amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
118 |
4. Check minimum number of eventsNone |
118 |
5. Include endpointsNone |
118 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E85
- Name in latin
- Amyloidosis systemica secundaria
Similar endpoints
↥List of similar endpoints to
Secondary systemic amyloidosis
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 873 | 392 |
| Only index persons | 670 | 472 | 198 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.38 | 66.66 | 65.34 |
| Only index persons | 64.41 | 64.70 | 63.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 109 | 65 | 44 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 63.08 | 60.49 | 66.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E85.3
ICD-10 Finland
Secondary systemic amyloidosis
+∞
151.8
108
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
40.4
89.3
70
45
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
36.9
85.4
82
79
L01BA01
ATC
methotrexate; systemic
53.5
82.5
52
18
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
23.8
54.4
46
32
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
20.6
48.0
43
33
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
25.9
47.6
37
21
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
103.9
45.8
48
8
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
22.8
42.8
35
22
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
42.4
38
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
166.2
42.2
42
*
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
40.0
36
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
125.9
34.0
35
*
A07EC01
ATC
sulfasalazine; oral, rectal
10.8
29.7
40
55
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
135.2
29.3
30
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
84.8
28.7
31
5
L04AX01
ATC
azathioprine; systemic
33.9
28.5
37
16
A11CC03
ATC
alfacalcidol; systemic
101.4
28.4
30
*
L04AX03
ATC
methotrexate; systemic
9.6
27.4
41
64
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
60.4
27.2
31
7
L04AA01
ATC
[U] ciclosporin
318.9
25.8
25
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
10.9
24.8
31
38
C03CA01
ATC
furosemide; systemic
7.1
22.3
78
278
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
45.4
20.9
25
7
A12AA04
ATC
calcium carbonate; oral
71.6
20.8
23
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
90.4
20.5
22
*
2773B
ICD-9 Finland
Other and unspecified disorders of metabolism, Amyloidosis[AMYLOIDOSIS SECUNDARIA]
+∞
20.4
19
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.4
19.8
36
68
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.1
19.6
25
31
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
85.3
19.5
21
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
+∞
19.3
18
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
+∞
19.3
18
*
TK800
NOMESCO Finland
Hemodialysis
37.7
19.3
24
8
P01BA02
ATC
hydroxychloroquine; oral
7.5
19.1
33
59
L04AA13
ATC
[U] leflunomide
33.5
18.8
24
9
N18.0
ICD-10 Finland
End-stage renal disease
113.5
18.2
19
*
B03XA01
ATC
erythropoietin; parenteral
212.5
18.1
18
*
N08.4
ICD-10 Finland
Glomerular disorders in other endocrine, nutritional and metabolic diseases
+∞
16.0
15
*
9283
FHL
Subtalar joint ossification surgery (or triple)
+∞
16.0
15
*
A46
ICD-10 Finland
Erysipelas
5.8
15.9
38
92
ZX120
NOMESCO Finland
Intravenous
6.5
15.9
31
62
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
20.3
15.6
23
14
L88
ICPC
Rheumatoid/seropositive arthritis
13.9
15.6
27
25
M05BA04
ATC
alendronic acid; oral
5.9
15.3
34
77
H02AB04
ATC
methylprednisolone; systemic
5.4
15.3
40
105
9314
FHL
Total knee endoprosthesis (also includes patellar part)
92.7
15.0
16
*
M01CB01
ATC
sodium aurothiomalate; parenteral
35.3
14.4
18
6
H02AB07
ATC
prednisone; oral
5.5
14.3
35
86
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
14.2
34
82
D06BB04
ATC
podophyllotoxin; topical
19.6
14.1
21
13
NF1AA
NOMESCO Finland
Hip X-ray examination
5.8
14.1
31
69
N02AX02
ATC
tramadol; systemic, rectal
4.6
13.9
73
325
L04AC07
ATC
tocilizumab; parenteral
+∞
13.8
13
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
13.8
13
*
Z94.0
ICD-10 Finland
Kidney transplant status
+∞
13.8
13
*
L01AA02
ATC
chlorambucil; oral
158.6
13.8
14
*
J01FF01
ATC
clindamycin; systemic
4.4
13.6
54
195
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
46.1
13.6
16
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
22.6
13.5
19
10
I50.9
ICD-10 Finland
Heart failure, unspecified
4.8
13.4
40
116
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.4
13.3
71
317
N19
ICD-10 Finland
Unspecified kidney failure
18.4
13.2
20
13
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
+∞
12.7
12
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
145.8
12.7
13
*
9256
FHL
Synovectomy (knee 9311)
145.8
12.7
13
*
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
42.9
12.6
15
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
30.7
12.4
16
6
H02AB06
ATC
prednisolone; systemic
4.5
12.3
79
395
L04AB04
ATC
adalimumab; parenteral
52.9
12.2
14
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.5
12.1
39
119
C90.0
ICD-10 Finland
Multiple myeloma
26.4
12.0
16
7
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
6.2
11.9
23
45
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
15.0
11.7
19
15
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
11.7
11
*
ZXA05
NOMESCO Finland
Left side
4.0
11.5
49
183
ZXD05
NOMESCO Finland
Urgent procedure
4.0
11.4
51
196
M04AA01
ATC
allopurinol; systemic
4.6
11.4
34
97
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.7
11.3
24
51
L04AB01
ATC
etanercept; parenteral
48.6
11.2
13
*
B03XA02
ATC
darbepoetin alfa; parenteral
31.7
11.0
14
5
V03AE01
ATC
polystyrene sulfonate; oral
24.4
11.0
15
7
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
10.9
54
222
I50.0
ICD-10 Finland
Congestive heart failure
5.5
10.9
24
53
127
Kela drug reimbursment
Transplant complication
66.6
10.9
12
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
66.6
10.9
12
*
B01AB04
ATC
dalteparin; parenteral
10.1
10.6
21
25
NHG20
NOMESCO Finland
Fusion of talocrural joint
121.0
10.6
11
*
NDG74
NOMESCO Finland
Fusion of first IP joint
+∞
10.6
10
*
E85.0
ICD-10 Finland
Non-neuropathic heredofamilial amyloidosis
+∞
10.6
10
*
L04AA11
ATC
[U] etanercept
+∞
10.6
10
*
M05BX04
ATC
denosumab; parenteral
5.9
10.5
21
42
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.3
10.1
32
95
N18.8
ICD-10 Finland
Other chronic renal failure
22.6
10.1
14
7
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.5
10.0
22
48
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
13.1
10.0
17
15
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
9.5
9.9
20
25
9272
FHL
Metatarsophalangeal joint resection
60.4
9.8
11
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
9.1
9.7
20
26
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
33.3
9.6
12
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
108.9
9.6
10
*
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
108.9
9.6
10
*
ZZH31
NOMESCO Finland
Bone allograft, small pieces
108.9
9.6
10
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.9
9.6
24
59
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
9.5
9
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
9.5
9
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
9.5
9
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
9.5
9
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.6
9.4
17
17
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
17.6
9.3
14
9
J01MA12
ATC
levofloxacin; systemic
3.7
9.3
40
147
H26.2
ICD-10 Finland
Complicated cataract
40.3
9.2
11
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
20.8
9.2
13
7
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
26.6
9.1
12
5
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
9.0
32
103
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
15.8
9.0
14
10
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.9
8.9
20
30
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.9
8.9
20
30
M01CB03
ATC
auranofin; oral
54.4
8.8
10
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.1
8.8
18
23
L04AA06
ATC
mycophenolic acid; systemic
22.2
8.7
12
6
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
8.7
8.6
18
24
9284
FHL
Wrist ossification surgery
97.1
8.5
9
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
97.1
8.5
9
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
9.3
8.5
17
21
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
8.4
8
*
E85.89
ICD-10 Finland
Other amyloidosis
+∞
8.4
8
*
V03AE02
ATC
sevelamer; oral
+∞
8.4
8
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
8.4
8
*
L01BB01, ,
ATC
+∞
8.4
8
*
L04AA17
ATC
[U] adalimumab
+∞
8.4
8
*
9289
FHL
Other measure in this category
+∞
8.4
8
*
L04AX04
ATC
lenalidomide; oral
36.3
8.2
10
*
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
36.3
8.2
10
*
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
24.2
8.2
11
5
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
8.0
8.2
18
26
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
8.1
34
122
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
8.1
74
422
NDG30
NOMESCO Finland
Fusion of wrist, total
48.5
7.8
9
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
48.5
7.8
9
*
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
48.5
7.8
9
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
27.2
7.7
10
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.7
7.7
16
21
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
85.6
7.5
8
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
85.6
7.5
8
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
7.4
19
47
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
17.2
7.4
11
7
A12AA12
ATC
[U] calcium acetate
+∞
7.4
7
*
9531
FHL
Arthrodesis of the hand joint
+∞
7.4
7
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
7.4
7
*
E87.5
ICD-10 Finland
Hyperkalaemia
+∞
7.4
7
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
7.4
7
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
+∞
7.4
7
*
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
+∞
7.4
7
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.7
7.3
27
88
M05BA07
ATC
risedronic acid; oral
7.9
7.3
16
23
R50.9
ICD-10 Finland
Fever, unspecified
3.6
7.3
28
94
L04AD01
ATC
ciclosporin; systemic
21.8
7.3
10
5
R4180
NOMESCO Finland
Podiatric therapy
32.3
7.3
9
*
H02AB08
ATC
triamcinolone; systemic
32.3
7.3
9
*
153
Kela drug reimbursment
Lenalidomid
32.3
7.3
9
*
A07AA09
ATC
vancomycin; oral
32.3
7.3
9
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.1
7.1
22
63
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
7.1
48
227
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.2
7.0
21
59
XW000
NOMESCO Finland
Bone marrow biopsy
7.3
6.9
16
25
NBB10
NOMESCO Finland
Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified
42.7
6.8
8
*
B01AA03
ATC
warfarin; systemic
3.1
6.8
36
147
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
13.4
6.7
11
9
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
13.4
6.7
11
9
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.4
6.7
28
99
ZXE10
NOMESCO Finland
More than one and less than three hours
2.8
6.7
55
287
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.4
6.6
28
100
NHG22
NOMESCO Finland
Fusion of subtalar joint
73.9
6.5
7
*
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
73.9
6.5
7
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
6.5
34
138
ZXA00
NOMESCO Finland
Right side
2.9
6.5
44
207
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
7.0
6.4
15
24
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.4
6.4
9
5
L01AA01
ATC
cyclophosphamide; systemic
28.5
6.3
8
*
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
6.3
6
*
M43.4
ICD-10 Finland
Other recurrent atlantoaxial subluxation
+∞
6.3
6
*
27699
ICD-8 Finland
Amyloidosis
+∞
6.3
6
*
NHB10
NOMESCO Finland
Primary partial prosthetic replacement of ankle joint
+∞
6.3
6
*
N084, E853,
ICD-10 Finland
+∞
6.3
6
*
M01AH02
ATC
rofecoxib; oral
3.3
6.3
28
103
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
9.5
6.2
12
14
B01AB05
ATC
enoxaparin; parenteral
2.7
6.2
49
248
WW200
NOMESCO Finland
Immunization
13.6
6.2
10
8
J01DA01
ATC
[U] cefalexin
3.0
6.2
82
540
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
6.1
22
70
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.0
6.1
13
18
WZA10
NOMESCO Finland
Extensive medical or dental certificate
16.1
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
33
9.00
17.27
11.7
3.5
0.77
2.44
ratio
1.11
16
17
46
143
4.79
14.19
5.1
2.1
19.81
21.26
%
0.40
46
130
46
152
4.46
12.95
5.4
2.1
1.95
2.24
g/l
2.87
46
135
23
27
10.44
11.76
1.9
1.4
16534.12
6857.12
e6/l
0.66
17
17
46
163
4.11
11.60
5.6
2.2
9.29
11.96
umol/l
2.51
46
149
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
14
13.12
9.42
3.1
2.6
0.21
0.37
iu/ml
—
9
9
27
75
4.44
9.24
3.3
2.8
45.57
61.62
ml/min/173m2
0.83
14
29
12
6
22.15
8.68
2.5
1.2
1672.83
1145.33
mg
—
12
6
52
235
3.28
8.61
5.0
2.9
388.40
341.62
umol/l
2.28
47
192
20
47
4.97
8.34
7.3
3.9
23.65
24.24
mmol/l
0.35
20
47
17
22
8.91
8.24
2.2
2.0
—
—
—
0
0
26
80
3.94
7.69
2.7
1.4
—
—
—
0
0
17
28
6.97
7.11
1.9
1.2
—
—
—
0
0
20
59
3.92
6.21
5.4
2.5
1.26
2.03
mmol/l
0.34
14
52
30
121
3.03
5.73
2.0
1.8
—
—
—
0
0
5
0
+∞
5.24
2.2
0.0
—
—
—
0
0
36
168
2.69
5.22
2.7
1.9
—
—
—
0
0
28
118
2.84
4.90
2.1
1.8
—
—
—
0
0
11
19
6.30
4.57
2.1
1.3
—
—
—
0
0
13
28
5.11
4.54
1.9
1.8
—
—
—
0
0
72
487
2.36
4.44
28.0
5.9
1.20
1.21
mmol/l
0.88
67
406
40
212
2.39
4.35
3.8
2.9
—
—
—
0
0
9
13
7.42
4.25
5.2
1.3
10.08
4.58
pmol/l
—
9
13
54
341
2.14
3.74
8.4
3.3
—
—
—
0
0
10
21
5.12
3.65
1.0
1.4
0.23
0.20
g/l
—
10
21
25
115
2.52
3.63
9.1
5.6
1.23
0.99
mmol/l
0.07
20
100
68
856
0.47
3.49
4.9
5.4
5.46
5.95
mmol/l
3.94
62
761
11
30
3.95
3.19
3.1
1.7
—
—
—
0
0
27
137
2.28
3.15
14.3
5.4
102.33
103.99
mmol/l
0.93
27
137
8
17
4.98
2.98
1.0
2.0
—
—
—
0
0
13
47
3.00
2.93
2.5
4.2
—
—
—
0
0
54
365
1.93
2.91
5.8
4.1
82.32
44.59
ng/l
1.08
44
287
6
9
6.97
2.90
2.7
2.3
—
—
—
0
0
6
9
6.97
2.90
2.7
2.3
—
—
—
0
0
6
9
6.97
2.90
2.7
2.3
—
—
—
0
0
6
9
6.97
2.90
1.2
1.2
—
—
—
0
0
6
9
6.97
2.90
1.2
1.2
—
—
—
0
0
12
39
3.32
2.88
1.5
1.1
—
—
—
0
0
59
412
1.92
2.87
4.9
3.0
—
—
estimate
—
0
0
9
23
4.16
2.84
3.1
1.8
—
—
—
0
0
35
209
1.99
2.66
1.9
1.5
4.99
1.60
mg/l
0.61
27
160
19
89
2.37
2.63
8.5
5.8
1.04
1.34
mmol/l
0.90
19
89
28
155
2.08
2.61
4.9
3.3
3.19
2.34
e6/l
0.21
19
75
10
33
3.23
2.43
3.0
1.7
—
—
—
0
0
13
54
2.59
2.29
10.2
7.0
23.00
24.64
mmol/l
0.96
13
54
7
18
4.08
2.29
2.1
1.1
—
—
—
0
0
7
18
4.08
2.29
2.4
1.3
—
169.68
—
0
5
7
19
3.86
2.19
1.4
1.1
—
—
—
0
0
15
69
2.36
2.16
9.9
6.6
93.68
94.77
%
0.53
15
69
12
50
2.57
2.11
5.8
2.6
0.82
0.62
%
1.34
12
50
12
50
2.57
2.11
5.8
2.6
1.13
1.19
%
0.09
12
50
5
11
4.70
1.96
1.0
1.4
—
—
—
0
0
5
11
4.70
1.96
1.0
1.4
270.80
209.61
u/l
—
5
11
5
11
4.70
1.96
3.6
1.4
—
—
—
0
0
6
17
3.67
1.86
1.8
1.4
—
—
—
0
0
6
17
3.67
1.86
1.8
1.4
—
—
—
0
0
28
174
1.81
1.84
4.4
3.2
0.58
1.19
e6/l
0.97
20
95
8
29
2.89
1.83
1.3
1.9
—
—
—
0
0
6
18
3.46
1.77
3.2
1.5
—
—
—
0
0
5
13
3.97
1.73
1.2
1.2
—
—
—
0
0
8
32
2.61
1.63
1.8
1.2
—
—
—
0
0
6
22
2.82
1.45
1.3
1.4
—
—
—
0
0
44
330
1.55
1.40
6.8
3.7
34.17
6.18
mg/mmol
2.22
36
192
5
17
3.03
1.37
3.6
1.4
—
—
—
0
0
16
93
1.84
1.29
2.8
2.3
0.21
0.21
g/l
0.05
16
88
39
290
1.53
1.27
3.6
2.4
71.33
87.16
u/l
0.30
39
265
11
57
2.03
1.22
2.6
1.4
—
—
—
0
0
8
38
2.19
1.21
5.0
2.0
—
—
—
0
0
6
26
2.38
1.20
1.0
1.2
—
—
—
0
0
7
30
2.42
1.14
1.6
1.4
—
—
—
0
0
5
21
2.44
1.10
3.0
1.7
—
—
—
0
0
7
34
2.13
1.05
4.3
1.8
—
—
—
0
0
17
108
1.68
1.04
5.5
4.0
—
—
—
0
0
27
193
1.53
1.03
2.0
1.8
1096.40
1352.18
nmol/l
0.65
21
145
61
513
1.42
1.01
9.8
7.3
9.49
11.17
umol/l
1.49
61
486
6
30
2.06
0.88
2.7
1.6
—
—
—
0
0
15
97
1.63
0.87
12.5
3.7
1.24
1.23
mmol/l
0.48
15
79
8
131
0.58
0.79
3.3
4.4
38.38
33.24
%
—
8
74
56
481
1.33
0.74
12.5
4.0
0.00
0.00
estimate
-0.00
17
113
16
223
0.67
0.72
2.2
5.2
16.70
21.40
%
—
7
126
5
26
1.97
0.71
3.0
1.7
—
—
—
0
0
23
175
1.40
0.65
4.9
3.5
185.48
389.42
ng/l
0.46
23
143
10
63
1.65
0.64
1.8
1.6
—
—
—
0
0
56
490
1.29
0.62
12.4
4.2
0.00
0.00
estimate
-0.00
17
108
0
20
0.00
0.61
0.0
2.0
—
—
—
0
0
55
483
1.27
0.58
12.7
4.1
0.00
0.00
estimate
-0.00
17
118
36
425
0.77
0.57
2.6
2.5
—
—
—
0
0
44
378
1.27
0.55
12.3
4.0
0.00
0.00
estimate
-0.00
14
91
15
111
1.41
0.50
22.9
7.3
—
—
—
0
0
5
81
0.60
0.48
1.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
5
36
1.41
0.38
2.2
1.1
—
—
—
0
0
5
36
1.41
0.38
2.2
1.1
—
—
—
0
0
34
296
1.21
0.36
13.5
4.3
0.00
0.00
estimate
-0.00
12
108
75
706
1.19
0.33
25.6
8.8
81.69
82.20
u/l
0.03
75
650
5
40
1.26
0.23
1.8
2.4
3.82
4.28
pmol/l
—
5
33
19
164
1.19
0.22
1.1
1.3
70.68
41.80
iu/ml
0.59
11
60
0
11
0.00
0.21
0.0
1.3
—
1.56
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
6
49
1.24
0.20
2.0
1.2
—
—
—
0
0
18
205
0.85
0.19
1.1
1.2
1.18
2.55
u/ml
—
6
46
10
116
0.85
0.12
1.3
1.5
—
—
—
0
0
26
276
0.92
0.08
10.5
3.3
0.00
0.00
estimate
-0.00
11
92
12
108
1.12
0.07
2.3
1.5
—
—
—
0
0
44
438
1.01
0.00
2.5
2.0
95.25
101.02
pmol/l
0.30
30
192
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
4.47
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYL_SCNDSYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_SCNDSYST | 7.651 [6.33, 9.25] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.982 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 583 females with E4_AMYL_SCNDSYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_SCNDSYST | 6.313 [4.57, 8.71] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 270 males with E4_AMYL_SCNDSYST died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMYL_SCNDSYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.594% | 1.358% |
| 5 | 4.313% | 7.536% |
| 10 | 11.776% | 18.552% |
| 15 | 22.493% | 31.996% |
| 20 | 36.046% | 49.217% |
Relationships between endpoints
↥Index endpoint: E4_AMYL_SCNDSYST – Secondary systemic amyloidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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