Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

D3_CVID_BCELL

obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D83.0
  • Cause of death: ICD-10 D83.0

2 out of 7 registries used, show all original rules.

99

4. Check minimum number of events

None

99

5. Include endpoints

None

99

6. Filter based on genotype QC (FinnGen only)

90

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D83
Name in latin
Deficientia immunalis variabilis communis praecipue cum abnormalitatibus numeri et functionis cellularum B

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 312 164 146
Only index persons 287 154 133
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 49.79 49.97 49.50
Only index persons 47.93 48.90 46.80

-FinnGen-

Key figures

All Female Male
Number of individuals 90 53 37
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 46.95 48.12 45.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
92
Matched controls
920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
132.5
92
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
75.8
62
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
71.4
59
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
38.5
57.6
40
18
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
56.1
48
*
ZX120
NOMESCO Finland
Intravenous
17.4
41.2
44
46
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
12.1
30.2
40
55
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
27.5
25
*
C01CA24
ATC
epinephrine; parenteral
13.0
26.3
30
33
J47
ICD-10 Finland
Bronchiectasis
94.0
25.4
27
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
25.1
23
*
J01MA12
ATC
levofloxacin; systemic
8.9
24.8
46
93
6BA02, ,
NOMESCO Finland
+∞
24.0
22
*
J01MA14
ATC
moxifloxacin; systemic
9.8
23.1
34
52
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
21.7
20
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
19.5
18
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.5
18.3
52
154
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.4
17.6
46
125
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.4
17.6
33
65
UGC12
NOMESCO Finland
Flexible bronchoscopy
20.8
17.5
26
17
J01FA15
ATC
telithromycin; oral
8.7
17.2
26
40
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
9.2
17.0
24
34
TDM10
NOMESCO Finland
Puncture of maxillary antrum
16.1
16.4
27
23
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
19.8
16.0
24
16
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.4
15.8
24
37
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
68.6
15.4
17
*
WW200
NOMESCO Finland
Immunization
27.9
15.0
20
9
Z3231
NOMESCO Finland
Registered nurse
5.5
14.9
48
153
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.0
14.7
67
284
H02AB07
ATC
prednisone; oral
6.5
13.9
28
58
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.7
13.6
26
51
Z01.8
ICD-10 Finland
Other specified special examinations
5.1
13.1
40
120
SPAT1262
SPAT
Handing over of treatment supplies
5.6
12.8
31
76
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
12.8
12
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
12.8
12
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.9
12.5
41
130
Z2221
NOMESCO Finland
Medical doctor
4.7
12.5
47
166
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
15.6
12.4
20
16
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
74.7
11.9
13
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.6
11.9
51
197
J01FF01
ATC
clindamycin; systemic
4.6
11.8
44
153
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
10.6
11.7
23
28
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
11.7
11
*
H02AB06
ATC
prednisolone; systemic
4.8
11.4
65
308
J01FA06
ATC
roxithromycin; oral
4.5
11.3
60
269
UJF30
NOMESCO Finland
Ileoscopy through colon
6.1
11.2
23
48
R50.9
ICD-10 Finland
Fever, unspecified
4.9
10.1
28
76
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
17.6
9.9
15
10
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
61.7
9.9
11
*
TGC00
NOMESCO Finland
Bronchial lavation
20.3
9.8
14
8
J01MA02
ATC
ciprofloxacin; systemic
3.8
9.4
51
225
JN4BD
NOMESCO Finland
Extensive body CT
5.7
9.1
19
40
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.2
9.0
20
30
J01FA09
ATC
clarithromycin; systemic
3.7
8.9
49
216
M05BA04
ATC
alendronic acid; oral
9.4
8.9
18
23
Z3226
NOMESCO Finland
Physiotherapist
4.4
8.8
28
84
GD1AD
NOMESCO Finland
Thorax CT examination
10.2
8.8
17
20
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.7
8.7
45
190
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
8.5
8
*
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
8.5
8
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
9.9
8.2
16
19
J45.9
ICD-10 Finland
Asthma, unspecified
4.0
8.0
29
95
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.8
7.6
19
34
OAB50, ,
SPAT
7.2
7.6
18
30
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
86.8
7.5
8
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.7
7.5
31
111
XW000
NOMESCO Finland
Bone marrow biopsy
17.6
7.4
11
7
UJF92
NOMESCO Finland
Capsular endoscopy
17.6
7.4
11
7
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
7.4
7
*
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
7.4
7
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
7.4
7
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
7.4
7
*
132
Kela drug reimbursment
Sarcoidosis
+∞
7.4
7
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.6
7.3
12
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.1
7.3
17
39
C03CA01
ATC
furosemide; systemic
3.6
7.2
31
114
R01AD09
ATC
mometasone; nasal
3.4
7.2
62
348
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.5
7.1
18
33
ZXE00
NOMESCO Finland
One hour or less
3.2
7.0
49
242
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
7.0
34
135
A07AA02
ATC
nystatin; oral
9.0
6.9
14
18
J32.4
ICD-10 Finland
Chronic pansinusitis
18.5
6.9
10
6
H02AB04
ATC
methylprednisolone; systemic
4.1
6.8
22
66
ZXD10
NOMESCO Finland
Scheduled procedure
3.1
6.7
45
216
A02BC01
ATC
omeprazole; systemic
3.2
6.6
36
152
D73.1
ICD-10 Finland
Hypersplenism
+∞
6.3
6
*
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
198
13.13
30.43
6.8
1.4
0.88
2.24
g/l
9.82
37
133
77
273
12.17
24.03
22.7
5.4
—
—
—
0
0
27
8
46.83
22.67
1.4
1.0
—
—
—
0
0
42
94
7.38
20.02
5.3
1.4
—
—
—
0
0
33
60
8.02
19.05
2.2
1.2
126.27
626.59
u/ml
0.62
19
55
54
191
5.42
14.80
7.5
4.5
—
—
—
0
0
40
110
5.66
14.76
4.1
2.9
—
—
—
0
0
20
11
22.77
14.13
4.4
2.5
—
—
—
0
0
19
9
26.13
14.02
1.3
1.3
0.51
0.58
e9/l
—
19
9
39
118
5.00
12.60
2.9
2.2
139.45
89.93
ug/g
0.69
33
95
34
95
5.09
12.03
2.5
1.7
—
—
—
0
0
24
50
6.14
11.73
6.5
2.3
85.67
66.50
e9/l
0.88
19
33
33
95
4.86
11.17
4.3
2.2
15.11
23.30
%
3.75
33
88
36
113
4.59
10.91
4.5
2.1
9.25
13.93
umol/l
4.71
36
106
71
375
4.91
10.38
9.0
8.6
1.21
1.22
mmol/l
0.39
64
332
34
107
4.45
10.18
4.2
2.1
2.44
2.37
g/l
0.21
34
99
25
63
5.08
9.82
11.2
4.7
0.37
0.44
%
0.15
15
18
25
67
4.75
9.08
13.6
4.7
0.86
0.77
%
0.06
14
22
32
105
4.14
8.94
4.3
3.6
4.03
7.19
e9/l
0.56
32
99
55
261
3.75
8.92
19.2
6.2
—
—
—
0
0
32
107
4.05
8.68
1.4
1.3
—
—
—
0
0
8
0
+∞
8.46
2.8
0.0
—
—
—
0
0
32
114
3.77
7.85
1.8
1.7
—
—
—
0
0
17
28
7.19
7.19
2.9
2.8
2.00
2.13
index
—
5
15
49
241
3.21
7.06
5.9
3.8
7.40
7.40
ph
0.13
43
166
19
53
4.26
6.43
1.5
1.3
—
—
—
0
0
21
64
3.96
6.32
15.6
4.8
0.00
0.06
%
0.48
11
18
17
45
4.41
6.14
1.2
2.4
—
—
—
0
0
9
6
16.41
6.03
1.0
1.0
—
—
—
0
0
44
220
2.92
5.92
4.5
2.8
0.21
0.39
e6/l
0.62
35
161
42
210
2.84
5.59
16.3
4.9
—
—
—
0
0
9
8
12.29
5.42
2.2
1.1
—
—
—
0
0
9
8
12.29
5.42
2.2
1.1
—
—
—
0
0
9
8
12.29
5.42
2.2
1.1
—
—
—
0
0
9
8
12.29
5.42
2.2
1.1
—
—
—
0
0
20
67
3.54
5.21
5.1
2.9
7.37
7.39
ph
0.62
14
45
8
6
14.42
5.18
1.3
1.0
1.72
1.50
g/l
—
8
6
19
67
3.31
4.55
17.4
4.9
0.00
0.06
%
—
9
18
22
86
3.05
4.45
6.1
15.2
-1.76
0.95
mmol/l
1.25
16
72
13
29
5.04
4.45
1.3
1.2
—
—
—
0
0
40
216
2.51
4.35
1.9
2.1
—
—
—
0
0
35
179
2.54
4.25
1.6
1.8
—
—
—
0
0
71
506
2.77
4.17
7.1
4.4
—
49.92
—
0
12
15
48
3.54
4.14
8.9
7.1
22.85
25.15
mmol/l
0.83
15
48
27
123
2.69
4.12
3.2
2.9
1.85
3.12
e6/l
0.50
13
66
57
369
2.43
4.08
3.4
2.8
—
—
estimate
—
0
0
15
49
3.46
4.02
2.0
1.2
—
—
—
0
0
45
266
2.35
3.92
4.6
3.1
43.24
31.00
e6/l
0.19
35
205
21
87
2.83
3.81
6.3
15.1
7.42
7.42
ph
0.04
12
46
13
36
4.03
3.67
1.3
17.6
—
—
—
0
0
48
298
2.28
3.66
2.9
2.0
85.89
97.52
pmol/l
1.00
34
150
49
307
2.28
3.66
5.6
3.9
332.27
36.23
e6/l
0.51
35
210
12
32
4.15
3.54
1.3
1.8
—
—
—
0
0
17
66
2.93
3.44
10.4
9.6
—
—
—
0
0
42
253
2.21
3.39
3.7
2.4
—
—
—
0
0
39
233
2.17
3.17
3.6
2.8
—
—
—
0
0
8
16
5.36
3.12
6.6
2.6
50.63
59.15
%
—
8
16
6
8
7.92
3.10
1.2
2.0
—
—
nmol/l
—
0
0
9
21
4.63
3.08
1.1
1.3
—
—
—
0
0
22
106
2.41
2.93
9.6
8.0
104.14
104.58
mmol/l
0.13
22
106
15
60
2.79
2.87
4.2
2.2
4.13
4.60
kpa
0.53
15
60
55
385
2.07
2.86
4.9
2.9
100.51
95.62
ug/l
0.08
55
366
13
48
2.99
2.85
8.6
12.8
92.79
92.66
%
0.02
13
48
19
88
2.46
2.74
1.5
1.6
—
—
—
0
0
46
308
1.99
2.65
2.1
1.9
—
—
—
0
0
11
37
3.24
2.59
6.5
2.4
24.09
24.83
mmol/l
0.40
11
37
84
721
2.90
2.59
60.8
16.9
14.24
13.45
%
4.64
84
715
6
11
5.75
2.58
7.0
3.1
3.43
3.39
e9/l
—
6
11
10
32
3.38
2.52
2.9
2.8
24.42
24.15
mmol/l
—
10
32
59
437
1.98
2.47
4.4
3.6
0.00
0.00
estimate
-0.00
14
81
6
12
5.26
2.44
1.0
2.1
—
—
—
0
0
5
8
6.53
2.40
1.0
1.1
—
—
—
0
0
5
8
6.53
2.40
1.4
1.0
—
—
—
0
0
59
440
1.95
2.39
4.6
3.7
0.00
0.00
estimate
-0.00
14
82
59
441
1.94
2.36
4.3
3.7
0.00
0.00
estimate
-0.00
13
82
12
48
2.73
2.29
9.3
12.6
0.54
0.65
%
0.68
12
48
5
9
5.80
2.24
1.0
1.0
—
—
—
0
0
5
9
5.80
2.24
5.2
1.3
—
—
—
0
0
8
25
3.40
2.15
1.9
1.2
—
—
—
0
0
34
218
1.89
2.13
1.4
1.3
0.44
1.70
u/ml
—
7
57
12
50
2.61
2.12
9.3
11.8
1.39
1.67
%
0.41
12
50
21
344
0.50
2.11
2.8
3.0
—
—
—
0
0
7
22
3.36
1.92
1.7
1.3
5.29
42.77
e6/l
—
7
13
7
22
3.36
1.92
1.7
1.2
3.80
3.59
mmol/l
—
7
22
7
22
3.36
1.92
1.7
1.4
27.00
149.69
e6/l
—
7
13
5
12
4.34
1.85
1.4
2.0
—
—
—
0
0
8
29
2.92
1.84
1.3
1.3
—
—
—
0
0
8
29
2.92
1.84
2.8
2.1
—
—
—
0
0
7
23
3.21
1.84
1.7
1.4
377.57
516.87
mg/l
—
7
23
16
82
2.15
1.83
1.3
1.2
—
—
—
0
0
12
55
2.36
1.76
4.3
3.1
1.24
1.23
mmol/l
0.38
12
47
5
13
4.00
1.74
4.8
2.2
37.00
33.77
umol/l
—
5
13
23
138
1.89
1.73
1.4
1.6
—
—
—
0
0
7
25
2.94
1.68
2.4
4.4
37.07
36.96
°c
—
7
25
5
14
3.71
1.63
5.8
1.4
7.43
7.41
ph
—
5
14
48
365
1.66
1.57
4.1
3.4
6.42
6.21
ph
0.59
25
201
5
16
3.24
1.45
1.4
1.1
—
—
—
0
0
5
16
3.24
1.45
1.4
1.1
—
—
—
0
0
34
244
1.62
1.36
4.0
4.0
2.06
10.15
mg/mmol
2.19
23
155
17
100
1.86
1.35
1.1
1.2
—
—
—
0
0
6
24
2.60
1.32
1.5
1.3
—
—
—
0
0
16
93
1.87
1.31
1.7
1.4
—
—
—
0
0
5
18
2.88
1.30
4.2
2.7
5.20
7.36
mmol/l
—
5
18
33
240
1.58
1.23
3.6
3.4
12.22
49.26
mg/l
2.69
22
159
5
19
2.72
1.23
2.0
1.5
—
—
—
0
0
5
19
2.72
1.23
1.2
1.0
—
—
—
0
0
8
38
2.21
1.22
2.5
1.8
3.14
1.59
%
—
8
38
8
38
2.21
1.22
2.5
1.8
0.68
0.69
%
—
8
38
5
20
2.58
1.16
1.2
1.0
—
—
—
0
0
5
21
2.46
1.10
5.0
2.5
1.82
1.37
mmol/l
—
5
21
5
22
2.34
1.04
2.8
3.9
—
—
—
0
0
5
101
0.47
0.96
1.4
1.3
—
—
—
0
0
6
30
2.07
0.88
1.2
1.3
—
—
—
0
0
26
193
1.48
0.86
2.1
1.7
1.42
1.18
mg/l
0.19
21
152
9
55
1.70
0.76
1.4
1.1
—
—
—
0
0
21
154
1.47
0.73
4.5
3.0
10.15
112.94
ng/l
1.18
13
96
32
255
1.39
0.72
1.4
1.6
—
—
—
0
0
5
29
1.76
0.65
1.0
1.2
—
—
—
0
0
6
36
1.71
0.58
2.5
1.9
—
—
—
0
0
6
36
1.71
0.58
1.5
2.1
—
—
—
0
0
29
237
1.33
0.55
5.0
3.8
0.00
0.04
estimate
0.74
12
76
6
40
1.53
0.52
1.0
1.1
—
—
—
0
0
16
121
1.39
0.48
1.9
1.8
—
—
—
0
0
15
113
1.39
0.46
3.0
2.4
0.62
0.64
ug/l
—
9
53
63
580
1.27
0.45
4.4
3.3
—
—
—
0
0
8
58
1.41
0.43
5.7
2.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
29
247
1.25
0.40
3.8
3.1
0.00
0.00
estimate
-0.00
12
64
6
45
1.36
0.34
1.5
1.9
—
11815.57
—
0
14
15
119
1.31
0.34
1.4
1.5
—
—
—
0
0
19
159
1.25
0.30
1.5
1.4
1.30
5.66
u/ml
—
6
59
37
337
1.16
0.24
4.9
3.4
0.00
0.06
estimate
0.68
11
69
5
38
1.33
0.23
1.4
2.6
—
0.00
estimate
—
0
10
6
49
1.24
0.20
7.7
3.3
—
—
—
0
0
5
60
0.82
0.08
2.0
2.3
—
—
—
0
0
5
60
0.82
0.08
2.0
2.3
—
—
—
0
0
86
847
1.24
0.08
31.6
11.6
—
—
—
0
0
26
274
0.93
0.07
4.3
3.1
12.97
19.30
ng/l
1.48
19
160
62
630
0.95
0.03
5.3
4.4
14.97
14.78
pmol/l
0.24
57
587
22
226
0.97
0.00
4.1
3.0
—
—
—
0
0
5
58
0.85
0.00
2.0
2.4
—
—
—
0
0
5
53
0.94
0.00
1.8
2.5
—
—
—
0
0
5
53
0.94
0.00
4.6
3.2
4.72
4.66
pmol/l
—
5
48
0
6
0.00
-0.00
0.0
1.2
—
70.67
—
0
6
0
5
0.00
-0.00
0.0
3.8
—
34.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
59
0.84
-0.00
2.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
-0.00
2.1
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
10.34
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
18.95
—
0
8
0
5
0.00
-0.00
0.0
7.6
—
8.80
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
111.33
—
0
6
5
49
1.02
-0.00
1.6
2.6
3.72
4.48
ug/l
—
5
42
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.4
34.40
23.15
iu/l
—
6
49
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
262.80
—
0
5

Mortality – FinRegistry

Association

Association between endpoint D3_CVID_BCELL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_CVID_BCELL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_CVID_BCELL – Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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