No definition available.
Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
E4_HYPOTHALDYSF
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
77 |
4. Check minimum number of eventsNone |
77 |
5. Include endpointsNone |
77 |
6. Filter based on genotype QC (FinnGen only) |
70 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Exclusions for E4_PCOS_BROAD
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 500 | 262 | 235 |
| Only index persons | 443 | 232 | 211 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 36.55 | 37.24 | 35.34 |
| Only index persons | 34.34 | 35.41 | 33.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 70 | 42 | 28 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 40.09 | 39.57 | 40.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 72
- Matched controls
- 720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
163.1
42.9
42
6
E23.1
ICD-10 Finland
Drug-induced hypopituitarism
+∞
40.5
35
*
E23.3
ICD-10 Finland
Hypothalamic dysfunction, not elsewhere classified
+∞
37.9
33
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
35.3
31
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
24.3
22
*
H03AA01
ATC
levothyroxine sodium; systemic
10.6
23.4
41
80
H01AC01
ATC
somatropin; parenteral
+∞
19.7
18
*
E23.03
ICD-10 Finland
Lack of ACTH
+∞
19.7
18
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.9
16.3
31
63
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
14.0
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
5.9
11.5
28
70
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.0
11.4
21
40
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.7
10
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.7
10.5
20
39
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
25.9
9.8
13
6
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
114.4
9.7
10
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
9.6
9
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
57.2
8.9
10
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
11.7
8.8
16
17
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
23.6
8.8
12
6
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
6.0
8.7
18
38
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
101.4
8.6
9
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
+∞
8.5
8
*
A28
ICPC
Limited function/disability NOS
5.3
8.2
20
49
L28
ICPC
Limited function/disability (L)
5.1
8.1
21
54
J01MA12
ATC
levofloxacin; systemic
4.8
8.1
23
64
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
12.1
8.0
14
14
XF400
NOMESCO Finland
ECG with 12 standard connections
5.3
7.8
19
46
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
7.0
7.6
19
35
H02AA02
ATC
fludrocortisone; oral
88.9
7.6
8
*
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
7.4
7
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
7.2
29
104
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.8
7.1
19
50
R03BB04
ATC
tiotropium bromide; inhalant
8.4
6.6
14
20
R50.9
ICD-10 Finland
Fever, unspecified
4.1
6.4
22
70
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.0
6.3
12
14
E23.0
ICD-10 Finland
Hypopituitarism
+∞
6.3
6
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
6.3
6
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
6.3
40
191
A41.9
ICD-10 Finland
Sepsis, unspecified
16.9
6.1
9
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
6.1
6.0
16
32
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.1
6.0
16
32
R03DA04
ATC
theophylline; systemic, rectal
12.7
6.0
10
9
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
55
5.32
8.84
7.6
5.6
2.89
1.49
mmol/l
0.87
17
46
22
60
4.84
7.92
14.1
5.9
104.36
104.75
mmol/l
0.16
22
60
14
15
11.27
7.70
5.0
3.5
24.72
23.89
mmol/l
0.37
14
15
25
78
4.38
7.57
4.5
2.3
2.17
2.39
g/l
1.14
25
70
7
0
+∞
7.41
1.1
0.0
—
—
—
0
0
25
80
4.26
7.30
3.9
2.0
—
—
—
0
0
25
84
4.03
6.78
4.5
2.4
11.85
13.69
umol/l
0.53
25
76
40
188
3.54
6.53
7.0
3.4
25.35
18.94
ng/l
0.36
29
111
16
31
6.32
6.16
2.9
1.6
—
—
—
0
0
16
48
4.00
4.95
47.9
10.7
0.89
1.21
mmol/l
0.08
11
39
18
60
3.67
4.80
4.1
1.7
—
—
—
0
0
18
60
3.67
4.80
4.2
1.8
—
—
—
0
0
8
9
9.81
4.40
5.3
3.6
17.04
17.26
%
—
8
9
61
433
3.68
4.16
19.0
7.8
78.62
74.69
u/l
0.35
61
409
18
70
3.10
3.73
1.8
1.7
1084.25
1295.49
nmol/l
0.32
12
52
11
28
4.44
3.46
1.3
1.2
—
—
—
0
0
7
10
7.61
3.45
5.6
1.4
—
—
—
0
0
8
15
5.85
3.29
5.0
2.4
—
—
—
0
0
8
16
5.48
3.15
4.1
1.7
—
—
—
0
0
12
37
3.68
3.11
24.4
9.0
23.64
24.74
mmol/l
0.50
12
37
5
5
10.60
3.02
24.2
3.2
10.02
10.64
kpa
—
5
5
5
5
10.60
3.02
24.2
3.2
5.37
4.68
kpa
—
5
5
6
9
7.15
2.92
1.3
2.2
—
—
—
0
0
12
40
3.39
2.86
4.8
2.3
59.29
75.86
ml/min/173m2
—
7
21
5
6
8.83
2.79
1.2
1.3
—
—
—
0
0
5
6
8.83
2.79
18.0
3.0
15.30
7.33
pmol/l
—
5
6
5
6
8.83
2.79
1.2
1.3
—
—
nmol/l
—
0
0
36
223
2.23
2.79
2.3
1.8
88.05
98.02
pmol/l
0.69
27
113
12
44
3.07
2.70
8.8
3.1
—
—
—
0
0
8
20
4.36
2.65
2.4
1.5
—
—
—
0
0
8
20
4.36
2.65
2.4
1.5
—
—
—
0
0
10
31
3.58
2.64
18.1
13.4
0.63
0.69
%
—
10
31
13
51
2.89
2.61
1.4
1.2
134.31
117.62
u/ml
0.14
13
45
10
32
3.46
2.55
18.4
13.1
1.81
1.17
%
—
10
32
6
13
4.93
2.32
2.5
1.3
—
—
—
0
0
29
175
2.10
2.31
10.3
3.6
0.00
0.00
estimate
-0.00
15
63
29
180
2.02
2.11
1.6
1.3
0.54
1.59
u/ml
—
10
49
7
20
3.76
2.11
1.1
1.8
1.28
1.20
g/l
—
7
20
7
20
3.76
2.11
1.1
1.8
0.28
0.27
g/l
—
7
20
66
568
2.94
2.09
10.6
4.9
1.57
1.89
mu/l
1.43
61
539
6
15
4.26
2.08
2.2
2.9
—
—
—
0
0
6
15
4.26
2.08
2.5
1.5
—
—
—
0
0
6
15
4.26
2.08
2.7
1.4
—
—
—
0
0
8
26
3.33
2.08
2.0
4.9
94.00
93.96
%
—
8
26
23
132
2.09
2.06
4.9
2.2
—
—
—
0
0
7
21
3.58
2.02
2.4
1.3
—
—
—
0
0
5
11
4.79
1.97
1.8
1.0
797.40
229.36
pmol/l
—
5
11
30
195
1.92
1.88
9.8
2.7
—
—
—
0
0
5
12
4.39
1.85
1.4
1.3
—
—
—
0
0
5
12
4.39
1.85
1.8
1.3
—
—
—
0
0
37
260
1.87
1.82
8.8
3.1
0.00
0.00
estimate
-0.00
14
58
6
143
0.37
1.77
1.3
2.4
—
—
—
0
0
5
13
4.05
1.74
1.2
1.5
—
—
—
0
0
45
343
1.83
1.65
8.1
3.4
0.00
0.00
estimate
-0.00
17
61
5
14
3.75
1.64
1.2
1.0
—
—
—
0
0
29
194
1.83
1.62
9.0
2.6
0.00
0.00
estimate
-0.00
15
56
6
135
0.39
1.62
1.3
2.3
—
—
—
0
0
5
16
3.28
1.46
2.6
2.6
—
—
—
0
0
44
341
1.75
1.45
8.3
3.3
0.00
0.00
estimate
-0.00
17
66
67
602
2.62
1.41
65.3
14.2
3.90
3.94
mmol/l
0.67
67
589
67
601
2.65
1.40
63.6
14.1
139.54
139.86
mmol/l
0.67
67
590
43
338
1.68
1.29
8.5
3.3
0.00
0.00
estimate
-0.00
16
67
35
261
1.66
1.28
7.3
2.7
—
—
estimate
—
0
0
67
606
2.52
1.26
52.4
12.9
20.59
21.56
mg/l
0.10
60
470
8
37
2.30
1.26
1.0
1.5
—
223.53
miu/ml
—
0
17
6
26
2.42
1.21
16.0
4.2
24.77
25.31
mmol/l
—
6
26
5
20
2.61
1.17
2.6
1.3
—
0.00
—
0
5
5
21
2.48
1.11
3.4
5.1
3.54
3.36
g/l
—
5
21
0
32
0.00
0.97
0.0
2.0
—
3.09
—
0
24
13
82
1.71
0.85
4.2
2.3
0.78
2.95
e6/l
—
8
26
5
23
2.26
0.78
2.2
1.3
—
—
—
0
0
5
23
2.26
0.78
1.4
3.7
284.20
173.09
%
—
5
23
15
102
1.59
0.75
4.7
3.4
18.40
216.62
ng/l
—
10
66
5
25
2.07
0.74
35.8
15.6
23.38
24.87
mmol/l
—
5
25
14
94
1.61
0.73
4.1
2.3
0.47
0.89
e6/l
—
9
38
6
40
1.54
0.53
1.7
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
19
156
1.30
0.36
7.1
3.3
1.02
1.02
kg/l
1.63
11
88
15
180
0.79
0.28
1.7
1.8
—
—
—
0
0
5
41
1.24
0.22
1.0
1.0
—
—
—
0
0
9
112
0.78
0.22
1.8
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
47
1.30
0.21
1.5
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
14
119
1.22
0.19
6.4
4.1
27.63
21.47
%
—
6
53
7
67
1.05
0.08
4.6
7.8
—
—
—
0
0
47
471
0.99
0.00
4.9
3.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.6
—
818.60
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
10.71
—
0
7
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOTHALDYSF and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYPOTHALDYSF.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYPOTHALDYSF – Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data