Subclinical iodine-deficiency hypothyroidism

E4_IODHYPSUB

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E02 Cause of death: ICD-10 — E02 2 out of 7 registries used, show all original rules.	58
4. Check minimum number of events None	58
5. Include endpoints None	58
6. Filter based on genotype QC (FinnGen only)	54

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E00-E07
Name in latin: Hypothyreosis subclinica ex deficientia iodi

NAME	E4_IODHYPSUB
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E02
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E02
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Subclinical iodine-deficiency hypothyroidism based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	326	238	86
Only index persons	302	223	79
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	64.28	63.43	66.30
Only index persons	62.37	60.81	66.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	36	18
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.41	60.25	60.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
55: Matched controls
550

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E02

ICD-10 Finland

Subclinical iodine-deficiency hypothyroidism

+∞

76.1

H03AA01

ATC

levothyroxine sodium; systemic

239.2

45.0

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

178.0

22.5

T86

ICPC

Hypothyroidism/myxoedema

+∞

9.6

104

Kela drug reimbursment

Thyroid insufficiency

+∞

8.5

E03

ICD-10 Finland

Other hypothyroidism

52.8

8.0

E04.2

ICD-10 Finland

Nontoxic multinodular goitre

+∞

7.4

E03.89

ICD-10 Finland

Other specified hypothyroidism

78.6

6.6

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

229

2.66

2.94

2.4

2.0

75.22

98.18

pmol/l

1.64

113

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.67

2.21

1.3

1.1

0.21

0.27

g/l

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

4.67

2.21

1.0

1.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

184

2.22

2.17

4.3

3.9

34.61

29.93

ng/l

0.11

138

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.35

2.10

1.3

1.1

1.20

1.32

g/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.27

1.75

4.5

6.2

106.73

103.29

mmol/l

2.75

(3013512) EKG study

178

2.02

1.73

5.1

4.1

—

(3020630) Protein [Mass/volume] in Serum or Plasma

2.55

1.66

2.8

3.4

69.84

67.48

g/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.55

1.66

3.5

3.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.81

1.65

1.2

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.20

1.64

1.2

1.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.27

1.59

4.4

4.1

1.07

1.03

mmol/l

0.25

(3007853) Bacteria identified in Skin by Aerobe culture

2.39

1.57

2.5

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.08

1.45

2.9

3.0

0.61

4.64

e6/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.36

1.42

6.3

7.8

0.93

1.18

mmol/l

—

(3032080) INR in Blood by Coagulation assay

246

1.85

1.37

11.5

14.7

1.28

1.26

inr

0.06

194

(3003396) Base excess in Arterial blood by calculation

2.16

1.35

5.3

7.2

0.27

1.78

mmol/l

1.58

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.43

1.31

6.9

9.2

0.59

0.74

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.43

1.31

6.9

8.7

23.88

25.51

mmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.36

1.28

1.3

1.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.36

1.28

6.9

9.1

1.44

1.51

—

(3018418) pH of Serum or Plasma

166

1.79

1.24

4.4

4.1

7.41

7.40

0.48

116

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.46

1.22

1.0

1.1

—

(36304419) Bacteria [Presence] in Urine

140

1.81

1.22

3.0

2.9

—

estimate

—

(3000991) Gas panel - Venous blood

2.23

1.21

7.9

9.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.89

1.20

2.2

1.3

2.97

2.49

g/l

0.26

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.13

1.15

6.0

8.1

131.10

116.85

g/l

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.40

1.05

1.4

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.40

1.05

1.4

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.40

1.05

1.4

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

182

1.68

1.04

5.0

3.0

—

(3027945) Reticulocytes/Erythrocytes in Blood

2.04

1.04

3.3

2.2

1.41

1.76

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

448

2.27

1.02

13.6

4.0

2.50

1.88

mu/l

1.15

405

(3001604) Monocytes [#/volume] in Blood

260

1.67

1.01

10.0

6.0

0.58

0.61

e9/l

0.24

213

(3012516) Albumin [Mass/volume] in Urine

165

1.68

1.01

5.0

3.3

68.81

46.04

mg/l

0.19

112

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.88

0.98

2.6

2.1

2.25

2.32

g/l

0.14

(3006315) Basophils [#/volume] in Blood

262

1.65

0.97

10.1

6.0

0.04

e9/l

0.09

210

(1761868) Lipid panel - Serum or Plasma

158

1.65

0.95

3.2

3.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.06

0.93

3.6

2.1

273.38

370.46

nmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.20

0.92

1.5

1.3

—

(3016502) Oxygen saturation in Arterial blood

1.92

0.90

5.6

7.6

96.17

94.05

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.73

0.90

2.7

2.8

0.84

1.06

e6/l

—

(3025941) Bacteria identified in Stool by Culture

1.98

0.84

1.0

1.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.74

0.79

2.5

2.2

12.42

12.78

umol/l

0.08

(3000494) Fungus identified in Specimen by Culture

1.77

0.79

1.7

1.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.29

0.78

4.0

3.0

24.92

23.72

mmol/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

2.19

0.76

4.0

3.0

0.00

g/l

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.81

0.73

1.9

2.6

31.04

6.66

ug/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

113

1.59

0.72

1.6

1.2

1.13

2.11

u/ml

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.71

0.72

2.7

2.0

23.65

23.40

0.02

(3013115) Eosinophils [#/volume] in Blood

275

1.50

0.69

10.0

6.4

0.20

0.19

e9/l

0.09

235

(3021589) Normoblasts [#/volume] in Blood

236

1.48

0.68

17.3

12.1

0.00

0.01

e9/l

0.51

178

(3019198) Lymphocytes [#/volume] in Blood

266

1.49

0.67

10.5

5.9

2.39

1.81

e9/l

0.52

231

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.79

0.65

2.0

2.6

1.92

1.70

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.79

0.65

5.2

3.7

59.88

43.91

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

382

1.58

0.63

6.0

4.4

14.72

12.55

mm/h

0.27

348

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

229

1.45

0.63

7.3

6.3

1.21

1.22

mmol/l

0.09

217

(3020682) Albumin/Creatinine [Ratio] in Urine

172

1.47

0.62

6.0

3.9

10.09

9.35

mg/mmol

0.03

110

(3008898) HLA-B27 [Presence]

0.00

0.61

0.0

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

2.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.80

0.60

5.5

5.3

24.53

25.59

mmol/l

—

(40768797) Stomach Pathology biopsy report

1.61

0.59

1.1

1.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.60

0.55

1.7

2.0

55.17

155.45

ng/l

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

398

1.53

0.54

30.1

20.9

13.76

13.87

0.21

391

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.54

0.50

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

247

1.37

0.48

2.9

—

estimate

—

(3026493) Urate [Moles/volume] in Serum or Plasma

142

1.40

0.46

4.0

2.7

369.22

347.10

umol/l

0.40

125

(42870588) Differential panel, method unspecified - Blood

171

1.37

0.45

7.7

5.4

—

(3026008) Bacteria identified in Urine by Culture

171

1.37

0.45

3.8

3.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.62

0.43

2.2

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.42

0.0

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.46

0.41

2.0

1.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.7

—

58.97

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.41

0.0

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.41

0.41

2.1

1.7

—

(3023368) Bacteria identified in Blood by Culture

145

1.36

0.41

4.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.47

0.40

2.0

1.3

—

(3018010) Neutrophils/Leukocytes in Blood

232

1.32

0.40

11.1

5.5

55.41

59.13

0.74

217

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

146

1.35

0.39

2.3

2.4

—

(3044640) Blood type and Crossmatch panel - Blood

194

1.32

0.38

2.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.37

0.35

1.3

2.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

297

1.28

0.32

12.8

11.6

3.89

4.23

e9/l

0.36

255

(3041096) Erythrocytes [Presence] in Urine by Automated

150

1.30

0.32

3.7

2.9

0.00

estimate

—

(40768804) Tissue Pathology biopsy report

221

1.24

0.27

3.1

2.1

—

(3015736) pH of Urine

222

1.23

0.25

4.3

3.6

6.47

6.31

0.32

114

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.31

0.23

1.0

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

108

1.27

0.22

8.9

4.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

166

1.22

0.22

1.8

2.5

32.53

30.92

u/l

0.14

156

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.21

0.0

2.1

—

15.52

—

(3021788) Differential panel - Synovial fluid

0.00

0.21

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.31

0.21

2.0

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

157

1.22

0.21

4.1

3.8

0.00

estimate

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.4

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.4

—

243.20

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

398

1.23

0.20

30.2

22.3

331.26

331.76

g/l

0.16

398

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.23

0.18

1.8

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

288

1.18

0.17

4.5

3.9

0.00

estimate

—

(3019150) Specific gravity of Urine by Refractometry

125

0.85

0.11

4.0

4.3

1.01

1.02

kg/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.18

0.11

2.0

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.10

0.10

3.4

1.7

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

490

1.22

0.09

27.2

19.4

139.80

139.50

mmol/l

0.41

479

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

216

1.11

0.08

4.3

3.6

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

286

1.11

0.08

4.5

3.8

0.00

34.55

estimate

—

(3042936) Bacteria identified in Isolate by Culture

1.07

0.07

2.4

1.8

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

120

1.11

0.05

2.4

3.2

2.44

2.45

mmol/l

0.17

107

(40758558) Short blood count panel - Blood

170

0.92

0.05

8.5

8.1

—

(3003694) ABO and Rh group [Type] in Blood

134

1.06

0.01

1.9

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

295

0.96

0.00

2.9

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

8.0

—

490.50

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.7

—

88.27

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.8

—

37.06

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.00

-0.00

1.0

1.4

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

-0.00

0.0

1.5

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

-0.00

0.0

1.6

—

0.61

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

1.8

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

1.43

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(3002256) Pathology report gross observation

0.92

-0.00

1.6

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

1.2

—

56.88

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

-0.00

0.0

1.5

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

-0.00

0.0

1.5

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

-0.00

0.0

1.5

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

-0.00

0.0

2.4

—

8.13

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.3

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_IODHYPSUB and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_IODHYPSUB	1.248 [0.81, 1.93]	0.321
Birth year	0.995 [0.99, 1.0]	0.261

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 212 females with E4_IODHYPSUB died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_IODHYPSUB.

N-year risk	Females	Males
1	0.133%	No data
5	0.77%	No data
10	1.857%	No data
15	3.379%	No data
20	5.813%	No data

Relationships between endpoints

↥

Index endpoint: E4_IODHYPSUB – Subclinical iodine-deficiency hypothyroidism

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Subclinical iodine-deficiency hypothyroidism

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints