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Haemophagocytic syndrome, infection-associated

D3_HAEMOPHAGOSDR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D76.2
  • Cause of death: ICD-10 D76.2

2 out of 7 registries used, show all original rules.

12

4. Check minimum number of events

None

12

5. Include endpoints

None

12

6. Filter based on genotype QC (FinnGen only)

8

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D76
Name in latin
Syndroma haemophagocyticum infectionem comitans

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 62 27 35
Only index persons 44 15 29
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population - 53.14 51.31
Only index persons 49.57 53.47 47.56

-FinnGen-

Key figures

All Female Male
Number of individuals 8 - -
Unadjusted period prevalence (%) 0.00 - -
Median age at first event (years) 44.98 - -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
5
82
0.22
1.50
6.6
7.3
31.20
41.00
mmol/mol
—
5
76
5
82
0.22
1.50
5.6
5.0
1.15
1.44
mmol/l
—
5
77
5
82
0.22
1.50
6.6
5.0
4.36
4.48
mmol/l
—
5
77
5
81
0.24
1.41
6.0
5.4
2.49
1.85
mu/l
—
5
75
5
79
0.27
1.27
7.2
4.1
1.39
1.31
mmol/l
—
5
73
0
11
0.00
0.23
0.0
1.5
—
—
—
0
0
0
10
0.00
0.23
0.0
1.0
—
—
—
0
0
0
10
0.00
0.23
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
7.38
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
36.84
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
23.77
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
51
0.96
-0.00
61.8
4.6
5.90
7.27
mmol/l
—
5
46
0
6
0.00
-0.00
0.0
1.7
—
26.68
—
0
6
0
9
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_HAEMOPHAGOSDR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMOPHAGOSDR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_HAEMOPHAGOSDR – Haemophagocytic syndrome, infection-associated

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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