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This is a non-core endpoint: only basic statistics are computed.

Disorders of zinc metabolism

E4_ZINC_MET

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E83.2
  • Cause of death: ICD-10 E83.2

2 out of 7 registries used, show all original rules.

6

4. Check minimum number of events

None

6

5. Include endpoints

None

6

6. Filter based on genotype QC (FinnGen only)

None

0

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E83
Name in latin
Perturbationes metabolismi zinci

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 75 40 35
Only index persons 58 32 26
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population - 40.45 28.42
Only index persons 41.01 42.32 39.39

-FinnGen-

Key figures

All Female Male
Number of individuals - - -
Unadjusted period prevalence (%) - - -
Median age at first event (years) - - -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
0
14
0.00
0.50
0.0
1.4
—
—
—
0
0
5
39
+∞
0.24
12.6
22.3
14.88
13.76
%
—
5
39
0
12
0.00
0.24
0.0
1.3
—
2.32
—
0
7
0
9
0.00
0.24
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
43
+∞
0.00
12.0
19.0
139.80
139.65
mmol/l
—
5
43
5
43
+∞
0.00
16.8
20.0
326.20
331.05
g/l
—
5
43
5
43
+∞
0.00
13.0
19.1
3.98
3.87
mmol/l
—
5
43
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
15.9
—
18.63
—
0
7
0
6
0.00
-0.00
0.0
15.3
—
98.38
—
0
6
0
7
0.00
-0.00
0.0
14.1
—
114.57
—
0
7
0
7
0.00
-0.00
0.0
15.7
—
2.63
—
0
7
5
50
0.00
-0.00
19.4
22.8
28.60
30.09
pg
—
5
50
5
50
0.00
-0.00
19.6
22.9
87.60
90.15
fl
—
5
50
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
75.86
—
0
7
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
5
50
0.00
-0.00
19.4
23.5
40.40
40.96
%
—
5
50
5
50
0.00
-0.00
19.6
23.1
131.80
136.12
g/l
—
5
50
0
7
0.00
-0.00
0.0
1.7
—
25.89
—
0
7
0
7
0.00
-0.00
0.0
15.9
—
5.90
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.02
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1.42
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.0
—
0.70
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.0
—
96.44
—
0
5
0
5
0.00
-0.00
0.0
15.0
—
1.26
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_ZINC_MET and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ZINC_MET.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_ZINC_MET – Disorders of zinc metabolism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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