Ototoxic hearing loss

H8_HL_OTOTOX

nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H91.0# Cause of death: ICD-10 — H91.0# 2 out of 7 registries used, show all original rules.	76
4. Check minimum number of events None	76
5. Include endpoints None	76
6. Filter based on genotype QC (FinnGen only)	68

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H91
Name in latin: Hypacusis ototoxica

NAME	H8_HL_OTOTOX
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H910
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H910
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Ototoxic hearing loss based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Ototoxic hearing loss, drug-induced

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	494	281	211
Only index persons	427	248	179
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	66.06	68.61	62.66
Only index persons	65.57	67.99	62.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	68	40	28
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.01	60.18	59.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
69: Matched controls
690

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H91.0

ICD-10 Finland

Ototoxic hearing loss

+∞

99.1

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

108.1

32.9

DAX00

NOMESCO Finland

Adjustment or review of hearing aid

142.9

11.8

DFF00

NOMESCO Finland

Pure tone audiometry

16.9

11.5

UDC00

NOMESCO Finland

Ear microscopy

14.9

11.4

Z01.1

ICD-10 Finland

Examination of ears and hearing

9.6

10.4

H91.1

ICD-10 Finland

Presbycusis

21.5

9.9

DAX08

NOMESCO Finland

Fitting of hearing aid

115.2

9.7

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

9.6

Z97.4

ICD-10 Finland

Presence of external hearing-aid

102.0

8.6

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

+∞

8.5

H81.0

ICD-10 Finland

Ménière disease

28.8

7.8

N07CA01

ATC

betahistine; oral

8.1

6.4

Z46.1

ICD-10 Finland

Fitting and adjustment of hearing aid

14.3

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.15

2.78

2.2

1.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

157

2.32

2.77

1.7

1.9

20.44

20.52

nmol/l

0.01

129

(3026008) Bacteria identified in Urine by Culture

191

2.01

2.05

4.1

3.2

—

(3022145) Colonoscopy Study observation

2.54

1.81

1.1

1.3

—

(3023368) Bacteria identified in Blood by Culture

172

1.94

1.80

4.7

4.2

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.75

1.75

1.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

4.06

1.74

2.0

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.10

1.70

2.9

2.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

239

1.83

1.65

2.0

2.3

99.16

96.97

pmol/l

0.08

120

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

278

1.82

1.61

11.7

9.2

1.22

1.21

mmol/l

0.69

233

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

111

1.98

1.60

6.5

4.0

19.50

346.40

ng/l

2.00

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.91

1.31

1.8

2.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.75

1.24

1.8

2.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.75

1.24

1.4

1.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.61

1.17

1.2

2.1

—

(3028626) Oxygen [Partial pressure] in Capillary blood

2.37

1.05

2.0

5.9

8.76

8.30

kpa

—

(3000991) Gas panel - Venous blood

1.88

0.99

15.7

11.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

492

1.73

0.96

4.8

5.2

4.52

4.54

mmol/l

0.05

446

(3031040) Bacteria [#/volume] in Urine by Automated count

378

1.55

0.91

7.2

5.0

—

31.38

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

531

1.77

0.85

33.5

21.6

138.31

139.50

mmol/l

1.34

516

(3018418) pH of Serum or Plasma

169

1.54

0.85

3.5

4.3

7.40

7.39

0.53

120

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.79

0.84

1.6

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

532

1.75

0.83

34.4

21.7

4.00

3.98

mmol/l

0.26

516

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

521

1.71

0.83

27.9

18.0

21.20

23.73

mg/l

0.32

435

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.81

0.0

1.2

—

0.29

—

(40768797) Stomach Pathology biopsy report

1.78

0.77

1.2

—

(3020891) Body temperature

1.99

0.72

18.4

3.0

37.00

36.90

°c

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

241

1.43

0.70

6.2

3.7

29.08

44.05

ng/l

0.45

175

(3026782) Osmolality of Urine

123

1.51

0.66

2.6

3.3

461.52

552.26

mosm/kgh2o

0.93

108

(3000850) Epithelial cells [#/volume] in Urine

132

1.49

0.66

2.6

2.8

7.31

4.61

e6/l

0.32

121

(3022313) Gas panel - Capillary blood

1.78

0.65

6.4

6.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.60

0.60

3.6

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.60

0.60

3.4

1.7

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

0.00

0.60

0.0

1.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.60

0.0

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

468

1.45

0.60

3.9

4.4

1.33

1.24

mmol/l

0.25

421

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.78

0.59

1.8

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.60

0.58

2.2

4.0

7.49

15.29

ug/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

387

1.38

0.57

7.0

4.9

—

(3009508) Creatinine [Moles/volume] in Urine

173

1.40

0.56

4.7

3.3

5.25

7.46

mmol/l

1.56

144

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

503

1.46

0.55

5.6

5.9

2.55

2.62

mmol/l

0.22

459

(3020564) Creatinine [Moles/volume] in Serum or Plasma

547

1.54

0.55

33.7

22.8

88.31

78.57

umol/l

0.60

538

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

487

1.38

0.47

4.9

5.1

1.50

1.47

mmol/l

0.22

441

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

245

1.32

0.46

3.6

2.9

—

estimate

—

(3042936) Bacteria identified in Isolate by Culture

1.46

0.46

2.5

2.0

—

(1761868) Lipid panel - Serum or Plasma

181

0.72

0.45

3.4

—

(3002582) Erythrocytes [#/volume] in Urine

198

1.33

0.45

3.6

3.4

19.19

42.17

e6/l

0.60

152

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

124

1.38

0.44

4.1

5.2

20.18

22.39

—

(40761511) CBC panel - Blood by Automated count

532

1.41

0.43

23.0

16.1

—

(3012516) Albumin [Mass/volume] in Urine

162

1.33

0.42

3.6

3.4

57.57

90.27

mg/l

—

106

(3041096) Erythrocytes [Presence] in Urine by Automated

162

1.33

0.42

4.8

4.1

0.00

estimate

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.42

0.0

1.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.45

0.41

1.3

1.6

—

(40768443) Skin Pathology biopsy report

0.00

0.41

0.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.42

0.40

2.3

1.7

—

(3002256) Pathology report gross observation

1.42

0.40

1.7

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.40

0.0

1.5

—

(3016879) Cocaine [Presence] in Urine

0.00

0.40

0.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.39

0.40

1.1

1.5

—

(3027008) Opiates [Presence] in Urine

0.00

0.39

0.0

1.5

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.39

0.0

1.5

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.39

0.0

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

173

1.31

0.39

3.0

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.42

0.39

1.6

2.2

—

(40761536) Microorganisms panel - Urine sediment

1.43

0.36

6.7

3.3

—

(40768804) Tissue Pathology biopsy report

194

1.28

0.36

3.1

2.0

—

(36660697) Celiac disease serology panel - Serum

1.36

0.35

1.8

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.38

0.32

1.6

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.33

0.30

2.0

1.7

—

(3007461) Platelets [#/volume] in Blood

562

1.34

0.30

40.8

26.3

242.19

251.57

e9/l

0.53

548

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.28

0.29

1.6

1.4

—

(3003694) ABO and Rh group [Type] in Blood

159

0.78

0.28

1.5

—

(3024731) MCV [Entitic mean volume] in Red Blood Cells

563

1.33

0.28

40.7

26.2

89.80

90.88

1.28

553

(3026361) Erythrocytes [#/volume] in Blood

563

1.33

0.28

40.8

26.3

4.38

4.43

e12/l

0.29

545

(3010813) Leukocytes [#/volume] in Blood

563

1.33

0.28

41.0

26.4

6.91

6.78

e9/l

0.17

546

(3000963) Hemoglobin [Mass/volume] in Blood

563

1.33

0.28

42.0

26.4

129.51

132.65

g/l

0.81

552

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

563

1.33

0.28

40.9

27.0

38.57

39.45

0.47

553

(3035941) MCH [Entitic mass]

563

1.33

0.28

40.7

26.1

29.80

30.20

1.05

553

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

125

1.26

0.25

2.9

2.8

—

(3018095) Leukocytes [#/volume] in Urine

221

1.21

0.25

4.3

4.2

57.95

95.38

e6/l

0.36

160

(3021601) Nitrite [Presence] in Urine by Test strip

300

1.19

0.24

6.5

4.3

0.00

estimate

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.30

0.23

1.4

1.6

—

(3019060) Gas panel - Arterial blood

1.30

0.23

2.0

4.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.30

0.23

5.0

11.4

25.14

25.35

mmol/l

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

505

1.21

0.21

5.1

5.3

6.10

5.96

mmol/l

0.32

454

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3011288) Drugs identified in Urine by Screen method Nominal

0.00

0.21

0.0

1.7

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

224

1.18

0.21

7.4

4.4

0.00

estimate

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

205

1.18

0.20

3.3

3.4

2.38

2.35

mmol/l

0.44

180

(40768793) Breast Pathology biopsy report

0.00

0.20

0.0

1.6

—

(3013512) EKG study

186

1.19

0.20

5.8

3.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.19

0.18

1.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

303

0.87

0.16

4.0

3.0

—

(3048689) Calprotectin [Mass/mass] in Stool

0.75

0.16

2.3

2.0

76.83

80.19

ug/g

—

(40760892) CBC W Ordered Manual Differential panel - Blood

118

0.82

0.15

12.2

5.9

—

(3009261) Glucose [Presence] in Urine by Test strip

308

1.14

0.15

6.7

4.4

0.00

estimate

—

(42870588) Differential panel, method unspecified - Blood

196

0.89

0.10

7.3

5.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.18

0.10

2.2

2.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

165

1.12

0.10

4.7

4.2

6.46

15.43

mg/mmol

—

104

(3035350) Ketones [Presence] in Urine by Test strip

304

1.10

0.09

6.7

4.3

0.00

26.62

estimate

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.81

0.08

1.8

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.78

0.08

12.0

8.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.05

0.08

1.4

2.2

25.29

26.21

u/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.87

0.07

14.8

8.4

100.25

104.04

mmol/l

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

437

1.09

0.07

30.3

22.5

13.87

13.78

0.15

431

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

101

0.87

0.07

1.2

1.7

—

(40758558) Short blood count panel - Blood

169

1.09

0.05

13.1

6.5

—

(3015736) pH of Urine

240

1.07

0.04

4.9

3.9

6.85

6.31

1.11

126

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

213

1.05

0.01

4.7

3.4

—

(3029937) Albumin [Presence] in Urine by Test strip

175

0.96

0.00

7.5

3.9

0.00

estimate

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.8

—

1.88

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.6

—

11.59

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.6

—

(3045414) Leukocytes [Presence] in Urine

0.98

-0.00

3.0

2.3

—

0.00

estimate

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.6

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

-0.00

0.0

1.6

—

6.39

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

1.8

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

2.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.4

—

(4195642) Thrombophilia screening test

0.00

-0.00

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.8

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

207.80

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.8

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

27.80

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.4

—

294.20

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

19.4

—

1595.80

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

13.4

—

822.20

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

7.6

—

199.34

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.00

-0.00

5.1

3.4

—

(4268621) Lupus anticoagulant assay

0.00

-0.00

0.0

2.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.8

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.7

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

1.76

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_HL_OTOTOX and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_HL_OTOTOX	1.148 [0.87, 1.51]	0.324
Birth year	0.997 [0.99, 1.01]	0.517

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 265 females with H8_HL_OTOTOX died.

Males

Parameter	HR [95% CI]	p-value
H8_HL_OTOTOX	1.377 [0.94, 2.03]	0.104
Birth year	0.988 [0.98, 1.0]	0.013

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 204 males with H8_HL_OTOTOX died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_OTOTOX.

N-year risk	Females	Males
1	0.153%	0.281%
5	0.764%	1.75%
10	1.721%	4.524%
15	3.425%	8.169%
20	5.855%	13.591%

Relationships between endpoints

↥

Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Ototoxic hearing loss

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints