Enterohaemorrhagic Escherichia coli infection

EHEC

dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A04.3 Cause of death: ICD-10 — A04.3 2 out of 7 registries used, show all original rules.	82
4. Check minimum number of events None	82
5. Include endpoints None	82
6. Filter based on genotype QC (FinnGen only)	66

Control definitions (FinnGen only)

Control exclude: IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A04
Name in latin: Infectio ab Escherichia coli enterohaemorrhagica

NAME	EHEC
CONTROL_EXCLUDE	IBD_BACT_INTEST_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A043
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A043
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Enterohaemorrhagic Escherichia coli infection based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	663	320	339
Only index persons	530	259	271
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	18.74	22.76	14.55
Only index persons	26.35	31.04	21.86

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	66	35	31
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	58.33	55.06	62.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
75: Matched controls
750

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A04.3

ICD-10 Finland

Enterohaemorrhagic Escherichia coli infection

+∞

102.4

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

9.8

22.8

JN3AD

NOMESCO Finland

Abdominal CT examination

4.9

7.2

H02AB06

ATC

prednisolone; systemic

3.6

6.7

239

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.7

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

11.81

22.53

3.2

1.5

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

20.26

14.14

2.8

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

19.25

12.05

2.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

151

5.05

11.14

7.1

5.1

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

7.23

6.77

4.2

2.2

1.68

2.00

mmol/l

0.17

(3005988) Vibrio sp identified in Specimen by Organism specific culture

16.20

6.60

3.3

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

16.20

6.60

3.3

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

16.77

6.07

3.6

1.7

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

16.77

6.07

3.6

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

16.77

6.07

3.6

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

16.77

6.07

3.6

1.7

—

(42870588) Differential panel, method unspecified - Blood

212

3.23

5.86

11.7

5.7

—

(3018010) Neutrophils/Leukocytes in Blood

316

3.31

5.41

12.2

6.1

59.36

58.04

0.32

305

(3025941) Bacteria identified in Stool by Culture

4.44

5.40

2.1

1.2

—

(3019069) Monocytes/Leukocytes in Blood

307

3.26

5.39

12.6

6.4

8.43

8.73

0.33

295

(3003327) Ova and parasites identified in Stool by Light microscopy

6.60

5.35

3.2

1.6

—

(3022145) Colonoscopy Study observation

3.59

5.07

1.7

1.3

—

(3031040) Bacteria [#/volume] in Urine by Automated count

430

3.91

4.90

8.8

4.6

41.17

5879.40

e6/l

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

104

3.11

4.69

9.1

3.6

0.81

0.82

mmol/l

0.12

(3006504) Eosinophils/Leukocytes in Blood

304

2.93

4.65

12.8

6.3

2.53

2.59

0.07

291

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

346

3.00

4.48

12.5

6.7

10.68

10.69

umol/l

0.00

330

(3019060) Gas panel - Arterial blood

3.97

4.43

11.7

15.2

—

(44806118) Parainfluenza type 4 nucleic acid detection

9.77

4.39

2.3

1.2

—

(44790047) Parainfluenza type 1 nucleic acid detection

9.77

4.39

2.3

1.2

—

(44790048) Parainfluenza type 2 nucleic acid detection

9.77

4.39

2.3

1.2

—

(44790049) Parainfluenza type 3 nucleic acid detection

9.77

4.39

2.3

1.2

—

(3022313) Gas panel - Capillary blood

5.94

4.34

6.1

2.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

6.61

4.29

2.1

1.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

5.67

4.19

5.1

2.0

23.44

24.75

mmol/l

0.51

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

6.23

4.13

2.2

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

5.41

4.06

3.9

2.3

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

6.65

3.95

2.4

2.6

3.47

3.74

g/l

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

7.31

3.78

2.1

1.4

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.02

3.62

13.9

6.1

1.06

mmol/l

0.00

(3028626) Oxygen [Partial pressure] in Capillary blood

6.25

3.44

2.6

2.3

8.50

8.28

kpa

—

(3044640) Blood type and Crossmatch panel - Blood

193

2.39

3.31

3.8

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

462

2.97

3.31

7.0

4.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.98

3.14

2.8

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

224

2.29

3.06

7.8

3.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.72

3.04

2.3

1.6

—

(3015736) pH of Urine

288

2.28

3.00

5.0

3.7

5.94

6.32

1.72

160

(3024561) Albumin [Mass/volume] in Serum or Plasma

252

2.26

2.99

11.6

5.1

33.84

35.74

g/l

1.07

247

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

5.81

2.94

2.3

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

7.13

2.92

1.5

1.1

—

(3000850) Epithelial cells [#/volume] in Urine

145

2.35

2.92

6.4

2.5

4.21

5.08

e6/l

0.19

133

(36660697) Celiac disease serology panel - Serum

2.88

2.92

1.5

1.1

—

(3017181) Myelocytes/Leukocytes in Blood

3.07

2.89

5.5

5.7

4.25

0.64

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.84

2.88

2.4

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.37

2.86

2.0

1.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.61

2.81

7.9

7.3

105.33

104.26

mmol/l

0.57

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

5.39

2.80

2.4

1.4

—

(3021901) Oxygen saturation in Capillary blood

5.39

2.80

2.6

2.3

91.36

91.12

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

133

2.32

2.74

2.2

1.9

0.97

0.93

mg/l

0.07

107

(3019150) Specific gravity of Urine by Refractometry

165

2.24

2.72

4.6

4.7

1.02

kg/l

0.31

114

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.03

2.66

1.6

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

5.03

2.66

1.6

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

5.03

2.66

1.6

1.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

112

2.36

2.65

3.3

2.1

11.04

14.41

umol/l

1.06

100

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

4.35

2.65

2.3

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

367

2.22

2.61

6.5

4.1

0.00

estimate

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

7.54

2.59

1.8

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

358

2.19

2.58

5.9

4.0

0.00

estimate

—

(3042936) Bacteria identified in Isolate by Culture

2.43

2.55

2.5

2.4

—

(36304419) Bacteria [Presence] in Urine

177

2.16

2.55

5.1

2.7

—

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

359

2.18

2.55

6.0

4.0

0.00

estimate

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

4.13

2.54

2.3

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

4.13

2.54

2.3

1.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.71

2.54

2.0

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

107

2.34

2.52

2.9

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.40

2.49

3.6

2.7

3.24

2.35

e6/l

0.20

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

6.59

2.41

1.8

1.9

—

(1616796) Gas panel - Central venous blood

6.59

2.41

17.4

4.6

—

(3023419) Bacteria identified in Sputum by Culture

6.59

2.41

5.6

2.6

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.59

2.41

2.2

1.0

—

(40758558) Short blood count panel - Blood

206

2.07

2.40

16.1

5.6

—

(3026008) Bacteria identified in Urine by Culture

173

2.10

2.37

4.4

3.0

—

(40768797) Stomach Pathology biopsy report

2.35

2.29

1.6

1.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

5.86

2.25

1.4

1.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.45

2.16

1.5

1.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

5.27

2.10

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

296

1.95

2.10

4.5

3.3

—

estimate

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.88

2.10

3.9

2.6

78.80

60.88

ng/l

—

(3000494) Fungus identified in Specimen by Culture

2.34

2.10

1.7

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

241

1.95

2.09

5.4

4.0

24.73

38.46

ng/l

0.69

165

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.05

2.08

2.7

25.00

24.48

mmol/l

—

(3032080) INR in Blood by Coagulation assay

279

1.93

2.04

9.3

12.6

1.16

1.20

inr

0.30

236

(3004789) Transferrin [Mass/volume] in Serum or Plasma

101

2.18

2.04

3.7

2.2

2.35

2.41

g/l

0.14

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

132

2.07

2.04

4.1

2.7

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.20

2.01

3.4

2.2

20.87

23.92

0.23

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

4.78

1.97

2.8

3.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.07

1.92

2.0

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

212

1.89

1.87

4.5

4.0

0.00

estimate

—

(3024928) Oxygen saturation in Venous blood

4.38

1.85

2.8

5.0

64.38

63.70

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.38

1.85

1.4

2.7

—

(3002032) Base excess in Venous blood by calculation

2.37

1.84

5.5

2.6

1.90

2.04

mmol/l

0.06

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

188

1.88

1.80

2.3

2.2

113.62

146.99

u/l

0.85

180

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.53

1.78

3.5

1.7

101.83

87.06

—

(3012544) pH of Venous blood

2.33

1.78

5.8

2.9

7.42

7.40

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

461

1.99

1.74

3.7

3.6

—

(3018418) pH of Serum or Plasma

190

1.86

1.73

13.0

3.6

7.39

7.40

0.45

144

(3001019) Free T4 and TSH panel - Serum or Plasma

2.76

1.71

1.9

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.75

1.64

1.4

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

265

1.78

1.64

2.5

2.0

92.60

94.22

pmol/l

0.06

137

(3026782) Osmolality of Urine

120

1.91

1.54

3.5

2.6

571.55

553.15

mosm/kgh2o

0.14

108

(3005719) IgG [Mass/volume] in Serum or Plasma

2.31

1.53

3.6

2.0

7.99

9.90

g/l

1.05

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.48

1.49

6.8

9.6

1.36

1.08

mmol/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.27

1.46

1.2

1.4

—

(3021440) Promyelocytes/Leukocytes in Blood

2.30

1.41

6.2

5.7

0.50

0.23

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.74

1.39

2.2

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

284

1.69

1.39

5.6

3.9

0.22

0.01

estimate

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

184

1.73

1.37

1.5

1.3

0.45

0.74

u/ml

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.01

1.36

2.6

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.04

1.34

4.3

8.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.63

1.33

2.7

2.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

151

1.75

1.33

7.1

5.5

—

(40768443) Skin Pathology biopsy report

2.52

1.27

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.01

1.21

2.8

2.1

338.25

406.18

nmol/l

0.51

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

601

2.07

1.20

30.1

14.1

84.68

85.98

ml/min/173m2

0.14

557

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.17

1.19

1.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

209

1.63

1.18

1.6

1.5

—

(3025159) Blasts/Leukocytes in Blood

2.11

1.17

5.9

6.1

0.00

0.08

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.11

1.17

1.0

1.2

—

(3013512) EKG study

219

1.62

1.15

3.9

3.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

220

1.61

1.13

5.8

3.1

0.00

estimate

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

511

1.72

1.10

4.2

15.35

14.75

pmol/l

1.29

470

(3000991) Gas panel - Venous blood

2.08

1.08

7.3

9.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.88

1.03

1.5

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

111

1.69

0.98

1.9

1.5

—

(3011288) Drugs identified in Urine by Screen method Nominal

2.24

0.94

2.3

1.3

—

(3012516) Albumin [Mass/volume] in Urine

193

1.53

0.90

4.5

3.3

87.33

85.51

mg/l

0.01

129

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.08

0.89

1.8

2.1

—

(21494755) Public health laboratory ask at order entry panel

1.81

0.88

1.5

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

223

1.49

0.85

4.7

3.0

7.31

8.02

mmol/l

0.51

202

(4035726) Immunohistochemistry procedure

1.78

0.84

2.4

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

152

1.53

0.81

4.2

2.9

358.57

343.62

umol/l

0.26

129

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.81

0.0

1.6

—

46.60

—

(4024509) Urine culture

2.25

0.78

1.4

1.6

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

551

1.57

0.75

37.0

18.8

13.88

13.54

1.05

546

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

128

1.53

0.75

2.7

2.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

164

1.48

0.74

1.9

1.4

1.85

2.42

g/l

0.86

106

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.64

0.70

3.8

4.8

33.33

33.09

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.77

0.65

18.0

7.9

25.42

24.49

mmol/l

—

(3002256) Pathology report gross observation

1.60

0.64

1.8

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

115

1.50

0.63

1.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.65

0.62

1.2

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.72

0.58

1.8

1.4

—

(3027008) Opiates [Presence] in Urine

1.67

0.57

1.8

1.3

—

(3028300) Cannabinoids [Presence] in Urine

1.67

0.57

1.8

1.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.67

0.57

1.2

1.1

—

(3016879) Cocaine [Presence] in Urine

1.67

0.57

1.8

1.3

—

(3027944) Amphetamines [Presence] in Urine

1.63

0.56

1.8

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

146

1.40

0.54

1.9

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

137

1.41

0.54

9.2

4.9

23.70

22.26

0.17

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.57

0.50

1.0

—

(3020891) Body temperature

1.60

0.43

10.8

3.9

37.02

36.94

°c

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.60

0.43

1.4

10.8

25.16

24.77

mmol/l

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.55

0.42

1.2

2.6

42.60

38.46

u/l

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.41

0.0

2.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.50

0.41

10.4

2.1

1.40

1.11

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.41

0.0

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

116

1.37

0.41

2.7

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

153

1.32

0.41

1.9

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.46

0.40

10.4

2.1

0.60

0.67

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.46

0.40

2.0

1.2

—

(3021589) Normoblasts [#/volume] in Blood

290

1.25

0.36

26.8

11.9

0.00

e9/l

0.50

235

(40768804) Tissue Pathology biopsy report

248

0.79

0.35

3.1

2.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

194

1.27

0.35

5.4

4.0

15.65

15.74

mg/mmol

0.00

126

(1761868) Lipid panel - Serum or Plasma

265

1.22

0.30

3.1

3.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.28

0.22

2.1

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.9

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

106.25

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

4.09

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

1.21

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.20

0.0

2.1

—

10.79

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.27

0.20

1.6

2.0

1.19

1.44

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.74

0.18

2.8

3.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.77

0.16

1.7

1.9

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.09

0.10

12.8

4.9

1.22

mmol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

195

1.11

0.09

2.7

2.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.03

0.08

3.1

2.6

—

(3000492) Spirometry study

0.82

0.08

2.5

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

118

0.92

0.03

1.8

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.2

—

125.00

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.96

-0.00

2.8

2.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.4

—

496.00

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

130.08

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.7

—

711.29

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.4

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

2.8

—

1820.00

—

(40761536) Microorganisms panel - Urine sediment

0.84

-0.00

7.2

3.2

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

-0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.8

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.4

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

-0.00

0.0

1.1

—

0.84

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

28.10

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.8

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

0.94

-0.00

2.3

1.6

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

1.6

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

26.75

—

Mortality – FinRegistry

↥

Association

Association between endpoint EHEC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have EHEC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: EHEC – Enterohaemorrhagic Escherichia coli infection

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Enterohaemorrhagic Escherichia coli infection

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints