No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpointsNone |
89 |
6. Filter based on genotype QC (FinnGen only) |
74 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E78
- Name in latin
- Deficientia lipoproteinorum
Similar endpoints
↥List of similar endpoints to
Lipoprotein deficiency
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 675 | 279 | 394 |
| Only index persons | 614 | 256 | 358 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.75 | 68.29 | 63.94 |
| Only index persons | 65.71 | 68.17 | 63.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 74 | 26 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 61.13 | 61.17 | 61.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E78.63
ICD-10 Finland
Low HDL syndrome
+∞
53.3
45
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
7.4
14.7
27
52
C10AA05
ATC
atorvastatin; oral
5.4
12.2
52
208
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.4
12.0
34
97
E78.69
ICD-10 Finland
Lipoprotein deficiency, other or unspecified
+∞
11.7
11
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.8
9.9
31
94
E78.6
ICD-10 Finland
Lipoprotein deficiency
+∞
9.6
9
*
T90
ICPC
Diabetes non-insulin dependent
4.6
9.3
31
98
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.7
9.1
28
83
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
100.3
8.6
9
*
N08.4*E78.6
ICD-10 Finland
Glomerular disorders in lecithin cholesterol acyltransferase deficiency
+∞
8.5
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.7
8.0
23
64
C07AB07
ATC
bisoprolol; oral
4.1
8.0
56
293
SPAT1262
SPAT
Handing over of treatment supplies
4.6
7.7
22
61
103
Kela drug reimbursment
Diabetes, insulin-treated
3.9
7.6
33
124
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
88.0
7.6
8
*
E78.61
ICD-10 Finland
Abetalipoproteinaemia
+∞
7.4
7
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
7.3
52
270
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.1
7.2
17
40
I10
ICD-10 Finland
Essential (primary) hypertension
4.4
7.1
63
374
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
9.2
7.0
14
18
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.2
6.9
23
71
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.4
6.8
20
56
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.8
6.7
27
96
C03CA01
ATC
furosemide; systemic
3.4
6.6
34
142
E87.6
ICD-10 Finland
Hypokalaemia
20.0
6.4
9
5
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.7
6.2
25
88
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
56
318
3.61
6.52
9.4
6.2
1.19
1.21
mmol/l
0.64
43
274
40
197
3.09
5.71
7.0
3.2
14.09
5.62
mg/mmol
0.59
27
129
39
192
3.04
5.53
2.9
1.8
352.59
176.24
u/l
0.65
34
185
51
292
3.11
5.51
8.3
5.3
1.20
1.21
mmol/l
0.20
51
269
45
255
2.78
4.72
2.8
1.8
2.29
1.46
mmol/l
1.14
36
203
14
36
4.50
4.26
6.1
9.6
23.11
24.57
mmol/l
0.85
14
36
44
259
2.58
4.11
2.6
2.0
91.98
97.64
pmol/l
0.37
25
143
24
105
2.85
4.03
5.6
1.9
11.71
13.13
umol/l
0.51
19
94
34
186
2.45
3.60
3.8
2.8
0.10
0.38
e6/l
1.66
23
137
71
567
3.49
3.58
6.3
4.8
2.09
1.94
mu/l
0.44
63
512
15
54
3.19
3.48
1.9
3.4
1.21
1.22
mmol/l
0.58
15
47
25
122
2.53
3.34
2.6
1.9
347.95
106364042.08
pmol/l
0.50
20
110
18
75
2.81
3.26
4.8
3.3
—
—
—
0
0
20
94
2.51
2.85
4.3
5.7
106.10
104.72
mmol/l
1.08
20
94
40
258
2.11
2.69
7.0
3.7
22.77
48.82
ng/l
0.98
31
191
8
21
4.12
2.54
1.0
1.5
—
—
—
0
0
22
115
2.27
2.47
2.4
3.7
0.86
0.81
mmol/l
1.09
22
109
33
205
2.05
2.39
3.5
3.1
841.65
1304.59
ng/l
0.67
26
173
20
103
2.26
2.31
3.7
2.7
2.25
1.05
e6/l
—
8
48
9
29
3.37
2.31
5.9
7.3
23.59
24.02
mmol/l
—
9
29
21
113
2.17
2.18
3.8
2.6
0.38
0.65
e6/l
—
9
59
74
649
3.21
2.16
32.8
17.7
4.05
4.00
mmol/l
0.81
74
633
29
180
1.97
2.06
2.2
1.7
18.99
20.89
nmol/l
0.31
24
144
47
346
1.88
1.97
5.3
3.6
0.00
0.00
estimate
-0.00
14
68
9
34
2.85
1.93
2.6
2.4
0.72
1.47
%
—
9
34
9
35
2.77
1.87
1.4
1.7
—
—
—
0
0
9
35
2.77
1.87
9.9
2.9
22.61
23.82
mmol/l
—
9
35
59
473
1.98
1.85
5.3
4.0
15.26
14.78
pmol/l
0.82
54
428
46
342
1.83
1.82
5.3
3.6
0.00
0.00
estimate
-0.00
15
72
13
62
2.31
1.77
8.1
2.9
-0.30
1.54
mmol/l
1.65
13
51
73
648
2.66
1.75
32.8
17.6
139.66
139.74
mmol/l
0.11
73
635
5
13
4.03
1.74
1.0
1.1
—
—
—
0
0
49
376
1.80
1.70
9.7
12.8
4.37
3.87
e9/l
1.07
44
327
74
662
2.86
1.69
35.0
20.4
89.74
79.25
umol/l
1.04
74
654
62
513
1.97
1.67
29.1
19.9
13.88
13.70
%
0.44
62
508
72
637
2.47
1.66
27.5
15.6
27.99
25.16
mg/l
0.32
64
526
72
638
2.45
1.66
8.5
5.6
2.31
2.74
mmol/l
3.02
66
590
5
14
3.74
1.64
1.0
1.5
—
—
—
0
0
19
115
1.86
1.41
2.3
2.1
—
—
—
0
0
44
340
1.66
1.38
5.5
3.6
0.00
0.00
estimate
-0.00
14
70
9
43
2.23
1.35
6.4
6.5
0.57
0.69
%
—
9
43
70
626
2.04
1.27
7.8
4.9
1.11
1.44
mmol/l
6.99
63
576
70
628
2.01
1.27
7.7
5.0
4.00
4.62
mmol/l
4.42
65
584
22
144
1.73
1.26
1.7
1.6
0.76
1.30
mg/l
0.50
17
110
69
611
2.02
1.25
7.1
5.0
6.73
5.93
mmol/l
1.45
64
564
38
289
1.61
1.23
4.5
2.7
—
—
estimate
—
0
0
5
19
2.74
1.23
1.0
1.8
0.00
0.00
g/l
—
5
19
69
612
2.01
1.23
6.0
4.2
2.09
1.28
mmol/l
2.34
64
560
35
262
1.60
1.21
4.7
3.6
0.00
0.03
estimate
0.49
12
60
28
199
1.63
1.19
4.9
3.7
0.00
0.00
estimate
-0.00
15
63
8
41
2.06
1.12
1.6
2.0
—
—
—
0
0
8
43
1.96
0.90
7.1
6.7
2.06
1.55
%
—
8
43
10
58
1.83
0.84
2.0
2.7
30.90
33.35
u/l
—
10
49
6
34
1.83
0.78
1.2
1.0
—
—
—
0
0
18
128
1.53
0.74
1.3
1.3
0.94
3.17
u/ml
—
5
40
11
70
1.66
0.69
1.9
2.9
0.18
0.21
g/l
0.56
11
64
21
157
1.46
0.68
4.7
2.4
—
—
—
0
0
13
90
1.53
0.60
1.4
1.9
—
—
—
0
0
24
190
1.38
0.57
4.2
2.8
0.00
0.04
estimate
0.49
11
56
6
37
1.67
0.57
1.5
1.3
—
—
—
0
0
42
368
1.30
0.50
3.0
3.1
—
—
—
0
0
12
86
1.47
0.48
1.3
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
5
77
0.63
0.38
4.6
8.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
177.29
—
0
10
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
6
76
0.77
0.16
4.2
5.3
2.68
6.69
ug/l
—
6
64
6
55
1.10
0.09
2.3
1.5
—
—
—
0
0
27
260
1.06
0.04
4.4
5.0
25.97
22.17
%
0.55
15
133
10
94
1.07
0.01
1.7
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.6
—
24.41
—
0
9
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.5
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
13.00
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
18.99
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_LIPODEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPODEF | 2.042 [1.38, 3.01] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 249 females with E4_LIPODEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPODEF | 2.28 [1.56, 3.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 343 males with E4_LIPODEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_LIPODEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.293% |
| 5 | 1.201% | 2.475% |
| 10 | 3.159% | 6.698% |
| 15 | 5.917% | 12.738% |
| 20 | 10.015% | 20.311% |
Relationships between endpoints
↥Index endpoint: E4_LIPODEF – Lipoprotein deficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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