cryoglobulinemia: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease ); and/or cancers of the blood or immune system . Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
71 |
4. Check minimum number of eventsNone |
71 |
5. Include endpointsNone |
71 |
6. Filter based on genotype QC (FinnGen only) |
57 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D89
- Name in latin
- Cryoglobulinaemia
Similar endpoints
↥List of similar endpoints to
Cryoglobulinemia
based on the number of shared cases.
Similar with more cases:
- Other disorders involving the immune mechanism, not elsewhere classified
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 308 | 146 | 161 |
| Only index persons | 253 | 121 | 132 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.79 | 59.34 | 58.14 |
| Only index persons | 56.02 | 55.87 | 56.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57 | 28 | 29 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 55.69 | 52.28 | 58.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 60
- Matched controls
- 600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D89.1
ICD-10 Finland
Cryoglobulinaemia
+∞
38.8
33
*
N08.2*D89.1
ICD-10 Finland
Glomerular disorders in cryoglobulinaemia
+∞
27.1
24
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
15.6
26.2
32
41
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
23.5
21
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
67.6
19.9
22
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
97.6
19.1
20
*
H02AB04
ATC
methylprednisolone; systemic
10.8
18.9
29
48
R50.9
ICD-10 Finland
Fever, unspecified
10.4
18.8
31
56
A11CC03
ATC
alfacalcidol; systemic
90.5
18.0
19
*
A12AA04
ATC
calcium carbonate; oral
115.9
16.5
17
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
23.9
15.5
22
14
L04AA06
ATC
mycophenolic acid; systemic
106.7
15.4
16
*
Z94.0
ICD-10 Finland
Kidney transplant status
178.8
14.1
14
*
127
Kela drug reimbursment
Transplant complication
89.4
13.2
14
*
B05DA
ATC
Isotonic solutions
+∞
13.0
12
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
13.0
12
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
13.0
12
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.6
12.7
24
30
C03CA01
ATC
furosemide; systemic
6.6
12.0
38
125
B03XA02
ATC
darbepoetin alfa; parenteral
54.1
11.4
13
*
TK800
NOMESCO Finland
Hemodialysis
29.7
10.8
14
6
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
10.7
10
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.3
10.7
25
61
N18.8
ICD-10 Finland
Other chronic renal failure
25.5
10.4
14
7
TPH04
NOMESCO Finland
Cathetrisation of vein
5.8
10.1
27
74
J01MA12
ATC
levofloxacin; systemic
6.0
10.1
25
64
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.3
9.9
45
193
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.9
9.9
19
38
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
15.1
9.8
16
14
V03AE01
ATC
polystyrene sulfonate; oral
117.8
9.7
10
*
N18.0
ICD-10 Finland
End-stage renal disease
117.8
9.7
10
*
L04AA01
ATC
[U] ciclosporin
117.8
9.7
10
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
9.6
9
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
9.6
9
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
44.0
9.4
11
*
L04AX01
ATC
azathioprine; systemic
16.1
8.9
14
11
B03XA01
ATC
erythropoietin; parenteral
104.1
8.7
9
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
104.1
8.7
9
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
+∞
8.5
8
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
8.5
8
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
8.5
8
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
8.5
8
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
39.2
8.4
10
*
L04AD01
ATC
ciclosporin; systemic
39.2
8.4
10
*
ZX120
NOMESCO Finland
Intravenous
8.7
8.2
18
28
KA1AE
NOMESCO Finland
Kidney ultrasound examination
52.0
7.9
9
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
90.9
7.6
8
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
90.9
7.6
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
7.6
20
53
B05DB
ATC
Hypertonic solutions
+∞
7.4
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.3
7.4
33
132
M05BA04
ATC
alendronic acid; oral
11.5
7.2
13
14
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.7
7.0
13
15
L04AD02
ATC
tacrolimus; systemic
45.3
6.9
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.1
6.9
34
144
M04AA01
ATC
allopurinol; systemic
4.9
6.9
19
52
R31
ICD-10 Finland
Unspecified haematuria
7.0
6.8
17
32
B01AB10
ATC
tinzaparin; parenteral
7.4
6.7
16
28
N17.9
ICD-10 Finland
Acute renal failure, unspecified
16.8
6.7
10
7
R4190
NOMESCO Finland
Nutritional therapy
16.8
6.7
10
7
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
16.8
6.7
10
7
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
77.8
6.6
7
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.4
6.5
13
17
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.4
6.4
12
14
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
6.4
6
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
6.4
6
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
14.7
6.3
10
8
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.9
6.3
13
18
S97
ICPC
Chronic ulcer skin
7.9
6.3
14
22
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
10.9
6.1
11
12
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
31
14.04
21.92
5.4
2.3
66.16
66.65
g/l
0.10
26
31
52
229
10.49
12.73
32.4
10.6
1.20
1.21
mmol/l
0.18
44
199
46
175
7.98
12.51
12.0
3.1
—
—
—
0
0
39
131
6.65
12.02
9.7
3.0
0.16
0.18
e6/l
0.09
34
93
18
14
17.75
11.60
3.1
1.4
1.16
1.15
g/l
0.01
18
14
18
14
17.75
11.60
3.4
1.3
0.22
0.26
g/l
0.69
18
14
30
83
6.23
11.32
10.0
2.4
22.66
22.25
%
0.06
30
76
18
18
13.74
10.43
4.2
1.3
3.79
3.57
g/l
0.15
18
18
18
18
13.74
10.43
4.2
1.3
7.64
8.48
g/l
1.17
18
18
18
18
13.74
10.43
4.2
1.3
4.31
4.35
g/l
0.07
18
18
29
86
5.59
9.93
3.9
4.7
0.80
0.84
mmol/l
0.75
29
81
17
17
13.44
9.82
4.4
1.3
3.01
3.04
g/l
0.03
17
17
16
14
15.07
9.78
4.3
1.1
9.91
9.19
g/l
0.19
16
14
30
93
5.45
9.72
10.1
2.4
11.08
12.90
umol/l
0.94
30
84
15
12
16.17
9.50
4.7
1.1
0.00
0.00
g/l
-0.00
15
12
15
12
16.17
9.50
1.5
1.4
—
—
—
0
0
29
89
5.37
9.47
10.3
2.4
2.09
2.32
g/l
1.56
29
78
14
13
13.62
8.32
1.5
1.3
—
—
—
0
0
14
13
13.62
8.32
2.4
1.7
—
—
—
0
0
18
28
8.70
8.22
11.1
7.0
23.34
24.88
mmol/l
0.79
18
28
24
70
5.05
8.16
3.4
2.5
29.90
29.38
s
0.21
24
70
15
18
10.70
7.90
2.5
1.2
—
—
—
0
0
20
54
5.06
7.37
5.3
4.1
—
—
—
0
0
12
11
13.27
7.17
5.1
1.1
0.00
0.00
g/l
-0.00
12
11
18
46
5.16
7.04
17.3
3.2
5.61
5.59
kpa
0.02
18
46
24
81
4.27
6.62
8.2
2.7
0.29
1.35
e6/l
1.63
17
45
11
10
13.13
6.61
1.5
2.2
—
—
—
0
0
38
186
3.84
6.02
10.3
4.4
35.36
14.17
mg/mmol
1.82
33
121
14
25
6.96
5.81
18.8
2.1
21.99
23.97
mmol/l
1.66
14
25
25
95
3.80
5.74
1.8
1.3
73.50
40.51
iu/ml
0.61
14
31
22
77
3.93
5.67
8.7
2.8
0.92
1.89
e6/l
0.32
14
41
23
84
3.82
5.57
3.0
1.7
—
—
—
0
0
9
8
12.94
5.49
1.2
1.1
—
—
—
0
0
28
119
3.54
5.37
4.0
3.2
—
—
—
0
0
15
34
5.52
5.20
14.0
9.6
1.20
1.36
mmol/l
0.17
15
34
15
42
4.43
5.15
2.0
1.6
—
—
—
0
0
11
17
7.65
5.04
1.4
1.9
99.27
85.29
%
0.59
11
17
13
26
6.08
4.98
6.5
2.2
0.67
0.65
%
0.06
13
26
47
286
3.97
4.95
10.3
3.7
0.00
0.00
estimate
-0.00
16
53
47
286
3.97
4.95
10.3
3.6
0.00
0.00
estimate
-0.00
16
54
19
66
3.75
4.88
2.8
1.5
—
—
—
0
0
47
288
3.92
4.86
10.2
3.7
0.00
0.00
estimate
-0.00
16
49
18
64
3.59
4.43
14.8
9.6
102.22
104.27
mmol/l
0.76
18
64
14
36
4.75
4.36
9.9
3.5
6.14
4.68
kpa
1.06
14
36
12
26
5.49
4.34
6.9
2.2
0.93
1.18
%
0.50
12
26
15
48
3.83
4.28
2.3
1.6
353.60
415.44
nmol/l
0.59
15
41
10
18
6.43
4.18
3.2
1.4
—
—
—
0
0
9
14
7.34
4.16
1.6
1.8
—
—
—
0
0
11
23
5.61
4.11
13.0
13.3
23.36
24.26
mmol/l
0.37
11
23
27
130
2.96
4.00
3.1
2.4
3.03
2.99
mg/l
0.03
27
122
40
239
3.02
3.97
4.6
3.4
—
—
estimate
—
0
0
12
29
4.90
3.97
12.3
13.0
94.03
93.05
%
0.21
12
29
14
40
4.25
3.94
15.4
5.2
1.20
1.22
mmol/l
0.28
14
34
17
63
3.37
3.89
3.1
1.5
—
—
—
0
0
7
8
9.70
3.88
1.4
1.4
—
—
—
0
0
9
16
6.41
3.82
1.3
1.8
—
—
—
0
0
9
17
6.02
3.67
1.3
1.8
—
—
—
0
0
31
168
2.75
3.60
9.2
3.5
0.00
0.00
estimate
-0.00
15
44
6
6
10.91
3.58
1.0
1.5
—
—
—
0
0
10
23
5.00
3.49
2.4
1.7
—
—
—
0
0
5
5
10.73
3.03
1.2
1.2
—
—
—
0
0
30
175
2.43
2.83
7.9
3.3
2.32
2.35
mmol/l
0.57
30
155
7
14
5.50
2.82
1.4
1.9
—
—
—
0
0
8
19
4.69
2.79
2.6
2.4
—
—
—
0
0
6
10
6.52
2.77
9.5
3.9
11.67
13.49
pmol/l
—
6
10
6
11
5.92
2.61
1.7
1.4
—
—
—
0
0
7
16
4.80
2.56
2.6
1.7
—
—
—
0
0
5
9
5.94
2.26
1.4
1.2
—
—
—
0
0
6
14
4.63
2.21
1.3
1.4
—
—
—
0
0
7
20
3.82
2.13
1.3
1.3
—
—
—
0
0
6
16
4.04
1.99
1.3
1.4
—
—
—
0
0
7
22
3.46
1.94
7.4
4.4
23.67
24.57
mmol/l
—
7
22
31
222
1.82
1.43
2.8
2.0
100.29
97.62
pmol/l
0.09
17
110
6
25
2.55
1.28
8.3
4.8
60.17
53.54
%
—
6
25
44
504
0.52
1.26
9.5
5.1
5.85
6.04
mmol/l
0.50
39
472
31
231
1.71
1.19
9.9
3.5
0.00
0.00
estimate
-0.00
16
45
39
310
1.74
1.18
4.9
3.0
—
—
—
0
0
13
81
1.77
0.90
1.9
1.6
—
—
—
0
0
23
169
1.59
0.88
8.5
3.1
0.00
0.00
estimate
-0.00
14
43
14
94
1.64
0.75
5.6
3.3
2.47
2.45
mmol/l
0.19
14
81
48
516
0.65
0.54
8.1
6.0
2.35
2.71
mmol/l
1.59
48
483
8
56
1.49
0.45
17.3
7.4
—
—
—
0
0
5
40
1.27
0.23
2.0
1.2
—
—
—
0
0
5
42
1.21
0.22
1.2
2.4
—
—
—
0
0
51
495
1.20
0.14
65.7
15.2
62.90
81.90
ml/min/173m2
3.74
51
462
42
438
0.86
0.14
72.1
20.2
329.38
332.63
g/l
1.66
42
438
13
116
1.15
0.10
1.6
2.0
429.69
484.80
pmol/l
0.39
13
101
6
56
1.08
0.09
2.0
2.1
1.90
1.39
%
—
6
49
16
166
0.95
0.00
4.1
4.8
29.12
22.03
%
—
9
82
35
355
0.97
0.00
5.8
3.5
62.00
47.61
u/l
0.49
35
336
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
4.59
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
6.88
—
0
5
0
5
0.00
-0.00
0.0
3.4
—
9.80
—
0
5
6
60
1.00
-0.00
2.7
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.5
—
28.28
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
61.83
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
7.34
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
9.80
—
0
6
5
49
1.02
-0.00
1.2
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_CRYOGLOBU and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CRYOGLOBU.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CRYOGLOBU – Cryoglobulinemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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