.0

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.81

5.46

3.4

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.25

4.85

3.1

1.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

221

2.82

4.47

5.1

2.4

152.82

111.07

ug/l

0.64

205

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

247

2.84

4.46

18.7

5.6

1.20

1.21

mmol/l

0.45

224

(40758558) Short blood count panel - Blood

143

2.72

3.94

10.2

6.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.26

3.71

1.9

1.7

—

(3052851) Hemolysis interference index of Serum or Plasma

5.88

3.64

2.3

3.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.77

3.61

1.8

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.77

3.61

1.8

1.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.20

3.61

3.1

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.79

3.58

2.5

1.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

7.61

3.45

1.4

—

(3000991) Gas panel - Venous blood

3.31

3.42

23.0

6.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

9.21

3.33

1.2

1.4

—

(3042936) Bacteria identified in Isolate by Culture

2.82

3.21

3.9

1.6

—

(3026782) Osmolality of Urine

111

2.58

3.17

4.3

2.7

461.43

521.38

mosm/kgh2o

0.94

(3042111) Morphology [Interpretation] in Bone marrow Narrative

10.60

3.02

1.6

2.0

—

(3001604) Monocytes [#/volume] in Blood

271

2.32

3.01

12.2

5.1

0.68

0.59

e9/l

0.83

238

(3006315) Basophils [#/volume] in Blood

272

2.31

2.97

12.2

5.1

0.05

0.04

e9/l

0.66

239

(3024928) Oxygen saturation in Venous blood

7.15

2.92

8.0

11.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.83

2.82

3.0

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

249

2.24

2.81

15.5

5.9

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

8.83

2.79

1.2

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

6.42

2.75

1.7

1.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

6.42

2.75

1.7

1.3

—

(3019198) Lymphocytes [#/volume] in Blood

279

2.21

2.72

12.3

5.1

1.96

1.81

e9/l

0.44

249

(3004588) Protein electrophoresis panel - Serum or Plasma

3.58

2.64

4.7

2.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

7.56

2.59

2.4

1.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.49

2.55

7.1

2.0

11.13

14.62

umol/l

1.20

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

3.23

2.55

4.5

5.2

59.83

68.11

ml/min/173m2

—

(3013115) Eosinophils [#/volume] in Blood

284

2.15

2.54

13.5

5.4

0.23

0.19

e9/l

0.25

250

(3007164) IgA [Mass/volume] in Serum or Plasma

115

2.31

2.51

2.0

1.5

2.45

2.46

g/l

0.01

(3022217) INR in Platelet poor plasma by Coagulation assay

276

2.13

2.49

18.6

14.3

1.33

1.32

inr

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.51

2.49

10.9

6.6

104.71

103.11

mmol/l

0.68

(36304419) Bacteria [Presence] in Urine

148

2.18

2.41

8.1

2.7

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

6.61

2.41

2.4

1.0

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

299

2.09

2.36

12.1

5.7

10.20

13.15

umol/l

1.10

283

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

4.19

2.31

1.6

1.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.19

2.31

1.6

1.2

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

5.87

2.25

1.8

1.3

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

5.87

2.25

1.8

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.87

2.25

3.2

1.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

128

2.17

2.24

2.1

1.5

18.98

21.61

nmol/l

0.38

104

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.57

2.20

3.3

1.1

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

2.34

2.17

7.4

3.0

0.79

0.81

mmol/l

0.33

(3019060) Gas panel - Arterial blood

2.97

2.17

8.3

4.6

—

(3044640) Blood type and Crossmatch panel - Blood

180

2.02

2.11

3.6

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

132

2.09

2.06

4.9

3.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.32

2.04

2.1

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.97

2.01

39.7

7.9

26.76

24.67

mmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

200

1.97

2.01

2.5

1.9

91.40

95.38

pmol/l

0.22

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.20

2.00

7.8

5.9

0.83

1.47

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.20

2.00

7.8

5.9

0.56

0.77

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

237

1.93

1.96

14.1

4.3

31.59

35.32

g/l

3.05

226

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.42

1.91

6.2

2.3

19.38

26.35

u/l

0.88

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.75

1.88

1.3

1.2

—

(1761868) Lipid panel - Serum or Plasma

186

0.41

1.86

3.6

3.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

121

2.04

1.84

3.7

1.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

197

1.90

1.81

7.2

2.7

—

(3034770) Mitochondria Ab [Titer] in Serum

4.05

1.74

1.0

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.75

1.64

2.4

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.87

1.62

1.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.58

0.0

1.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.02

1.54

1.2

1.7

—

(3018095) Leukocytes [#/volume] in Urine

206

1.78

1.53

9.7

3.4

20.02

58.49

e6/l

0.92

137

(3014007) Fractional oxyhemoglobin in Arterial blood

2.56

1.52

10.9

7.6

92.54

92.68

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.28

1.46

7.4

5.7

252.20

183.69

—

(3026008) Bacteria identified in Urine by Culture

182

1.77

1.45

4.5

3.1

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

343

1.73

1.40

10.3

4.6

7.13

6.60

mmol/l

0.80

320

(3021589) Normoblasts [#/volume] in Blood

231

1.69

1.33

21.2

9.3

0.02

0.00

e9/l

0.48

190

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.90

1.30

10.0

2.2

19.40

28.38

u/ml

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.37

1.29

1.8

1.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.30

1.26

1.5

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.75

1.23

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

1.17

0.0

1.1

—

123.85

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.48

1.11

7.6

3.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.95

1.05

6.1

3.1

—

(1002224) Polysomnography panel

0.00

1.00

0.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.97

0.0

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.71

0.89

10.1

2.8

8.38

4.72

e6/l

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.88

0.89

4.9

4.3

3.35

23.28

ug/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

420

1.52

0.85

20.0

6.8

97.39

80.08

u/l

1.10

390

(3019832) Treponema pallidum Ab [Presence] in Serum

1.79

0.84

1.7

1.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

169

1.53

0.84

3.6

3.1

2128.26

1142.79

ng/l

0.63

138

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

263

1.47

0.81

4.0

2.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

372

1.47

0.80

9.6

4.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.65

0.79

10.1

2.6

0.88

1.01

e6/l

—

(3022313) Gas panel - Capillary blood

2.07

0.74

39.8

3.6

—

(3025941) Bacteria identified in Stool by Culture

1.83

0.74

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.99

0.72

2.8

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.91

0.70

16.8

8.1

—

(3020891) Body temperature

1.91

0.70

8.4

4.3

—

(3002256) Pathology report gross observation

1.68

0.66

1.5

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

364

1.37

0.59

3.9

3.2

—

(3002385) Erythrocyte distribution width [Ratio]

478

1.41

0.57

52.1

15.7

15.63

15.04

0.31

470

(3000963) Hemoglobin [Mass/volume] in Blood

618

0.68

0.52

60.3

19.7

122.47

135.64

g/l

7.37

609

(3009542) Hematocrit [Volume Fraction] of Blood

618

0.68

0.52

59.5

19.8

37.08

40.06

2.88

588

(3026361) Erythrocytes [#/volume] in Blood

618

0.68

0.52

60.0

19.6

4.17

4.52

e12/l

4.27

599

(3035941) MCH [Entitic mass]

618

0.68

0.52

59.9

19.4

29.80

30.15

0.68

610

(3010813) Leukocytes [#/volume] in Blood

618

0.68

0.52

59.7

19.6

8.35

6.68

e9/l

2.65

599

(36660697) Celiac disease serology panel - Serum

1.61

0.51

1.4

1.2

—

(3007461) Platelets [#/volume] in Blood

617

0.69

0.50

60.0

19.6

259.72

247.53

e9/l

0.51

603

(3024731) MCV [Entitic volume]

617

0.69

0.50

60.0

19.5

90.84

90.54

0.15

609

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.44

0.46

2.1

2.8

4.54

5.78

ug/l

—

(3000492) Spirometry study

1.51

0.45

1.1

1.4

—

(4035726) Immunohistochemistry procedure

1.48

0.44

2.1

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.5

—

32.82

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

210

1.29

0.40

4.0

3.8

41.52

31.99

ng/l

0.22

149

(3000494) Fungus identified in Specimen by Culture

1.39

0.40

2.3

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.38

0.32

1.9

2.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

148

0.77

0.28

4.0

3.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

16.82

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

1.7

—

3.69

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.20

0.0

1.5

—

(3013512) EKG study

153

0.82

0.20

4.6

3.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.25

0.19

2.6

2.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.23

0.19

1.4

1.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

405

1.15

0.18

3.3

4.0

14.76

14.71

pmol/l

0.03

371

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.75

0.18

3.8

2.2

1635.20

439.20

nmol/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

501

0.87

0.15

4.5

4.6

1.93

mu/l

0.01

457

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

511

1.14

0.13

36.6

12.1

76.74

81.27

ml/min/173m2

0.55

423

(40768804) Tissue Pathology biopsy report

215

1.10

0.09

3.2

2.2

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

564

0.89

0.09

55.9

15.4

138.69

139.64

mmol/l

2.27

553

(40768797) Stomach Pathology biopsy report

1.09

0.08

1.1

1.3

—

(3048689) Calprotectin [Mass/mass] in Stool

1.11

0.08

3.9

1.8

78.25

106.89

ug/g

—

(3044889) 12 lead EKG panel

384

0.93

0.07

5.2

3.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

592

0.90

0.07

22.3

9.7

22.14

25.74

u/l

1.76

572

(3020564) Creatinine [Moles/volume] in Serum or Plasma

582

0.90

0.07

48.3

15.4

96.98

76.90

umol/l

1.56

582

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

101

1.11

0.04

1.7

1.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

111

1.10

0.04

1.4

1.7

498.33

454.53

pmol/l

0.16

(3003694) ABO and Rh group [Type] in Blood

159

0.93

0.03

1.6

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

133

1.07

0.02

2.2

1.9

1.47

1.36

mmol/l

0.22

112

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

211

0.99

0.00

3.8

4.1

—

(40761511) CBC panel - Blood by Automated count

584

0.96

0.00

35.2

12.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

68.40

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.1

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

208.96

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.95

-0.00

22.0

9.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.1

—

4.16

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

16.03

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.1

—

(3045424) Erythrocytes [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

-0.00

0.0

4.4

—

30.54

—

Mortality – FinRegistry

↥

Association

Association between endpoint HAEMOPHIL_SEPTICHE and mortality.

Females

Parameter	HR [95% CI]	p-value
HAEMOPHIL_SEPTICHE	3.291 [1.69, 6.41]	< 0.001
Birth year	0.999 [0.99, 1.01]	0.79

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 192 females with HAEMOPHIL_SEPTICHE died.

Males

Parameter	HR [95% CI]	p-value
HAEMOPHIL_SEPTICHE	3.733 [1.8, 7.73]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 182 males with HAEMOPHIL_SEPTICHE died.

Mortality risk

Mortality risk for people of age

years, who have HAEMOPHIL_SEPTICHE.

N-year risk	Females	Males
1	0.445%	0.698%
5	2.386%	3.852%
10	5.776%	9.398%
15	10.766%	17.086%
20	18.101%	28.376%

Relationships between endpoints

↥

Index endpoint: HAEMOPHIL_SEPTICHE – Haemophilus septicemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Haemophilus septicemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints