Lens-induced iridocyclitis

H7_IRIDOLENS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H20.2
  • Cause of death: ICD-10 H20.2

2 out of 7 registries used, show all original rules.

62

4. Check minimum number of events

None

62

5. Include endpoints

None

62

6. Filter based on genotype QC (FinnGen only)

59

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H20
Name in latin
Iridocyclitis phakogenes

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 330 171 157
Only index persons 311 165 146
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.04 53.69 52.23
Only index persons 53.04 53.29 52.76

-FinnGen-

Key figures

All Female Male
Number of individuals 59 34 25
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 58.94 57.75 60.55

-FinRegistry-

Age distribution of first events

01020304050607080051015202530354045505560AgeIndividuals

-FinnGen-

Age distribution of first events

0405060700246810121416AgeIndividuals

-FinRegistry-

Year distribution of first events

19701975198019851990199520002005201020152020202201020304050607080YearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952005201020152020202502468101214YearIndividuals

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H20.2
ICD-10 Finland
Lens-induced iridocyclitis
+∞
89.0
62
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
883.1
42.5
37
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
16.4
15
*
S01BA04
ATC
prednisolone; ophthalmic
44.2
11.8
14
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.0
11.6
23
48
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
48.6
10.4
12
*
S01BC03
ATC
diclofenac; ophthalmic
+∞
8.5
8
*
S01BA01
ATC
dexamethasone; ophthalmic
20.8
8.5
12
7
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.5
8.4
21
53
S01ED01
ATC
timolol; ophthalmic
14.6
8.0
13
11
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
7.4
7
*
S01EA03
ATC
apraclonidine; ophthalmic
+∞
7.4
7
*
S01FA04
ATC
cyclopentolate; ophthalmic
45.1
6.9
8
*
S01EE01
ATC
latanoprost; ophthalmic
7.6
6.5
15
25
H26.2
ICD-10 Finland
Complicated cataract
30.1
6.4
8
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
30.1
6.4
8
*
H26.4
ICD-10 Finland
After-cataract
6.3
6.4
17
35

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
236
2.96
4.04
12.9
6.3
—
—
—
0
0
45
298
2.86
3.41
11.9
9.8
4.34
4.31
e9/l
0.02
45
263
30
163
2.63
3.39
5.2
4.0
7.40
7.40
ph
—
7
30
54
410
3.45
3.29
9.8
7.7
89.02
77.64
u/l
0.67
54
383
27
143
2.57
3.17
3.2
2.9
—
—
—
0
0
9
21
4.82
3.13
2.8
4.5
—
—
—
0
0
27
146
2.50
3.01
3.4
3.0
0.32
0.41
e6/l
0.18
21
113
17
73
2.83
2.97
4.6
7.0
103.94
103.44
mmol/l
0.19
17
73
12
40
3.47
2.90
3.7
1.9
717.75
188.69
ng/l
0.40
12
32
38
247
2.39
2.76
12.1
5.3
0.57
0.58
e9/l
0.14
38
218
38
247
2.39
2.76
12.0
5.4
0.05
0.04
e9/l
1.23
38
217
39
258
2.38
2.70
12.0
5.6
0.21
0.20
e9/l
0.16
39
231
39
259
2.36
2.66
6.2
6.9
1.21
1.21
mmol/l
0.17
32
222
38
250
2.34
2.64
6.8
5.2
0.00
0.00
estimate
—
9
50
38
251
2.33
2.61
5.6
3.8
0.00
0.00
estimate
—
9
47
5
8
6.67
2.41
9.6
7.5
—
—
—
0
0
37
248
2.22
2.37
5.7
3.8
0.00
0.00
estimate
—
10
49
35
231
2.18
2.32
13.0
5.1
0.65
0.62
%
0.20
35
217
10
36
3.11
2.26
3.1
1.9
8.96
8.80
g/l
—
10
31
7
19
4.01
2.22
1.0
1.1
—
—
—
0
0
24
139
2.19
2.17
6.8
4.1
0.00
0.00
estimate
—
8
45
35
236
2.11
2.14
13.1
5.3
2.91
2.76
%
0.17
35
224
35
236
2.11
2.14
12.4
5.5
56.92
58.38
%
0.39
35
223
5
10
5.33
2.11
1.0
1.1
—
—
—
0
0
35
238
2.08
2.07
13.6
5.8
8.45
8.33
%
0.09
35
227
6
16
4.03
1.98
2.3
4.1
3.70
3.88
mmol/l
—
6
16
18
97
2.21
1.91
1.4
1.6
1329.44
1231.01
nmol/l
0.16
18
75
30
197
2.01
1.91
3.9
3.6
152.48
67.62
e6/l
0.30
24
142
31
206
2.01
1.91
3.2
3.5
20.20
48.99
ng/l
0.96
24
146
35
243
2.01
1.91
13.5
5.6
28.14
27.04
%
0.29
35
232
45
346
2.10
1.80
6.4
4.1
—
—
—
0
0
5
13
4.08
1.75
12.0
3.4
—
—
—
0
0
10
41
2.71
1.74
2.5
4.2
—
—
—
0
0
36
260
1.92
1.68
17.4
10.6
1.14
1.26
inr
0.36
11
74
10
44
2.51
1.65
5.0
3.6
—
—
—
0
0
10
44
2.51
1.65
1.6
2.1
4.89
5.61
ug/l
—
10
38
11
51
2.41
1.62
1.5
1.5
—
—
—
0
0
10
45
2.46
1.56
7.5
3.2
—
—
—
0
0
13
69
2.12
1.41
1.5
1.7
—
—
—
0
0
21
134
1.86
1.38
8.2
7.4
—
—
—
0
0
24
162
1.79
1.31
3.9
3.0
—
—
—
0
0
8
38
2.27
1.24
2.9
9.8
1.53
1.56
%
—
8
38
22
151
1.71
1.11
4.7
3.8
3.13
8.05
mg/mmol
1.18
15
98
7
34
2.19
1.07
1.1
1.3
—
—
—
0
0
11
61
1.98
1.06
1.6
1.5
—
—
—
0
0
10
54
2.02
1.03
3.2
2.5
17.50
8.65
umol/l
—
10
46
18
119
1.72
1.03
7.1
3.5
—
—
—
0
0
20
138
1.66
0.98
4.0
3.7
—
—
—
0
0
14
88
1.76
0.94
1.3
3.0
0.83
0.82
mmol/l
0.09
14
82
13
80
1.79
0.93
1.1
1.3
0.98
10.00
u/ml
—
8
30
8
42
2.04
0.93
2.9
3.5
1.22
1.23
mmol/l
—
8
37
21
149
1.62
0.92
4.0
3.9
—
—
—
0
0
41
341
1.60
0.92
7.0
4.2
—
40.00
—
0
8
6
30
2.10
0.89
9.0
6.3
26.38
25.83
mmol/l
—
6
30
23
168
1.59
0.89
1.9
2.4
—
—
—
0
0
20
144
1.57
0.82
4.1
3.3
26.85
50.49
mg/l
0.84
15
99
6
33
1.90
0.81
1.5
1.3
—
—
—
0
0
9
55
1.74
0.78
5.8
3.4
74.67
69.83
e9/l
—
9
45
5
25
2.08
0.74
1.0
1.2
—
—
—
0
0
7
41
1.80
0.73
1.0
1.4
—
—
—
0
0
19
139
1.53
0.72
4.1
4.5
—
—
—
0
0
7
44
1.66
0.67
3.6
9.5
—
—
—
0
0
42
366
1.46
0.64
5.0
3.9
—
—
—
0
0
0
19
0.00
0.61
0.0
4.1
—
24.75
—
0
19
0
21
0.00
0.61
0.0
4.1
—
0.24
—
0
9
6
34
1.84
0.60
1.3
1.3
—
—
—
0
0
0
23
0.00
0.59
0.0
1.0
—
—
—
0
0
7
49
1.48
0.48
5.3
1.9
408.14
403.09
nmol/l
—
7
43
5
32
1.61
0.43
1.4
2.7
5.07
5.13
e9/l
—
5
26
11
80
1.46
0.42
1.5
1.6
—
—
—
0
0
6
44
1.40
0.35
2.3
2.5
0.26
0.21
g/l
—
6
39
18
214
0.78
0.33
1.8
2.3
—
—
—
0
0
8
105
0.73
0.32
1.5
1.3
—
0.84
—
0
30
7
55
1.31
0.31
1.1
1.2
—
—
—
0
0
48
452
1.27
0.27
27.2
17.2
14.32
15.16
%
0.78
48
442
10
78
1.34
0.26
1.3
1.2
—
—
—
0
0
55
528
1.37
0.24
23.5
16.8
139.49
139.69
mmol/l
0.22
55
516
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
6
48
1.28
0.21
4.7
2.9
1.67
3.03
mmol/l
—
6
40
0
13
0.00
0.21
0.0
1.5
—
258.57
—
0
7
6
49
1.25
0.21
3.5
3.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
5
67
0.72
0.18
1.2
1.3
—
—
—
0
0
55
532
1.30
0.15
24.2
16.7
3.98
3.98
mmol/l
0.04
55
520
55
531
1.32
0.15
23.3
13.6
—
—
—
0
0
16
176
0.88
0.11
3.9
3.0
—
—
—
0
0
15
135
1.15
0.11
1.4
1.4
—
—
—
0
0
5
45
1.12
0.10
1.8
1.5
—
—
—
0
0
7
67
1.05
0.08
1.4
1.4
—
—
—
0
0
12
109
1.13
0.06
2.0
1.7
0.88
1.06
mg/l
—
7
91
22
214
1.04
0.00
2.4
2.0
95.96
98.34
pmol/l
0.07
14
104
6
61
0.98
-0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
11.32
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.4
—
18.89
—
0
9
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
60.89
—
0
9
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
149.53
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
0.84
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
0.92
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_IRIDOLENS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDOLENS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_IRIDOLENS – Lens-induced iridocyclitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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