marasmus: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
83 |
4. Check minimum number of eventsNone |
83 |
5. Include endpointsNone |
83 |
6. Filter based on genotype QC (FinnGen only) |
70 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio gravis ex deficientia energetica (marasmus nutritionalis)
Similar endpoints
↥List of similar endpoints to
Nutritional marasmus
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 547 | 434 |
| Only index persons | 714 | 397 | 317 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.82 | 66.09 | 60.76 |
| Only index persons | 59.82 | 61.49 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 70 | 44 | 26 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 55.86 | 51.92 | 62.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 74
- Matched controls
- 740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E41
ICD-10 Finland
Nutritional marasmus
+∞
98.5
71
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.7
10.9
27
68
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.4
9.2
37
136
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.6
6.8
40
183
N05BA01
ATC
diazepam; systemic, rectal
4.7
6.1
16
41
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
179
4.11
8.36
2.9
2.1
2.72
2.73
mg/l
0.01
35
162
19
46
5.21
7.83
16.6
9.6
1.40
1.29
mmol/l
0.19
19
46
27
92
4.05
7.20
3.0
1.5
1676.05
1098.60
nmol/l
2.21
22
73
27
100
3.68
6.30
2.2
2.3
2.29
2.37
g/l
0.24
27
94
23
79
3.77
5.95
12.1
8.0
105.26
103.49
mmol/l
0.37
23
79
15
35
5.10
4.98
21.4
9.1
94.37
94.98
%
0.21
15
35
45
254
2.97
4.93
2.5
2.0
83.65
101.86
pmol/l
1.77
23
125
52
326
3.00
4.55
15.6
7.7
1.21
1.21
mmol/l
0.15
42
291
15
39
4.56
4.52
21.0
8.4
1.26
1.33
%
0.15
15
39
13
30
5.03
4.39
2.9
4.4
0.64
0.65
%
0.04
13
30
13
32
4.70
4.15
2.8
4.3
1.47
1.29
%
0.16
13
32
14
38
4.30
4.07
22.9
8.4
0.76
0.63
%
0.64
14
38
26
119
2.83
4.06
2.3
1.9
476.85
453.94
pmol/l
0.14
20
104
34
179
2.66
4.05
6.9
3.6
0.00
0.00
estimate
-0.00
11
66
16
55
3.44
4.03
5.6
4.9
24.71
24.17
mmol/l
0.20
16
55
10
19
5.91
3.99
21.8
5.4
25.12
24.79
mmol/l
—
10
19
36
198
2.59
3.90
1.7
1.4
8.01
0.83
u/ml
0.51
14
53
15
51
3.43
3.83
6.2
3.2
—
—
—
0
0
24
109
2.78
3.77
2.8
2.5
2.94
0.78
mg/l
0.88
17
97
9
18
5.53
3.49
5.1
4.8
254.56
195.33
%
—
9
18
9
18
5.53
3.49
5.1
4.9
3.50
3.48
g/l
—
9
18
21
97
2.63
3.15
2.6
1.9
—
—
—
0
0
6
9
7.13
2.92
2.2
3.1
16.73
15.16
%
—
6
9
52
372
2.34
2.80
17.7
5.1
6.98
6.44
mmol/l
0.33
52
354
11
35
3.51
2.78
2.3
4.3
96.40
59.93
ml/min/173m2
—
5
15
14
58
2.74
2.55
7.8
7.6
—
—
—
0
0
17
78
2.53
2.55
2.3
1.7
—
—
—
0
0
6
13
4.92
2.32
1.3
1.5
—
—
—
0
0
16
75
2.45
2.29
3.0
1.7
—
—
—
0
0
34
220
2.01
2.21
3.6
4.0
22.95
35.29
ng/l
0.52
23
155
11
43
2.83
2.19
1.5
1.5
—
—
—
0
0
9
32
3.06
2.08
2.0
1.9
—
—
—
0
0
23
139
1.95
1.75
3.0
2.2
—
—
—
0
0
6
19
3.34
1.70
4.2
1.7
—
—
—
0
0
19
110
1.98
1.62
5.2
2.7
0.82
0.83
e6/l
0.01
12
58
6
20
3.17
1.61
1.7
1.2
0.22
0.24
g/l
—
6
20
46
353
1.80
1.61
6.5
3.6
0.00
0.00
estimate
-0.00
12
71
46
356
1.77
1.54
6.5
3.5
0.00
0.00
estimate
-0.00
12
67
6
21
3.02
1.54
3.5
1.6
—
—
—
0
0
6
21
3.02
1.54
3.5
1.7
—
—
—
0
0
6
22
2.87
1.46
1.7
1.1
1.18
1.18
g/l
—
6
22
45
351
1.72
1.42
6.6
3.5
0.00
0.00
estimate
-0.00
13
72
17
101
1.89
1.34
4.8
2.8
6.60
3.39
e6/l
—
10
50
35
261
1.65
1.26
6.7
3.5
0.00
0.02
estimate
0.49
11
62
6
26
2.42
1.21
1.3
1.5
—
—
—
0
0
8
41
2.06
1.12
11.9
5.5
25.05
24.64
mmol/l
—
8
41
37
286
1.59
1.12
3.6
2.6
—
—
estimate
—
0
0
5
21
2.48
1.11
2.0
2.3
10.20
2.27
index
—
5
11
24
169
1.62
1.06
3.6
4.2
2205.88
1212.55
ng/l
0.43
24
151
63
678
0.52
1.00
53.6
22.1
36.77
39.87
%
6.41
63
671
63
678
0.52
1.00
50.1
21.8
122.46
133.88
g/l
6.96
63
671
63
678
0.52
1.00
48.7
21.6
91.69
90.13
fl
1.25
63
671
7
40
1.83
0.74
1.0
2.3
2.49
4.14
ug/l
—
7
35
0
21
0.00
0.61
0.0
3.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
50
540
0.77
0.41
42.8
18.5
332.18
333.06
g/l
0.31
50
540
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
23
192
1.29
0.38
4.8
3.0
0.00
0.00
estimate
—
9
59
63
607
1.25
0.21
46.5
16.9
138.16
139.59
mmol/l
2.88
63
596
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
14
164
0.82
0.21
1.9
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
63
608
1.24
0.20
46.5
16.9
3.96
3.95
mmol/l
0.11
63
596
11
92
1.23
0.17
3.5
2.6
—
—
—
0
0
63
613
1.19
0.13
31.3
14.5
23.99
21.66
mg/l
0.36
57
492
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
43
446
0.91
0.09
2.7
3.5
—
—
—
0
0
12
133
0.88
0.08
3.0
5.9
2.02
1.97
ug/l
0.03
12
120
63
640
0.89
0.05
41.8
18.0
63.76
72.70
umol/l
1.34
63
632
10
102
0.98
0.00
2.0
1.5
—
—
—
0
0
52
523
0.98
0.00
29.4
14.5
90.64
83.85
ml/min/173m2
0.95
47
479
8
87
0.91
0.00
3.4
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
72.30
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.96
—
0
5
0
5
0.00
-0.00
0.0
2.8
—
1.40
—
0
5
0
7
0.00
-0.00
0.0
2.1
—
7.29
—
0
7
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
16.33
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
0.12
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_MARASMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 5.254 [2.49, 11.07] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.322 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 307 females with E4_MARASMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 6.144 [2.76, 13.69] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 242 males with E4_MARASMUS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MARASMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.561% | 1.389% |
| 5 | 2.995% | 8.042% |
| 10 | 7.721% | 19.488% |
| 15 | 14.526% | 35.354% |
| 20 | 23.997% | 52.914% |
Relationships between endpoints
↥Index endpoint: E4_MARASMUS – Nutritional marasmus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data