This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorders of glycoprotein metabolism
E4_GLYCOPROT
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
46 |
4. Check minimum number of eventsNone |
46 |
5. Include endpoints |
46 |
6. Filter based on genotype QC (FinnGen only) |
41 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E70-E90
- Name in latin
- Perturbationes metabolismi glycoproteinorum
Similar endpoints
↥List of similar endpoints to
Disorders of glycoprotein metabolism
based on the number of shared cases.
Similar with more cases:
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 490 | 243 | 246 |
| Only index persons | 390 | 191 | 199 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 39.76 | 40.27 | 39.07 |
| Only index persons | 38.47 | 38.07 | 38.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 41 | 23 | 18 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 52.12 | 52.52 | 51.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
8
11.92
4.74
5.9
3.9
55.28
45.79
%
—
8
8
32
174
4.28
4.42
17.2
5.8
1.22
1.21
mmol/l
0.10
32
150
7
7
11.62
4.17
1.1
1.4
—
—
—
0
0
27
144
3.35
3.58
7.4
4.6
35.10
36.55
g/l
0.61
27
135
19
88
3.08
3.10
2.9
2.5
752.05
759.15
ng/l
0.01
19
73
7
16
5.00
2.59
1.6
1.3
—
—
—
0
0
23
138
2.43
2.10
2.2
1.8
97.72
103.88
pmol/l
0.21
13
63
6
16
4.18
2.01
7.2
3.9
1.18
0.99
%
—
6
16
5
11
4.98
2.00
1.0
1.0
—
—
—
0
0
11
47
2.80
1.97
1.8
1.7
—
—
—
0
0
12
55
2.64
1.88
2.6
1.7
462.25
478.77
pmol/l
0.12
12
47
22
135
2.29
1.85
3.4
3.3
35.41
29.55
u/l
1.10
22
127
19
110
2.30
1.82
4.6
2.1
0.00
0.00
estimate
—
6
29
6
18
3.70
1.81
1.8
1.2
—
—
—
0
0
20
124
2.15
1.59
5.1
2.8
—
—
—
0
0
5
15
3.62
1.57
1.4
1.7
—
—
—
0
0
17
100
2.16
1.53
3.8
1.9
503.47
118.32
u/l
0.48
17
90
9
165
0.43
1.52
1.9
2.0
1.91
1.26
mmol/l
—
9
137
24
163
2.07
1.48
3.5
2.3
78.25
77.37
nmol/l
0.06
24
151
5
17
3.18
1.40
13.8
10.8
25.90
25.89
mmol/l
—
5
17
8
34
2.65
1.38
1.6
1.7
—
—
—
0
0
8
36
2.50
1.33
1.6
1.7
—
—
—
0
0
19
124
1.95
1.26
4.2
2.3
18.59
25.44
ng/l
0.46
14
71
5
19
2.84
1.25
1.0
1.6
—
—
—
0
0
15
91
2.00
1.21
1.7
1.5
21.43
24.51
nmol/l
0.23
15
81
27
202
1.90
1.16
4.6
2.8
0.00
0.00
estimate
—
9
37
22
156
1.84
1.10
4.9
2.8
0.00
0.00
estimate
—
7
32
6
28
2.32
0.96
6.5
3.7
25.48
23.99
mmol/l
—
6
28
23
171
1.74
0.94
3.0
2.9
—
—
estimate
—
0
0
30
347
0.55
0.87
7.3
4.7
6.94
5.82
mmol/l
2.09
30
315
25
197
1.64
0.78
7.2
5.9
19.76
13.40
umol/l
0.31
25
186
26
207
1.65
0.78
4.7
2.8
0.00
0.00
estimate
—
9
36
7
40
1.89
0.76
6.7
7.7
103.57
105.10
mmol/l
—
7
40
26
208
1.63
0.75
4.6
2.9
0.00
0.00
estimate
—
7
37
12
80
1.69
0.69
2.6
2.5
3.42
2.80
mg/l
0.40
12
67
5
29
1.82
0.66
4.8
3.5
5.00
5.04
kpa
—
5
29
6
36
1.77
0.59
6.5
7.4
5.02
5.31
kpa
—
6
36
32
281
1.54
0.52
15.1
7.3
101.91
85.08
u/l
0.92
32
263
7
47
1.58
0.51
2.4
1.4
1236.57
1288.41
nmol/l
—
7
33
5
32
1.63
0.44
3.6
6.4
24.20
25.17
mmol/l
—
5
32
43
413
+∞
0.41
40.5
19.4
36.40
40.78
%
1.51
43
407
43
413
+∞
0.41
40.4
18.9
89.71
90.07
fl
0.22
43
408
19
156
1.39
0.41
20.6
6.1
1.19
1.21
mmol/l
0.85
19
146
31
281
1.37
0.33
7.8
4.0
18.71
9.62
mm/h
1.55
31
255
27
241
1.32
0.31
5.0
3.4
89.11
44.79
u/l
1.82
27
230
34
355
0.80
0.27
7.8
4.8
4.51
4.82
mmol/l
1.15
34
332
13
109
1.28
0.22
2.8
3.0
0.00
0.00
estimate
—
7
35
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
35
361
0.84
0.18
8.4
5.4
2.68
2.84
mmol/l
0.52
35
333
19
170
1.21
0.18
6.1
2.6
121.11
97.06
ug/l
0.26
19
157
34
351
0.85
0.17
7.5
4.7
1.22
1.51
mmol/l
5.65
34
325
36
343
1.30
0.16
21.6
11.6
79.22
84.49
ml/min/173m2
0.66
36
310
36
342
1.32
0.16
15.5
5.4
45.98
38.42
mmol/mol
2.97
36
323
12
103
1.23
0.16
9.8
5.5
14.13
1.98
ug/l
0.48
12
85
33
345
0.81
0.14
7.5
5.0
1.94
1.83
mu/l
0.24
33
317
5
47
1.07
0.10
2.6
3.4
26.60
5.05
umol/l
—
5
42
6
53
1.15
0.09
2.2
1.6
2.18
1.35
%
—
6
44
7
64
1.11
0.08
4.3
3.2
1.68
0.65
ug/l
—
7
37
10
90
1.14
0.06
3.3
2.4
—
—
—
0
0
25
240
1.10
0.05
3.3
3.2
—
—
—
0
0
13
121
1.11
0.04
4.3
2.7
2.29
2.37
mmol/l
1.85
13
110
33
336
0.92
0.01
7.2
3.9
1.76
1.24
mmol/l
2.26
33
310
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
2.2
2.6
2.46
2.45
mmol/l
—
6
50
0
5
0.00
-0.00
0.0
2.4
—
15.40
—
0
5
5
55
0.90
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
4.70
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
45.79
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GLYCOPROT and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GLYCOPROT | 5.737 [3.32, 9.92] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 195 males with E4_GLYCOPROT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GLYCOPROT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.985% |
| 5 | No data | 5.653% |
| 10 | No data | 14.629% |
| 15 | No data | 26.381% |
| 20 | No data | 40.026% |
Relationships between endpoints
↥Index endpoint: E4_GLYCOPROT – Disorders of glycoprotein metabolism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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